GO:0060394

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Name negative regulation of pathway-restricted SMAD protein phosphorylation
Categary Process
Go Slim No
Go Link GO:0060394
Unique Molecular Interactions 75
Total Molecular Interactions 98
Total Single Events 682
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
10 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
11 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
12 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
13 INT32719 ENG Regulation of LH 2 0.00 0 0.64
14 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
15 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
16 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
17 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
18 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
19 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
20 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
21 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
22 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
23 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
24 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
25 INT102213 Binding of ENG and HP 1 0.01 0 0.47
26 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
27 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
28 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
29 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
30 INT55404 Binding of ENG and Th 1 0.02 0 0.3
31 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
32 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
33 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
34 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
35 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
36 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
37 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
38 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
39 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
40 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
41 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
42 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
43 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
44 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
45 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
46 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
47 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
48 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
49 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
50 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
51 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04
52 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
53 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
54 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
55 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
56 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
57 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0
58 INT32148 POMC Regulation of ENG 1 0.24 0 0
59 INT218663 Olr811 Positive_regulation of Gene_expression of Smad7 1 0.01 0.45 0
60 INT134836 Binding of SMAD7 and YAP1 1 0.53 0.89 0
61 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
62 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
63 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
64 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
65 INT347155 Mirlet7a-1 Negative_regulation of Smad7 1 0.10 0 0
66 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
67 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
68 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
69 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0
70 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of pathway-restricted SMAD protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of pathway-restricted SMAD protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
6 INT23375 Binding of ENG 17 0.47 6.02 6.46
7 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
8 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
9 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
10 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
11 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
12 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
13 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
14 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
15 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
16 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
17 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
18 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
19 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
20 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
21 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
22 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
23 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
24 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
25 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
26 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
27 INT184716 Binding of Smad7 2 0.34 0.91 0.29
28 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
29 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
30 INT272889 Negative_regulation of Smad6 2 0.20 1.31 0.19
31 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
32 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
33 INT90940 Binding of Eng 5 0.35 1.92 0.13
34 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
35 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
36 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
37 INT265338 Regulation of Eng 2 0.42 0.94 0.05
38 INT347149 Localization of Smad7 1 0.67 0 0.05
39 INT172971 Gene_expression of Smad6 2 0.37 1.77 0.04
40 INT311898 Positive_regulation of Gene_expression of Smad6 1 0.33 0.53 0.04
41 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
42 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
43 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
44 INT289876 Localization of Eng 3 0.44 0.59 0
45 INT190471 Transcription of ENG 3 0.21 1.76 0
46 INT265314 Regulation of Gene_expression of Eng 2 0.42 0.68 0
47 INT265324 Negative_regulation of Gene_expression of Eng 2 0.40 0.9 0
48 INT347148 Regulation of Smad7 1 0.26 0 0
49 INT197394 Protein_catabolism of Eng 1 0.07 0.13 0
50 INT218701 Negative_regulation of Binding of Smad7 1 0.14 0.15 0
51 INT166121 Binding of SMAD7 1 0.30 0.39 0
52 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
53 INT310171 Phosphorylation of Eng 1 0.24 0.5 0
54 INT347145 Transcription of Smad7 1 0.68 0 0
55 INT218685 Binding of Smad7 1 0.13 0.15 0
56 INT310173 Binding of Smad6 1 0.05 0 0
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