GO:0060527

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Name prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
Categary Process
Go Slim No
Go Link GO:0060527
Unique Molecular Interactions 470
Total Molecular Interactions 642
Total Single Events 6461
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
3 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
4 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
5 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
6 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
7 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
8 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
9 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
10 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
11 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
12 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
13 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
14 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
15 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
16 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
17 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
18 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
19 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
20 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
21 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
22 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
23 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
24 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
25 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
26 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
27 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
28 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
29 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
30 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
31 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
32 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
33 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
34 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
35 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
36 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
37 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
38 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
39 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
40 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
41 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
42 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
43 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
44 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
45 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
46 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
47 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
48 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
49 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
50 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
51 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
52 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
53 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
54 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
55 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
56 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
57 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
58 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
59 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
60 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
61 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
62 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
63 INT158734 Esr1 Regulation of Esrrb 1 0.00 0.28 0.29
64 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
65 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
66 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
67 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
68 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
69 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
70 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
71 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
72 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
73 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
74 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
75 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
76 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
77 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
78 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
79 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
80 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
81 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
82 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
83 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
84 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
85 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
86 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
87 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
88 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
89 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
90 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
91 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
92 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
93 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
94 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
95 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
96 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
97 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
98 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
99 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
100 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
101 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
102 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
103 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
104 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
105 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
106 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
107 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
108 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
109 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
110 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
111 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
112 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
113 INT19045 ESR1 Positive_regulation of Salpa1 1 0.02 0.6 0.17
114 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
115 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
116 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
117 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
118 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
119 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
120 INT309154 Esr1 Positive_regulation of Gsdmc 1 0.01 0.44 0.15
121 INT309155 Negative_regulation of Esr1 Positive_regulation of Gsdmc 1 0.01 0.45 0.15
122 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
123 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
124 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
125 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
126 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
127 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
128 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
129 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
130 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
131 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
132 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
133 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
134 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
135 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
136 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
137 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
138 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
139 INT297312 Esr1 Positive_regulation of Scap 1 0.00 1.58 0.13
140 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13
141 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
142 INT86429 Binding of Hspb1 and Esr1 1 0.19 0.26 0.13
143 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
144 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
145 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
146 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
147 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
148 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
149 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
150 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
151 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
152 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
153 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11
154 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
155 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
156 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
157 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
158 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
159 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
160 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
161 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1
162 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
163 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
164 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
165 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
166 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1
167 INT237819 Binding of Esr1 and soc 1 0.04 0 0.1
168 INT279407 Binding of ESR1 and IGKV2-19 1 0.02 0.4 0.1
169 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
170 INT125000 Binding of Esr1 and Tas2r108 1 0.04 0.33 0.1
171 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
172 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
173 INT237812 Esr1 Positive_regulation of Positive_regulation of soc 1 0.05 0.6 0.1
174 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
175 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09
176 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
177 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
178 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
179 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
180 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
181 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
182 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
183 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
184 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
185 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
186 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
187 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
188 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
189 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08
190 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
191 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
192 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
193 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
194 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
195 INT199973 ESR1 Negative_regulation of EEF1B2P2 1 0.01 0.46 0.08
196 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08
197 INT38188 PGR Positive_regulation of Gene_expression of ESR1 1 0.42 0.22 0.07
198 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
199 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
