GO:0060397

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Name JAK-STAT cascade involved in growth hormone signaling pathway
Categary Process
Go Slim No
Go Link GO:0060397
Unique Molecular Interactions 1091
Total Molecular Interactions 1406
Total Single Events 10389
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JAK-STAT cascade involved in growth hormone signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for JAK-STAT cascade involved in growth hormone signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
3 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
4 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
5 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
6 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
7 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
8 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
9 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
10 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25
11 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
12 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
13 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
14 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
15 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12
16 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
17 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
18 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
19 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
20 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07
21 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
22 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
23 INT33135 Binding of NFKBIL1 and PRL 1 0.09 0.29 1.01
24 INT25155 TRH Positive_regulation of PRL 2 0.50 0.4 1
25 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
26 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
27 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98
28 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98
29 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
30 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
31 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
32 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
33 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94
34 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
35 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
36 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
37 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
38 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
39 INT35160 GH1 Regulation of PRL 2 0.37 0 0.89
40 INT325807 CXCL13 Positive_regulation of CISH 1 0.16 3.65 0.89
41 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
42 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
43 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
44 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
45 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
46 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
47 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
48 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
49 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
50 INT54260 SST Regulation of GH1 1 0.18 0.06 0.81
51 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
52 INT90381 Binding of GH1 and LAMC2 1 0.34 0.05 0.81
53 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
54 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
55 INT2000 ASNA1 Positive_regulation of Localization of PRL 1 0.07 0 0.79
56 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
57 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
58 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
59 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
60 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
61 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
62 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
63 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
64 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
65 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
66 INT40127 Lhb Regulation of Localization of PRL 1 0.20 0.41 0.75
67 INT40126 PRL Regulation of Localization of Lhb 1 0.20 0.41 0.75
68 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73
69 INT44519 Penk Regulation of PRL 1 0.01 0 0.73
70 INT16894 Regulation of GHRH Regulation of GH1 2 0.37 0 0.72
71 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
72 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
73 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
74 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
75 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
76 INT150148 Binding of CISH and Myoz1 1 0.01 0.7 0.68
77 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
78 INT40470 GH1 Positive_regulation of GHRH 1 0.06 0 0.67
79 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
80 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
81 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
82 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
83 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61
84 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
85 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
86 INT35159 FSHR Regulation of PRL 2 0.34 0 0.6
87 INT35154 PLOD1 Regulation of PRL 2 0.17 0 0.6
88 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
89 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
90 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
91 INT25156 TRH Regulation of PRL 2 0.27 0.81 0.56
92 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
93 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
94 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
95 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
96 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54
97 INT84067 IGFBP1 Regulation of GH1 1 0.02 1.18 0.54
98 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
99 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
100 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
101 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
102 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
103 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
104 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
105 INT33513 GH1 Positive_regulation of PRL 1 0.30 0 0.53
106 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53
107 INT49696 Trh Regulation of GH1 2 0.02 0.22 0.52
108 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
109 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
110 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
111 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
112 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
113 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
114 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
115 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
116 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
117 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
118 INT120852 PRL Positive_regulation of IRF1 1 0.44 0.99 0.51
119 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
120 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
121 INT121822 Binding of STAT3 and Olr1583 1 0.00 0.21 0.51
122 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
123 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
124 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
125 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
126 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
127 INT44523 Penk Regulation of Gene_expression of PRL 1 0.01 0 0.49
128 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
129 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49
130 INT44521 Penk Regulation of Localization of PRL 1 0.01 0 0.49
131 INT46051 ABAT Regulation of Localization of GH1 1 0.19 0 0.49
