GO:0060348

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Name bone development
Categary Process
Go Slim No
Go Link GO:0060348
Unique Molecular Interactions 165
Total Molecular Interactions 224
Total Single Events 2833
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bone development. They are ordered first by their pain relevance and then by number of times they were reported for bone development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
3 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
4 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
5 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
6 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02
7 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02
8 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
9 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
10 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
11 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
12 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8
13 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
14 INT28975 Ins1 Positive_regulation of Positive_regulation of Dbh 1 0.21 0 0.66
15 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
16 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
17 INT139750 Ubqln1 Regulation of Dbh 1 0.00 0 0.52
18 INT139751 Dbh Regulation of Localization of Prl 1 0.02 0 0.52
19 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
20 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51
21 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47
22 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47
23 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
24 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
25 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
26 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42
27 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
28 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
29 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39
30 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
31 INT296306 Binding of BGLAP and SPIN1 1 0.05 1.69 0.37
32 INT88068 Ptger2 Positive_regulation of Transcription of Ptger4 1 0.15 0 0.36
33 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
34 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
35 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34
36 INT304320 Binding of Ptger2 and Ptger4 2 0.26 0.06 0.33
37 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
38 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
39 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
40 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
41 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
42 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
43 INT128934 Il1b Positive_regulation of Transcription of Ptger4 1 0.00 0 0.29
44 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
45 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
46 INT128933 Il1b Positive_regulation of Gene_expression of Ptger4 1 0.00 0 0.29
47 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
48 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
49 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
50 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
51 INT42354 Dbh Regulation of Localization of Gh1 1 0.07 0 0.28
52 INT78484 Binding of DBH and TH 1 0.09 0 0.28
53 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
54 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
55 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
56 INT304321 Ptger4 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.59 0.23
57 INT304324 VEGFA Positive_regulation of Gene_expression of Ptger4 1 0.27 0.16 0.23
58 INT207456 LGALS3 Negative_regulation of Gene_expression of BGLAP 1 0.13 0.5 0.22
59 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
60 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
61 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
62 INT193214 Binding of PTGER2 and PTGER4 2 0.08 2.51 0.18
63 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
64 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
65 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
66 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
67 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
68 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
69 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
70 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
71 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14
72 INT253468 Ptger2 Positive_regulation of Ptger4 1 0.12 1.19 0.13
73 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
74 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
75 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
76 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
77 INT64188 ART3 Negative_regulation of HSD17B2 1 0.00 0 0.09
78 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
79 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
80 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
81 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
82 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
83 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
84 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
85 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
86 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
87 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
88 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
89 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
90 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
91 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
92 INT207463 Negative_regulation of LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
93 INT207458 LGALS3 Negative_regulation of Negative_regulation of BGLAP 1 0.12 0.18 0.06
94 INT207468 LGALS3 Regulation of Gene_expression of BGLAP 1 0.11 0.13 0.06
95 INT207467 LGALS3 Negative_regulation of BGLAP 1 0.13 0.18 0.06
96 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
97 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
98 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
99 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
100 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
101 INT197646 DPH1 Negative_regulation of Localization of BGLAP 1 0.01 0.26 0.04
102 INT263337 Ptger4 Regulation of Ppara 1 0.02 0.3 0.04
103 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
104 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04
105 INT346303 Binding of MR1 and Col2a1 1 0.00 0.09 0.04
106 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
107 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
108 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
109 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
110 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
111 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
112 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
113 INT331959 Binding of Ptger4 and Ptgfr 1 0.01 0.15 0.03
114 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
115 INT300179 Binding of BGLAP and INCENP 1 0.02 0.08 0.03
116 INT207457 LGALS3 Positive_regulation of Gene_expression of BGLAP 1 0.12 0.1 0.03
117 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
118 INT331963 Positive_regulation of Binding of Ptger4 and Ptgfr 1 0.01 0.15 0.03
