GO:0060688

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Name regulation of morphogenesis of a branching structure
Categary Process
Go Slim No
Go Link GO:0060688
Unique Molecular Interactions 117
Total Molecular Interactions 168
Total Single Events 1011
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of morphogenesis of a branching structure. They are ordered first by their pain relevance and then by number of times they were reported for regulation of morphogenesis of a branching structure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
2 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
3 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
4 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
5 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
6 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
7 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
8 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
9 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
10 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
11 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
12 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
13 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
14 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
15 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3
16 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
17 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
18 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
19 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
20 INT180770 Gdnf Positive_regulation of Zbtb38 1 0.00 0.27 0.99
21 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
22 INT180780 Ngf Regulation of Gdnf 1 0.22 0.28 0.96
23 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
24 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
25 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92
26 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
27 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
28 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
29 INT103331 Ngf Positive_regulation of Gdnf 1 0.01 0.57 0.8
30 INT103334 Gdnf Regulation of Gene_expression of TRPV1 1 0.02 0.53 0.77
31 INT103333 Gdnf Regulation of TRPV1 1 0.02 0.53 0.77
32 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
33 INT180783 Binding of Gdnf and Man2a2 1 0.00 0.52 0.71
34 INT180775 Binding of Gdnf and Gfra1 1 0.06 0.52 0.71
35 INT102121 Gdnf Regulation of Gene_expression of Cnr1 1 0.45 0.42 0.71
36 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
37 INT122777 Gdnf Negative_regulation of Gene_expression of Trpv1 1 0.36 0.8 0.62
38 INT122774 Gdnf Negative_regulation of Positive_regulation of Trpv1 1 0.32 0.78 0.61
39 INT242584 Gdnf Regulation of Gene_expression of Qrfp 1 0.00 0.09 0.58
40 INT91267 Gdnf Negative_regulation of Gdnf 1 0.05 0.81 0.58
41 INT242598 Binding of Gdnf and Gfra2 4 0.16 0.38 0.51
42 INT242614 Binding of Gdnf and Gfra1 1 0.03 0 0.51
43 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
44 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5
45 INT242597 Gene_expression of Gdnf Negative_regulation of Trpv1 1 0.27 0.08 0.5
46 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5
47 INT242638 Binding of BDNF and Gdnf 1 0.29 0 0.49
48 INT242600 Binding of Gdnf and Gopc 1 0.06 0 0.49
49 INT165582 Binding of Bdnf and Gdnf 1 0.36 0.47 0.49
50 INT242604 Gdnf Regulation of Gene_expression of Trpv1 1 0.17 0.36 0.48
51 INT98119 Gdnf Regulation of SCN10A 1 0.01 0.34 0.45
52 INT98118 Gdnf Regulation of SCN11A 1 0.01 0.34 0.45
53 INT104459 Gdnf Regulation of Ngf 1 0.26 0.56 0.45
54 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
55 INT127072 Gdnf Regulation of Gene_expression of Fos 1 0.38 0.28 0.43
56 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
57 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
58 INT148436 Binding of Gdnf and Ngf 1 0.35 1.14 0.4
59 INT78627 Gdnf Negative_regulation of Negative_regulation of P2rx3 1 0.00 0.42 0.38
60 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
61 INT289766 Pgf Positive_regulation of Ptgfr 1 0.04 0.07 0.31
62 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
63 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
64 INT260831 Pgf Positive_regulation of TNF 1 0.60 0.75 0.29
65 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 0.01 0.73 0.28
66 INT180788 Gdnf Regulation of Trpv1 1 0.13 0.2 0.28
67 INT277434 Cd5 Regulation of Gdnf 1 0.01 0 0.21
68 INT260827 Binding of Flt1 and Pgf 1 0.27 0.6 0.2
69 INT326385 Mtdh Regulation of Gdnf 1 0.00 0.41 0.14
70 INT193551 Mtpn Positive_regulation of Gene_expression of Gdnf 1 0.02 0.34 0.13
71 INT193552 Gdnf Positive_regulation of Gene_expression of Mtpn 1 0.02 0.34 0.13
72 INT277433 Wibg Positive_regulation of Gdnf 1 0.01 0.6 0.13
