GO:0060999

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Name positive regulation of dendritic spine development
Categary Process
Go Slim No
Go Link GO:0060999
Unique Molecular Interactions 150
Total Molecular Interactions 206
Total Single Events 1629
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of dendritic spine development. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of dendritic spine development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
2 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
3 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
4 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
5 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47
6 INT86172 Pdyn Positive_regulation of Gene_expression of Il2 1 0.20 0 1.33
7 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
8 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
9 INT142154 Trpv1 Positive_regulation of Gene_expression of Il2 1 0.22 0 1.21
10 INT287749 Dmbx1 Positive_regulation of Gene_expression of Lpar1 1 0.41 0.82 1.16
11 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08
12 INT54501 beta-End6-31 Positive_regulation of Gene_expression of Il2 1 0.03 0 1.06
13 INT231391 Binding of Lpar1 and Rbm39 1 0.00 1.04 1.04
14 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93
15 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
16 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92
17 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91
18 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86
19 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
20 INT53199 Positive_regulation of Cd4 Positive_regulation of Gene_expression of Il2 1 0.52 0.72 0.8
21 INT344974 Lpar1 Regulation of Gene_expression of Mag 1 0.25 0.98 0.76
22 INT209035 Il2 Positive_regulation of Ccr1 1 0.00 0.38 0.73
23 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73
24 INT209052 Il2 Positive_regulation of Il17a 1 0.03 0.38 0.73
25 INT209053 Il2 Positive_regulation of Elf1 1 0.06 0.38 0.73
26 INT209036 Il2 Positive_regulation of Cxcl1 1 0.04 0.38 0.73
27 INT209051 Il2 Positive_regulation of Csf2 1 0.02 0.38 0.73
28 INT351351 Prkcg Regulation of Lpar1 1 0.12 0.58 0.72
29 INT351350 Prkaca Regulation of Lpar1 1 0.04 0.58 0.72
30 INT151681 Il2 Negative_regulation of Art2a-ps 1 0.00 1.23 0.7
31 INT151678 Il2 Negative_regulation of Oas1b 1 0.13 1.23 0.7
32 INT54502 Pomc Positive_regulation of Gene_expression of Il2 1 0.16 0 0.68
33 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67
34 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
35 INT82382 Penk Positive_regulation of Gene_expression of Il2 1 0.10 0 0.66
36 INT72504 IgG Negative_regulation of Il2 1 0.37 0 0.65
37 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
38 INT86171 Oprl1 Positive_regulation of Gene_expression of Il2 1 0.30 0 0.64
39 INT60375 Il2 Regulation of Localization of Penk 1 0.03 0 0.59
40 INT287753 Lpar3 Positive_regulation of Gene_expression of Lpar1 1 0.46 0.39 0.58
41 INT287744 Lpar3 Positive_regulation of Positive_regulation of Lpar1 1 0.46 0.39 0.58
42 INT287752 Dmbx1 Positive_regulation of Positive_regulation of Lpar1 1 0.41 0.39 0.58
43 INT60374 Il2 Positive_regulation of Pomc 1 0.07 0 0.58
44 INT60372 Il2 Positive_regulation of Localization of Pomc 1 0.08 0 0.58