132 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49
133 INT67984 GHRH Regulation of PRL 1 0.22 0 0.49
134 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
135 INT182705 NPFF Regulation of Localization of PRL 1 0.03 0 0.48
136 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
137 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
138 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
139 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
140 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
141 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
142 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
143 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
144 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
145 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
146 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
147 INT72203 GH1 Regulation of OGG1 1 0.10 0 0.46
148 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
149 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45
150 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
151 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
152 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45
153 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
154 INT46008 OPRM1 Regulation of Localization of PRL 1 0.14 0 0.44
155 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
156 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
157 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
158 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
159 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43
160 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
161 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
162 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
163 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
164 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
165 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
166 INT16302 GHRH Regulation of Localization of GH1 1 0.65 0.62 0.4
167 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4
168 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
169 INT34786 KCNA1 Positive_regulation of Localization of PRL 1 0.05 0 0.4
170 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
171 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39
172 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39
173 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
174 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39
175 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39
176 INT105772 SST Negative_regulation of Localization of GH1 1 0.10 0.54 0.38
177 INT48115 GH1 Positive_regulation of CGB 1 0.06 0 0.38
178 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
179 INT328818 Regulation of Il6 Positive_regulation of Stat3 1 0.04 0 0.38
180 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
181 INT182497 IL1B Regulation of Localization of GH1 1 0.00 0.84 0.38
182 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
183 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
184 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
185 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
186 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
187 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
188 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37
189 INT303982 Il6 Positive_regulation of STAT3 1 0.03 0.41 0.37
190 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
191 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37
192 INT328825 Il6 Positive_regulation of Stat3 1 0.07 0 0.37
193 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
194 INT35363 Binding of GH1 and GHRH 2 0.36 0.94 0.36
195 INT356274 Egf Positive_regulation of Localization of Stat3 1 0.13 0.22 0.36
196 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
197 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
198 INT261044 CHR Positive_regulation of CISH 1 0.01 0.05 0.35
199 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
200 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for JAK-STAT cascade involved in growth hormone signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in JAK-STAT cascade involved in growth hormone signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT425 Localization of PRL 455 0.81 189.64 144.8
2 INT252 Localization of GH1 529 0.80 227.4 122.05
3 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31
4 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
5 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91
6 INT253 Regulation of PRL 184 0.62 47.27 65.79
7 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41
8 INT921 Regulation of GH1 172 0.60 52.88 51.04
9 INT531 Gene_expression of GH1 376 0.75 193.45 46.24
10 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
11 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3
12 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13
13 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3
14 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92
15 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
16 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
17 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
18 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
19 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01
20 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15
21 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
22 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
23 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
24 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18
25 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
26 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
27 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
28 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
29 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44
30 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97
31 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
32 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
33 INT12367 Binding of PRLR 17 0.03 2.05 9.69
34 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
35 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
36 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
37 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28
38 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
39 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
40 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09
41 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8
42 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
43 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17
44 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
45 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28
46 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
47 INT9683 Binding of GH1 57 0.47 21.14 5.99
48 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
49 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
50 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85
51 INT1649 Localization of CSH1 15 0.46 3.65 5.75
52 INT9895 Binding of GHR 18 0.36 4.8 5.65
53 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
54 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
55 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
56 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39
57 INT21067 Regulation of Regulation of PRL 11 0.60 2 5.31
58 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23
59 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03
60 INT13313 Regulation of PRLR 7 0.07 1.65 4.77
61 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
62 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61
63 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
64 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
65 INT6021 Binding of PRL 18 0.48 12.55 4.3