73 INT277430 Wibg Positive_regulation of Gene_expression of Gdnf 1 0.01 0.6 0.13
74 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
75 INT141281 ARTN Regulation of Gdnf 1 0.48 0.32 0.12
76 INT141279 Nrtn Regulation of Gdnf 1 0.14 0.32 0.12
77 INT141280 PSPN Regulation of Gdnf 1 0.48 0.32 0.12
78 INT96518 Regulation of Gdnf Positive_regulation of Ret 1 0.00 0.23 0.11
79 INT213554 Gdnf Regulation of Bdnf 1 0.13 0.14 0.1
80 INT213550 Bdnf Regulation of Gdnf 1 0.13 0.14 0.1
81 INT96519 Gdnf Positive_regulation of Ret 1 0.00 0.22 0.1
82 INT356275 Gdnf Positive_regulation of Phosphorylation of Mapk1 1 0.05 0.21 0.09
83 INT242594 Binding of Gdnf and Ret 1 0.21 0 0.08
84 INT326381 Binding of Gdnf and Pcdhb16 1 0.00 0.3 0.08
85 INT326382 Binding of Gdnf and Ncam1 1 0.01 0.3 0.08
86 INT277431 Positive_regulation of Grm3 Positive_regulation of Gene_expression of Gdnf 1 0.18 0 0.07
87 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
88 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
89 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
90 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06
91 INT289767 Ptgfr Positive_regulation of Positive_regulation of Pgf 1 0.03 0 0.05
92 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
93 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
94 INT289762 Pgf Positive_regulation of Gene_expression of Sat1 1 0.21 0 0.04
95 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04
96 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04
97 INT289764 Pgf Regulation of Adcy3 1 0.12 0 0.03
98 INT242601 Gdnf Positive_regulation of Chat 1 0.29 0.15 0.03
99 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
100 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03
101 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03
102 INT277428 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.29 0.47 0.03
103 INT115368 Binding of GDNF and RAPGEF5 1 0.32 0 0
104 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
105 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0
106 INT342043 Binding of Gdnf and Unc5a 1 0.20 0.78 0
107 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
108 INT240271 Binding of GDNF and RET 1 0.09 1.04 0
109 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
110 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
111 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
112 INT312331 Binding of Flt1 and Pgf 1 0.08 0.31 0
113 INT342038 Binding of Gdnf and Ntn1 1 0.01 0.78 0
114 INT356271 Gdnf Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.25 0
115 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of morphogenesis of a branching structure. They are ordered first by their pain relevance and then by number of times they were reported in regulation of morphogenesis of a branching structure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06
2 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49
3 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08
4 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28
5 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77
6 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5
7 INT85844 Regulation of Gdnf 18 0.50 11.08 10.43
8 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62
9 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29
10 INT77795 Localization of Gdnf 26 0.81 6.29 8.55
11 INT77794 Binding of Gdnf 15 0.48 8.38 8.22
12 INT92003 Positive_regulation of Transcription of Gdnf 10 0.66 5.54 7.84
13 INT87546 Transcription of Gdnf 15 0.71 7.49 7.76
14 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65
15 INT87548 Negative_regulation of Gene_expression of Gdnf 9 0.54 5.67 5.94
16 INT115087 Negative_regulation of Gdnf 10 0.51 5.78 5.73
17 INT78626 Regulation of Gdnf 7 0.45 3.3 4.64
18 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61
19 INT78625 Regulation of Gene_expression of Gdnf 7 0.37 2.5 3.47
20 INT209744 Transcription of Gdnf 5 0.67 1.36 2.84
21 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41
22 INT98650 Positive_regulation of Localization of Gdnf 4 0.68 0.94 2.27
23 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14
24 INT180801 Regulation of Binding of Gdnf 1 0.20 1.31 2.03
25 INT209745 Positive_regulation of Transcription of Gdnf 4 0.58 0.97 1.91
26 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
27 INT93182 Binding of Gdnf 7 0.35 1.96 1.64
28 INT98651 Regulation of Positive_regulation of Gdnf 3 0.44 0.97 1.58
29 INT21951 Negative_regulation of Gene_expression of GDNF 5 0.43 2.82 1.57
30 INT87547 Negative_regulation of Transcription of Gdnf 1 0.58 1.24 1.4
31 INT108130 Localization of GDNF 3 0.74 1.36 1.38
32 INT98653 Negative_regulation of Localization of Gdnf 1 0.57 0.31 1.35
33 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
34 INT180795 Positive_regulation of Positive_regulation of Gdnf 2 0.29 0.1 1.07
