GO:0061036

From wiki-pain
Jump to: navigation, search
Name positive regulation of cartilage development
Categary Process
Go Slim No
Go Link GO:0061036
Unique Molecular Interactions 81
Total Molecular Interactions 116
Total Single Events 983
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cartilage development. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
2 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
3 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
4 INT263756 Binding of Bmp1 and Neto1 1 0.30 0.11 0.54
5 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
6 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
7 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
8 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
9 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
10 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
11 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
12 INT350723 MIR219-1 Negative_regulation of Sox6 1 0.01 0.4 0.15
13 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
14 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
15 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
16 INT307627 Binding of BMP1 and CSF2 1 0.01 0.33 0.12
17 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
18 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
19 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
20 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
21 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
22 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
23 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
24 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
25 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
26 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
27 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
28 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
29 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
30 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
31 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
32 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
33 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
34 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
35 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
36 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
37 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
38 INT184209 IL1B Negative_regulation of Gene_expression of SOX6 1 0.46 0.05 0.03
39 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
40 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
41 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
42 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
43 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
44 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
45 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
46 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
47 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
48 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
49 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
50 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
51 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
52 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
53 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
54 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
55 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
56 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cartilage development. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cartilage development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73
2 INT307634 Binding of BMP1 1 0.36 3.12 3.26
3 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
4 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
5 INT282596 Localization of BMP1 2 0.61 4.04 1.97
6 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
7 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
8 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
9 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
10 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
11 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
12 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
13 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
14 INT114664 Binding of BMP2 12 0.37 6.54 0.91
15 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
16 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
17 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
18 INT307628 Negative_regulation of Binding of BMP1 1 0.32 0.05 0.72
19 INT181636 Positive_regulation of Gene_expression of BMP1 2 0.44 4.46 0.68
20 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
21 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
22 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
23 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
24 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
25 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
26 INT85808 Localization of BMP2 7 0.77 1.94 0.51
27 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
28 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
29 INT263670 Binding of Bmp1 2 0.22 0.91 0.46
30 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
31 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
32 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
33 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41
34 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
35 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
36 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39
37 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
38 INT307635 Positive_regulation of Localization of BMP1 1 0.38 1.35 0.36
39 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
40 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
41 INT280944 Gene_expression of Bmp1 1 0.22 0.91 0.31
42 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
43 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
44 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
45 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
46 INT307631 Positive_regulation of Binding of BMP1 1 0.38 2.99 0.24
47 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
48 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
49 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
50 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
51 INT307630 Negative_regulation of Localization of BMP1 1 0.32 1.41 0.21
52 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
53 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18
54 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
55 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
56 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
57 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14
58 INT28930 Negative_regulation of BMP1 1 0.57 1.03 0.14
59 INT254335 Gene_expression of Sox6 2 0.43 0.25 0.12
60 INT307632 Regulation of Binding of BMP1 1 0.34 1.53 0.12
61 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
62 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
63 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
64 INT307633 Positive_regulation of Positive_regulation of BMP1 1 0.38 0.33 0.11
65 INT307629 Positive_regulation of BMP1 1 0.53 0.33 0.11
66 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
67 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
68 INT307636 Regulation of BMP1 1 0.21 0.32 0.1
69 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
70 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
71 INT287912 Localization of BMP4 1 0.18 1.13 0.1
72 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
73 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
74 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
75 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
76 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
77 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
78 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
79 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
80 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
81 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
82 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
83 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
84 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
85 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
86 INT311890 Binding of Smad1 2 0.23 0.46 0.04
87 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
88 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
89 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
90 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
91 INT184219 Gene_expression of SOX6 4 0.59 0.13 0.03
92 INT225365 Binding of Sox9 2 0.28 0.48 0.03
93 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
94 INT278034 Transcription of BMP1 1 0.07 0.25 0.03
95 INT311888 Negative_regulation of Phosphorylation of Smad1 1 0.25 0.48 0.03
96 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
97 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
98 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
99 INT245757 Localization of SOX9 4 0.62 0.8 0
100 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
101 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
102 INT196027 Binding of Bmp4 2 0.13 0.97 0
103 INT142119 Regulation of Bmp4 2 0.58 0.29 0
104 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
105 INT269895 Binding of Sox6 2 0.27 0.33 0
106 INT196031 Binding of Bmp2 1 0.16 0 0
107 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
108 INT329771 Positive_regulation of SMAD1 1 0.36 2.3 0
109 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
110 INT97730 Binding of Scx 1 0.32 0 0
111 INT329780 Negative_regulation of Positive_regulation of SMAD1 1 0.22 0.51 0
112 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
113 INT339667 Localization of Bmp4 1 0.38 0.27 0
114 INT211943 Transcription of Sox9 1 0.50 0.3 0
115 INT184226 Regulation of Negative_regulation of SOX6 1 0.34 0 0
116 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
117 INT251809 Localization of SOX6 1 0.45 0 0
118 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
119 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
120 INT184225 Regulation of Gene_expression of SOX6 1 0.47 0 0
121 INT322886 Transcription of Sox9 1 0.50 0.25 0
122 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
123 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
124 INT184224 Negative_regulation of Gene_expression of SOX6 1 0.44 0 0
125 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
126 INT352006 Negative_regulation of Sox6 1 0.31 0.08 0
127 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
128 INT245765 Binding of SOX9 1 0.31 0.87 0
129 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
130 INT184221 Negative_regulation of SOX6 1 0.32 0 0
131 INT351554 Negative_regulation of Gene_expression of BMP4 1 0.26 0 0
132 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
133 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox