GO:0060402

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Name calcium ion transport into cytosol
Categary Process
Go Slim No
Go Link GO:0060402
Unique Molecular Interactions 102
Total Molecular Interactions 142
Total Single Events 1116
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium ion transport into cytosol. They are ordered first by their pain relevance and then by number of times they were reported for calcium ion transport into cytosol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
2 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
3 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
4 INT75920 Slc8a1 Negative_regulation of Cpox 1 0.03 0.85 0.89
5 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
6 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
7 INT91655 SLC8A1 Negative_regulation of CASP1 1 0.02 0.43 0.75
8 INT297490 Itpr3 Regulation of Ltp 1 0.02 0 0.7
9 INT76877 Binding of Slc3a1 and Slc8a1 1 0.02 0 0.64
10 INT240066 KCNIP3 Regulation of SLC8A3 1 0.39 0.73 0.59
11 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
12 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
13 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
14 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
15 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
16 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
17 INT118519 Slc8a1 Negative_regulation of Positive_regulation of Nfkb1 1 0.16 0.59 0.42
18 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
19 INT350241 Binding of Pgp and Slc8a2 1 0.02 0.79 0.39
20 INT91656 SLC8A1 Negative_regulation of Positive_regulation of CASP1 1 0.01 0.2 0.38
21 INT91652 Negative_regulation of SLC8A1 Negative_regulation of CASP1 1 0.02 0.21 0.37
22 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
23 INT353689 Binding of Slc8a1 and Ca2 1 0.15 0.58 0.33
24 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
25 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
26 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
27 INT247475 P2RY6 Positive_regulation of ITPR3 1 0.01 0.45 0.23
28 INT353691 Slc8a1 Positive_regulation of Ca2 1 0.18 0.45 0.22
29 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
30 INT33714 Positive_regulation of Binding of ITPR3 and Trh 1 0.00 0.46 0.21
31 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
32 INT353697 Binding of NA and Slc8a1 1 0.01 0.42 0.19
33 INT303866 Positive_regulation of NAA50 Negative_regulation of Gene_expression of CACNA1C 1 0.13 0.08 0.16
34 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
35 INT34451 Binding of Itpr3 and Ptprg 1 0.03 0 0.15
36 INT335459 ABCA1 Positive_regulation of ITPR3 1 0.00 0 0.15
37 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
38 INT292383 Binding of Itpr3 and Mrvi1 1 0.18 0 0.11
39 INT33712 Trh Positive_regulation of Localization of ITPR3 1 0.00 0.8 0.1
40 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
41 INT249183 Binding of ITPR3 and GOPC 2 0.01 0.26 0.09
42 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09
43 INT350216 ITPR3 Regulation of Localization of TNIP3 1 0.01 0.08 0.09
44 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09
45 INT241040 Slc8a1 Negative_regulation of Gene_expression of Ca2 1 0.15 1.35 0.09
46 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
47 INT237820 Binding of Itpr3 and soc 1 0.02 0 0.09
48 INT208979 Binding of Itpr3 and Trpc3 1 0.00 0.33 0.09
49 INT237814 Itpr3 Positive_regulation of Localization of Tmie 1 0.01 0.68 0.08
50 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08
51 INT237815 Binding of Itpr3 and Stim1 1 0.04 0 0.07
52 INT350219 ITPR3 Positive_regulation of CA2 1 0.22 0 0.05
53 INT34447 Ptprg Positive_regulation of Itpr3 1 0.04 0 0.05
54 INT208988 Binding of CALM1 and Itpr3 1 0.01 0.15 0.05
55 INT208982 Negative_regulation of Binding of Itpr3 and Trpc3 1 0.00 0.17 0.04
56 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
57 INT297207 Myoz1 Regulation of Gene_expression of Slc8a1 1 0.09 0.26 0.03
58 INT318073 Itpr3 Regulation of Ca2 1 0.01 0 0.03
59 INT249159 HSPG2 Positive_regulation of Gene_expression of ITPR3 2 0.01 0.06 0
60 INT126931 Slc8a2 Positive_regulation of Localization of Il10 1 0.12 0.08 0
61 INT329993 Binding of CACNA1C and KCNMA1 1 0.32 0.19 0
62 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
63 INT326979 HLN2 Negative_regulation of JPH3 1 0.02 2.05 0
