GO:0060766

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Name negative regulation of androgen receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0060766
Unique Molecular Interactions 353
Total Molecular Interactions 490
Total Single Events 3640
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of androgen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of androgen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
3 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
4 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
5 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
6 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
7 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
8 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
9 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
10 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
11 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
12 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
13 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
14 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
15 INT108811 Esr2 Positive_regulation of Binding of Oprm1 1 0.46 0.44 0.79
16 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
17 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
18 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
19 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
20 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59
21 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
22 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
23 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
24 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
25 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
26 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
27 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
28 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
29 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
30 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
31 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
32 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
33 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
34 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
35 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
36 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
37 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
38 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
39 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
40 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
41 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
42 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
43 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
44 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
45 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
46 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
47 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37
48 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
49 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
50 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
51 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
52 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
53 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32
54 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32
55 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
56 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
57 INT281127 Tcf21 Positive_regulation of Gene_expression of Cxcr4 1 0.08 0.42 0.3
58 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
59 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
60 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
61 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
62 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28
63 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
64 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28
65 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
66 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
67 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
68 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
69 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
70 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
71 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
72 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
73 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
74 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
75 INT197590 Esr2 Positive_regulation of Negative_regulation of Pgr 1 0.16 0 0.24
76 INT159163 Binding of Esr2 and Regulation of Gper 1 0.41 0.27 0.23
77 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
78 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
79 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
80 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
81 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
82 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
83 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
84 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
85 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
86 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
87 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
88 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
89 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
90 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
91 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
92 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
93 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
94 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
95 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
96 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
97 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
98 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
99 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
100 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
101 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
102 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
103 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
104 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
105 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
106 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
107 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
108 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
109 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
110 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
111 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
112 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
113 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
114 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
115 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
116 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
117 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
118 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
119 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
120 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
121 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
122 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
123 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
124 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
125 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
126 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
127 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
128 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
129 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
130 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
131 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
132 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
133 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
134 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
135 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
136 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
137 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
138 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
139 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1
140 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
141 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
142 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
143 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1
144 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
145 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
146 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
147 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09
148 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
149 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
150 INT201618 Uvbi1 Positive_regulation of Phb 1 0.04 0.28 0.09
151 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
152 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
153 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
154 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
155 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
156 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
157 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08
158 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
159 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
160 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
161 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
162 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08
163 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
164 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
165 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07
166 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
167 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
168 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
169 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
170 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07
171 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
172 INT70762 IGF1 Regulation of Gh 1 0.00 0.17 0.07
173 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
174 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
175 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
176 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
177 INT51273 IGF1 Positive_regulation of IGFBP2 1 0.37 0.13 0.06
178 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
179 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
180 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
181 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
182 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
183 INT197594 Esr1 Regulation of Esr2 1 0.04 0 0.06
184 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
185 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
186 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
187 INT51276 IGF1 Negative_regulation of GH1 1 0.10 0.13 0.06
188 INT187845 Binding of ESR1 and Esr2 1 0.01 0.17 0.06
189 INT197592 Esr2 Regulation of Esr1 1 0.04 0 0.06
190 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
191 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
192 INT197586 Esr2 Regulation of Pgr 1 0.09 0 0.06
193 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
194 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
195 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05
196 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