45 INT60373 Il2 Positive_regulation of Localization of Penk 1 0.52 0 0.58
46 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
47 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
48 INT32597 Pomc Regulation of Gene_expression of Il2 1 0.29 0 0.49
49 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46
50 INT175788 Il2 Positive_regulation of Localization of Avp 1 0.03 0.41 0.46
51 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46
52 INT287751 Rbm39 Positive_regulation of Positive_regulation of Lpar1 1 0.01 0.48 0.39
53 INT287754 Lpar2 Positive_regulation of Gene_expression of Lpar1 1 0.44 0.48 0.39
54 INT287745 Rbm39 Positive_regulation of Gene_expression of Lpar1 1 0.01 0.48 0.39
55 INT287740 Lpar3 Regulation of Gene_expression of Lpar1 1 0.60 0.53 0.39
56 INT287743 Lpar2 Positive_regulation of Positive_regulation of Lpar1 1 0.44 0.48 0.39
57 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36
58 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36
59 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
60 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
61 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
62 INT212568 Fst Regulation of Gene_expression of Il2 1 0.30 0.07 0.24
63 INT298993 Il2 Positive_regulation of Gene_expression of Il13 1 0.01 0.73 0.24
64 INT331087 Csf2 Positive_regulation of Gene_expression of Il2 1 0.00 0.22 0.24
65 INT62451 Il2 Regulation of Localization of Crh 1 0.53 0.19 0.2
66 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
67 INT345172 Lpar1 Positive_regulation of S1pr1 1 0.21 0.19 0.19
68 INT171391 Lpar1 Positive_regulation of Mapk1 1 0.04 0.13 0.18
69 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18
70 INT52790 D5Nam12 Regulation of Localization of Il2 1 0.01 0 0.18
71 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
72 INT345176 Lpar1 Positive_regulation of Gene_expression of Car2 1 0.03 0.11 0.16
73 INT211310 Trav6-3 Positive_regulation of Positive_regulation of Il2 1 0.02 0.2 0.15
74 INT345157 Lpar1 Positive_regulation of Gene_expression of Gtf3a 1 0.00 0.89 0.15
75 INT345175 Lpar1 Regulation of Gpbar1 1 0.05 0.22 0.15
76 INT302826 Negative_regulation of Binding of Il2 and Kit 1 0.01 1.28 0.14
77 INT302827 Binding of Il2 and Kit 1 0.01 1.27 0.14
78 INT315492 Hspg2 Negative_regulation of Gene_expression of Il2 1 0.06 0.14 0.14
79 INT252336 Il2 Positive_regulation of Akt1 1 0.01 0 0.13
80 INT215010 Myoz1 Positive_regulation of Gene_expression of Il2 1 0.05 0.13 0.13
81 INT37134 Il2 Regulation of Ril 1 0.22 0.31 0.12
82 INT299782 Cd28 Regulation of Gene_expression of Il2 1 0.01 0.43 0.11
83 INT299781 Cd80 Regulation of Gene_expression of Il2 1 0.01 0.43 0.11
84 INT253074 Prok2 Regulation of Gene_expression of Il2 1 0.09 0.15 0.1
85 INT303179 Binding of Dlgap1 and Shank1 1 0.22 0.31 0.1
86 INT345194 Lpar1 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.87 0.1
87 INT315490 Hspg2 Negative_regulation of Il2 1 0.08 0 0.09
88 INT303180 Trim3 Negative_regulation of Shank1 1 0.40 0 0.09
89 INT345169 Lpar1 Negative_regulation of Dmbx1 1 0.08 2.26 0.08
90 INT318074 Polr1a Negative_regulation of Gene_expression of Il2 1 0.00 0.46 0.08
91 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07
92 INT345178 S1pr1 Positive_regulation of Lpar1 1 0.14 0.09 0.07
93 INT182897 Mak Positive_regulation of Gene_expression of Il2 1 0.38 0.09 0.07
