GO:0061035

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Name regulation of cartilage development
Categary Process
Go Slim No
Go Link GO:0061035
Unique Molecular Interactions 83
Total Molecular Interactions 94
Total Single Events 725
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of cartilage development. They are ordered first by their pain relevance and then by number of times they were reported for regulation of cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
2 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
3 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
4 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
5 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
6 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
7 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
8 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
9 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
10 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
11 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
12 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
13 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
14 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
15 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
16 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
17 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
18 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
19 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
20 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
21 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
22 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
23 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
24 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
25 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
26 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
27 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
28 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
29 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
30 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
31 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
32 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
33 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
34 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
35 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
36 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
37 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
38 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
39 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
40 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
41 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
42 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
43 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
44 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
45 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
46 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
47 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
48 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
49 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
50 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
51 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
52 INT251232 Slc17a6 Positive_regulation of Tgfb1 1 0.03 0 0.08
53 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
54 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
55 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04
56 INT340086 Binding of Tgfb1 and Cndp2 1 0.04 0.38 0
57 INT314865 Binding of Ltbp3 and Tgfb1 1 0.24 0.51 0
58 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0
59 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0
60 INT121314 Tgfb1 Positive_regulation of Egfr 1 0.08 0.16 0
61 INT121316 Tgfb1 Negative_regulation of Xrcc1 1 0.06 0.08 0
62 INT121318 Tgfb1 Negative_regulation of Ercc1 1 0.06 0.08 0
63 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0
64 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
65 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
66 INT248948 Binding of Klrd1 and Tgfb1 1 0.04 0.16 0
67 INT121313 Tgfb1 Positive_regulation of Ercc1 1 0.07 0.08 0
68 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
69 INT248947 Binding of Cd8a and Tgfb1 1 0.05 0.16 0
70 INT81743 Tgfb1 Negative_regulation of Gene_expression of Atp9a 1 0.00 0.21 0
71 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
72 INT71539 Tgfb1 Positive_regulation of Localization of Gnrh1 1 0.01 0 0
73 INT137933 TGFB3 Regulation of Tgfb1 1 0.00 0 0
74 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
75 INT137934 IGF1 Regulation of Tgfb1 1 0.00 0 0
76 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0
77 INT125799 Olr720 Negative_regulation of Positive_regulation of Tgfb1 1 0.00 0 0
78 INT280264 Negative_regulation of Binding of Cxcr4 and Tgfb1 1 0.07 0.89 0
79 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
80 INT280273 Tgfb1 Regulation of VEGFA 1 0.01 0.88 0
81 INT137935 Tgfb1 Regulation of TGFB3 1 0.00 0 0
82 INT254856 Tgfb1 Negative_regulation of Rock1 1 0.01 0 0
83 INT121317 Tgfb1 Positive_regulation of Xrcc1 1 0.07 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of cartilage development. They are ordered first by their pain relevance and then by number of times they were reported in regulation of cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
2 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
3 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
4 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
5 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
6 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
7 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
8 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
9 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
10 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
11 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
12 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
13 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
14 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
15 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
16 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
17 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
18 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
19 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
20 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
21 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
22 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
23 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
24 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
25 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
26 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
27 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
28 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
29 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
30 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
31 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
32 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
33 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
34 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
35 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
36 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
37 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
38 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
39 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
40 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
41 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
42 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24
43 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
44 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
45 INT85330 Positive_regulation of Regulation of Tgfb1 1 0.41 0.67 0.17
46 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
47 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
48 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
49 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
50 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
51 INT251230 Positive_regulation of Negative_regulation of Tgfb1 1 0.09 0 0.05
52 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
53 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
54 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
55 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
56 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
57 INT196027 Binding of Bmp4 2 0.13 0.97 0
58 INT142119 Regulation of Bmp4 2 0.58 0.29 0
59 INT97730 Binding of Scx 1 0.32 0 0
60 INT133097 Positive_regulation of Phosphorylation of Tgfb1 1 0.05 0.07 0
61 INT339667 Localization of Bmp4 1 0.38 0.27 0
62 INT254788 Negative_regulation of Regulation of Tgfb1 1 0.06 0.61 0
63 INT254800 Positive_regulation of Phosphorylation of Tgfb1 1 0.04 0.24 0
64 INT133099 Negative_regulation of Phosphorylation of Tgfb1 1 0.04 0.08 0
65 INT133098 Phosphorylation of Tgfb1 1 0.06 0.07 0
66 INT128712 Positive_regulation of Regulation of Tgfb1 1 0.15 0 0
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