GO:0060396

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Name growth hormone receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0060396
Unique Molecular Interactions 769
Total Molecular Interactions 1162
Total Single Events 11792
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for growth hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for growth hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
7 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
8 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
9 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
10 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
11 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
12 INT3576 Sst Negative_regulation of Localization of Gh1 6 0.23 0 2.13
13 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
14 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
15 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
16 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
17 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
18 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
19 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
20 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
21 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
22 INT52568 HTR1D Regulation of Localization of Gh 2 0.20 0.16 1.34
23 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
24 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
25 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
26 INT70570 su Positive_regulation of Gh 1 0.01 0.15 1.24
27 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
28 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
29 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
30 INT14199 GNRH1 Positive_regulation of Localization of Gh1 2 0.05 0 1.12
31 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
32 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
33 INT33338 Adarb1 Positive_regulation of Localization of Gh1 1 0.04 0 1.08
34 INT33336 Adarb1 Positive_regulation of Negative_regulation of Gh1 1 0.03 0 1.08
35 INT33337 Adarb1 Positive_regulation of Gh1 1 0.03 0 1.08
36 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
37 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
38 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
39 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98
40 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
41 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
42 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
43 INT36682 Gh1 Regulation of Gene_expression of Gnrhr 2 0.08 0 0.96
44 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95
45 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
46 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
47 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
48 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
49 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
50 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
51 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
52 INT39201 Olr824 Positive_regulation of Localization of Gh1 1 0.03 0 0.91
53 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
54 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
55 INT35160 GH1 Regulation of PRL 2 0.37 0 0.89
56 INT61046 Oprm1 Positive_regulation of Gh1 1 0.21 0 0.89
57 INT61047 Oprm1 Positive_regulation of Localization of Gh1 1 0.29 0 0.89
58 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
59 INT44589 Negative_regulation of Oprl1 Positive_regulation of Gh1 1 0.22 0.53 0.87
60 INT44590 Oprl1 Positive_regulation of Gh1 1 0.23 0.53 0.87
61 INT40742 Pomc Regulation of Localization of Gh1 1 0.37 0 0.86
62 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
63 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
64 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
65 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
66 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
67 INT5103 Gal Regulation of Localization of Gh1 1 0.33 0.08 0.82
68 INT54260 SST Regulation of GH1 1 0.18 0.06 0.81
69 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
70 INT90381 Binding of GH1 and LAMC2 1 0.34 0.05 0.81
71 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
72 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
73 INT40743 Binding of Gh1 and Pomc 1 0.22 0 0.8
74 INT54800 Grin1 Regulation of Gene_expression of Gh 1 0.01 0 0.79
75 INT105250 Cyb5b Regulation of Localization of Gh1 1 0.00 0 0.79
76 INT92793 Gh Positive_regulation of CTS 1 0.04 1.39 0.78
77 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
78 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
79 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
80 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
81 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
82 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
83 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
84 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
85 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
86 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
87 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
88 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
89 INT222528 Abat Positive_regulation of Gene_expression of Gh1 1 0.01 0 0.75
90 INT54802 SST Negative_regulation of Localization of Gh 1 0.01 0 0.75
91 INT54801 SST Negative_regulation of Positive_regulation of Gh 1 0.01 0 0.75
92 INT17528 Prl Regulation of Gh 2 0.28 1.28 0.73
93 INT16894 Regulation of GHRH Regulation of GH1 2 0.37 0 0.72
94 INT14196 Glra2 Positive_regulation of Localization of Gh1 1 0.06 0 0.71
95 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
96 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
97 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
98 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
99 INT784 Prss12 Positive_regulation of Gh1 1 0.06 0 0.7
100 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
