GO:0061045

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Name negative regulation of wound healing
Categary Process
Go Slim No
Go Link GO:0061045
Unique Molecular Interactions 86
Total Molecular Interactions 150
Total Single Events 978
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of wound healing. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of wound healing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
2 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
3 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
4 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
5 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
6 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
7 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
8 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
9 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
10 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
11 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
12 INT56090 TNF Regulation of SERPINE1 1 0.43 0.41 0.33
13 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
14 INT56092 FGFR1 Positive_regulation of Transcription of SERPINE1 1 0.29 0.41 0.29
15 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
16 INT238632 Binding of EPB41 and Cask 1 0.44 0.78 0.27
17 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
18 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22
19 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
20 INT48713 PTGER1 Negative_regulation of Gene_expression of SERPINE1 1 0.02 0.28 0.22
21 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
22 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
23 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
24 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
25 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
26 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
27 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
28 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
29 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
30 INT99737 Serpinf2 Negative_regulation of Localization of SERPINE1 1 0.00 0.24 0.12
31 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
32 INT22670 PLAT Positive_regulation of SERPINE1 1 0.03 0.1 0.1
33 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1
34 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1
35 INT22672 Positive_regulation of Binding of SERPINE1 and PLAT 1 0.03 0.1 0.1
36 INT238631 Regulation of Binding of EPB41 and Cask 1 0.29 0.24 0.07
37 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07
38 INT57268 SERPINE1 Positive_regulation of SERPINC1 1 0.07 0.94 0.07
39 INT122480 Binding of SERPINE1 and PLAU 4 0.40 2.75 0.06
40 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
41 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06
42 INT238622 Binding of Grin2d and Cask 1 0.05 0 0.04
43 INT239320 Eef1a2 Negative_regulation of Hmgcr 1 0.06 0.89 0.04
44 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
45 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
46 INT319120 CRP Positive_regulation of Gene_expression of SERPINE1 1 0.70 0.54 0.04
47 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03
48 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
49 INT238578 Binding of Cask and Sumo1 1 0.26 0.33 0
50 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
51 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
52 INT238577 Binding of Cask and Sumo2 1 0.13 0 0
53 INT238572 Negative_regulation of Binding of Cask and Sumo1 1 0.23 0.33 0
54 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
55 INT355637 OLR1 Positive_regulation of Gene_expression of SERPINE1 1 0.03 1.15 0
56 INT238575 Binding of Cask and Magi1 1 0.04 0.17 0
57 INT316355 Binding of CR1 and Hmgcr 1 0.01 0.59 0
58 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
59 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0
60 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
61 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
62 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
63 INT22668 PNMA1 Regulation of SERPINE1 1 0.03 0 0
64 INT238570 Regulation of Binding of Cask and Magi1 1 0.03 0.17 0
65 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
66 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
67 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
68 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
69 INT238579 Binding of Cask and Sumo3 1 0.15 0 0
70 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
71 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
72 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
73 INT130414 TNFSF14 Positive_regulation of SERPINE1 1 0.29 0 0
74 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
75 INT197040 SERPINE1 Regulation of PLAU 1 0.31 0.68 0
76 INT238623 Binding of Cask and Cadm1 1 0.09 0.08 0
77 INT282287 Binding of Cpox and Hmgcr 1 0.01 0.99 0
78 INT265934 SREBF1 Positive_regulation of Transcription of SERPINE1 1 0.01 0.62 0
79 INT238621 Binding of Sdc2 and Cask 1 0.06 0.08 0
80 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
81 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
82 INT22677 Binding of SERPINE1 and SGCG 1 0.36 0 0
83 INT329221 Prkag1 Negative_regulation of Hmgcr 1 0.06 0.48 0
84 INT238630 Negative_regulation of Binding of EPB41 and Cask 1 0.45 0 0
85 INT295499 Lcat Regulation of Transcription of Hmgcr 1 0.04 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of wound healing. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of wound healing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
2 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
3 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
