GO:0060708

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Name spongiotrophoblast differentiation
Categary Process
Go Slim No
Go Link GO:0060708
Unique Molecular Interactions 119
Total Molecular Interactions 156
Total Single Events 611
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for spongiotrophoblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported for spongiotrophoblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
2 INT8415 LIF Regulation of VIP 1 0.13 0.36 1.04
3 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
4 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
5 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
6 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
7 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82
8 INT149597 Lif Regulation of Regulation of Gal 1 0.30 0.69 0.73
9 INT149596 Lif Negative_regulation of Negative_regulation of Gal 1 0.10 0.5 0.7
10 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63
11 INT82267 Lif Regulation of Gene_expression of Gal 1 0.40 2.76 0.62
12 INT149595 Lif Negative_regulation of Negative_regulation of Trpv1 1 0.34 0.44 0.61
13 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
14 INT98480 Lif Positive_regulation of Pnoc 1 0.18 0.2 0.49
15 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48
16 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48
17 INT98484 Lif Regulation of Gene_expression of Gal 1 0.04 0.16 0.47
18 INT98482 Lif Positive_regulation of Gene_expression of Pnoc 1 0.16 0.17 0.46
19 INT264136 IFNA1 Positive_regulation of Socs3 1 0.01 0.38 0.46
20 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45
21 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45
22 INT188205 OSM Regulation of LIF 1 0.09 1.12 0.43
23 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43
24 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
25 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39
26 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
27 INT91719 Binding of BDNF and LIF 1 0.09 1.65 0.38
28 INT184128 Socs3 Negative_regulation of Il6 1 0.12 1.14 0.36
29 INT184095 Il10 Positive_regulation of Socs3 1 0.21 0.49 0.34
30 INT184082 Binding of Socs3 and Il6 1 0.11 0.49 0.33
31 INT315200 Negative_regulation of Binding of Socs3 and Stat3 1 0.26 1.18 0.27
32 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22
33 INT82268 Lif Regulation of Gene_expression of Iapp 1 0.06 0.9 0.2
34 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17
35 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17
36 INT32211 POMC Positive_regulation of Gene_expression of Lif 1 0.01 0.61 0.15
37 INT250778 Binding of Socs3 and Atl1 1 0.01 0.6 0.14
38 INT184104 Binding of Socs3 and Gopc 1 0.10 0 0.14
39 INT188197 LIF Positive_regulation of STAT3 1 0.35 0.27 0.12
40 INT294440 KLK4 Negative_regulation of LIF 1 0.00 0 0.1
41 INT188357 Csf2 Positive_regulation of Socs3 1 0.36 0.15 0.1
42 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
43 INT179871 IK Positive_regulation of SOCS3 1 0.01 1 0.1
44 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08
45 INT273373 SOCS3 Regulation of Phosphorylation of STAT3 1 0.42 0.06 0.08
46 INT299539 Lif Positive_regulation of Phosphorylation of Stat3 1 0.08 0 0.08
47 INT355020 Lif Positive_regulation of SOAT1 1 0.02 0.7 0.08
48 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
49 INT184119 Socs3 Negative_regulation of Csf3 1 0.21 0.64 0.08
50 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
51 INT273369 SOCS3 Negative_regulation of JAK1 1 0.03 0 0.07
52 INT12987 LIF Regulation of Localization of Prl 1 0.09 0 0.07
53 INT299535 Binding of Egf and Lif 1 0.07 0 0.07
54 INT273363 SOCS3 Regulation of Protein_catabolism of SOCS1 1 0.02 0 0.07
55 INT273364 SOCS3 Regulation of SOCS1 1 0.02 0 0.07
56 INT316492 Stat3 Positive_regulation of Socs3 1 0.46 0.19 0.06
57 INT238218 STAT3 Positive_regulation of Gene_expression of Socs3 1 0.14 0 0.05
58 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05
59 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
60 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
61 INT268652 Binding of CLDN4 and LIF 1 0.35 0.44 0.04
62 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
63 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
64 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
65 INT266075 LIF Regulation of Gene_expression of PAEP 1 0.19 0.43 0.03
66 INT266070 LIF Regulation of Gene_expression of PAPPA 1 0.35 0.49 0.03
67 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 0.17 0.43 0.03
68 INT266067 PAPPA Regulation of Gene_expression of LIF 1 0.35 0.49 0.03
69 INT266076 LIF Regulation of Gene_expression of LGALS1 1 0.17 0.43 0.03