101 INT30409 Negative_regulation of Negative_regulation of Positive_regulation of Gh1 1 0.02 0.1 0.7
102 INT30408 Negative_regulation of Negative_regulation of Gh1 1 0.02 0.1 0.7
103 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
104 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
105 INT47264 Abat Regulation of Localization of Gh1 1 0.14 0 0.67
106 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
107 INT40470 GH1 Positive_regulation of GHRH 1 0.06 0 0.67
108 INT222552 Abat Regulation of Gene_expression of Gh1 1 0.00 0 0.67
109 INT31260 Sst Negative_regulation of Gh1 2 0.11 0 0.66
110 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
111 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
112 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
113 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
114 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
115 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
116 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
117 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
118 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63
119 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62
120 INT15731 SST Regulation of Gh 1 0.04 0 0.62
121 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
122 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
123 INT56520 DDX21 Positive_regulation of Localization of Gh 1 0.11 0.16 0.6
124 INT56391 Pomc Negative_regulation of Localization of Gh1 1 0.26 0 0.59
125 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
126 INT30462 Gnrhr Positive_regulation of Localization of Gh1 2 0.21 0.08 0.58
127 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
128 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
129 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
130 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
131 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
132 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
133 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
134 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
135 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54
136 INT84067 IGFBP1 Regulation of GH1 1 0.02 1.18 0.54
137 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
138 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
139 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
140 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
141 INT33513 GH1 Positive_regulation of PRL 1 0.30 0 0.53
142 INT49696 Trh Regulation of GH1 2 0.02 0.22 0.52
143 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
144 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
145 INT24869 GAL Regulation of Localization of Gh 1 0.19 0.4 0.51
146 INT32479 Gh1 Negative_regulation of Dbi 1 0.01 0 0.51
147 INT24205 Gh1 Negative_regulation of Gal 1 0.34 0 0.51
148 INT121822 Binding of STAT3 and Olr1583 1 0.00 0.21 0.51
149 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
150 INT56671 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.40 0 0.49
151 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
152 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49
153 INT46051 ABAT Regulation of Localization of GH1 1 0.19 0 0.49
154 INT70930 Sstr2 Regulation of Localization of Gh1 1 0.15 0 0.49
155 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49
156 INT36684 Gh1 Regulation of Prl 2 0.18 1.25 0.48
157 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
158 INT55020 Gh1 Regulation of Gene_expression of Prl 1 0.19 0 0.48
159 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
160 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
161 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
162 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
163 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
164 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
165 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
166 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
167 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
168 INT47222 Binding of Gh and Prl 1 0.22 0.18 0.46
169 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
170 INT72203 GH1 Regulation of OGG1 1 0.10 0 0.46
171 INT47221 Prl Regulation of Localization of Gh 1 0.28 0.27 0.46
172 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
173 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
174 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45
175 INT30412 Sst Regulation of Gene_expression of Gh1 1 0.19 0.06 0.45
176 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
177 INT8181 Grm5 Positive_regulation of Gh 1 0.00 0 0.44
178 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
179 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
180 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
181 INT122237 Gnrh1 Positive_regulation of Gh1 1 0.20 0 0.43
182 INT40446 Cck Regulation of Gh1 1 0.36 0 0.43
183 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43
184 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
185 INT64069 Sst Regulation of Localization of Gh1 1 0.10 0.1 0.42
186 INT3571 Sst Regulation of Negative_regulation of Gh1 1 0.24 0 0.42
187 INT222490 Npy Positive_regulation of Localization of Gh1 1 0.02 0.06 0.41
188 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41
189 INT16302 GHRH Regulation of Localization of GH1 1 0.65 0.62 0.4
190 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4
191 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
192 INT62107 Ghrh Negative_regulation of Regulation of Gh 1 0.06 0 0.39
193 INT36812 Olr824 Positive_regulation of Gh1 1 0.04 0 0.39
194 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
195 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
196 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39
197 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
198 INT62110 SLC25A4 Negative_regulation of Regulation of Gh 1 0.06 0 0.39
199 INT36814 Olr824 Regulation of Gh1 1 0.02 0 0.39
200 INT3634 Trh Regulation of Gh1 3 0.20 0.23 0.38

