GO:0060347

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Name heart trabecula formation
Categary Process
Go Slim No
Go Link GO:0060347
Unique Molecular Interactions 96
Total Molecular Interactions 118
Total Single Events 677
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heart trabecula formation. They are ordered first by their pain relevance and then by number of times they were reported for heart trabecula formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
2 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
3 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
4 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48
5 INT184460 Il1 Positive_regulation of Adamts1 1 0.04 0.99 0.4
6 INT184459 Il1 Regulation of Gene_expression of Adamts1 1 0.03 0.73 0.34
7 INT181896 TNF Regulation of TEK 1 0.03 1.21 0.33
8 INT184466 Adamts1 Positive_regulation of Adamts4 1 0.13 1.03 0.3
9 INT184457 Adamts1 Positive_regulation of Positive_regulation of Adamts4 1 0.13 1.03 0.3
10 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
11 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
12 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
13 INT318551 Binding of VEGFA and Adamts1 1 0.13 1.13 0.27
14 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27
15 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22
16 INT303029 Binding of TEK and Angpt1 1 0.26 1.82 0.22
17 INT312517 Rapgef1 Negative_regulation of Rbp4 1 0.01 0.9 0.22
18 INT184458 Il17a Positive_regulation of Transcription of Adamts1 1 0.05 0.87 0.18
19 INT256586 Binding of RBP4 and TTR 1 0.07 1.92 0.18
20 INT184464 Gtf3a Positive_regulation of Adamts1 1 0.01 0.87 0.17
21 INT184467 Gtf3a Positive_regulation of Transcription of Adamts1 1 0.01 0.87 0.17
22 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16
23 INT238333 Binding of PDGFA and Regulation of Gene_expression of ADAMTS1 1 0.06 0 0.14
24 INT238341 GOPC Regulation of Transcription of ADAMTS1 1 0.04 0 0.14
25 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
26 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
27 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14
28 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
29 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
30 INT213053 Hdl1 Negative_regulation of Gene_expression of Adamts1 1 0.07 0.88 0.1
31 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
32 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
33 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
34 INT298699 Kdr Regulation of Tek 1 0.11 0.28 0.06
35 INT298701 Manea Regulation of Tek 1 0.03 0.28 0.06
36 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
37 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
38 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
39 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
40 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
41 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
42 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04
43 INT298703 Angpt1 Regulation of Tek 1 0.12 0.27 0.03
44 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
45 INT318549 Positive_regulation of Stmn1 Positive_regulation of Gene_expression of Adamts1 1 0.01 0.73 0
46 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
47 INT318550 Adamts1 Regulation of Gene_expression of Tsp1 1 0.33 0.77 0
48 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
49 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
50 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
51 INT238819 Binding of LTF and RBP4 1 0.04 0.26 0
52 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
53 INT318545 Adamts1 Regulation of Tsp1 1 0.20 1.39 0
54 INT189555 EGLN1 Regulation of Gene_expression of VEGFA 1 0.07 0.57 0
55 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
56 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
57 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
58 INT318548 Adamts1 Regulation of Stmn1 1 0.00 1.3 0
59 INT273949 Binding of Crem and Smarca4 1 0.01 0 0
60 INT238822 TF Regulation of Localization of RBP4 1 0.14 0.28 0
61 INT318547 Negative_regulation of Adamts1 Positive_regulation of Tsp1 1 0.35 1.73 0
62 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0
63 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
64 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
65 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
66 INT238827 RBP4 Positive_regulation of Gene_expression of INS 1 0.14 1.15 0
67 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
68 INT298702 Tek Regulation of Kdr 1 0.03 0.33 0
69 INT268887 Binding of ANGPT1 and Tek 1 0.10 0 0
70 INT176096 Regulation of Binding of Angpt1 and Tek 1 0.07 0.54 0
