GO:0060586

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Name multicellular organismal iron ion homeostasis
Categary Process
Go Slim No
Go Link GO:0060586
Unique Molecular Interactions 38
Total Molecular Interactions 50
Total Single Events 255
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for multicellular organismal iron ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for multicellular organismal iron ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152490 Slc40a1 Negative_regulation of Faah 1 0.01 0.73 0.98
2 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
3 INT209063 Slc11a1 Positive_regulation of Il17a 1 0.11 0.4 0.65
4 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
5 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
6 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43
7 INT209047 Slc11a1 Positive_regulation of Localization of Il10 1 0.10 0.52 0.36
8 INT272412 VSX1 Positive_regulation of Gene_expression of Slc11a1 1 0.00 0.57 0.35
9 INT326438 Binding of HFE and TAPVR1 1 0.01 0.48 0.29
10 INT262809 Il10 Positive_regulation of Regulation of Slc11a1 1 0.17 1.12 0.27
11 INT262810 Slc11a1 Positive_regulation of Gene_expression of Il10 1 0.20 0.97 0.27
12 INT209066 Slc11a1 Positive_regulation of Binding of TNF 1 0.01 1.11 0.24
13 INT226911 Slc11a1 Positive_regulation of Gene_expression of Il6 1 0.09 1.12 0.24
14 INT276241 Slc11a1 Positive_regulation of Gene_expression of Hand1 1 0.02 1.24 0.21
15 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
16 INT226901 Slc11a1 Regulation of Hist1h3f 1 0.02 0.41 0.15
17 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
18 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
19 INT226899 Slc11a1 Positive_regulation of Localization of Gtf3a 1 0.00 0.54 0.11
20 INT226910 Slc11a1 Positive_regulation of Localization of Nfkb1 1 0.11 0.62 0.11
21 INT226912 Slc11a1 Positive_regulation of Localization of IL8 1 0.05 0.58 0.08
22 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
23 INT318387 Binding of Slc40a1 and Hrct1 1 0.02 0.88 0.08
24 INT226913 Slc11a1 Positive_regulation of Gene_expression of IL8 1 0.05 0.63 0.07
25 INT338827 Binding of Slc40a1 and HAMP 1 0.00 0.27 0.05
26 INT226897 Binding of Slc11a1 and Tg(CAG-EGFP)D4Nagy 1 0.01 0.17 0.04
27 INT226905 Slc11a1 Regulation of Nfkb1 1 0.04 0.41 0.03
28 INT272441 Binding of IFNA2 and Slc11a1 1 0.02 0.97 0
29 INT221113 Slc11a1 Negative_regulation of Upk1b 1 0.19 0.37 0
30 INT226896 Slc11a1 Positive_regulation of Binding of Nfkb1 1 0.11 0.08 0
31 INT221114 Slc11a1 Negative_regulation of Upk1a 1 0.23 0.37 0
32 INT226909 Positive_regulation of Binding of Nfkb1 and Slc11a1 1 0.07 0.18 0
33 INT226898 Binding of Nfkb1 and Slc11a1 1 0.06 0.2 0
34 INT242858 Binding of HFE and INS 1 0.06 1.64 0
35 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for multicellular organismal iron ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in multicellular organismal iron ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
2 INT59723 Binding of Slc40a1 5 0.35 1.31 5.17
3 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
4 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33
5 INT209027 Positive_regulation of Positive_regulation of Slc11a1 3 0.14 2.41 2.18
6 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14
7 INT59722 Negative_regulation of Slc40a1 3 0.11 0.56 1.73
8 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66
9 INT58456 Gene_expression of HFE 10 0.58 7.68 1.65
10 INT132882 Gene_expression of Slc40a1 4 0.17 1.35 1.6
11 INT82345 Regulation of Slc40a1 2 0.23 0.33 1.28
12 INT58457 Positive_regulation of HFE 3 0.28 2.75 1.04
13 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
14 INT221108 Negative_regulation of Slc11a1 5 0.33 3.76 0.69
15 INT209023 Positive_regulation of Gene_expression of Slc11a1 3 0.22 1.19 0.6
16 INT209015 Positive_regulation of Localization of Slc11a1 1 0.14 0.45 0.54
17 INT209020 Negative_regulation of Gene_expression of Slc11a1 3 0.16 0.78 0.49
18 INT187778 Gene_expression of Slc11a1 12 0.33 7.37 0.35
19 INT11941 Binding of Slc11a1 3 0.14 2.18 0.35
20 INT226881 Regulation of Positive_regulation of Slc11a1 1 0.09 0.95 0.32
21 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31
22 INT162252 Positive_regulation of Slc40a1 4 0.36 0.79 0.25
23 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22
24 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22
25 INT241865 Positive_regulation of Protein_catabolism of SLC40A1 1 0.02 0.61 0.22
26 INT150594 Negative_regulation of HFE 1 0.00 0 0.2
27 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
28 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13
29 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
30 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
31 INT242865 Binding of HFE 7 0.42 6.01 0.12
32 INT183042 Localization of HFE 2 0.56 1.35 0.12
33 INT288682 Binding of Slc11a2 1 0.47 0 0.12
34 INT204146 Localization of Slc40a1 1 0.05 0.99 0.11
35 INT204144 Negative_regulation of Localization of Slc40a1 1 0.03 0.99 0.11
36 INT318386 Negative_regulation of Gene_expression of Slc40a1 1 0.11 0.48 0.09
37 INT296384 Regulation of SLC40A1 2 0.01 0.83 0.03
38 INT183072 Positive_regulation of Localization of HFE 1 0.05 0.2 0.03
39 INT187781 Positive_regulation of Slc11a1 3 0.24 1.76 0
40 INT242866 Regulation of HFE 2 0.39 1.84 0
41 INT296387 Localization of SLC40A1 2 0.44 0.94 0
42 INT187780 Localization of Slc11a1 2 0.28 0.9 0
43 INT221110 Regulation of Regulation of Slc11a1 1 0.35 0.22 0
44 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0
45 INT262807 Positive_regulation of Transcription of Slc11a1 1 0.19 0.08 0
46 INT187779 Regulation of Slc11a1 1 0.10 0.75 0
47 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0
48 INT315575 Transcription of SLC40A1 1 0.40 0.85 0
49 INT187777 Positive_regulation of Localization of Slc11a1 1 0.19 0.27 0
50 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0
51 INT262808 Transcription of Slc11a1 1 0.26 0.08 0
52 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0
53 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0
54 INT272440 Negative_regulation of Slc11a1 1 0.02 0.81 0
55 INT226886 Regulation of Binding of Slc11a1 1 0.09 0.15 0
56 INT315558 Negative_regulation of SLC40A1 1 0.25 0.63 0
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