94 INT303176 Gene_expression of Trim3 Positive_regulation of Protein_catabolism of Shank1 1 0.44 0 0.07
95 INT345179 Binding of Lpar1 and Gpbar1 1 0.05 0.15 0.07
96 INT192407 Col7a1 Positive_regulation of Gene_expression of Il2 1 0.01 0.09 0.07
97 INT345164 Binding of Lpar1 and P2ry10 1 0.14 0.09 0.07
98 INT215006 Myoz1 Regulation of Transcription of Il2 1 0.06 0.44 0.06
99 INT25399 Il2 Positive_regulation of Gene_expression of Csf2 1 0.41 0.07 0.05
100 INT182098 Binding of IL8 and Il2 1 0.00 0 0.04
101 INT299762 Binding of Cd28 and Positive_regulation of Gene_expression of Il2 1 0.03 0.07 0.04
102 INT345190 Lpar1 Regulation of Localization of Il6 1 0.05 1.19 0.04
103 INT354963 Binding of Cttn and Shank1 1 0.12 0 0.04
104 INT354971 Binding of HOMER1 and Shank1 1 0.01 0 0.04
105 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04
106 INT182099 Binding of TNF and Il2 1 0.01 0 0.04
107 INT345170 Pla2g6 Positive_regulation of Gene_expression of Lpar1 1 0.07 0 0.04
108 INT265226 Binding of IFN1@ and Il2 1 0.07 0.19 0.04
109 INT182095 Binding of Il2 and Il6 1 0.01 0 0.04
110 INT120449 Pparg Positive_regulation of Negative_regulation of Il2 1 0.75 0 0.04
111 INT345182 Binding of Lpar1 and Gsn 1 0.04 0 0.04
112 INT303170 Gene_expression of Trim3 Negative_regulation of Shank1 1 0.40 0.12 0.04
113 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03
114 INT345167 Binding of S1pr1 and Lpar1 1 0.13 0.07 0.03
115 INT345187 Positive_regulation of Binding of Alb and Lpar1 1 0.04 0.92 0.03
116 INT272594 Binding of Dlg4 and Shank1 1 0.20 0 0.03
117 INT345155 Lpar1 Positive_regulation of Lpar3 1 0.23 0.07 0.03
118 INT345161 Lpar1 Positive_regulation of Lpar2 1 0.36 0.07 0.03
119 INT345156 Binding of Alb and Lpar1 1 0.04 0.92 0.03
120 INT301410 Binding of Lpar1 and Lpar2 2 0.20 0.65 0
121 INT303159 Trim3 Negative_regulation of Gene_expression of Shank1 1 0.40 0 0
122 INT126180 Camk1 Positive_regulation of Camkk1 1 0.16 0 0
123 INT345163 Lpar1 Positive_regulation of Gtf3a 1 0.00 0.77 0
124 INT345168 Binding of Lpar1 and Ppard 1 0.03 0.21 0
125 INT303185 Binding of Shank1 and Trim3 1 0.35 0 0
126 INT345149 Enpp2 Regulation of Gene_expression of Lpar1 1 0.01 0.41 0
127 INT82387 Binding of Il2 and Barhl1 1 0.01 0 0
128 INT82389 Il2 Positive_regulation of Gene_expression of MSMB 1 0.05 0 0
129 INT82390 MSMB Positive_regulation of Il2 1 0.07 0 0
130 INT345158 Lpar1 Positive_regulation of Gene_expression of Sele 1 0.02 0.21 0
131 INT345162 Dmbx1 Regulation of Gene_expression of Lpar1 1 0.03 0.41 0
132 INT345152 Binding of Lpar1 and Siva1 1 0.03 0.66 0
133 INT270660 Binding of Il2 and Idd3 1 0.29 0.92 0
134 INT345154 Lpar1 Positive_regulation of Phosphorylation of Gsn 1 0.05 0 0
135 INT345148 Lpar1 Positive_regulation of Gene_expression of Vcam1 1 0.07 0.21 0
136 INT303161 Gene_expression of Trim3 Positive_regulation of Shank1 1 0.44 0 0
137 INT146022 Oprl1 Positive_regulation of Negative_regulation of Il2 1 0.16 0.07 0
138 INT270662 Ctex Regulation of Il2 1 0.32 0.51 0
139 INT134560 Cpe Negative_regulation of Gene_expression of Il2 1 0.17 0 0
140 INT345189 Dmbx1 Positive_regulation of Lpar1 1 0.06 0.23 0
141 INT345150 Lpar1 Regulation of Gene_expression of Cd1 1 0.11 0.15 0
142 INT278438 Lbp Positive_regulation of Il2 1 0.12 0.89 0
