GO:0060452

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Name positive regulation of cardiac muscle contraction
Categary Process
Go Slim No
Go Link GO:0060452
Unique Molecular Interactions 70
Total Molecular Interactions 88
Total Single Events 1235
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cardiac muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cardiac muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 0.00 0 1.25
2 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
3 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
4 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
5 INT122191 Binding of Crh and Ucn 4 0.36 0.79 0.82
6 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
7 INT126304 Binding of Rgs2 and Pag1 1 0.16 0.41 0.72
8 INT67887 SCN5A Negative_regulation of INA 1 0.02 0.13 0.71
9 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
10 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
11 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
12 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
13 INT111244 Binding of BRS3 and SCN5A 1 0.00 0.72 0.48
14 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
15 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42
16 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
17 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
18 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
19 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
20 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
21 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
22 INT26577 SCN5A Positive_regulation of co 1 0.00 0 0.27
23 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
24 INT316815 Ctgf Negative_regulation of Gene_expression of Sparc 1 0.47 0.64 0.24
25 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22
26 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
27 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
28 INT143394 Ucn Regulation of Crh 1 0.44 0.19 0.2
29 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2
30 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
31 INT153460 Inhba Positive_regulation of Gene_expression of Ctgf 1 0.77 1.14 0.19
32 INT153461 Tnf Positive_regulation of Gene_expression of Ctgf 1 0.48 1.13 0.19
33 INT196303 Binding of SCN5A and ACCS 1 0.00 1.43 0.18
34 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17
35 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16
36 INT153458 Ctgf Positive_regulation of Gene_expression of Il6 1 0.34 1.03 0.15
37 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1
38 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
39 INT186242 Binding of ALB and SCN5A 1 0.04 0.36 0.1
40 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
41 INT294448 KLK4 Negative_regulation of CTGF 1 0.01 0 0.1
42 INT257342 Mapk4 Positive_regulation of Gene_expression of Ctgf 1 0.01 0.39 0.08
43 INT205033 Ucn Positive_regulation of Crhr2 1 0.22 0.15 0.08
44 INT159461 SCN5A Negative_regulation of HPSE 1 0.00 0 0.07
45 INT316819 Sparc Negative_regulation of Gene_expression of Ctgf 1 0.41 0.24 0.06
46 INT316822 Sparc Regulation of Gene_expression of Ctgf 1 0.68 0.48 0.06
47 INT222544 Binding of Ucn and Crh 1 0.02 0 0.05
48 INT222417 Ucn Positive_regulation of Localization of Pomc 1 0.01 0 0.04
49 INT254860 Ctgf Negative_regulation of Col7a1 1 0.00 0.51 0.03
50 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
51 INT222469 Binding of Ucn and Crhr2 1 0.00 0 0.03
52 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03
53 INT254867 Ctgf Negative_regulation of Serpine1 1 0.04 0.51 0.03
54 INT316825 Ctgf Negative_regulation of Sparc 1 0.56 0.14 0
55 INT187672 Binding of DBT and SCN5A 1 0.00 0.2 0
56 INT268517 MYC Regulation of CTGF 1 0.03 0.92 0
57 INT325599 Pls1 Regulation of Rgs2 1 0.00 0 0
58 INT337916 sb Negative_regulation of Ctgf 1 0.00 0.13 0
59 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
60 INT100265 Hsp90aa1 Regulation of Positive_regulation of Esrrb 1 0.10 0.1 0
61 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
62 INT265264 Binding of NA and SCN5A 1 0.03 0.55 0
63 INT265265 SCN5A Regulation of Gene_expression of NAV1 1 0.01 0.16 0
