GO:0060389

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Name pathway-restricted SMAD protein phosphorylation
Categary Process
Go Slim No
Go Link GO:0060389
Unique Molecular Interactions 368
Total Molecular Interactions 445
Total Single Events 2634
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
3 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
4 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
5 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
6 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
7 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
8 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
9 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
10 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
11 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
12 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
13 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
14 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
15 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
16 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
17 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
18 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
19 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
20 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
21 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
22 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
23 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
24 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
25 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
26 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
27 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
28 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
29 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
30 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
31 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
32 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
33 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
34 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
35 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
36 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
37 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
38 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
39 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
40 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
41 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
42 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
43 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
44 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
45 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
46 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
47 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
48 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
49 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
50 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
51 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
52 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
53 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
54 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
55 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
56 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
57 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
58 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
59 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
60 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
61 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
62 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
63 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
64 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
65 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
66 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
67 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
68 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
69 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
70 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
71 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
72 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
73 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
74 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
75 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
76 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
77 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
78 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
79 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
80 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
81 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
82 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
83 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
84 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
85 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
86 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
87 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
88 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
89 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
90 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
91 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
92 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
93 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
94 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
95 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
96 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
97 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
98 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21
99 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
100 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
101 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
102 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
103 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
104 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
105 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
106 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
107 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
108 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
109 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
110 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
111 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
112 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
113 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
114 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
115 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
116 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
117 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
118 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
119 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
120 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
121 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
122 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
123 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
124 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
125 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
126 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
127 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
128 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
129 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
130 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
131 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
132 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
133 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
134 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
135 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
136 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
137 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
138 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
139 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
140 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
141 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1
142 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
143 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
144 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
145 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
146 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
147 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
148 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
149 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
150 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
151 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
152 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
153 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
154 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
155 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
156 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
157 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
158 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
159 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
160 INT251232 Slc17a6 Positive_regulation of Tgfb1 1 0.03 0 0.08
161 INT134835 TGFB1 Regulation of Gene_expression of YAP1 1 0.49 0.69 0.08
162 INT134834 TGFB1 Positive_regulation of YAP1 1 0.55 0.81 0.08
163 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
164 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
165 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
166 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
167 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07
168 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
169 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
170 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
171 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
172 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
173 INT94851 TGFB1 Regulation of Gene_expression of COL7A1 1 0.03 0.06 0.06
174 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
175 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
176 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
177 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
178 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04
179 INT271452 Binding of TGFB1 and Eln 1 0.00 0.38 0.04
180 INT271449 Binding of TGFB1 and Lox 1 0.01 0.38 0.04
181 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
182 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
183 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
184 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
185 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
186 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
187 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
188 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
189 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
190 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
191 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
192 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
193 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
194 INT340086 Binding of Tgfb1 and Cndp2 1 0.04 0.38 0
195 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
196 INT314865 Binding of Ltbp3 and Tgfb1 1 0.24 0.51 0
197 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
198 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
199 INT312221 Binding of TGFB1 and INPP5K 1 0.09 0 0
