GO:0060711

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Name labyrinthine layer development
Categary Process
Go Slim No
Go Link GO:0060711
Unique Molecular Interactions 69
Total Molecular Interactions 79
Total Single Events 485
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for labyrinthine layer development. They are ordered first by their pain relevance and then by number of times they were reported for labyrinthine layer development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
3 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
4 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
5 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
6 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
7 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
8 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
9 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
10 INT54945 Gab1 Regulation of Positive_regulation of Ltp 1 0.01 0.29 0.42
11 INT54946 Gab1 Regulation of Ltp 1 0.01 0.29 0.42
12 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
13 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
14 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31
15 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24
16 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
17 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
18 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
19 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
20 INT86892 Glp2r Regulation of Gene_expression of Cdx2 1 0.38 0 0.17
21 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
22 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
23 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
24 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
25 INT120573 Positive_regulation of Binding of Egfr and Gab1 1 0.63 1.22 0.05
26 INT120571 Binding of Egfr and Gab1 1 0.44 1.21 0.05
27 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
28 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
29 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
30 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
31 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
32 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
33 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
34 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
35 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03
36 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
37 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
38 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
39 INT164217 Binding of Cdx1 and Cdx2 1 0.36 0 0
40 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
41 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
42 INT189555 EGLN1 Regulation of Gene_expression of VEGFA 1 0.07 0.57 0
43 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
44 INT234621 CDX2 Negative_regulation of IGFBP3 1 0.38 0.8 0
45 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
46 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0
47 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0
48 INT234623 Binding of CDX2 and IGFBP3 1 0.32 1.71 0
49 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0
50 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0
51 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
52 INT164218 Regulation of Binding of Cdx1 and Cdx2 1 0.27 0 0
53 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0
54 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
55 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0
56 INT336606 Binding of Mapk8 and Map2k1 1 0.09 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for labyrinthine layer development. They are ordered first by their pain relevance and then by number of times they were reported in labyrinthine layer development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
2 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
3 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
4 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
5 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
6 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
7 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
8 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
9 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
10 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
11 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
12 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
13 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
14 INT86889 Gene_expression of Cdx2 8 0.60 4.23 1.02
15 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
16 INT54940 Positive_regulation of Gab1 1 0.04 0.48 0.79
17 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
18 INT54939 Regulation of Gab1 1 0.04 0.39 0.59
19 INT143958 Negative_regulation of Gene_expression of Cdx2 1 0.13 0.1 0.58
20 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
21 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
22 INT54937 Negative_regulation of Gab1 1 0.03 0.27 0.42
23 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
24 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
25 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
26 INT190032 Negative_regulation of Cdx2 2 0.38 0.74 0.3
27 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
28 INT190010 Transcription of Cdx2 1 0.53 0.69 0.26
29 INT156595 Gene_expression of CDX2 10 0.69 7.8 0.25
30 INT164210 Gene_expression of Cdx2 3 0.56 2.22 0.25
31 INT181914 Positive_regulation of EGLN1 1 0.36 2.03 0.25
32 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
33 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
34 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
35 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
36 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
37 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12
38 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
39 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
40 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
41 INT210255 Positive_regulation of Negative_regulation of Cdx2 1 0.33 0 0.07
42 INT86888 Regulation of Gene_expression of Cdx2 1 0.48 0 0.07
43 INT158616 Localization of EGLN1 1 0.73 0.54 0.06
44 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04
45 INT329571 Binding of MAP2K1 2 0.11 0.4 0
46 INT189577 Negative_regulation of EGLN1 1 0.31 1.73 0
47 INT189603 Negative_regulation of Transcription of EGLN1 1 0.31 0.94 0
48 INT185018 Positive_regulation of CDX2 1 0.62 0.36 0
49 INT281758 Positive_regulation of Protein_catabolism of Map2k1 1 0.29 0.13 0
50 INT198405 Binding of CDX2 1 0.32 1.01 0
51 INT281756 Protein_catabolism of Map2k1 1 0.42 0.13 0
52 INT189605 Regulation of EGLN1 1 0.33 1.65 0
53 INT175533 Regulation of Gene_expression of Map2k1 1 0.20 1.55 0
54 INT189617 Transcription of EGLN1 1 0.50 0.94 0
55 INT225247 Phosphorylation of Gab1 1 0.36 0.29 0
56 INT219966 Phosphorylation of CDX2 1 0.71 0.63 0
57 INT164203 Binding of Cdx2 1 0.33 0 0
58 INT164202 Regulation of Cdx2 1 0.25 0 0
59 INT184983 Negative_regulation of Gene_expression of CDX2 1 0.52 0.71 0
60 INT189572 Positive_regulation of Gene_expression of EGLN1 1 0.34 0.92 0
61 INT164215 Positive_regulation of Gene_expression of Cdx2 1 0.43 0 0
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