GO:0061371

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Name determination of heart left/right asymmetry
Categary Process
Go Slim No
Go Link GO:0061371
Unique Molecular Interactions 128
Total Molecular Interactions 152
Total Single Events 1309
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for determination of heart left/right asymmetry. They are ordered first by their pain relevance and then by number of times they were reported for determination of heart left/right asymmetry. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
2 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
3 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
4 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
5 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98
6 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
7 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
8 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
9 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69
10 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55
11 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54
12 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
13 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48
14 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
15 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
16 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
17 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
18 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
19 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
20 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
21 INT112018 Binding of Hand1 and IgG2a 2 0.22 0.84 0.32
22 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
23 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
24 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
25 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
26 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
27 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
28 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
29 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
30 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
31 INT188707 Binding of IFNA1 and Hand1 1 0.01 0.56 0.32
32 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
33 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
34 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
35 INT243631 Binding of Hand1 and Nfatc1 1 0.04 0.76 0.3
36 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
37 INT252604 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Hand1 1 0.24 0.5 0.29
38 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
39 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
40 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
41 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
42 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
43 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
44 INT246439 Hand1 Positive_regulation of Gene_expression of Cd79a 1 0.04 0.78 0.27
45 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
46 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
47 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
48 INT294514 Safb Positive_regulation of Localization of Hand1 1 0.08 0.38 0.25
49 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
50 INT287098 Binding of FL and T 1 0.10 0.66 0.23
51 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
52 INT333758 Hand1 Positive_regulation of Eae1 1 0.05 1.6 0.22
53 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22
54 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
55 INT311987 Binding of Cd40 and Negative_regulation of Regulation of Hand1 1 0.28 0.27 0.21
56 INT276241 Slc11a1 Positive_regulation of Gene_expression of Hand1 1 0.02 1.24 0.21
57 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
58 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
59 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
60 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
61 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
62 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
63 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
64 INT238010 Binding of Cxcr3 and Hand1 1 0.12 1.55 0.19
65 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19
66 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
67 INT284889 Gene_expression of Hand1 Positive_regulation of Gene_expression of Il4 1 0.21 0.4 0.18
68 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18
69 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
70 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
71 INT252600 Ppig Regulation of Hand1 1 0.06 0.43 0.17
72 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
73 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
74 INT252598 Ppig Regulation of Gene_expression of Hand1 1 0.06 0.43 0.17
75 INT277990 Binding of Cd3e and Hand1 1 0.01 0.5 0.16
76 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
77 INT279102 Renbp Regulation of Hand1 1 0.02 0.27 0.14
78 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
79 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
80 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
81 INT294761 Binding of Hand1 and Cerk 1 0.23 0.36 0.14
82 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
83 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
84 INT225989 Il10 Negative_regulation of Gene_expression of Hand1 1 0.11 0.68 0.13
85 INT347019 Cd80 Regulation of Hand1 1 0.01 0.05 0.13
86 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
87 INT347014 Cd86 Regulation of Hand1 1 0.02 0.05 0.13
88 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
89 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
90 INT325057 Binding of Hand1 and Ang 1 0.01 1.29 0.12
91 INT318993 Hand1 Positive_regulation of Gene_expression of Fas 1 0.03 0.76 0.12
92 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
93 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
94 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12
95 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
96 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
97 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
98 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
99 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
100 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
101 INT278218 Hand1 Negative_regulation of Gene_expression of Il4 1 0.20 0.37 0.08
102 INT350721 Binding of Hand1 and TBX21 1 0.13 0.22 0.08
103 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
104 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
105 INT271493 Ctbs Negative_regulation of Hand1 1 0.04 0.63 0.07
106 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
107 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
108 INT267780 Binding of Mvp and Positive_regulation of Hand1 1 0.16 0.48 0.05
109 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
110 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
111 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
112 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04
113 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
114 INT276972 Tlr2 Negative_regulation of Gene_expression of Hand1 1 0.14 0.65 0.03
115 INT316481 Positive_regulation of Stat3 Positive_regulation of Localization of Hand1 1 0.19 1.48 0.03
116 INT294515 Safb Regulation of Phosphorylation of Hand1 1 0.08 0.07 0
117 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
118 INT279101 Binding of Hand1 and Renbp 1 0.02 0 0
119 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
120 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
121 INT279100 Regulation of Binding of Hand1 and Renbp 1 0.01 0 0
122 INT263497 Hand1 Regulation of Binding of IFN1@ 1 0.28 0.16 0
123 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for determination of heart left/right asymmetry. They are ordered first by their pain relevance and then by number of times they were reported in determination of heart left/right asymmetry. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
2 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
3 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
4 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
5 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
6 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
7 INT173505 Localization of Hand2 63 0.57 45.32 13.66
8 INT20378 Localization of Hand1 53 0.71 41.96 13.31
9 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
10 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
11 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
12 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
13 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
14 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05
15 INT204449 Gene_expression of T 17 0.32 9.77 4.77
16 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
17 INT151736 Binding of Hand1 15 0.26 9.77 4.04
18 INT156131 Binding of Hand2 14 0.25 10.35 3.99
19 INT94463 Regulation of Gene_expression of Hand1 10 0.36 5.17 2.72
20 INT53434 Positive_regulation of T 7 0.07 3.67 2.09
21 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06
22 INT112015 Negative_regulation of Regulation of Hand1 5 0.33 3.48 2.05
23 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
24 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61
25 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
26 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
27 INT226407 Negative_regulation of T 2 0.21 1.81 1.18
28 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09
29 INT208427 Regulation of T 3 0.25 3.28 1.08
30 INT325047 Gene_expression of Hand1 1 0.07 6.42 1.06
31 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
32 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
33 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
34 INT287093 Positive_regulation of Gene_expression of T 1 0.28 1.47 0.86
35 INT287090 Regulation of Gene_expression of T 1 0.18 2.77 0.86
36 INT287094 Transcription of T 1 0.29 1.41 0.8
37 INT185049 Transcription of Hand1 5 0.47 1.84 0.71
38 INT226411 Binding of T 2 0.15 1.56 0.68
39 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
40 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
41 INT181529 Regulation of Positive_regulation of Hand1 2 0.16 2.62 0.61
42 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
43 INT325055 Binding of Hand1 1 0.04 2.15 0.58
44 INT279099 Regulation of Regulation of Hand1 3 0.20 1.31 0.5
45 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
46 INT287095 Negative_regulation of Gene_expression of T 1 0.24 0.47 0.41
47 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
48 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
49 INT252590 Regulation of Transcription of Hand1 1 0.36 0.76 0.36
50 INT192400 Positive_regulation of Binding of Hand1 2 0.25 0.24 0.33
51 INT339621 Regulation of Negative_regulation of Hand1 1 0.04 0.75 0.29
52 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
53 INT325048 Positive_regulation of Gene_expression of Hand1 1 0.05 1.16 0.28
54 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
55 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
56 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
57 INT271486 Negative_regulation of Negative_regulation of Hand1 2 0.16 1.07 0.2
58 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
59 INT262806 Positive_regulation of Positive_regulation of Hand1 3 0.28 1.58 0.13
60 INT325045 Negative_regulation of Hand1 1 0.04 1.26 0.12
61 INT237770 Phosphorylation of Hand1 2 0.40 0.51 0.11
62 INT286583 Localization of PKD2 1 0.35 0.17 0.06
63 INT261879 Binding of PKD2 3 0.13 2.59 0.05
64 INT325051 Regulation of Hand1 1 0.04 1.87 0.04
65 INT69474 Protein_catabolism of T 1 0.64 0 0.04
66 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
67 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
68 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
69 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
70 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
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