GO:0061032

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Name visceral serous pericardium development
Categary Process
Go Slim No
Go Link GO:0061032
Unique Molecular Interactions 161
Total Molecular Interactions 208
Total Single Events 1543
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for visceral serous pericardium development. They are ordered first by their pain relevance and then by number of times they were reported for visceral serous pericardium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11
2 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
3 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
4 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63
5 INT248170 Epo Regulation of Ltp 1 0.11 0.74 0.62
6 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52
7 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
8 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
9 INT333168 Tlx2 Negative_regulation of Gene_expression of Vcam1 1 0.14 0.71 0.51
10 INT333160 asa Negative_regulation of Gene_expression of Vcam1 1 0.19 0.71 0.5
11 INT333161 asa Negative_regulation of Positive_regulation of Vcam1 1 0.22 0.57 0.47
12 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
13 INT261603 Il6 Regulation of Gene_expression of Vcam1 1 0.16 1.74 0.46
14 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
15 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
16 INT99015 Binding of Selp and Vcam1 2 0.27 1.76 0.35
17 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
18 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
19 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
20 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
21 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
22 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
23 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
24 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
25 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
26 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
27 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
28 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
29 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
30 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
31 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
32 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
33 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
34 INT306937 Tnfsf12 Positive_regulation of Gene_expression of Vcam1 1 0.05 1.79 0.27
35 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
36 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
37 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
38 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24
39 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21
40 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
41 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
42 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
43 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
44 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
45 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
46 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
47 INT99010 Selp Regulation of Vcam1 1 0.20 1.35 0.18
48 INT99008 Regulation of Binding of Selp and Vcam1 1 0.33 1.36 0.18
49 INT312550 DAK Positive_regulation of Rxra 1 0.00 1.48 0.18
50 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
51 INT279960 TNF Positive_regulation of Vcam1 1 0.56 0.27 0.18
52 INT99007 Sell Regulation of Vcam1 1 0.12 1.35 0.18
53 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
54 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
55 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
56 INT213041 Hdl1 Negative_regulation of Gene_expression of Vcam1 1 0.14 0.9 0.17
57 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
58 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
59 INT343484 Epo Regulation of Gene_expression of VEGFA 1 0.24 0.41 0.16
60 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
61 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
62 INT214614 DAK Regulation of Gene_expression of Vcam1 1 0.00 0.28 0.14
63 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
64 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
65 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
66 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
67 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
68 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
69 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
70 INT253929 Binding of Vcam1 and Cd99l2 1 0.00 0.61 0.13
71 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
72 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
73 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
74 INT343472 Epo Positive_regulation of Gene_expression of Mmp2 1 0.15 0.62 0.12
75 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
76 INT226904 Nfkb1 Regulation of Gene_expression of Vcam1 1 0.14 0.27 0.12
77 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
78 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
79 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
80 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
81 INT256061 Gopc Positive_regulation of Gene_expression of Vcam1 1 0.18 0.29 0.1
82 INT256060 Gopc Positive_regulation of Vcam1 1 0.13 0.29 0.1
83 INT200811 Epo Positive_regulation of Akt1 2 0.30 1.77 0.09