64 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
65 INT325588 Nppa Regulation of Localization of Rgs2 1 0.32 0 0
66 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
67 INT91242 Binding of SCN5A and PIRT 1 0.00 0 0
68 INT91245 Binding of SCN5A and EMID1 1 0.00 0 0
69 INT269918 Binding of Scn5a and Sox17 1 0.18 0.15 0
70 INT325608 Rgs2 Regulation of Pls1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cardiac muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cardiac muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73
2 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88
3 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
4 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
5 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
6 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
7 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
8 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
9 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
10 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
11 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3
12 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
13 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06
14 INT335 Binding of Adra1a 16 0.36 6.16 6
15 INT23598 Binding of SCN5A 32 0.40 16 5.35
16 INT30209 Localization of SCN5A 24 0.72 7.95 5.35
17 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
18 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
19 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47
20 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47
21 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43
22 INT156148 Gene_expression of CTGF 16 0.78 9.98 2.87
23 INT93777 Negative_regulation of Rgs2 3 0.43 2.5 2.81
24 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39
25 INT15211 Localization of Adra1a 3 0.16 0 2.08
26 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
27 INT127250 Positive_regulation of Positive_regulation of SCN5A 3 0.38 1.71 1.86
28 INT77656 Gene_expression of Hsp90aa1 12 0.78 24.27 1.81
29 INT80162 Localization of Ucn 6 0.80 0.6 1.66
30 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
31 INT92685 Transcription of Ctgf 7 0.72 3.92 1.44
32 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
33 INT88855 Negative_regulation of Hsp90aa1 4 0.54 2.16 1.34
34 INT143451 Negative_regulation of Gene_expression of Scn5a 2 0.43 4.63 1.34
35 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33
36 INT92848 Gene_expression of Scn5a 3 0.73 0.23 1.25
37 INT158565 Regulation of Ctgf 3 0.61 3.93 1.14
38 INT158563 Negative_regulation of Ctgf 6 0.56 4.31 1.12
39 INT100612 Positive_regulation of Hsp90aa1 4 0.64 5.3 1.01
40 INT105986 Positive_regulation of Transcription of Ctgf 2 0.69 2.43 1.01
41 INT164079 Regulation of Gene_expression of CTGF 4 0.44 2 0.9
42 INT88861 Positive_regulation of Gene_expression of Hsp90aa1 4 0.64 7.43 0.9
43 INT84571 Gene_expression of Rgs2 6 0.67 3.18 0.89
44 INT143450 Negative_regulation of Scn5a 3 0.43 2.71 0.88
45 INT80159 Gene_expression of Ucn 3 0.67 0.47 0.82
46 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
47 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71
48 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
49 INT84570 Positive_regulation of Gene_expression of Rgs2 3 0.50 0.67 0.67
50 INT52590 Transcription of SCN5A 4 0.55 0.91 0.65
51 INT88859 Transcription of Hsp90aa1 1 0.58 1.51 0.6
52 INT166086 Binding of Hsp90aa1 1 0.28 0.08 0.6
53 INT88857 Negative_regulation of Transcription of Hsp90aa1 1 0.36 1.52 0.6
54 INT80160 Negative_regulation of Ucn 2 0.58 0.29 0.56
55 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
56 INT98814 Negative_regulation of Ucn 2 0.27 0.14 0.55
57 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
58 INT252612 Regulation of Gene_expression of SCN5A 5 0.35 0.56 0.53
59 INT122186 Binding of Ucn 2 0.23 0.37 0.53
60 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
61 INT80163 Positive_regulation of Gene_expression of Ucn 1 0.50 0.41 0.52
62 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
63 INT167377 Regulation of Gene_expression of Ctgf 2 0.25 1.35 0.48
64 INT158296 Positive_regulation of Gene_expression of Ctgf 5 0.47 4.82 0.47