143 INT303169 Trim3 Regulation of Gene_expression of Shank1 1 0.42 0 0
144 INT345177 Lpar1 Positive_regulation of Gpbar1 1 0.05 0 0
145 INT345184 Lpar1 Positive_regulation of Rock1 1 0.00 0.62 0
146 INT130902 Jag2 Regulation of Localization of Il2 1 0.01 0.05 0
147 INT303163 Shank1 Positive_regulation of Trim3 1 0.47 0 0
148 INT303173 Negative_regulation of Trim3 Negative_regulation of Shank1 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of dendritic spine development. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of dendritic spine development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
2 INT11807 Gene_expression of Il2 266 0.78 112 64.97
3 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
4 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63
5 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
6 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93
7 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96
8 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14
9 INT22098 Positive_regulation of Il2 27 0.69 14.77 14.1
10 INT20381 Localization of Il2 71 0.77 34.23 13.03
11 INT32595 Positive_regulation of Gene_expression of Il2 30 0.70 6.55 12.56
12 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08
13 INT12344 Negative_regulation of Gene_expression of Il2 28 0.59 15.53 10.23
14 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77
15 INT166119 Negative_regulation of Gene_expression of Lpar1 17 0.51 13.86 8.7
16 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08
17 INT32596 Regulation of Gene_expression of Il2 13 0.61 6.85 7.83
18 INT62452 Regulation of Il2 14 0.61 12.11 7.64
19 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22
20 INT25385 Positive_regulation of Localization of Il2 17 0.45 9.53 6.45
21 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37
22 INT12066 Localization of Il2 16 0.75 3.06 5.7
23 INT11805 Regulation of Gene_expression of Il2 19 0.62 6.62 5.2
24 INT165490 Regulation of Lpar1 8 0.45 15.31 5.05
25 INT351354 Localization of Lpar1 1 0.40 6.93 5.05
26 INT59320 Transcription of Il2 32 0.69 6.39 4.95
27 INT231377 Regulation of Gene_expression of Lpar1 7 0.53 5.55 3.12
28 INT351355 Positive_regulation of Localization of Lpar1 1 0.25 3.94 2.87
29 INT11815 Regulation of Il2 16 0.59 4.81 2.83
30 INT25382 Binding of Il2 16 0.37 11.69 2.32
31 INT72531 Binding of Il2 2 0.48 0.18 2.32
32 INT52789 Regulation of Localization of Il2 9 0.30 1.9 1.88
33 INT157050 Regulation of Localization of Il2 1 0.06 0 1.67
34 INT87236 Regulation of Negative_regulation of Il2 3 0.24 0.75 1.62
35 INT351356 Positive_regulation of Gene_expression of Lpar1 1 0.35 1.98 1.41
36 INT351361 Binding of Lpar1 1 0.18 0.96 1.35
37 INT236091 Positive_regulation of Transcription of Il2 2 0.44 2.78 1.19
38 INT128413 Positive_regulation of Shank1 2 0.70 0.61 1.16
39 INT85869 Transcription of Il2 5 0.23 2.49 0.95
40 INT153912 Binding of Lpar1 4 0.46 4.64 0.95
41 INT128411 Regulation of Shank1 2 0.45 0.81 0.95
42 INT70817 Negative_regulation of Transcription of Il2 5 0.40 0.25 0.87
43 INT120447 Negative_regulation of Localization of Il2 9 0.56 1.74 0.86
44 INT230516 Negative_regulation of Localization of Il2 5 0.15 2.64 0.79
45 INT70815 Negative_regulation of Positive_regulation of Il2 4 0.40 1.37 0.76
46 INT91274 Negative_regulation of Positive_regulation of Il2 2 0.42 1.12 0.74
