GO:0060338

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Name regulation of type I interferon-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0060338
Unique Molecular Interactions 60
Total Molecular Interactions 66
Total Single Events 605
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of type I interferon-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of type I interferon-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
2 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69
3 INT129920 IFNA2 Regulation of ADO 1 0.00 0.64 0.64
4 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
5 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
6 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
7 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
8 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
9 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
10 INT41787 IFNA2 Negative_regulation of Glb1 1 0.04 0.09 0.23
11 INT355981 IFNAR2 Positive_regulation of IDO1 1 0.01 1.13 0.23
12 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19
13 INT338898 Binding of PECAM1 and PTPN11 1 0.04 0.38 0.19
14 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
15 INT226339 Binding of IK and JAK1 1 0.00 0.46 0.16
16 INT226367 INCENP Negative_regulation of SOCS1 1 0.01 0.47 0.15
17 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
18 INT226366 Binding of CISH and JAK1 1 0.00 0.46 0.15
19 INT295273 STAT1 Regulation of Transcription of Hp 1 0.00 0.63 0.15
20 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
21 INT295272 STAT1 Regulation of Hp 1 0.00 0.63 0.14
22 INT343861 Binding of IFN1@ and STAT1 1 0.00 0.13 0.14
23 INT295271 STAT1 Regulation of Gbp2 1 0.00 0.63 0.14
24 INT226378 INCENP Positive_regulation of Transcription of SOCS1 1 0.01 0.41 0.13
25 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
26 INT179871 IK Positive_regulation of SOCS3 1 0.01 1 0.1
27 INT338901 Binding of PECAM1 and PTPN6 1 0.03 0.18 0.1
28 INT335772 MIR155 Regulation of SOCS1 1 0.01 0.29 0.09
29 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08
30 INT273373 SOCS3 Regulation of Phosphorylation of STAT3 1 0.42 0.06 0.08
31 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08
32 INT49609 IFNA2 Positive_regulation of Alpk1 1 0.00 0.73 0.07
33 INT273369 SOCS3 Negative_regulation of JAK1 1 0.03 0 0.07
34 INT273363 SOCS3 Regulation of Protein_catabolism of SOCS1 1 0.02 0 0.07
35 INT273364 SOCS3 Regulation of SOCS1 1 0.02 0 0.07
36 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
37 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
38 INT60089 IL2 Regulation of IFNA2 1 0.25 0.09 0.05
39 INT268677 IFNA2 Positive_regulation of XRCC1 1 0.05 0.75 0.05
40 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04
41 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
42 INT60088 IFNA2 Positive_regulation of IL2 1 0.12 0.07 0.03
43 INT285580 Binding of PTPN11 and S100A8 1 0.05 0.2 0
44 INT280543 Binding of GAST and STAT1 1 0.05 0.58 0
45 INT322546 Negative_regulation of PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
46 INT210707 Binding of IFNA2 and IL2 1 0.06 0.91 0
47 INT206088 IL6 Positive_regulation of JAK1 1 0.18 0.05 0
48 INT272441 Binding of IFNA2 and Slc11a1 1 0.02 0.97 0
49 INT194924 CD22 Positive_regulation of PTPN6 1 0.05 0.08 0
50 INT268809 Binding of IFNA2 and PAEP 1 0.01 0.16 0
51 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0
52 INT164891 STAT1 Positive_regulation of Gene_expression of IL1RL1 1 0.41 0.06 0
53 INT322545 PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