65 INT88856 Negative_regulation of Gene_expression of Hsp90aa1 2 0.39 2.31 0.45
66 INT296806 Positive_regulation of Gene_expression of Scn5a 1 0.50 2.73 0.45
67 INT140090 Negative_regulation of Gene_expression of Ctgf 5 0.58 1.77 0.44
68 INT284882 Positive_regulation of Scn5a 3 0.50 1.73 0.44
69 INT123831 Regulation of Ucn 2 0.42 0 0.42
70 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
71 INT268558 Regulation of CTGF 5 0.23 4.7 0.37
72 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
73 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
74 INT119248 Binding of Ctgf 1 0.35 1.5 0.35
75 INT153465 Regulation of Gene_expression of Ctgf 3 0.61 2.5 0.33
76 INT163321 Protein_catabolism of SCN5A 1 0.64 0.25 0.31
77 INT284877 Transcription of Scn5a 3 0.72 1.41 0.3
78 INT168140 Regulation of Ctgf 2 0.60 2.15 0.29
79 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
80 INT219162 Localization of CTGF 1 0.50 2.62 0.29
81 INT137042 Negative_regulation of Transcription of SCN5A 1 0.34 0.23 0.29
82 INT294476 Negative_regulation of CTGF 1 0.27 1.86 0.29
83 INT164080 Negative_regulation of Gene_expression of CTGF 1 0.41 0.51 0.29
84 INT77654 Regulation of Gene_expression of Hsp90aa1 4 0.62 2.41 0.28
85 INT136840 Positive_regulation of Ctgf 2 0.35 1.34 0.27
86 INT280795 Positive_regulation of Ucn 1 0.31 0.06 0.27
87 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
88 INT92850 Transcription of Scn5a 1 0.52 0.17 0.26
89 INT122676 Positive_regulation of Ucn 1 0.43 0.92 0.26
90 INT143391 Gene_expression of Ucn 1 0.67 0.2 0.26
91 INT92849 Positive_regulation of Gene_expression of Scn5a 1 0.49 0.17 0.26
92 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
93 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
94 INT325579 Phosphorylation of Rgs2 2 0.55 0.06 0.2
95 INT158567 Negative_regulation of Transcription of Ctgf 1 0.43 0.73 0.2
96 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
97 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
98 INT164291 Regulation of Positive_regulation of SCN5A 2 0.38 0.73 0.15
99 INT219160 Positive_regulation of CTGF 2 0.29 2.95 0.15
100 INT263243 Regulation of Gene_expression of Rgs2 1 0.27 1.65 0.15
101 INT337910 Binding of Ctgf 1 0.22 3.04 0.15
102 INT153463 Localization of Ctgf 1 0.65 0.97 0.13
103 INT57198 Negative_regulation of Positive_regulation of SCN5A 2 0.30 0.17 0.12
104 INT67512 Negative_regulation of Negative_regulation of SCN5A 1 0.01 0 0.1
105 INT280234 Localization of Ctgf 3 0.51 2.35 0.09
106 INT284878 Regulation of Scn5a 2 0.27 1.15 0.09
107 INT249663 Negative_regulation of Phosphorylation of SCN5A 1 0.05 0.74 0.09
108 INT249661 Positive_regulation of Phosphorylation of SCN5A 1 0.06 0.74 0.09
109 INT249660 Phosphorylation of SCN5A 1 0.10 0.73 0.09
110 INT284868 Binding of Scn5a 2 0.36 0.7 0.08
111 INT325569 Binding of Rgs2 2 0.30 0.19 0.07
112 INT280766 Localization of Ucn 1 0.46 0 0.07
113 INT156147 Positive_regulation of Gene_expression of CTGF 1 0.70 0.14 0.07
114 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
115 INT325568 Positive_regulation of Rgs2 1 0.41 0.13 0.05
116 INT271818 Negative_regulation of Ctgf 1 0.21 0.41 0.04
117 INT263238 Localization of Rgs2 2 0.75 0.96 0.03
118 INT222594 Binding of Ucn 1 0.06 0 0.03
119 INT263239 Negative_regulation of Localization of Rgs2 1 0.43 0.96 0.03
120 INT254801 Phosphorylation of Ctgf 3 0.48 0.62 0
121 INT187724 Positive_regulation of Localization of SCN5A 2 0.24 0.15 0
122 INT263242 Regulation of Rgs2 1 0.27 0.59 0
123 INT342935 Positive_regulation of Transcription of Ctgf 1 0.33 0 0
124 INT325566 Negative_regulation of Gene_expression of Rgs2 1 0.35 0 0
125 INT325567 Positive_regulation of Localization of Rgs2 1 0.41 0 0
126 INT284874 Regulation of Transcription of Scn5a 1 0.26 0.33 0
127 INT211184 Positive_regulation of Binding of SCN5A 1 0.22 0.48 0
128 INT342929 Transcription of Ctgf 1 0.38 0 0
129 INT325577 Positive_regulation of Binding of Rgs2 1 0.41 0.05 0
130 INT268556 Regulation of Positive_regulation of CTGF 1 0.23 1.81 0
131 INT352011 Positive_regulation of Localization of Ctgf 1 0.23 0.17 0
132 INT296819 Phosphorylation of Scn5a 1 0.82 0.07 0
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