70 INT66341 LIF Positive_regulation of Gene_expression of FOS 1 0.11 1.07 0
71 INT66339 LIF Positive_regulation of Phosphorylation of CLIP2 1 0.45 1.57 0
72 INT268651 NUPL2 Positive_regulation of Gene_expression of LIF 1 0.66 0.07 0
73 INT66342 LIF Positive_regulation of Phosphorylation of CLIP1 1 0.60 1.57 0
74 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
75 INT66353 LIF Regulation of Ctf2p 1 0.02 0.47 0
76 INT66340 LIF Positive_regulation of C1orf61 1 0.12 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for spongiotrophoblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported in spongiotrophoblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
2 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27
3 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76
4 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71
5 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7
6 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4
7 INT76240 Positive_regulation of Lif 6 0.69 6.04 3.13
8 INT184005 Negative_regulation of Gene_expression of Socs3 6 0.48 8.76 2.74
9 INT142465 Negative_regulation of Socs3 8 0.48 8.31 2.62
10 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34
11 INT44027 Positive_regulation of Lif 7 0.40 2.76 1.9
12 INT253751 Localization of Lif 3 0.73 3.94 1.58
13 INT50437 Regulation of LIF 6 0.44 2.12 1.53
14 INT184032 Regulation of Socs3 6 0.37 4.08 1.48
15 INT50436 Negative_regulation of Positive_regulation of LIF 1 0.37 0.33 1.42
16 INT34933 Positive_regulation of Gene_expression of LIF 6 0.67 3.41 1.38
17 INT184056 Regulation of Gene_expression of Socs3 4 0.45 4.24 1.22
18 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14
19 INT184020 Localization of Socs3 3 0.75 4.05 1.06
20 INT149594 Positive_regulation of Gene_expression of Lif 2 0.47 0.89 1
21 INT102819 Regulation of Lif 8 0.53 2.05 0.87
22 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84
23 INT82262 Regulation of Lif 3 0.31 1.67 0.83
24 INT354449 Positive_regulation of Localization of Lif 1 0.33 1.24 0.83
25 INT184026 Binding of Socs3 7 0.42 1.93 0.81
26 INT68794 Negative_regulation of LIF 6 0.41 1.38 0.7
27 INT2109 Negative_regulation of Gene_expression of LIF 4 0.41 0.89 0.66
28 INT184065 Phosphorylation of Socs3 2 0.81 2.67 0.53
29 INT216834 Localization of Lif 2 0.34 0.23 0.46
30 INT299516 Phosphorylation of Lif 1 0.26 0.56 0.46
31 INT234580 Regulation of Positive_regulation of Socs3 1 0.26 0.54 0.46
32 INT179887 Positive_regulation of SOCS3 10 0.50 13.06 0.45
33 INT2110 Localization of LIF 5 0.73 1.59 0.44
34 INT32207 Regulation of Gene_expression of Lif 3 0.19 1.01 0.42
35 INT299519 Binding of Lif 2 0.21 0.67 0.29
36 INT188235 Phosphorylation of LIF 1 0.53 0.48 0.23
37 INT226426 Negative_regulation of SOCS3 2 0.15 10.24 0.22
38 INT318610 Positive_regulation of Binding of Lif 1 0.28 0.67 0.19
39 INT188224 Regulation of Gene_expression of LIF 1 0.23 0.53 0.18
40 INT188216 Positive_regulation of Regulation of LIF 1 0.39 1.13 0.17
41 INT234581 Transcription of Socs3 2 0.51 0.22 0.15
42 INT338147 Negative_regulation of Gene_expression of Lif 1 0.38 0.29 0.15
43 INT216451 Negative_regulation of Lif 1 0.36 0.77 0.15
44 INT273407 Transcription of SOCS3 1 0.62 0.17 0.11
45 INT184044 Positive_regulation of Protein_catabolism of Socs3 2 0.38 0.47 0.1
46 INT184010 Protein_catabolism of Socs3 2 0.54 0.46 0.1
47 INT179890 Localization of SOCS3 1 0.54 1.02 0.1
48 INT315199 Regulation of Phosphorylation of Socs3 1 0.45 1.22 0.09
49 INT352530 Positive_regulation of Positive_regulation of SOCS3 1 0.15 1.77 0.08
50 INT273403 Positive_regulation of Transcription of SOCS3 1 0.40 0.06 0.08
51 INT333440 Protein_catabolism of Lif 1 0.23 0.2 0.08
52 INT216454 Binding of Lif 2 0.27 0.85 0.07
53 INT140267 Negative_regulation of Positive_regulation of Socs3 1 0.31 0.53 0.07
54 INT273397 Binding of SOCS3 1 0.42 0 0.07
55 INT273405 Negative_regulation of Binding of SOCS3 1 0.37 0 0.07
56 INT299524 Positive_regulation of Localization of Lif 1 0.21 0 0.06
57 INT300107 Positive_regulation of Gene_expression of SOCS3 1 0.15 3.58 0.05
58 INT333439 Positive_regulation of Gene_expression of Lif 1 0.18 0.18 0.04
59 INT300092 Regulation of SOCS3 1 0.08 3.03 0.03
60 INT266088 Positive_regulation of Localization of LIF 1 0.34 0.45 0.03
61 INT66346 Binding of LIF 7 0.47 0.9 0
62 INT159329 Transcription of Lif 1 0.36 0.15 0
63 INT332349 Positive_regulation of Regulation of Socs3 1 0.42 0.19 0
64 INT300189 Negative_regulation of Localization of Lif 1 0.41 0.47 0
65 INT268657 Regulation of Localization of LIF 1 0.38 0.07 0
66 INT300103 Positive_regulation of Negative_regulation of SOCS3 1 0.15 1.75 0
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