66 INT1640 Regulation of Localization of CSH1 3 0.19 0 4.12
67 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
68 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06
69 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
70 INT922 Regulation of Positive_regulation of PRL 7 0.60 3.57 3.95
71 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89
72 INT1645 Negative_regulation of CSH1 20 0.42 1.71 3.7
73 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68
74 INT121818 Binding of STAT3 25 0.47 11.16 3.67
75 INT18825 Gene_expression of PRLR 8 0.40 2 3.47
76 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
77 INT10059 Binding of CSH1 17 0.35 5.28 3.37
78 INT18407 Regulation of Regulation of GH1 6 0.44 0.14 3.37
79 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15
80 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
81 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
82 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
83 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03
84 INT97393 Localization of Stat3 11 0.75 7.33 3.01
85 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
86 INT919 Regulation of Positive_regulation of GH1 7 0.47 1.09 2.75
87 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
88 INT25646 Negative_regulation of PRLR 5 0.08 0.08 2.62
89 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
90 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
91 INT1643 Regulation of CSH1 10 0.26 2.45 2.53
92 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
93 INT129917 Negative_regulation of Phosphorylation of Stat3 6 0.41 0.85 2.51
94 INT113339 Binding of JAK2 6 0.40 5.31 2.4
95 INT22019 Regulation of GHR 9 0.62 2.56 2.39
96 INT140993 Negative_regulation of Positive_regulation of Stat3 6 0.38 3.39 2.39
97 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
98 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
99 INT34891 Transcription of PRL 4 0.72 0.69 2.36
100 INT34266 Negative_regulation of Binding of PRLR 3 0.01 0 2.35
101 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
102 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
103 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27
104 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
105 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
106 INT140268 Negative_regulation of Positive_regulation of Stat3 9 0.47 7.59 2.05
107 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04
108 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
109 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
110 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
111 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
112 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
113 INT26341 Positive_regulation of Regulation of PRL 4 0.70 1.43 1.92
114 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
115 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
116 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
117 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
118 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
119 INT165617 Localization of STAT3 28 0.78 9.04 1.72
120 INT278981 Negative_regulation of JAK3 5 0.46 2.12 1.69
121 INT192965 Localization of Stat3 15 0.74 7.05 1.68
122 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
123 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
124 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
125 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52
126 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
127 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
128 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
129 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
130 INT121207 Negative_regulation of Phosphorylation of Stat3 16 0.45 9.35 1.4
131 INT121820 Binding of STAT1 9 0.46 2.54 1.4
132 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
133 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
134 INT97394 Regulation of Stat3 6 0.41 2.52 1.34
135 INT232445 Positive_regulation of Transcription of PRL 1 0.50 0 1.32
136 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
137 INT163592 Localization of CISH 5 0.54 5.9 1.26
138 INT136470 Positive_regulation of Positive_regulation of Stat3 3 0.40 0.75 1.23
139 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2
140 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
141 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14
142 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
143 INT20080 Localization of PRLR 2 0.03 0.42 1.12
144 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1
145 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
146 INT142068 Positive_regulation of Localization of Stat3 3 0.47 1.6 1.07
147 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
148 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03
149 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
150 INT155053 Transcription of Stat3 6 0.50 3.97 1
151 INT101240 Regulation of Phosphorylation of STAT3 5 0.57 3.04 0.98
152 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
153 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97
154 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
155 INT226480 Positive_regulation of JAK3 4 0.45 0.96 0.95
156 INT17574 Binding of CISH 23 0.31 4.3 0.93
157 INT169336 Binding of Jak2 2 0.42 1.31 0.93
158 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
159 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
160 INT39955 Positive_regulation of Negative_regulation of PRL 3 0.70 0.47 0.9
161 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
162 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
163 INT73784 Regulation of Binding of GH1 2 0.26 0.82 0.86
164 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
165 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
166 INT167942 Binding of Stat5b 1 0.26 0 0.82
167 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
168 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
169 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
170 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76
171 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
172 INT178186 Regulation of Stat3 7 0.44 6.23 0.74
173 INT206664 Positive_regulation of Gene_expression of CISH 3 0.20 0.59 0.74
174 INT205476 Binding of Stat3 12 0.47 4.73 0.72
175 INT4397 Transcription of CSH1 7 0.57 0.65 0.72
176 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
177 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
178 INT70362 Transcription of GH1 9 0.56 2.01 0.69
179 INT42496 Regulation of Negative_regulation of PRL 1 0.45 0.36 0.69
180 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
181 INT34889 Regulation of Transcription of PRL 2 0.42 0.55 0.67
182 INT127604 Negative_regulation of CISH 8 0.37 1.61 0.66
183 INT17698 Positive_regulation of Regulation of GH1 6 0.46 0.9 0.65
184 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64
185 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
186 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
187 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
188 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
189 INT188137 Regulation of CISH 7 0.04 0.97 0.6
190 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
191 INT165618 Negative_regulation of Localization of STAT3 2 0.39 0.31 0.59
192 INT75524 Positive_regulation of Regulation of MAPK1 1 0.43 1.12 0.59
193 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
194 INT166018 Protein_catabolism of MAPK3 1 0.23 0.59 0.56
195 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55
196 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
197 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5
198 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
199 INT205477 Transcription of Stat3 4 0.68 3.15 0.5
200 INT129635 Positive_regulation of SOCS1 3 0.49 0.92 0.49
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