200 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
3 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
4 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
5 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
6 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
7 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
8 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
9 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
10 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
11 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
12 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
13 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
14 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
15 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
16 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
17 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
18 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
19 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
20 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
21 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
22 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
23 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
24 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
25 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
26 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
27 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
28 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
29 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
30 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
31 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
32 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
33 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
34 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
35 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
36 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
37 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
38 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
39 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
40 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
41 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
42 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
43 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
44 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
45 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
46 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
47 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
48 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
49 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
50 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
51 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
52 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
53 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
54 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
55 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
56 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
57 INT114664 Binding of BMP2 12 0.37 6.54 0.91
58 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
59 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
60 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
61 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
62 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
63 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
64 INT93737 Gene_expression of Tgfb2 2 0.03 1.16 0.77
65 INT93736 Positive_regulation of Gene_expression of Tgfb2 2 0.02 1.16 0.77
66 INT141150 Localization of BMP7 4 0.56 2.84 0.76
67 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
68 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
69 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
70 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
71 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
72 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
73 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
74 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65
75 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
76 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
77 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
78 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
79 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
80 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
81 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
82 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58
83 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
84 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
85 INT130047 Localization of TGFB2 3 0.16 3.65 0.53
86 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
87 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
88 INT85808 Localization of BMP2 7 0.77 1.94 0.51
89 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
90 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
91 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
92 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
93 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
94 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
95 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
96 INT248931 Positive_regulation of Tgfb2 1 0.03 0 0.4
97 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
98 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
99 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
100 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
101 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
102 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
103 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
104 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
105 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
106 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3
107 INT184716 Binding of Smad7 2 0.34 0.91 0.29
108 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
109 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
110 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
111 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24
112 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
113 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
114 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22
115 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
116 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
117 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
118 INT85330 Positive_regulation of Regulation of Tgfb1 1 0.41 0.67 0.17
119 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
120 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
121 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
122 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
123 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
124 INT297455 Positive_regulation of Gdf2 1 0.01 0.75 0.15
125 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
126 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
127 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
128 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
129 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
130 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
131 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
132 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
133 INT14738 Negative_regulation of Regulation of TGFB1 2 0.41 0.81 0.09
134 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
135 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
136 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
137 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08
138 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
139 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
140 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
141 INT343551 Positive_regulation of Localization of TGFB2 1 0.10 1.48 0.08
142 INT316570 Binding of BMP7 3 0.37 0.95 0.07
143 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
144 INT251229 Negative_regulation of Tgfb2 1 0.34 0.06 0.07
145 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
146 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
147 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
148 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
149 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
150 INT251230 Positive_regulation of Negative_regulation of Tgfb1 1 0.09 0 0.05
151 INT347149 Localization of Smad7 1 0.67 0 0.05
152 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
153 INT136115 Positive_regulation of Regulation of TGFB1 1 0.11 0.16 0.05
154 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
155 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
156 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04
157 INT185020 Positive_regulation of Negative_regulation of TGFB1 1 0.43 0.44 0.04
158 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
159 INT180881 Regulation of Positive_regulation of TGFB1 2 0.32 1.32 0.03
160 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
161 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
162 INT173651 Gene_expression of GDF6 3 0.42 0.3 0
163 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
164 INT265316 Binding of Tgfbr1 2 0.35 0.59 0
165 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
166 INT265326 Regulation of Tgfbr1 2 0.43 0.17 0
167 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0
168 INT196031 Binding of Bmp2 1 0.16 0 0
169 INT314821 Binding of Tgfb2 1 0.36 0.51 0
170 INT320040 Positive_regulation of Gene_expression of GDF6 1 0.03 0 0
171 INT260766 Negative_regulation of Gene_expression of Bmp7 1 0.35 0 0
172 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
173 INT315214 Negative_regulation of Regulation of Tgfbr1 1 0.41 0 0
174 INT133097 Positive_regulation of Phosphorylation of Tgfb1 1 0.05 0.07 0
175 INT347148 Regulation of Smad7 1 0.26 0 0
176 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0
177 INT159211 Positive_regulation of Gene_expression of TGFB2 1 0.06 0 0
178 INT218701 Negative_regulation of Binding of Smad7 1 0.14 0.15 0
179 INT254788 Negative_regulation of Regulation of Tgfb1 1 0.06 0.61 0
180 INT166121 Binding of SMAD7 1 0.30 0.39 0
181 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
182 INT201963 Positive_regulation of Binding of Bmp7 1 0.05 0 0
183 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
184 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
185 INT314125 Regulation of Transcription of Bmp7 1 0.25 0.88 0
186 INT272228 Localization of TGFBR1 1 0.34 0.74 0
187 INT310177 Binding of Tgfbr2 1 0.24 0 0
188 INT351109 Transcription of TGFB2 1 0.24 0.94 0
189 INT254800 Positive_regulation of Phosphorylation of Tgfb1 1 0.04 0.24 0
190 INT347145 Transcription of Smad7 1 0.68 0 0
191 INT133099 Negative_regulation of Phosphorylation of Tgfb1 1 0.04 0.08 0
192 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
193 INT265319 Positive_regulation of Negative_regulation of Tgfbr1 1 0.47 0.53 0
194 INT310181 Binding of Gdf2 1 0.04 0 0
195 INT144920 Positive_regulation of Gene_expression of TGFBR1 1 0.65 0 0
196 INT83122 Transcription of TGFBR2 1 0.09 0 0
197 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
198 INT133098 Phosphorylation of Tgfb1 1 0.06 0.07 0
199 INT128712 Positive_regulation of Regulation of Tgfb1 1 0.15 0 0
200 INT310182 Gene_expression of Gdf2 1 0.06 0.48 0
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