84 INT343486 Epo Positive_regulation of Localization of VEGFA 1 0.25 0.41 0.09
85 INT343485 Epo Positive_regulation of Gene_expression of VEGFA 1 0.25 0.51 0.09
86 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
87 INT282102 Binding of Crp and Vcam1 1 0.00 1.55 0.09
88 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
89 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09
90 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
91 INT273649 Binding of Vcam1 and Itga1 1 0.01 0.4 0.08
92 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
93 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07
94 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07
95 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07
96 INT168976 Binding of Wt1 and Calb2 1 0.01 1.39 0.07
97 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
98 INT343477 Epo Positive_regulation of Pdgfb 1 0.11 0.31 0.06
99 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
100 INT343480 Epo Positive_regulation of Mmp2 1 0.15 0.31 0.06
101 INT329972 Hspb8 Positive_regulation of Gene_expression of Vcam1 1 0.01 0.78 0.06
102 INT343471 Epo Positive_regulation of Gene_expression of Pdgfb 1 0.11 0.31 0.06
103 INT285384 Binding of Rare1 and Rxra 1 0.01 0.08 0.05
104 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
105 INT224679 Il18 Positive_regulation of Gene_expression of Vcam1 1 0.01 0.41 0.05
106 INT226043 Epo Positive_regulation of Ecm1 1 0.04 1.35 0.05
107 INT254161 Epo Positive_regulation of Nos2 1 0.37 0.54 0.05
108 INT307218 Binding of Rxra and D0Nrs1 1 0.00 0.1 0.05
109 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
110 INT254162 Epo Positive_regulation of NOS1 1 0.01 0.53 0.05
111 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
112 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
113 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
114 INT276583 Binding of Wt1 and IgG 1 0.07 0 0.04
115 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
116 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03
117 INT200809 Binding of Akt1 and Epo 1 0.23 0.98 0.03
118 INT343487 Epo Positive_regulation of Gene_expression of EPOR 1 0.76 0.32 0.03
119 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03
120 INT210592 Binding of Cd4 and Vcam1 1 0.01 0.65 0.03
121 INT200814 Epo Positive_regulation of Lyn 1 0.36 1.42 0.03
122 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
123 INT343476 Epo Positive_regulation of Kdr 1 0.11 0.31 0.03
124 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03
125 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
126 INT343474 Epo Positive_regulation of Gene_expression of Kdr 1 0.11 0.32 0.03
127 INT343488 Epo Positive_regulation of EPOR 1 0.24 0.31 0.03
128 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0
129 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
130 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0
131 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
132 INT288617 Binding of CSF2RB and Epor 1 0.19 0.73 0
133 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 0.02 0.96 0
134 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
135 INT343473 Epo Positive_regulation of Gene_expression of Akt1 1 0.45 0.05 0
136 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
137 INT291715 Binding of DR1 and Rxra 1 0.09 0 0
138 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
139 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
140 INT220286 Epo Regulation of hb 1 0.23 0.21 0
141 INT345148 Lpar1 Positive_regulation of Gene_expression of Vcam1 1 0.07 0.21 0
142 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0
143 INT236719 Binding of Dr1 and Rxra 1 0.01 0 0
144 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0
145 INT291712 Binding of Rxra and SPNS1 1 0.04 0 0
146 INT291711 Rxra Positive_regulation of VDR 1 0.09 0 0
147 INT304171 Il13 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.89 0
148 INT181599 Binding of EWSR1 and WT1 1 0.40 0.29 0
149 INT186365 Vcam1 Regulation of Binding of Irf1 1 0.05 0.83 0
150 INT291713 Binding of TNFRSF10B and Rxra 1 0.05 0 0
151 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
152 INT276590 Binding of Wt1 and KTWS 1 0.02 0.3 0
153 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for visceral serous pericardium development. They are ordered first by their pain relevance and then by number of times they were reported in visceral serous pericardium development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96
3 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
4 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
5 INT173505 Localization of Hand2 63 0.57 45.32 13.66
6 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
7 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
8 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
9 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58
10 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
11 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35
12 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28
13 INT181186 Binding of Rxra 78 0.35 14.93 4.87
14 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
15 INT156131 Binding of Hand2 14 0.25 10.35 3.99
16 INT130080 Negative_regulation of Rxra 6 0.53 2.08 2.92
17 INT169318 Positive_regulation of Rxra 15 0.42 4.35 2.12
18 INT130082 Regulation of Rxra 6 0.42 3.78 1.96
19 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
20 INT199724 Positive_regulation of Gene_expression of Rxra 11 0.45 6.22 1.88