35 INT108985 Negative_regulation of Regulation of Gdnf 1 0.43 1.11 1.04
36 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
37 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
38 INT4541 Positive_regulation of Pgf 6 0.60 0.93 0.8
39 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
40 INT121947 Negative_regulation of Positive_regulation of Gdnf 1 0.20 0.07 0.76
41 INT260822 Positive_regulation of Pgf 7 0.36 3.36 0.72
42 INT258 Gene_expression of Pgf 5 0.42 1.75 0.72
43 INT236094 Localization of Gdnf 4 0.70 2.51 0.68
44 INT209746 Regulation of Positive_regulation of Gdnf 2 0.37 0.11 0.68
45 INT2827 Localization of Pgf 3 0.68 0.75 0.67
46 INT4540 Negative_regulation of Pgf 2 0.29 0.14 0.66
47 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
48 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
49 INT260825 Regulation of Pgf 2 0.22 1.44 0.63
50 INT241673 Phosphorylation of GDNF 2 0.79 1.06 0.61
51 INT85138 Binding of GDNF 6 0.37 2.01 0.58
52 INT2830 Negative_regulation of Localization of Pgf 2 0.42 0.67 0.58
53 INT98112 Positive_regulation of Negative_regulation of Gdnf 1 0.05 0.44 0.57
54 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
55 INT127069 Regulation of Localization of Gdnf 1 0.34 0.46 0.46
56 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
57 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
58 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
59 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
60 INT148433 Negative_regulation of Binding of Gdnf 1 0.41 1.14 0.4
61 INT260824 Binding of Pgf 1 0.29 1.1 0.33
62 INT283244 Gene_expression of Pgf 7 0.52 2.41 0.32
63 INT88012 Regulation of Gene_expression of GDNF 2 0.43 0.48 0.31
64 INT39057 Regulation of Pgf 2 0.28 0.52 0.29
65 INT242536 Negative_regulation of Gene_expression of Gdnf 1 0.30 0.06 0.28
66 INT289734 Positive_regulation of Gene_expression of Pgf 1 0.25 0.7 0.27
67 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
68 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
69 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
70 INT111573 Negative_regulation of Gene_expression of Pgf 1 0.10 0.14 0.21
71 INT289742 Regulation of Negative_regulation of Pgf 1 0.22 0 0.21
72 INT289727 Negative_regulation of Pgf 1 0.21 0 0.21
73 INT4538 Negative_regulation of Positive_regulation of Pgf 2 0.36 0.45 0.2
74 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
75 INT88007 Regulation of GDNF 2 0.34 0.82 0.16
76 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12
77 INT277419 Positive_regulation of Positive_regulation of Gdnf 1 0.47 0 0.12
78 INT88013 Transcription of GDNF 2 0.40 0.22 0.11
79 INT88011 Positive_regulation of Transcription of GDNF 1 0.35 0.22 0.11
80 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
81 INT351643 Negative_regulation of Positive_regulation of Pgf 1 0.17 2.66 0.08
82 INT277418 Regulation of Binding of Gdnf 1 0.42 0 0.08
83 INT347981 Positive_regulation of Phosphorylation of Gdnf 1 0.11 0.79 0.07
84 INT347993 Regulation of Phosphorylation of Gdnf 1 0.10 0.87 0.07
85 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
86 INT347980 Phosphorylation of Gdnf 1 0.19 0.79 0.07
87 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
88 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
89 INT289722 Localization of Pgf 3 0.45 0.63 0.04
90 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
91 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
92 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
93 INT289723 Negative_regulation of Gene_expression of Pgf 1 0.21 0.7 0.03
94 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
95 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
96 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
97 INT207729 Regulation of FGFR2 4 0.22 2.35 0
98 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0
99 INT99716 Transcription of FGFR2 2 0.34 0.22 0
100 INT305351 Positive_regulation of Regulation of FGFR2 2 0.37 0.97 0
101 INT99715 Regulation of Gene_expression of FGFR2 2 0.22 0.19 0
102 INT196027 Binding of Bmp4 2 0.13 0.97 0
103 INT142119 Regulation of Bmp4 2 0.58 0.29 0
104 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0
105 INT289736 Positive_regulation of Localization of Pgf 1 0.25 0 0
106 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
107 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
108 INT339667 Localization of Bmp4 1 0.38 0.27 0
109 INT289735 Positive_regulation of Positive_regulation of Pgf 1 0.28 0 0
110 INT312329 Binding of Pgf 1 0.14 0.31 0
111 INT99717 Positive_regulation of Transcription of FGFR2 1 0.10 0.08 0
112 INT183117 Positive_regulation of Binding of FGFR2 1 0.09 0.81 0
113 INT331205 Protein_catabolism of Gdnf 1 0.03 0.57 0
114 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
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