64 INT279704 Binding of CIB1 and Positive_regulation of ITPR3 1 0.06 0.17 0
65 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0
66 INT292384 Itpr3 Regulation of Car2 1 0.07 0 0
67 INT31765 Positive_regulation of Binding of Itpr3 and Ca2 1 0.21 0 0
68 INT292387 Lrmp Regulation of Itpr3 1 0.45 0.31 0
69 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
70 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
71 INT292386 Binding of Itpr3 and Lrmp 1 0.41 0.67 0
72 INT326980 HSD11B1 Negative_regulation of JPH3 1 0.03 2.05 0
73 INT249176 Binding of ITPR3 and TRPC1 1 0.02 0 0
74 INT249163 Binding of CISH and ITPR3 1 0.00 0.5 0
75 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
76 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
77 INT126932 Slc8a2 Positive_regulation of Il10 1 0.09 0.06 0
78 INT31766 Binding of Itpr3 and Ca2 1 0.16 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium ion transport into cytosol. They are ordered first by their pain relevance and then by number of times they were reported in calcium ion transport into cytosol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
2 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
3 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
4 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
5 INT75919 Gene_expression of Slc8a1 23 0.63 16.44 9.84
6 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
7 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
8 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22
9 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
10 INT36040 Localization of Itpr3 21 0.70 4.87 7.77
11 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
12 INT335 Binding of Adra1a 16 0.36 6.16 6
13 INT73935 Gene_expression of Slc8a2 2 0.65 5.24 5.99
14 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
15 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
16 INT31762 Gene_expression of Itpr3 22 0.74 1.6 4.15
17 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
18 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
19 INT167913 Gene_expression of CACNA1C 3 0.75 0.38 3.34
20 INT37180 Negative_regulation of Itpr3 6 0.51 1.43 3.27
21 INT54999 Regulation of Itpr3 6 0.24 0.18 3.11
22 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93
23 INT118518 Positive_regulation of Slc8a1 7 0.56 5.31 2.59
24 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
25 INT37347 Positive_regulation of Itpr3 6 0.34 1.3 2.31
26 INT31763 Positive_regulation of Gene_expression of Itpr3 10 0.30 0.83 2.28
27 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
28 INT63081 Localization of Itpr3 13 0.67 1.08 2.12
29 INT15211 Localization of Adra1a 3 0.16 0 2.08
30 INT55000 Positive_regulation of Regulation of Itpr3 1 0.41 0 2.08
31 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
32 INT37181 Negative_regulation of Localization of Itpr3 3 0.37 0.83 1.97
33 INT160634 Gene_expression of Slc8a1 2 0.64 2.12 1.92
34 INT25835 Binding of Slc8a1 3 0.36 0.47 1.79
35 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
36 INT73355 Negative_regulation of Slc8a1 5 0.47 2.35 1.61
37 INT31760 Negative_regulation of Itpr3 5 0.23 0.84 1.61
38 INT37346 Positive_regulation of Localization of Itpr3 3 0.47 0.45 1.59
39 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
40 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
41 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24
42 INT37241 Negative_regulation of Localization of ITPR3 7 0.13 1.22 1.05
43 INT80500 Localization of Slc8a1 4 0.61 1.37 1.02
44 INT116829 Regulation of Itpr3 2 0.39 0 1.02
45 INT55243 Positive_regulation of Positive_regulation of Itpr3 4 0.58 0.89 0.95
46 INT91666 Localization of SLC8A1 2 0.02 0.25 0.82
47 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
48 INT116830 Binding of Itpr3 10 0.45 0.29 0.78
49 INT31764 Negative_regulation of Positive_regulation of Itpr3 4 0.25 0 0.77
50 INT62887 Regulation of Gene_expression of ITPR3 3 0.14 0.95 0.76
51 INT129797 Negative_regulation of Binding of ITPR3 3 0.14 0.58 0.75
52 INT26333 Positive_regulation of Localization of ITPR3 6 0.43 0.17 0.68
53 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
54 INT26336 Regulation of Localization of ITPR3 2 0.13 0.37 0.61
55 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
56 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
57 INT59819 Phosphorylation of ITPR3 2 0.06 0 0.54
58 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