21 INT178030 Localization of Epo 11 0.78 6.03 1.86
22 INT73674 Regulation of Gene_expression of Vcam1 9 0.33 11.23 1.64
23 INT144993 Gene_expression of Epor 4 0.75 5.7 1.61
24 INT99004 Negative_regulation of Vcam1 8 0.33 7.29 1.58
25 INT144992 Positive_regulation of Epor 3 0.67 2.09 1.57
26 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
27 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46
28 INT178023 Regulation of Epo 11 0.45 3.87 1.22
29 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
30 INT98992 Binding of Vcam1 13 0.34 12.97 1.04
31 INT99003 Regulation of Vcam1 7 0.41 6.91 1.04
32 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
33 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
34 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95
35 INT83946 Transcription of Vcam1 2 0.40 3.33 0.95
36 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
37 INT288606 Negative_regulation of Gene_expression of Epor 1 0.41 3.73 0.8
38 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7
39 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
40 INT13724 Positive_regulation of WT1 5 0.69 4.99 0.59
41 INT248166 Protein_catabolism of Epo 1 0.89 0.71 0.59
42 INT199723 Localization of Rxra 8 0.59 1.31 0.58
43 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
44 INT114277 Regulation of Gene_expression of Rxra 1 0.28 0.75 0.58
45 INT88694 Gene_expression of WT1 17 0.75 21.88 0.56
46 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
47 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
48 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
49 INT288608 Localization of Epor 1 0.73 3.34 0.37
50 INT241717 Regulation of Localization of Epo 1 0.10 0.55 0.37
51 INT226037 Binding of Epo 5 0.36 2.99 0.32
52 INT199725 Negative_regulation of Gene_expression of Rxra 2 0.38 0.3 0.3
53 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
54 INT114703 Positive_regulation of Wt1 5 0.46 4.25 0.24
55 INT236564 Positive_regulation of Binding of Rxra 2 0.18 1.3 0.24
56 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
57 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
58 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
59 INT288607 Binding of Epor 1 0.36 0.44 0.21
60 INT154282 Positive_regulation of Gene_expression of WT1 3 0.55 3.41 0.19
61 INT248168 Positive_regulation of Transcription of Epor 1 0.36 0 0.19
62 INT248169 Positive_regulation of Transcription of Epo 1 0.50 0 0.19
63 INT248165 Transcription of Epo 1 0.69 0 0.19
64 INT248167 Transcription of Epor 1 0.49 0 0.19
65 INT200796 Negative_regulation of Epo 7 0.43 3.22 0.18
66 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
67 INT13723 Negative_regulation of Positive_regulation of WT1 1 0.03 1.26 0.17
68 INT319048 Transcription of WT1 2 0.56 1.87 0.16
69 INT171850 Negative_regulation of Positive_regulation of Vcam1 1 0.05 1.03 0.16
70 INT101208 Positive_regulation of Gene_expression of Wt1 3 0.47 3.08 0.15
71 INT288611 Protein_catabolism of Epor 1 0.64 0.3 0.14
72 INT228608 Positive_regulation of Gene_expression of Epo 5 0.68 2.85 0.13
73 INT332915 Positive_regulation of Localization of Rxra 1 0.03 0.3 0.11
74 INT288610 Negative_regulation of Epor 1 0.41 0.9 0.11
75 INT178195 Localization of Wt1 4 0.69 2.64 0.1
76 INT343457 Regulation of Binding of Epo 1 0.44 0 0.09
77 INT168975 Binding of Wt1 14 0.43 7.37 0.07
78 INT166389 Binding of WT1 7 0.36 8.25 0.07
79 INT171853 Positive_regulation of Positive_regulation of Vcam1 1 0.07 0.88 0.07
80 INT256518 Positive_regulation of Transcription of Rxra 1 0.04 0.24 0.06
81 INT291692 Regulation of Binding of Rxra 4 0.32 0.57 0.05
82 INT307902 Negative_regulation of Localization of Wt1 1 0.34 0.21 0.05
83 INT187453 Localization of Vcam1 2 0.60 1 0.04
84 INT226039 Positive_regulation of Positive_regulation of Epo 1 0.45 1.38 0.04
85 INT187462 Positive_regulation of Localization of Vcam1 1 0.40 0.89 0.04
86 INT225406 Transcription of Rxra 3 0.41 0.33 0.03
87 INT220284 Phosphorylation of Epo 2 0.63 1.2 0.03
88 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
89 INT256507 Regulation of Transcription of Rxra 1 0.04 0.12 0.03
90 INT181604 Localization of WT1 1 0.63 1.41 0.03
91 INT291693 Negative_regulation of Binding of Rxra 1 0.22 0.07 0.03
92 INT285960 Negative_regulation of WT1 6 0.47 10.02 0
93 INT276530 Negative_regulation of Wt1 5 0.53 2.97 0
94 INT285959 Negative_regulation of Gene_expression of WT1 3 0.46 4.9 0
95 INT276519 Regulation of Wt1 2 0.24 1.7 0
96 INT276550 Transcription of Wt1 2 0.66 1.35 0
97 INT276547 Positive_regulation of Binding of Wt1 1 0.63 0.29 0
98 INT307906 Negative_regulation of Transcription of Wt1 1 0.54 1.3 0
99 INT231922 Negative_regulation of Positive_regulation of Rxra 1 0.06 0.33 0
100 INT276551 Positive_regulation of Localization of Wt1 1 0.45 0 0
101 INT291694 Negative_regulation of Localization of Rxra 1 0.22 0 0
102 INT276534 Negative_regulation of Binding of Wt1 1 0.38 0 0
103 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
104 INT291695 Regulation of Negative_regulation of Rxra 1 0.23 0.14 0
105 INT319051 Regulation of Positive_regulation of WT1 1 0.36 1.11 0
106 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
107 INT291698 Negative_regulation of Negative_regulation of Rxra 1 0.22 0 0
108 INT228609 Negative_regulation of Localization of Epo 1 0.42 0.62 0
109 INT307903 Negative_regulation of Gene_expression of Wt1 1 0.39 1.31 0
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