GO:0060373

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Name regulation of ventricular cardiomyocyte membrane depolarization
Categary Process
Go Slim No
Go Link GO:0060373
Unique Molecular Interactions 35
Total Molecular Interactions 40
Total Single Events 560
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of ventricular cardiomyocyte membrane depolarization. They are ordered first by their pain relevance and then by number of times they were reported for regulation of ventricular cardiomyocyte membrane depolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 0.00 0 1.25
2 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
3 INT67887 SCN5A Negative_regulation of INA 1 0.02 0.13 0.71
4 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
5 INT111244 Binding of BRS3 and SCN5A 1 0.00 0.72 0.48
6 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
7 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
8 INT26577 SCN5A Positive_regulation of co 1 0.00 0 0.27
9 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22
10 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2
11 INT196303 Binding of SCN5A and ACCS 1 0.00 1.43 0.18
12 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16
13 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1
14 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
15 INT186242 Binding of ALB and SCN5A 1 0.04 0.36 0.1
16 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
17 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
18 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
19 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
20 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
21 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
22 INT159461 SCN5A Negative_regulation of HPSE 1 0.00 0 0.07
23 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
24 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
25 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03
26 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
27 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
28 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0
29 INT134836 Binding of SMAD7 and YAP1 1 0.53 0.89 0
30 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
31 INT347155 Mirlet7a-1 Negative_regulation of Smad7 1 0.10 0 0
32 INT265264 Binding of NA and SCN5A 1 0.03 0.55 0
33 INT265265 SCN5A Regulation of Gene_expression of NAV1 1 0.01 0.16 0
34 INT91242 Binding of SCN5A and PIRT 1 0.00 0 0
35 INT91245 Binding of SCN5A and EMID1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of ventricular cardiomyocyte membrane depolarization. They are ordered first by their pain relevance and then by number of times they were reported in regulation of ventricular cardiomyocyte membrane depolarization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73
2 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88
3 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3
4 INT23598 Binding of SCN5A 32 0.40 16 5.35
5 INT30209 Localization of SCN5A 24 0.72 7.95 5.35
6 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
7 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47
8 INT127250 Positive_regulation of Positive_regulation of SCN5A 3 0.38 1.71 1.86
9 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33
10 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
11 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
12 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71
13 INT52590 Transcription of SCN5A 4 0.55 0.91 0.65
14 INT252612 Regulation of Gene_expression of SCN5A 5 0.35 0.56 0.53
15 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
16 INT163321 Protein_catabolism of SCN5A 1 0.64 0.25 0.31
17 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
18 INT184716 Binding of Smad7 2 0.34 0.91 0.29
19 INT137042 Negative_regulation of Transcription of SCN5A 1 0.34 0.23 0.29
20 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
21 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
22 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
23 INT164291 Regulation of Positive_regulation of SCN5A 2 0.38 0.73 0.15
24 INT57198 Negative_regulation of Positive_regulation of SCN5A 2 0.30 0.17 0.12
25 INT67512 Negative_regulation of Negative_regulation of SCN5A 1 0.01 0 0.1
26 INT249663 Negative_regulation of Phosphorylation of SCN5A 1 0.05 0.74 0.09
27 INT249661 Positive_regulation of Phosphorylation of SCN5A 1 0.06 0.74 0.09
28 INT249660 Phosphorylation of SCN5A 1 0.10 0.73 0.09
29 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
30 INT347149 Localization of Smad7 1 0.67 0 0.05
31 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
32 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
33 INT187724 Positive_regulation of Localization of SCN5A 2 0.24 0.15 0
34 INT347148 Regulation of Smad7 1 0.26 0 0
35 INT166121 Binding of SMAD7 1 0.30 0.39 0
36 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
37 INT211184 Positive_regulation of Binding of SCN5A 1 0.22 0.48 0
38 INT347145 Transcription of Smad7 1 0.68 0 0
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