47 INT351359 Negative_regulation of Lpar1 1 0.22 1.21 0.72
48 INT171379 Positive_regulation of Positive_regulation of Lpar1 4 0.44 0.32 0.7
49 INT344968 Regulation of Regulation of Lpar1 1 0.39 1.15 0.7
50 INT220662 Gene_expression of Camk1 3 0.66 3.17 0.58
51 INT327693 Regulation of Palm 1 0.18 0 0.54
52 INT62456 Negative_regulation of Regulation of Il2 1 0.36 0.06 0.53
53 INT114450 Gene_expression of Camk1 4 0.03 1.17 0.52
54 INT102051 Negative_regulation of Negative_regulation of Il2 1 0.58 0.08 0.52
55 INT285338 Negative_regulation of Transcription of Il2 1 0.08 1.97 0.48
56 INT83660 Localization of Lpar1 7 0.57 6.7 0.46
57 INT309707 Positive_regulation of Palm 1 0.39 0.28 0.46
58 INT287729 Transcription of Lpar1 3 0.56 1.96 0.43
59 INT114447 Negative_regulation of Regulation of Camk1 1 0.00 0.72 0.43
60 INT114453 Regulation of Camk1 1 0.01 0.72 0.43
61 INT76966 Regulation of Negative_regulation of Il2 1 0.39 0.98 0.41
62 INT212566 Regulation of Regulation of Il2 1 0.27 1.16 0.4
63 INT303211 Gene_expression of Shank1 1 0.64 0.48 0.4
64 INT354977 Regulation of Positive_regulation of Il2 1 0.07 0.82 0.4
65 INT25388 Regulation of Binding of Il2 2 0.37 0.2 0.37
66 INT153907 Protein_catabolism of Lpar1 2 0.55 2.3 0.32
67 INT114448 Regulation of Gene_expression of Camk1 1 0.01 0.52 0.3
68 INT114452 Regulation of Regulation of Camk1 1 0.00 0.38 0.22
69 INT345105 Negative_regulation of Positive_regulation of Lpar1 1 0.28 0.16 0.21
70 INT120448 Positive_regulation of Negative_regulation of Il2 1 0.45 0.19 0.19
71 INT11806 Positive_regulation of Positive_regulation of Il2 2 0.50 1.02 0.18
72 INT303216 Protein_catabolism of Shank1 1 0.83 0 0.15
73 INT114451 Negative_regulation of Camk1 1 0.00 0.35 0.14
74 INT215001 Phosphorylation of Il2 1 0.41 0.05 0.14
75 INT114449 Negative_regulation of Gene_expression of Camk1 1 0.00 0.34 0.13
76 INT120445 Negative_regulation of Negative_regulation of Il2 1 0.42 0.11 0.12
77 INT303217 Binding of Shank1 1 0.36 0 0.11
78 INT303233 Negative_regulation of Gene_expression of Shank1 1 0.49 0.07 0.1
79 INT274151 Positive_regulation of Transcription of Il2 1 0.11 0.12 0.1
80 INT60073 Negative_regulation of Binding of Il2 2 0.42 1.03 0.09
81 INT315489 Regulation of Transcription of Il2 1 0.11 0 0.09
82 INT303212 Positive_regulation of Protein_catabolism of Shank1 1 0.42 0 0.08
83 INT272574 Gene_expression of Shank1 2 0.61 0.22 0.06
84 INT303195 Positive_regulation of Gene_expression of Shank1 1 0.42 0.08 0.06
85 INT303204 Negative_regulation of Shank1 1 0.42 0.11 0.04
86 INT303227 Regulation of Negative_regulation of Shank1 1 0.26 0 0
87 INT301394 Positive_regulation of Localization of Lpar1 1 0.36 2.32 0
88 INT345132 Phosphorylation of Lpar1 1 0.46 0 0
89 INT303202 Negative_regulation of Protein_catabolism of Shank1 1 0.49 0 0
90 INT303209 Positive_regulation of Positive_regulation of Shank1 1 0.34 0 0
91 INT345120 Positive_regulation of Binding of Lpar1 1 0.29 0 0
92 INT303193 Localization of Shank1 1 0.62 0.19 0
93 INT298752 Negative_regulation of Camk1 1 0.37 0.74 0
94 INT303199 Regulation of Gene_expression of Shank1 1 0.23 0 0
95 INT354939 Positive_regulation of Gene_expression of Shank1 1 0.45 0.14 0
96 INT303232 Regulation of Protein_catabolism of Shank1 1 0.38 0 0
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