GO:0061309

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Name cardiac neural crest cell development involved in outflow tract morphogenesis
Categary Process
Go Slim No
Go Link GO:0061309
Unique Molecular Interactions 135
Total Molecular Interactions 162
Total Single Events 1271
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cardiac neural crest cell development involved in outflow tract morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for cardiac neural crest cell development involved in outflow tract morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
2 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
3 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
4 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
5 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
6 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
7 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
8 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
9 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
10 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
11 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
12 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
13 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
14 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
15 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
16 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
17 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
18 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
19 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
20 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
21 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
22 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
23 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
24 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
25 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
26 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
27 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
28 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
29 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
30 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
31 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
32 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
33 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
34 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
35 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
36 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
37 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
38 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
39 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
40 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
41 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
42 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
43 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
44 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
45 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
46 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
47 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
48 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
49 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
50 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
51 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
52 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
53 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
54 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
55 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
56 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
57 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
58 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
59 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
60 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
61 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
62 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
63 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
64 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
65 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
66 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
67 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
68 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
69 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
70 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
71 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
72 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
73 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
74 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
75 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
76 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
77 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
78 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
79 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
80 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
81 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
82 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
83 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
84 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
85 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
86 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
87 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
88 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
89 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
90 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
91 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
92 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
93 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
94 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
95 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
96 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
97 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
98 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
99 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
100 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
101 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
102 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
103 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
104 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
105 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
106 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
107 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
108 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
109 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
110 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
111 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
112 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
113 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
114 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
115 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
116 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
117 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
118 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
119 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
120 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
121 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
122 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
123 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
124 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0
125 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
126 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
127 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
128 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
129 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0
130 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
131 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0
132 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0
133 INT264739 Mir199b Negative_regulation of Gene_expression of Hes1 1 0.07 0.82 0
134 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
135 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cardiac neural crest cell development involved in outflow tract morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in cardiac neural crest cell development involved in outflow tract morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
3 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
4 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
5 INT173505 Localization of Hand2 63 0.57 45.32 13.66
6 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
7 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
8 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
9 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
10 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
11 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
12 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
13 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
14 INT156131 Binding of Hand2 14 0.25 10.35 3.99
15 INT116540 Binding of Twist1 35 0.48 16.32 2.85
16 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
17 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
18 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
19 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
20 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
21 INT10873 Localization of Twist1 21 0.74 10.43 1.37
22 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
23 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
24 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
25 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
26 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
27 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
28 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
29 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
30 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
31 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
32 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
33 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
34 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
35 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
36 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
37 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
38 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
39 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
40 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
41 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
42 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
43 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
44 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
45 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
46 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03
47 INT264704 Regulation of Hes1 4 0.44 1.03 0.03
48 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
49 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03
50 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
51 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
52 INT264719 Regulation of Gene_expression of Hes1 2 0.28 0.12 0
53 INT264708 Transcription of Hes1 1 0.67 0.83 0
54 INT280151 Positive_regulation of Regulation of Twist1 1 0.41 0.67 0
55 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0
56 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0
57 INT264705 Binding of Hes1 1 0.35 0.07 0
58 INT275080 Positive_regulation of Negative_regulation of Twist1 1 0.05 0.11 0
59 INT264706 Positive_regulation of Hes1 1 0.40 0.14 0
60 INT243609 Negative_regulation of Transcription of Twist1 1 0.42 0 0
61 INT243602 Regulation of Localization of Twist1 1 0.45 0 0
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