Single Events

The table below shows the top 100 pain related interactions that have been reported for growth hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in growth hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT876 Localization of Gh1 843 0.80 67.75 340.82
2 INT1893 Localization of Gh 1041 0.79 340.23 256.58
3 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
4 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23
5 INT252 Localization of GH1 529 0.80 227.4 122.05
6 INT1530 Regulation of Gh 382 0.61 115.96 112.47
7 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98
8 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
9 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97
10 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91
11 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
12 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
13 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
14 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
15 INT1782 Regulation of Gh1 125 0.62 22 55.74
16 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
17 INT921 Regulation of GH1 172 0.60 52.88 51.04
18 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75
19 INT531 Gene_expression of GH1 376 0.75 193.45 46.24
20 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
21 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3
22 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92
23 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
24 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15
25 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
26 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49
27 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
28 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96
29 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
30 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
31 INT4242 Negative_regulation of Positive_regulation of Gh1 26 0.58 1.47 15.75
32 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
33 INT4298 Positive_regulation of Positive_regulation of Gh1 30 0.50 1.79 13.32
34 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97
35 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
36 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
37 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
38 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16
39 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
40 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28
41 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
42 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86
43 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8
44 INT4299 Positive_regulation of Gene_expression of Gh1 27 0.50 5.24 7.31
45 INT878 Regulation of Gene_expression of Gh1 13 0.43 1.13 6.98
46 INT28861 Binding of Gh 61 0.46 25.61 6.38
47 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28
48 INT9683 Binding of GH1 57 0.47 21.14 5.99
49 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
50 INT10843 Regulation of Regulation of Gh 14 0.22 5.56 5.93
51 INT3614 Negative_regulation of Gene_expression of Gh1 16 0.42 6.8 5.74
52 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
53 INT9895 Binding of GHR 18 0.36 4.8 5.65
54 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39
55 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
56 INT4611 Transcription of Gh1 12 0.68 1.04 4.97
57 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
58 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
59 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61
60 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
61 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
62 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33
63 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
64 INT10842 Transcription of Gh 18 0.64 2.94 4.13
65 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
66 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
67 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06
68 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
69 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88
70 INT11605 Regulation of Positive_regulation of Gh 10 0.45 2.08 3.85
71 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
72 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68
73 INT121818 Binding of STAT3 25 0.47 11.16 3.67
74 INT7365 Binding of Gh1 17 0.37 2.83 3.54
75 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42
76 INT18407 Regulation of Regulation of GH1 6 0.44 0.14 3.37
77 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
78 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
79 INT13272 Regulation of Positive_regulation of Gh1 4 0.44 0.35 3.02
80 INT97393 Localization of Stat3 11 0.75 7.33 3.01
81 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
82 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
83 INT919 Regulation of Positive_regulation of GH1 7 0.47 1.09 2.75
84 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73
85 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
86 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
87 INT129917 Negative_regulation of Phosphorylation of Stat3 6 0.41 0.85 2.51
88 INT113339 Binding of JAK2 6 0.40 5.31 2.4
89 INT22019 Regulation of GHR 9 0.62 2.56 2.39
90 INT140993 Negative_regulation of Positive_regulation of Stat3 6 0.38 3.39 2.39
91 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
92 INT20410 Regulation of Regulation of Gh1 5 0.30 0.66 2.36
93 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
94 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
95 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
96 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27
97 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
98 INT4610 Negative_regulation of Transcription of Gh1 4 0.42 0.51 2.17
99 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
100 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