200 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
5 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
6 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
7 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
8 INT37296 Binding of Esr1 117 0.43 62.51 27.33
9 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
10 INT20462 Binding of ESR1 210 0.44 102.7 26.34
11 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
12 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
13 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
14 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
15 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
16 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
17 INT92354 Localization of ESR1 77 0.75 33.04 15.51
18 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
19 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
20 INT2038 Localization of Esr1 104 0.79 40.12 13.27
21 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
22 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
23 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
24 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
25 INT34777 Localization of IGF1 82 0.80 42.68 8.62
26 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
27 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
28 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
29 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
30 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
31 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
32 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
33 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
34 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
35 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
36 INT151032 Localization of Igf1 49 0.76 26.32 5.71
37 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
38 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
39 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
40 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
41 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
42 INT49360 Localization of Igf1 22 0.76 6.96 4.26
43 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
44 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
45 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
46 INT20461 Binding of Esr1 34 0.48 9.58 3.66
47 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
48 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
49 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
50 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
51 INT16130 Binding of IGF1 67 0.48 27.43 2.95
52 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
53 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
54 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
55 INT66544 Binding of Igf1 23 0.46 8.33 2.44
56 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
57 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
58 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
59 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
60 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
61 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
62 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
63 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
64 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
65 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
66 INT90491 Binding of Igf1 25 0.44 9.75 1.36
67 INT8511 Localization of Esr1 6 0.80 3.27 1.26
68 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
69 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
70 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
71 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
72 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
73 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06
74 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
75 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
76 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98
77 INT154468 Negative_regulation of Transcription of ESR1 3 0.29 1.14 0.96
78 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95
79 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
80 INT236576 Positive_regulation of Binding of Esr1 3 0.41 2.39 0.92
81 INT154465 Negative_regulation of Transcription of Esr1 1 0.05 0 0.92
82 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9
83 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84
84 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
85 INT174728 Positive_regulation of Transcription of ESR1 10 0.47 3.3 0.83
86 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82
87 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
88 INT33818 Positive_regulation of Negative_regulation of Esr1 3 0.40 0.98 0.82
89 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
90 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73
91 INT92082 Regulation of Binding of ESR1 5 0.45 2.41 0.73
92 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72
93 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7
94 INT191177 Regulation of Localization of ESR1 7 0.42 2.04 0.64
95 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
96 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
97 INT9836 Negative_regulation of Negative_regulation of Esr1 3 0.29 0.95 0.63
98 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
99 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
100 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
101 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55
102 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
103 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
104 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52
105 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
106 INT190899 Negative_regulation of Phosphorylation of ESR1 3 0.33 1.01 0.49
107 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
108 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
109 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47
110 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
111 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
112 INT174725 Positive_regulation of Localization of ESR1 8 0.47 2.45 0.41
113 INT268930 Regulation of Regulation of Esr1 2 0.41 0.48 0.38
114 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
115 INT178630 Positive_regulation of Negative_regulation of ESR1 2 0.04 0.64 0.35
116 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
117 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34
118 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33
119 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
120 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
121 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
122 INT183916 Negative_regulation of Binding of Esr1 1 0.06 0.91 0.32
123 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31
124 INT73915 Negative_regulation of Negative_regulation of Esr1 1 0.40 0.06 0.31
125 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27
126 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
127 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
128 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
129 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
130 INT96972 Positive_regulation of Binding of Esr1 4 0.22 1.35 0.21
131 INT186021 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0.19
132 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
133 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
134 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17
135 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
136 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
137 INT291955 Positive_regulation of Protein_catabolism of Esr1 1 0.06 0.14 0.17
138 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
139 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16
140 INT176461 Protein_catabolism of Esr1 1 0.12 0.37 0.16
141 INT183400 Positive_regulation of Transcription of Esr1 4 0.30 1.06 0.14
142 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
143 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
144 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
145 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
146 INT162109 Negative_regulation of Gene_expression of Esr1 4 0.16 2.41 0.12
147 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
148 INT232556 Positive_regulation of Phosphorylation of Esr1 1 0.20 0.41 0.12
149 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
150 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
151 INT224299 Positive_regulation of Protein_catabolism of ESR1 3 0.64 1.43 0.07
152 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
153 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
154 INT178868 Regulation of Positive_regulation of ESR1 1 0.42 0.52 0.07
155 INT253882 Positive_regulation of Localization of Esr1 1 0.30 1.21 0.06
156 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
157 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
158 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
159 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
160 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
161 INT272379 Positive_regulation of Transcription of Esr1 1 0.04 0.13 0.04
162 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
163 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03
164 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
165 INT174726 Regulation of Regulation of ESR1 1 0.41 0.73 0.03
166 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
167 INT207729 Regulation of FGFR2 4 0.22 2.35 0
168 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
169 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
170 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
171 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
172 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
173 INT99716 Transcription of FGFR2 2 0.34 0.22 0
174 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
175 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
176 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
177 INT174724 Regulation of Transcription of ESR1 2 0.18 0.49 0
178 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
179 INT178629 Positive_regulation of Phosphorylation of ESR1 2 0.36 0.93 0
180 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
181 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
182 INT335681 Regulation of Negative_regulation of Esr1 1 0.03 0 0
183 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
184 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
185 INT173746 Regulation of Transcription of Esr1 1 0.04 0 0
186 INT234505 Gene_expression of HOXD13 1 0.01 0 0
187 INT315189 Binding of SFRP1 1 0.15 2.96 0
188 INT163413 Positive_regulation of HOXD13 1 0.34 0 0
189 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
190 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
191 INT223607 Regulation of Phosphorylation of ESR1 1 0.35 0.65 0
192 INT274266 Regulation of Positive_regulation of IGF1 1 0.35 0.17 0
193 INT264308 Negative_regulation of Regulation of IGF1 1 0.39 0.23 0
194 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
195 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
196 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
197 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
198 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
199 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
200 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
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