GO:0061028

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Name establishment of endothelial barrier
Categary Process
Go Slim No
Go Link GO:0061028
Unique Molecular Interactions 80
Total Molecular Interactions 116
Total Single Events 828
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for establishment of endothelial barrier. They are ordered first by their pain relevance and then by number of times they were reported for establishment of endothelial barrier. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
2 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
3 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
4 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
5 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
6 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
7 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
8 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
9 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
10 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
11 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
12 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
13 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
14 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
15 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
16 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
17 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
18 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
19 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
20 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
21 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
22 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
23 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
24 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
25 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5
26 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
27 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
28 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
29 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
30 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
31 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
32 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
33 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
34 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
35 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
36 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
37 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
38 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
39 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
40 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
41 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
42 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
43 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
44 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
45 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
46 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
47 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
48 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
49 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
50 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
51 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
52 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
53 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
54 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
55 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
56 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
57 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
58 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
59 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
60 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
61 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
62 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
63 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
64 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04
65 INT105260 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0 0.03
66 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
67 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
68 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
69 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
70 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
71 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
72 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
73 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
74 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
75 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
76 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
77 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
78 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
79 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
80 INT341540 Positive_regulation of F2RL1 Positive_regulation of Gene_expression of AREG 1 0.18 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for establishment of endothelial barrier. They are ordered first by their pain relevance and then by number of times they were reported in establishment of endothelial barrier. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
2 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
3 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
4 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
5 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
6 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
7 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
8 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
9 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
10 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
11 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
12 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
13 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
14 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
15 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
16 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
17 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
18 INT111017 Regulation of F2rl1 3 0.22 0 2.61
19 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
20 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
21 INT137270 Positive_regulation of PDE4D 4 0.48 2.48 2.39
22 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
23 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
24 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
25 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
26 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
27 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
28 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
29 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
30 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
31 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
32 INT64529 Localization of Pde2a 1 0.59 0 1.63
33 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
34 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
35 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
36 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
37 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
38 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
39 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
40 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
41 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
42 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
43 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
44 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
45 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
46 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
47 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
48 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
49 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
50 INT265568 Binding of PDE4D 1 0.05 0.81 0.85
51 INT226473 Negative_regulation of PDE4D 5 0.19 3.54 0.83
52 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
53 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
54 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
55 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
56 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
57 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
58 INT198330 Gene_expression of Sox18 1 0.18 0.18 0.67
59 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
60 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
61 INT213617 Gene_expression of PDE4D 3 0.53 1.98 0.62
62 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
63 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
64 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
65 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
66 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
67 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
68 INT273179 Localization of PDE4D 1 0.34 2.01 0.5
69 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
70 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
71 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
72 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
73 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
74 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
75 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
76 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
77 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
78 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
79 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
80 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
81 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
82 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
83 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
84 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
85 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
86 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
87 INT273181 Negative_regulation of Localization of PDE4D 1 0.18 0.68 0.2
88 INT275543 Negative_regulation of Gene_expression of PDE4D 1 0.11 0.87 0.19
89 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
90 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
91 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
92 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
93 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
94 INT198328 Negative_regulation of Sox18 1 0.11 0 0.12
95 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
96 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
97 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
98 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
99 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
100 INT198325 Binding of Sox18 1 0.09 0 0.08
101 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
102 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
103 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
104 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
105 INT198332 Regulation of Sox18 1 0.11 0 0.05
106 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
107 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
108 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
109 INT248265 Regulation of Pde4d 1 0.21 0.87 0
110 INT162918 Transcription of PDE2A 1 0.65 0 0
111 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
112 INT198334 Localization of Sox18 1 0.17 0.2 0
113 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
114 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
115 INT219570 Negative_regulation of Positive_regulation of Pde4d 1 0.42 0 0
116 INT219575 Positive_regulation of Binding of Pde4d 1 0.49 0 0
117 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
118 INT198329 Negative_regulation of Gene_expression of Sox18 1 0.10 0 0
119 INT292596 Positive_regulation of Binding of F2RL1 1 0.41 0 0
120 INT183430 Binding of Pde2a 1 0.07 0 0
121 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
122 INT198326 Positive_regulation of Sox18 1 0.12 0 0
123 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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