101 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
102 INT140268 Negative_regulation of Positive_regulation of Stat3 9 0.47 7.59 2.05
103 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04
104 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
105 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
106 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
107 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
108 INT1780 Regulation of Negative_regulation of Gh1 3 0.49 0.09 1.8
109 INT165617 Localization of STAT3 28 0.78 9.04 1.72
110 INT192965 Localization of Stat3 15 0.74 7.05 1.68
111 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
112 INT45719 Positive_regulation of Transcription of Gh 5 0.47 0.68 1.66
113 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
114 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
115 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
116 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
117 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
118 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
119 INT16528 Positive_regulation of Regulation of Gh1 5 0.48 0.37 1.47
120 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
121 INT121207 Negative_regulation of Phosphorylation of Stat3 16 0.45 9.35 1.4
122 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38
123 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
124 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
125 INT97394 Regulation of Stat3 6 0.41 2.52 1.34
126 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
127 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
128 INT136470 Positive_regulation of Positive_regulation of Stat3 3 0.40 0.75 1.23
129 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2
130 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
131 INT87346 Binding of PTK2 6 0.37 4.03 1.18
132 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
133 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1
134 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
135 INT47495 Protein_catabolism of Gh 2 0.98 0.68 1.08
136 INT142205 Negative_regulation of Transcription of Gh 1 0.16 0 1.08
137 INT142068 Positive_regulation of Localization of Stat3 3 0.47 1.6 1.07
138 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
139 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
140 INT155053 Transcription of Stat3 6 0.50 3.97 1
141 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
142 INT101240 Regulation of Phosphorylation of STAT3 5 0.57 3.04 0.98
143 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
144 INT62246 Positive_regulation of Transcription of Gh1 1 0.26 0 0.94
145 INT169336 Binding of Jak2 2 0.42 1.31 0.93
146 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
147 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
148 INT55982 Negative_regulation of Negative_regulation of Gh 4 0.55 1.02 0.88
149 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
150 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
151 INT7867 Regulation of Negative_regulation of Gh 5 0.33 1.92 0.87
152 INT73784 Regulation of Binding of GH1 2 0.26 0.82 0.86
153 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
154 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
155 INT3560 Negative_regulation of Regulation of Gh1 5 0.40 2.44 0.85
156 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
157 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
158 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
159 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
160 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
161 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
162 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
163 INT178186 Regulation of Stat3 7 0.44 6.23 0.74
164 INT205476 Binding of Stat3 12 0.47 4.73 0.72
165 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
166 INT35208 Positive_regulation of Negative_regulation of Gh1 3 0.49 0.08 0.7
167 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
168 INT70362 Transcription of GH1 9 0.56 2.01 0.69
169 INT17698 Positive_regulation of Regulation of GH1 6 0.46 0.9 0.65
170 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64
171 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
172 INT47563 Negative_regulation of Negative_regulation of Gh1 3 0.41 0.7 0.64
173 INT184030 Gene_expression of Socs2 8 0.74 3.54 0.63
174 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
175 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
176 INT165618 Negative_regulation of Localization of STAT3 2 0.39 0.31 0.59
177 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
178 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52
179 INT184038 Negative_regulation of Socs2 5 0.31 1.68 0.51
180 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5
181 INT205477 Transcription of Stat3 4 0.68 3.15 0.5
182 INT184062 Binding of Jak2 5 0.37 3.13 0.47
183 INT263240 Regulation of Socs2 2 0.02 0.96 0.46
184 INT117772 Binding of Ptk2 1 0.37 0.17 0.46
185 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
186 INT87505 Positive_regulation of Binding of Gh 2 0.49 0 0.42
187 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
188 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
189 INT121816 Positive_regulation of Binding of STAT3 3 0.49 0.8 0.4
190 INT107462 Localization of Jak2 2 0.60 0.78 0.4
191 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
192 INT271521 Phosphorylation of Ptk2 10 0.59 11.45 0.39
193 INT101242 Regulation of Gene_expression of STAT3 4 0.62 2.11 0.39
194 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
195 INT78447 Protein_catabolism of GH1 2 0.36 1.2 0.36
196 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
197 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
198 INT119371 Regulation of Positive_regulation of STAT3 2 0.42 0.36 0.35
199 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
200 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
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