119 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
120 INT302171 PTGER4 Positive_regulation of RASGRP1 1 0.01 1.03 0.03
121 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
122 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
123 INT340214 BGLAP Regulation of Gene_expression of NFATC1 1 0.02 0.76 0
124 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
125 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
126 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
127 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
128 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
129 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0
130 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
131 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
132 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
133 INT63391 SLTM Regulation of Gene_expression of Col2a1 1 0.00 0 0
134 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
135 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
136 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
137 INT344893 Binding of ADCY1 and Ptger4 1 0.00 0 0
138 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
139 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
140 INT293625 Binding of BGLAP and SHBG 1 0.03 0.1 0
141 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
142 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0
143 INT254043 Binding of BGLAP and EBF1 1 0.07 0.11 0
144 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
145 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
146 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0
147 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
148 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
149 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
150 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
151 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
152 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
153 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
154 INT312345 Binding of COL2A1 and COL5A2 1 0.00 1.21 0
155 INT323804 NFAT5 Regulation of Transcription of COL2A1 1 0.43 0.07 0
156 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
157 INT201799 PGR Regulation of HSD17B2 1 0.12 0.08 0
158 INT254044 Binding of BGLAP and NEU4 1 0.04 0.29 0
159 INT312213 INPP5K Regulation of COL2A1 1 0.06 0 0
160 INT207462 CRX Negative_regulation of Gene_expression of BGLAP 1 0.02 0 0
161 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0
162 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
163 INT183134 Binding of SULF1 and Panc1 1 0.03 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for bone development. They are ordered first by their pain relevance and then by number of times they were reported in bone development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
2 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
3 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
4 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
5 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
6 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
7 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
8 INT4073 Localization of Dbh 28 0.81 6.06 16.37
9 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
10 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
11 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
12 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64
13 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
14 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
15 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
16 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
17 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
18 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
19 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
20 INT47546 Binding of Dbh 11 0.44 5.69 7.84
21 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
22 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
23 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
24 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
25 INT88784 Negative_regulation of stm 11 0.56 0.51 5.33
26 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07
27 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03
28 INT88062 Gene_expression of Ptger4 13 0.77 2.4 4.94
29 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
30 INT68260 Localization of BGLAP 34 0.78 16.04 4.63
31 INT88059 Positive_regulation of Ptger4 9 0.69 1.41 4.4
32 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
33 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96
34 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
35 INT99889 Transcription of SRD5A1 5 0.71 1.45 3.74
36 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
37 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
38 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
39 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
40 INT119470 Regulation of Ptger4 6 0.43 3.94 3.24
41 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
42 INT15253 Binding of DBH 7 0.36 3.21 3.17
43 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
44 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
45 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02
46 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
47 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
48 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
49 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96
50 INT91342 Negative_regulation of Negative_regulation of BGLAP 2 0.55 1.39 2.88
51 INT28376 Regulation of Localization of Dbh 1 0.31 0 2.87
52 INT68962 Positive_regulation of Ptger4 20 0.67 7.3 2.79
53 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
54 INT2958 Transcription of Dbh 4 0.71 2.57 2.64
55 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
56 INT2695 Regulation of DBH 5 0.45 1.09 2.48
57 INT28971 Positive_regulation of Gene_expression of Dbh 4 0.47 0.58 2.39
58 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
59 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14
60 INT94615 Localization of Ptger4 5 0.28 0.35 2.13
61 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
62 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
63 INT2961 Regulation of Regulation of Dbh 3 0.24 0.95 2.05
64 INT342815 Positive_regulation of Transcription of SRD5A1 1 0.49 0.33 2.04
65 INT186893 Binding of BGLAP 10 0.37 6.19 2.02
66 INT88783 Positive_regulation of stm 4 0.39 0 1.98
67 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
68 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
69 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
70 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
71 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
72 INT169786 Localization of Ptger4 7 0.69 1.82 1.65
73 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
74 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
75 INT113279 Gene_expression of HSD17B2 3 0.24 3.65 1.59
76 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
77 INT4074 Negative_regulation of Localization of Dbh 4 0.59 0.61 1.48
78 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
79 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
80 INT131188 Negative_regulation of Gene_expression of PTGER4 1 0.41 2.51 1.41
81 INT145809 Gene_expression of stm 9 0.65 3.66 1.4