71 INT238818 LTF Positive_regulation of RBP4 1 0.06 0.29 0
72 INT238826 Binding of INS and RBP4 1 0.10 2.07 0
73 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
74 INT176097 Binding of Angpt1 and Tek 1 0.06 0.48 0
75 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
76 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
77 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
78 INT238824 LTF Positive_regulation of Localization of RBP4 1 0.08 0.29 0
79 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
80 INT318546 Positive_regulation of Stmn1 Positive_regulation of Adamts1 1 0.01 0.74 0
81 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
82 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
83 INT184461 Binding of Adamts1 and Furin 1 0.09 0 0
84 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
85 INT313024 Acp6 Positive_regulation of Gene_expression of Rbp4 1 0.01 0 0
86 INT298704 Tek Regulation of Manea 1 0.02 0.33 0
87 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
88 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
89 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0
90 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heart trabecula formation. They are ordered first by their pain relevance and then by number of times they were reported in heart trabecula formation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
2 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
3 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
4 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19
5 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
6 INT153719 Gene_expression of TEK 10 0.49 9.82 1.88
7 INT184440 Positive_regulation of Adamts1 18 0.68 13.28 1.87
8 INT187246 Gene_expression of ADAMTS1 3 0.24 1.17 1.84
9 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
10 INT218313 Localization of RBP4 5 0.79 15.68 1.4
11 INT184431 Transcription of Adamts1 9 0.67 4.94 1.35
12 INT133888 Negative_regulation of Adamts1 6 0.50 18.52 1.04
13 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
14 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
15 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
16 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
17 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
18 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
19 INT26531 Regulation of Srf 3 0.18 0.62 0.9
20 INT184427 Negative_regulation of Gene_expression of Adamts1 3 0.57 9.47 0.88
21 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85
22 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
23 INT45293 Transcription of Srf 2 0.47 0.79 0.76
24 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
25 INT184449 Regulation of Adamts1 6 0.44 5.05 0.68
26 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
27 INT184436 Regulation of Gene_expression of Adamts1 6 0.60 9.53 0.62
28 INT184445 Binding of Adamts1 7 0.38 1.24 0.61
29 INT187245 Negative_regulation of Gene_expression of ADAMTS1 1 0.18 0.51 0.6
30 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
31 INT238828 Regulation of RBP4 6 0.60 2.7 0.58
32 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
33 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
34 INT184434 Localization of Adamts1 5 0.63 1.95 0.41
35 INT176085 Regulation of Tek 6 0.37 3.36 0.4
36 INT238348 Transcription of ADAMTS1 1 0.22 0 0.39
37 INT176079 Positive_regulation of Tek 6 0.41 3.15 0.36
38 INT254367 Transcription of TEK 1 0.14 1.08 0.36
39 INT311100 Binding of ADAMTS1 1 0.47 0.45 0.35
40 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
41 INT218314 Binding of RBP4 9 0.36 6.27 0.33
42 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
43 INT181921 Binding of TEK 2 0.09 1.88 0.32
44 INT238356 Positive_regulation of Gene_expression of ADAMTS1 1 0.16 0.15 0.32
45 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
46 INT254372 Negative_regulation of TEK 1 0.12 1.05 0.31
47 INT218316 Positive_regulation of RBP4 2 0.68 7.54 0.3
48 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
49 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
50 INT7610 Localization of Srf 3 0.67 0.98 0.27
51 INT46827 Negative_regulation of ADAMTS1 2 0.42 0.93 0.26
52 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
53 INT181914 Positive_regulation of EGLN1 1 0.36 2.03 0.25
54 INT184439 Protein_catabolism of Adamts1 1 0.51 1.08 0.23
55 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
56 INT184455 Positive_regulation of Transcription of Adamts1 2 0.27 0.59 0.2
57 INT181788 Positive_regulation of Gene_expression of TEK 1 0.27 1.26 0.2
58 INT178481 Binding of Tek 2 0.28 1.55 0.19
59 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