4 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
5 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
6 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
7 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
8 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
9 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
10 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
11 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
12 INT238608 Gene_expression of Cask 1 0.73 2.74 1.9
13 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85
14 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67
15 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
16 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
17 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
18 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
19 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
20 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
21 INT48717 Positive_regulation of Localization of SERPINE1 6 0.66 2.64 0.83
22 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69
23 INT238602 Binding of Cask 1 0.40 0.9 0.63
24 INT70971 Negative_regulation of Positive_regulation of SERPINE1 3 0.40 2.65 0.58
25 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52
26 INT238589 Phosphorylation of Cask 1 0.77 0.13 0.52
27 INT56094 Protein_catabolism of SERPINE1 2 0.61 1.66 0.47
28 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38
29 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
30 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
31 INT238618 Positive_regulation of Cask 1 0.66 0.4 0.35
32 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33
33 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
34 INT232236 Negative_regulation of Gene_expression of Hmgcr 3 0.35 1.36 0.31
35 INT238592 Positive_regulation of Phosphorylation of Cask 1 0.41 0 0.31
36 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
37 INT322907 Positive_regulation of Gene_expression of Hmgcr 4 0.03 1.45 0.28
38 INT48719 Negative_regulation of Transcription of SERPINE1 1 0.42 0.17 0.26
39 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
40 INT180280 Positive_regulation of Phosphorylation of SERPINE1 2 0.48 0 0.24
41 INT180281 Phosphorylation of SERPINE1 2 0.78 0 0.24
42 INT202186 Negative_regulation of Phosphorylation of SERPINE1 1 0.41 0 0.24
43 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23
44 INT182749 Binding of Hmgcr 3 0.32 0.55 0.22
45 INT100870 Positive_regulation of Binding of SERPINE1 2 0.49 1.24 0.21
46 INT48723 Regulation of Transcription of SERPINE1 1 0.27 0.26 0.2
47 INT238611 Localization of Cask 1 0.76 0.67 0.18
48 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
49 INT270426 Regulation of Binding of SERPINE1 1 0.06 0.42 0.17
50 INT238597 Positive_regulation of Gene_expression of Cask 1 0.66 0.88 0.17
51 INT87196 Regulation of Hmgcr 3 0.45 0.7 0.14
52 INT67181 Positive_regulation of Positive_regulation of SERPINE1 3 0.49 3.02 0.14
53 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
54 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
55 INT238613 Negative_regulation of Gene_expression of Cask 1 0.41 0.12 0.12
56 INT305016 Positive_regulation of Negative_regulation of SERPINE1 1 0.10 1.13 0.11
57 INT238590 Negative_regulation of Binding of Cask 1 0.41 0.23 0.1
58 INT142342 Regulation of Negative_regulation of Hmgcr 1 0.20 0.48 0.1
59 INT277070 Negative_regulation of Negative_regulation of SERPINE1 1 0.12 0.55 0.1
60 INT238615 Positive_regulation of Binding of Cask 1 0.47 0.06 0.09
61 INT228554 Negative_regulation of Negative_regulation of Hmgcr 1 0.24 0.44 0.08
62 INT238588 Regulation of Binding of Cask 1 0.43 0.15 0.07
63 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
64 INT153688 Negative_regulation of Negative_regulation of Hmgcr 1 0.42 1.21 0.06
65 INT153690 Localization of Hmgcr 1 0.74 1.21 0.06
66 INT81879 Regulation of Regulation of SERPINE1 1 0.27 0.73 0.06
67 INT153689 Negative_regulation of Localization of Hmgcr 1 0.42 1.21 0.06
68 INT262799 Localization of Smad3 6 0.56 2.09 0.04
69 INT282271 Positive_regulation of Regulation of Hmgcr 1 0.12 1.44 0.04
70 INT295501 Negative_regulation of Gene_expression of Hmgcr 1 0.26 0.21 0.04
71 INT311758 Regulation of Gene_expression of Hmgcr 1 0.08 0 0.04
72 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
73 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
74 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
75 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
76 INT265337 Binding of Smad3 2 0.35 1 0
77 INT176185 Transcription of Hmgcr 2 0.31 0.56 0
78 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
79 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
80 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
81 INT238601 Protein_catabolism of Cask 1 0.62 0 0
82 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
83 INT238593 Negative_regulation of Cask 1 0.41 0.32 0
84 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
85 INT238594 Positive_regulation of Localization of Cask 1 0.44 0 0
86 INT238600 Regulation of Cask 1 0.43 0.06 0
87 INT247129 Positive_regulation of Protein_catabolism of Hmgcr 1 0.06 0.38 0
88 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
89 INT176209 Negative_regulation of Transcription of Hmgcr 1 0.25 0.3 0
90 INT173493 Regulation of Gene_expression of Hmgcr 1 0.33 0 0
91 INT247134 Protein_catabolism of Hmgcr 1 0.14 0.38 0
92 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
93 INT203686 Negative_regulation of Positive_regulation of Hmgcr 1 0.02 0.4 0
94 INT295506 Transcription of Hmgcr 1 0.43 0.19 0
95 INT268363 Binding of SMAD3 1 0.20 0.56 0
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