82 INT296755 Positive_regulation of Gene_expression of PTGER4 2 0.33 2.03 1.34
83 INT141233 Negative_regulation of Positive_regulation of Dbh 2 0.42 0.39 1.33
84 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
85 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
86 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
87 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26
88 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
89 INT140877 Regulation of Ptger4 6 0.36 2.2 1.23
90 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
91 INT88063 Binding of Ptger4 2 0.37 0.35 1.2
92 INT38650 Positive_regulation of Negative_regulation of Dbh 3 0.50 0 1.16
93 INT183127 Localization of SULF1 1 0.77 3.45 1.13
94 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
95 INT23716 Localization of DBH 1 0.29 0.06 1.11
96 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
97 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
98 INT28972 Regulation of Gene_expression of Dbh 2 0.42 0.86 1.08
99 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
100 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
101 INT154493 Regulation of Gene_expression of SRD5A1 3 0.45 0.58 1.03
102 INT132770 Positive_regulation of Gene_expression of HSD17B2 1 0.02 2.28 1.01
103 INT50812 Regulation of Positive_regulation of Dbh 2 0.45 1.04 1
104 INT193256 Positive_regulation of PTGER4 6 0.19 4.38 0.99
105 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
106 INT91035 Positive_regulation of HSD17B2 7 0.66 5.2 0.98
107 INT30598 Negative_regulation of Transcription of Dbh 1 0.42 0.35 0.91
108 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
109 INT275075 Localization of stm 1 0.08 0.06 0.85
110 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
111 INT169788 Negative_regulation of Ptger4 5 0.51 2.11 0.82
112 INT169792 Positive_regulation of Gene_expression of Ptger4 5 0.60 2 0.82
113 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
114 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
115 INT28974 Negative_regulation of Negative_regulation of Dbh 1 0.40 0 0.78
116 INT173506 Positive_regulation of Col2a1 4 0.20 3.42 0.76
117 INT312011 Negative_regulation of Binding of BGLAP 1 0.11 1.04 0.76
118 INT88067 Negative_regulation of Positive_regulation of Ptger4 2 0.58 0.3 0.75
119 INT77591 Binding of Ptger4 3 0.36 1.09 0.74
120 INT131186 Negative_regulation of PTGER4 2 0.41 2.97 0.74
121 INT2959 Regulation of Transcription of Dbh 2 0.45 1.18 0.73
122 INT169790 Negative_regulation of Localization of Ptger4 1 0.37 0.77 0.72
123 INT169784 Regulation of Localization of Ptger4 1 0.39 0.77 0.72
124 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
125 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7
126 INT4072 Positive_regulation of Positive_regulation of Dbh 3 0.50 1.77 0.67
127 INT88061 Positive_regulation of Gene_expression of Ptger4 1 0.69 0 0.67
128 INT88066 Transcription of Ptger4 2 0.71 0 0.64
129 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
130 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
131 INT134599 Regulation of HSD17B2 2 0.44 1.28 0.63
132 INT235398 Regulation of Gene_expression of BGLAP 3 0.27 1.03 0.61
133 INT63389 Localization of Col2a1 7 0.68 1.95 0.6
134 INT183133 Negative_regulation of Localization of SULF1 1 0.41 1.34 0.59
135 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
136 INT275074 Positive_regulation of Gene_expression of stm 1 0.05 0.17 0.56
137 INT82332 Regulation of stm 2 0.08 0 0.55
138 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
139 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
140 INT342811 Positive_regulation of Gene_expression of SRD5A1 1 0.45 0.22 0.5
141 INT86132 Transcription of Ptger4 4 0.47 0.85 0.49
142 INT32183 Positive_regulation of Negative_regulation of Col2a1 2 0.46 1.01 0.49
143 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
144 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
145 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
146 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
147 INT3381 Positive_regulation of Regulation of Dbh 2 0.44 0.37 0.47
148 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
149 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
150 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
151 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45
152 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
153 INT224428 Positive_regulation of Localization of BGLAP 5 0.30 2.34 0.44
154 INT133179 Transcription of DBH 1 0.70 0.23 0.44
155 INT113653 Regulation of Gene_expression of Ptger4 1 0.30 0.19 0.44
156 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
157 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
158 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
159 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
160 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
161 INT47547 Positive_regulation of Binding of Dbh 1 0.47 0 0.39
162 INT88782 Positive_regulation of Negative_regulation of stm 1 0.15 0 0.39
163 INT193255 Transcription of PTGER4 2 0.19 1.4 0.38
164 INT57118 Transcription of BGLAP 4 0.56 1.65 0.37
165 INT68965 Positive_regulation of Positive_regulation of Ptger4 3 0.43 1.43 0.37
166 INT183114 Positive_regulation of Gene_expression of SULF1 1 0.48 7.61 0.37
167 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
168 INT128931 Negative_regulation of Gene_expression of Ptger4 1 0.01 0 0.36
169 INT88064 Positive_regulation of Transcription of Ptger4 1 0.50 0 0.36
170 INT183116 Positive_regulation of SULF1 1 0.67 3.22 0.34
171 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
172 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
173 INT146534 Regulation of PTGER4 1 0.02 0.35 0.33
174 INT54833 Positive_regulation of Col2a1 5 0.52 1.1 0.32
175 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
176 INT130070 Negative_regulation of Gene_expression of HSD17B2 1 0.08 0.7 0.3
177 INT88060 Positive_regulation of Positive_regulation of Ptger4 1 0.46 0 0.3
178 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29
179 INT304318 Negative_regulation of Gene_expression of Ptger4 1 0.34 0 0.29
180 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
181 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
182 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
183 INT181524 Negative_regulation of Binding of Col2a1 1 0.13 1.05 0.25
184 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
185 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
186 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
187 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22
188 INT275310 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.88 0.22
189 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
190 INT340249 Positive_regulation of Positive_regulation of BGLAP 1 0.04 0.95 0.21
191 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
192 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
193 INT13931 Protein_catabolism of Dbh 1 0.58 0 0.2
194 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
195 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
196 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
197 INT111306 Negative_regulation of Gene_expression of Dbh 1 0.25 0.45 0.17
198 INT220208 Regulation of Protein_catabolism of COL2A1 1 0.26 0.28 0.17
199 INT63646 Localization of Col2a1 3 0.77 0.37 0.16
200 INT158445 Gene_expression of Npr2 3 0.36 1.19 0.15
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