59 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
60 INT64935 Negative_regulation of Regulation of Itpr3 1 0.26 0 0.49
61 INT241034 Negative_regulation of Gene_expression of Slc8a1 4 0.34 2.23 0.48
62 INT241035 Positive_regulation of Gene_expression of Slc8a1 4 0.41 1.89 0.47
63 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
64 INT130556 Binding of CACNA1C 3 0.22 1.84 0.4
65 INT63082 Binding of Itpr3 12 0.12 0.54 0.39
66 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
67 INT55577 Negative_regulation of Gene_expression of Itpr3 1 0.06 0 0.39
68 INT241036 Regulation of Slc8a1 5 0.22 3.43 0.37
69 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
70 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
71 INT303879 Positive_regulation of Gene_expression of CACNA1C 2 0.49 0.08 0.34
72 INT240951 Positive_regulation of Positive_regulation of Itpr3 1 0.03 0.06 0.33
73 INT353695 Regulation of Negative_regulation of Slc8a1 1 0.36 0.38 0.32
74 INT33706 Regulation of ITPR3 6 0.28 0.46 0.3
75 INT350239 Localization of Slc8a2 1 0.46 0.42 0.3
76 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
77 INT55240 Regulation of Positive_regulation of Itpr3 1 0.52 0.48 0.28
78 INT149738 Regulation of Gene_expression of Itpr3 1 0.22 0.09 0.27
79 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
80 INT264627 Positive_regulation of CACNA1C 1 0.22 0.1 0.26
81 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
82 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
83 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
84 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
85 INT119792 Negative_regulation of Localization of SLC8A1 1 0.01 0 0.18
86 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
87 INT195015 Negative_regulation of Positive_regulation of Slc8a1 1 0.04 0.31 0.15
88 INT216609 Protein_catabolism of Itpr3 2 0.24 0.42 0.14
89 INT237797 Positive_regulation of Gene_expression of Itpr3 3 0.05 1.08 0.11
90 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
91 INT63111 Gene_expression of JPH3 3 0.65 3.29 0.08
92 INT281233 Positive_regulation of Protein_catabolism of Itpr3 1 0.11 0.16 0.08
93 INT272152 Positive_regulation of Positive_regulation of ITPR3 1 0.06 0 0.08
94 INT120506 Negative_regulation of Negative_regulation of ITPR3 1 0.01 0.08 0.08
95 INT160627 Positive_regulation of Slc8a1 2 0.22 0.27 0.07
96 INT281239 Negative_regulation of Protein_catabolism of Itpr3 1 0.10 0.16 0.07
97 INT216802 Positive_regulation of Localization of Itpr3 1 0.07 0 0.06
98 INT192016 Localization of RYR2 5 0.25 4.18 0.05
99 INT192012 Binding of RYR2 2 0.30 3.61 0.05
100 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
101 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
102 INT63083 Positive_regulation of Binding of Itpr3 2 0.11 0.16 0.04
103 INT33707 Positive_regulation of Transcription of ITPR3 1 0.01 0.27 0.04
104 INT33705 Transcription of ITPR3 1 0.02 0.27 0.04
105 INT249279 Regulation of Binding of ITPR3 1 0.03 0.44 0.04
106 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
107 INT214002 Localization of Slc8a1 1 0.34 1.07 0.04
108 INT249235 Positive_regulation of Binding of ITPR3 3 0.17 0.2 0.03
109 INT288855 Positive_regulation of JPH3 2 0.22 2.92 0.03
110 INT297201 Regulation of Gene_expression of Slc8a1 1 0.22 0.2 0.03
111 INT326992 Phosphorylation of JPH3 1 0.16 2.15 0
112 INT292373 Regulation of Gene_expression of Itpr3 1 0.57 0.14 0
113 INT296910 Regulation of Gene_expression of Slc8a1 1 0.18 0.68 0
114 INT323058 Negative_regulation of SLC8A1 1 0.07 1.57 0
115 INT326074 Positive_regulation of Gene_expression of JPH3 1 0.24 0.5 0
116 INT326990 Binding of JPH3 1 0.07 1.95 0
117 INT333531 Regulation of CACNA1C 1 0.60 0.69 0
118 INT118100 Protein_catabolism of Slc8a1 1 0.33 0 0
119 INT326995 Localization of JPH3 1 0.15 1.82 0
120 INT292378 Regulation of Binding of Itpr3 1 0.25 0 0
121 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
122 INT292377 Regulation of Localization of Itpr3 1 0.37 0 0
123 INT296919 Transcription of Slc8a1 1 0.24 1.28 0
124 INT296908 Regulation of Regulation of Slc8a1 1 0.12 0.61 0
125 INT297188 Negative_regulation of Slc8a1 1 0.31 0.31 0
126 INT326994 Regulation of JPH3 1 0.05 2.28 0
127 INT281234 Negative_regulation of Binding of Itpr3 1 0.14 0 0
128 INT296918 Positive_regulation of Transcription of Slc8a1 1 0.21 1.29 0
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