54 INT279534 Binding of CFH and PTPN11 1 0.02 2.54 0
55 INT103769 AMY2A Positive_regulation of IFNA2 1 0.01 0.26 0
56 INT241300 Binding of IGHG3 and PTPN11 1 0.01 1.47 0
57 INT317311 Binding of Cdc37 and Pink1 1 0.13 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of type I interferon-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of type I interferon-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68
2 INT5871 Binding of IFNA2 38 0.48 20.35 6.46
3 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
4 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13
5 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3
6 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29
7 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
8 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57
9 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87
10 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
11 INT206144 Phosphorylation of JAK1 6 0.57 1.77 1.64
12 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
13 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45
14 INT121820 Binding of STAT1 9 0.46 2.54 1.4
15 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22
16 INT155846 Transcription of JAK1 4 0.67 1.93 1.19
17 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
18 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14
19 INT40189 Localization of IFNA2 6 0.74 7.7 1.04
20 INT55562 Gene_expression of IFNAR2 2 0.31 0.44 0.98
21 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
22 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
23 INT30568 Regulation of IFNAR2 2 0.12 0.42 0.73
24 INT119836 Positive_regulation of Gene_expression of PTPN11 5 0.67 3.44 0.69
25 INT40190 Positive_regulation of Regulation of IFNA2 1 0.49 0.07 0.68
26 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
27 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
28 INT165847 Positive_regulation of HSP90AB1 1 0.60 0.31 0.6
29 INT165849 Protein_catabolism of HSP90AB1 1 0.56 0.28 0.56
30 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55
31 INT264129 Protein_catabolism of JAK1 1 0.02 0.38 0.55
32 INT129635 Positive_regulation of SOCS1 3 0.49 0.92 0.49
33 INT226580 Localization of JAK1 3 0.11 0.52 0.49
34 INT179887 Positive_regulation of SOCS3 10 0.50 13.06 0.45
35 INT129636 Transcription of SOCS1 2 0.52 1.29 0.45
36 INT119826 Positive_regulation of PTPN11 2 0.45 2.67 0.43
37 INT71024 Negative_regulation of Gene_expression of IFNA2 1 0.53 0.08 0.42
38 INT241304 Regulation of Transcription of PTPN11 3 0.43 4.49 0.41
39 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
40 INT279298 Gene_expression of JAK1 7 0.65 5.5 0.37
41 INT280551 Negative_regulation of Gene_expression of JAK1 2 0.41 1.02 0.37
42 INT22074 Negative_regulation of Regulation of IFNA2 1 0.39 1.16 0.36
43 INT30567 Negative_regulation of IFNAR2 1 0.03 1.12 0.36
44 INT317742 Positive_regulation of Transcription of JAK1 1 0.49 0.57 0.35
45 INT206142 Localization of STAT1 7 0.78 3.09 0.31
46 INT121817 Positive_regulation of Binding of STAT1 2 0.67 0.49 0.3
47 INT129812 Gene_expression of HSP90AB1 1 0.75 0.72 0.27
48 INT280561 Binding of JAK1 2 0.26 0.39 0.26
49 INT252757 Negative_regulation of PTPN6 4 0.10 0.74 0.25
50 INT226426 Negative_regulation of SOCS3 2 0.15 10.24 0.22
51 INT258447 Positive_regulation of TYK2 1 0.21 1.27 0.21
52 INT250818 Positive_regulation of Localization of IFNA2 4 0.12 5.06 0.2
53 INT241302 Transcription of PTPN11 3 0.67 2.81 0.2
54 INT321425 Gene_expression of PTPN6 1 0.03 0.89 0.2
55 INT121819 Regulation of Binding of STAT1 1 0.59 0.05 0.19