197 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
198 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
199 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
200 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of androgen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of androgen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
3 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
4 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
5 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
6 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
7 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
8 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
9 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
10 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
11 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
12 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
13 INT34777 Localization of IGF1 82 0.80 42.68 8.62
14 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
15 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
16 INT31333 Gene_expression of Esr2 19 0.69 8.78 6.83
17 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
18 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
19 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
20 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
21 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
22 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
23 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
24 INT151032 Localization of Igf1 49 0.76 26.32 5.71
25 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
26 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
27 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
28 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
29 INT49360 Localization of Igf1 22 0.76 6.96 4.26
30 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92
31 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
32 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
33 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
34 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
35 INT16130 Binding of IGF1 67 0.48 27.43 2.95
36 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
37 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
38 INT66544 Binding of Igf1 23 0.46 8.33 2.44
39 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
40 INT108796 Binding of ESR2 5 0.46 6.84 2.36
41 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3
42 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
43 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
44 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
45 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
46 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
47 INT109800 Binding of Esr2 8 0.42 1.79 1.93
48 INT316162 Localization of TCF21 1 0.18 0.28 1.71
49 INT153918 Binding of Esr2 3 0.33 2.56 1.7
50 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
51 INT30076 Negative_regulation of Esr2 1 0.01 0 1.63
52 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
53 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
54 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
55 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
56 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
57 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
58 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
59 INT90491 Binding of Igf1 25 0.44 9.75 1.36
60 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
61 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19
62 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
63 INT180580 Binding of HEYL 7 0.17 4.49 1.15
64 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
65 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
66 INT332771 Phosphorylation of Tcf21 1 0.09 0.21 1.07
67 INT332772 Positive_regulation of Phosphorylation of Tcf21 1 0.06 0.21 1.07
68 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
69 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
70 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
71 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
72 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
73 INT66862 Regulation of Esr2 3 0.24 1.56 1.01
74 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
75 INT102677 Negative_regulation of TCF21 2 0.41 0.22 0.89
76 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
77 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
78 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
79 INT158075 Positive_regulation of Esr2 1 0.28 0.5 0.77
80 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
81 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68
82 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
83 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
84 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
85 INT281366 Regulation of Tcf21 1 0.09 0.23 0.59
86 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
87 INT316161 Negative_regulation of Gene_expression of TCF21 1 0.10 0.11 0.56
88 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
89 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
90 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
91 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
92 INT180578 Regulation of HEYL 3 0.06 3.15 0.49
93 INT30075 Localization of Esr2 2 0.01 0.78 0.49
94 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
95 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
96 INT222229 Localization of Tcf21 1 0.57 0.45 0.45
97 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
98 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
99 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
100 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
101 INT109801 Transcription of Esr2 2 0.69 2.08 0.41
102 INT348631 Regulation of Esr2 1 0.40 0.87 0.4
103 INT186535 Negative_regulation of Gene_expression of Esr2 2 0.25 1.07 0.38
104 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
105 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
106 INT194086 Negative_regulation of Gene_expression of ESR2 1 0.03 1.22 0.35
107 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
108 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
109 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
110 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
111 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
112 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
113 INT66863 Regulation of Gene_expression of Esr2 1 0.03 0 0.31
114 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
115 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
116 INT102801 Regulation of ESR2 1 0.51 0 0.27
117 INT102800 Regulation of Gene_expression of ESR2 1 0.22 0 0.27
118 INT138751 Localization of ESR2 2 0.72 1.51 0.24
119 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
120 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
121 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
122 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
123 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
124 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
125 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
126 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
127 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
128 INT180592 Negative_regulation of Gene_expression of HEYL 1 0.03 0.3 0.15
129 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
130 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
131 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
132 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
133 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
134 INT180593 Positive_regulation of Gene_expression of HEYL 1 0.03 0.18 0.12
135 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
136 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
137 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
138 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
139 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
140 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
141 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
142 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
143 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
144 INT261361 Negative_regulation of Esr2 1 0.15 0.67 0.09
145 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
146 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
147 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
148 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
149 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
150 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
151 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
152 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
153 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
154 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
155 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
156 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
157 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
158 INT176573 Positive_regulation of Esr2 2 0.01 1.43 0.04
159 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
160 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
161 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
162 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
163 INT260908 Positive_regulation of Smarca4 2 0.21 0.53 0.03
164 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
165 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
166 INT204349 Regulation of SIRT1 8 0.61 1.99 0
167 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
168 INT256134 Localization of Sirt1 5 0.50 2.99 0
169 INT277595 Localization of Hdac1 4 0.73 0.81 0
170 INT204353 Transcription of SIRT1 3 0.68 0.67 0
171 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
172 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
173 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
174 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
175 INT261751 Regulation of Hdac1 2 0.41 0 0
176 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
177 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
178 INT180583 Negative_regulation of HEYL 1 0.03 0 0
179 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
180 INT319154 Transcription of Hdac1 1 0.66 0 0
181 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
182 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
183 INT289569 Transcription of Sirt1 1 0.71 0.25 0
184 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
185 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
186 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
187 INT300287 Localization of Sirt1 1 0.66 1.46 0
188 INT307589 Positive_regulation of Gene_expression of ESR2 1 0.42 0.5 0
189 INT243078 Gene_expression of Phb 1 0.42 0.09 0
190 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
191 INT210818 Phosphorylation of HEYL 1 0.04 0.08 0
192 INT315189 Binding of SFRP1 1 0.15 2.96 0
193 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
194 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
195 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
196 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
197 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
198 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
199 INT138752 Transcription of ESR2 1 0.60 0 0
200 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
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