60 INT176091 Regulation of Positive_regulation of Tek 1 0.37 0.22 0.18
61 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17
62 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16
63 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
64 INT89766 Binding of SRF 1 0.17 0.89 0.15
65 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
66 INT238831 Regulation of Localization of RBP4 1 0.27 1.71 0.15
67 INT184453 Positive_regulation of Gene_expression of Adamts1 4 0.68 12.98 0.14
68 INT298697 Negative_regulation of Tek 2 0.35 0.85 0.14
69 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
70 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
71 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12
72 INT286293 Binding of Rbp4 3 0.17 0.61 0.12
73 INT226281 Regulation of TEK 1 0.60 1.33 0.11
74 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
75 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
76 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
77 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
78 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
79 INT299319 Localization of FKBP1A 1 0.44 0 0.09
80 INT22789 Binding of Srf 1 0.37 0.07 0.07
81 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
82 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
83 INT190544 Transcription of Srf 1 0.19 0.43 0.06
84 INT158616 Localization of EGLN1 1 0.73 0.54 0.06
85 INT190570 Localization of Srf 1 0.20 0.49 0.06
86 INT178495 Negative_regulation of Positive_regulation of Tek 1 0.14 1.05 0.06
87 INT200861 Negative_regulation of Binding of Tek 1 0.32 0.3 0.06
88 INT238355 Negative_regulation of Transcription of ADAMTS1 1 0.18 0 0.06
89 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
90 INT178484 Positive_regulation of Phosphorylation of Tek 1 0.23 0.79 0.04
91 INT178486 Phosphorylation of Tek 1 0.27 0.73 0.04
92 INT260908 Positive_regulation of Smarca4 2 0.21 0.53 0.03
93 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
94 INT268102 Transcription of SRF 1 0.53 0.85 0.03
95 INT225413 Binding of Srf 1 0.10 0.27 0.03
96 INT312192 Protein_catabolism of ADAMTS1 1 0.11 0.05 0.03
97 INT312928 Localization of Tek 1 0.31 0.66 0.03
98 INT238318 Regulation of Transcription of Adamts1 1 0.02 0 0.03
99 INT157800 Gene_expression of Srf 2 0.45 0.88 0
100 INT184443 Negative_regulation of Positive_regulation of Adamts1 2 0.37 2.12 0
101 INT238829 Negative_regulation of Localization of RBP4 1 0.57 1.21 0
102 INT236567 Positive_regulation of Gene_expression of Rbp4 1 0.40 0 0
103 INT189577 Negative_regulation of EGLN1 1 0.31 1.73 0
104 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
105 INT189603 Negative_regulation of Transcription of EGLN1 1 0.31 0.94 0
106 INT238832 Negative_regulation of Gene_expression of RBP4 1 0.57 1.23 0
107 INT238830 Positive_regulation of Localization of RBP4 1 0.68 2.98 0
108 INT236577 Positive_regulation of Rbp4 1 0.40 0 0
109 INT312931 Negative_regulation of Regulation of Tek 1 0.19 0.23 0
110 INT218765 Regulation of Localization of TEK 1 0.02 0.87 0
111 INT184432 Negative_regulation of Protein_catabolism of Adamts1 1 0.29 0 0
112 INT312190 Positive_regulation of ADAMTS1 1 0.09 0 0
113 INT200860 Transcription of Tek 1 0.39 0.26 0
114 INT189605 Regulation of EGLN1 1 0.33 1.65 0
115 INT238836 Positive_regulation of Gene_expression of RBP4 1 0.68 3.46 0
116 INT218764 Localization of TEK 1 0.04 0.87 0
117 INT318531 Regulation of Negative_regulation of Adamts1 1 0.38 1.38 0
118 INT189617 Transcription of EGLN1 1 0.50 0.94 0
119 INT184438 Negative_regulation of Binding of Adamts1 1 0.39 0 0
120 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
121 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
122 INT243005 Positive_regulation of Positive_regulation of Tek 1 0.10 0.98 0
123 INT260913 Negative_regulation of Smarca4 1 0.18 0.29 0
124 INT260903 Regulation of Rbp4 1 0.06 0.27 0
125 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
126 INT273916 Binding of Smarca4 1 0.01 0 0
127 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
128 INT238833 Negative_regulation of RBP4 1 0.42 2.41 0
129 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
130 INT238834 Regulation of Gene_expression of RBP4 1 0.44 2.49 0
131 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
132 INT189572 Positive_regulation of Gene_expression of EGLN1 1 0.34 0.92 0
133 INT318537 Regulation of Positive_regulation of Adamts1 1 0.44 1.82 0
134 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
135 INT236583 Regulation of Positive_regulation of Rbp4 1 0.36 0 0
136 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
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