56 INT188215 Negative_regulation of Phosphorylation of STAT1 2 0.31 0.48 0.17
57 INT335807 Localization of SOCS1 1 0.36 0.41 0.15
58 INT231559 Negative_regulation of Gene_expression of STAT1 2 0.06 0.36 0.14
59 INT226477 Positive_regulation of Transcription of SOCS1 1 0.21 0.41 0.13
60 INT273407 Transcription of SOCS3 1 0.62 0.17 0.11
61 INT241305 Binding of PTPN11 9 0.46 6.08 0.1
62 INT267568 Negative_regulation of PTPN11 7 0.28 0.36 0.1
63 INT186065 Positive_regulation of Phosphorylation of STAT1 3 0.25 1.95 0.1
64 INT293340 Negative_regulation of Negative_regulation of JAK1 1 0.02 0.34 0.1
65 INT179890 Localization of SOCS3 1 0.54 1.02 0.1
66 INT268281 Negative_regulation of SOCS1 3 0.21 1.12 0.08
67 INT252729 Phosphorylation of PTPN6 2 0.03 0.67 0.08
68 INT19108 Positive_regulation of Negative_regulation of IFNA2 2 0.49 1.7 0.08
69 INT194938 Regulation of PTPN6 2 0.29 0.48 0.08
70 INT343445 Binding of SOCS1 1 0.02 0.07 0.08
71 INT352530 Positive_regulation of Positive_regulation of SOCS3 1 0.15 1.77 0.08
72 INT273403 Positive_regulation of Transcription of SOCS3 1 0.40 0.06 0.08
73 INT331322 Protein_catabolism of PTPN11 1 0.06 0.96 0.08
74 INT276339 Localization of PTPN6 1 0.10 1.31 0.08
75 INT52199 Regulation of Gene_expression of IFNA2 2 0.06 1.69 0.07
76 INT273397 Binding of SOCS3 1 0.42 0 0.07
77 INT273405 Negative_regulation of Binding of SOCS3 1 0.37 0 0.07
78 INT241303 Localization of PTPN11 8 0.77 10.23 0.06
79 INT206148 Positive_regulation of Transcription of STAT1 2 0.21 0.72 0.06
80 INT273400 Protein_catabolism of SOCS1 1 0.05 0 0.06
81 INT326329 Regulation of Localization of PTPN11 1 0.20 0.74 0.06
82 INT139018 Negative_regulation of Positive_regulation of STAT1 1 0.27 0.82 0.06
83 INT300107 Positive_regulation of Gene_expression of SOCS3 1 0.15 3.58 0.05
84 INT300102 Gene_expression of TYK2 1 0.29 2.34 0.05
85 INT300092 Regulation of SOCS3 1 0.08 3.03 0.03
86 INT285583 Regulation of PTPN11 3 0.44 1.17 0
87 INT100350 Protein_catabolism of IFNA2 2 0.44 0.46 0
88 INT300109 Positive_regulation of Phosphorylation of TYK2 1 0.24 1.14 0
89 INT280552 Phosphorylation of IFNAR2 1 0.02 0.57 0
90 INT277762 Negative_regulation of Negative_regulation of STAT1 1 0.42 0.29 0
91 INT280557 Negative_regulation of Binding of JAK1 1 0.30 0.4 0
92 INT206164 Positive_regulation of Phosphorylation of JAK1 1 0.19 0.19 0
93 INT139020 Regulation of Negative_regulation of STAT1 1 0.29 0.35 0
94 INT332190 Regulation of Regulation of PTPN11 1 0.13 0.34 0
95 INT292404 Negative_regulation of PTPN1 1 0.25 1.19 0
96 INT280558 Positive_regulation of Binding of JAK1 1 0.35 0.39 0
97 INT241301 Positive_regulation of Localization of PTPN11 1 0.45 2.78 0
98 INT285584 Positive_regulation of Binding of PTPN11 1 0.06 0 0
99 INT280562 Positive_regulation of IFNAR2 1 0.01 0.57 0
100 INT347597 Negative_regulation of Gene_expression of PTPN11 1 0.42 0.44 0
101 INT315883 Positive_regulation of Positive_regulation of JAK1 1 0.01 0.38 0
102 INT144040 Negative_regulation of Positive_regulation of JAK1 1 0.04 0.08 0
103 INT268826 Regulation of Localization of IFNA2 1 0.07 0.43 0
104 INT293680 Positive_regulation of Localization of HSP90AB1 1 0.45 0 0
105 INT300094 Phosphorylation of TYK2 1 0.39 1.07 0
106 INT293675 Localization of HSP90AB1 1 0.68 0 0
107 INT194944 Positive_regulation of PTPN6 1 0.06 0.46 0
108 INT306211 Phosphorylation of PTPN11 1 0.79 1.13 0
109 INT300103 Positive_regulation of Negative_regulation of SOCS3 1 0.15 1.75 0
110 INT300097 Binding of TYK2 1 0.23 1.13 0
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