GO:0070032

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Name synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Categary Component
Go Slim No
Go Link GO:0070032
Unique Molecular Interactions 83
Total Molecular Interactions 150
Total Single Events 896
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. They are ordered first by their pain relevance and then by number of times they were reported for synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT252145 Binding of Napb and Snap25 9 0.19 0.85 0.75
2 INT255287 Binding of Stx1a and Vti1b 1 0.35 0 0.58
3 INT255283 Regulation of Binding of Napb and Snap25 1 0.24 0 0.39
4 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
5 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
6 INT255292 Regulation of Binding of Napb and Vamp2 1 0.07 0 0.3
7 INT328185 Slc3a1 Negative_regulation of Snap25 1 0.00 0.07 0.3
8 INT252140 Binding of Cck and Snap25 1 0.30 0.39 0.3
9 INT255286 Binding of Napb and Vamp2 1 0.09 0 0.29
10 INT255291 Binding of Napb and Stx1a 1 0.21 0 0.29
11 INT255288 Binding of Snap25 and Vti1b 1 0.36 0 0.29
12 INT255284 Binding of Vamp2 and Vti1b 1 0.16 0 0.29
13 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
14 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
15 INT94890 MBTPS1 Positive_regulation of SNAP25 1 0.16 0.39 0.2
16 INT273441 Binding of Vamp1 and Snap25 1 0.02 0.13 0.14
17 INT249403 Binding of Snap25 and Napa 1 0.19 0 0.14
18 INT234104 Binding of Snap25 and DTNBP1 1 0.29 0.09 0.13
19 INT214952 Vamp2 Regulation of Rims1 1 0.17 0 0.12
20 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
21 INT214957 Vamp2 Regulation of Neu3 1 0.00 0 0.1
22 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
23 INT249413 Binding of Vamp2 and Napa 1 0.15 0.05 0.09
24 INT263761 Grin1 Regulation of Localization of Vamp2 1 0.27 0.17 0.07
25 INT263777 Grin2a Regulation of Localization of Vamp2 1 0.26 0.17 0.07
26 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
27 INT252141 Binding of Snap25 and Spata20 1 0.01 0 0.07
28 INT263739 Grin2b Regulation of Localization of Vamp2 1 0.24 0.17 0.07
29 INT263735 Localization of Neto1 Regulation of Localization of Vamp2 1 0.35 0.18 0.05
30 INT268111 Binding of MARCKS and SNAP25 1 0.09 0 0.05
31 INT273440 Positive_regulation of Binding of Vamp1 and Snap25 1 0.02 0.13 0.04
32 INT249415 Binding of Snap25 and Dcaf12l2 1 0.01 0.07 0.04
33 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
34 INT249414 Binding of Stx1a and Dcaf12l2 1 0.00 0 0.04
35 INT249404 Binding of Snap25 and Vamp2 1 0.16 0 0.04
36 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
37 INT249426 Mbp Positive_regulation of Stx1a 1 0.10 0.11 0
38 INT273443 Positive_regulation of Binding of Snap25 and Napa 1 0.05 0 0
39 INT249401 Mbp Positive_regulation of Snap25 1 0.17 0.11 0
40 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0
41 INT249408 Mbp Positive_regulation of Localization of Stx1a 1 0.11 0.33 0
42 INT320401 Dbn1 Regulation of Protein_catabolism of Snap25 1 0.02 0 0
43 INT249405 Binding of Mbp and Stx1a 1 0.11 0 0
44 INT249419 Mbp Positive_regulation of Localization of Snap25 1 0.17 0.33 0
45 INT320397 Tax1bp1 Regulation of Protein_catabolism of Snap25 1 0.04 0 0
46 INT130533 BACE1 Regulation of SNAP25 1 0.27 0.18 0
47 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
48 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
49 INT130532 BACE2 Regulation of SNAP25 1 0.12 0.18 0
50 INT249425 Binding of Mbp and Snap25 1 0.16 0 0
51 INT249407 Mbp Positive_regulation of Localization of Vamp2 1 0.13 0.11 0
52 INT273442 Binding of Snap25 and Napa 1 0.05 0 0
53 INT255290 Snap25 Positive_regulation of Gene_expression of Upf1 1 0.02 0 0
54 INT196209 Binding of REST and SNAP25 1 0.25 0 0
55 INT249422 Binding of Mbp and Vamp2 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. They are ordered first by their pain relevance and then by number of times they were reported in synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184844 Gene_expression of Snap25 130 0.78 14.32 12.13
2 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83
3 INT120339 Phosphorylation of SNAP25 5 0.51 2.97 5.3
4 INT120334 Negative_regulation of Phosphorylation of SNAP25 4 0.37 1.71 3.21
5 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84
6 INT252124 Transcription of Snap25 21 0.72 1.56 2.71
7 INT346375 Protein_catabolism of Vamp2 1 0.33 1.56 2.46
8 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4
9 INT81500 Protein_catabolism of Snap25 10 0.66 1.12 2.12
10 INT101582 Negative_regulation of SNAP25 9 0.57 4.34 2.12
11 INT115303 Localization of SNAP25 8 0.73 1.43 1.82
12 INT184843 Regulation of Gene_expression of Snap25 4 0.62 2.15 1.74
13 INT151790 Binding of SNAP25 11 0.24 1.09 1.73
14 INT171816 Gene_expression of Stx1a 5 0.20 1.67 1.65
15 INT148426 Gene_expression of Snap25 12 0.68 1.72 1.63
16 INT139985 Negative_regulation of Snap25 20 0.59 3.73 1.41
17 INT252127 Negative_regulation of Gene_expression of Snap25 18 0.59 2.76 1.38
18 INT252133 Positive_regulation of Gene_expression of Snap25 19 0.70 2.36 1.35
19 INT120337 Positive_regulation of Phosphorylation of SNAP25 2 0.29 0.11 1.19
20 INT109443 Negative_regulation of Snap25 3 0.27 0.15 1.1
21 INT184841 Localization of Snap25 12 0.81 1.45 1.09
22 INT249383 Binding of Vamp2 5 0.23 0.33 1.03
23 INT120336 Positive_regulation of Gene_expression of SNAP25 2 0.37 0 1.03
24 INT234076 Regulation of Snap25 8 0.62 1.85 1.02
25 INT81501 Negative_regulation of Protein_catabolism of Snap25 1 0.30 0.1 0.99
26 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95
27 INT234081 Gene_expression of Vamp2 9 0.51 0.71 0.94
28 INT249377 Localization of Vamp2 4 0.51 0.4 0.93
29 INT201222 Positive_regulation of STX1A 1 0.45 0.51 0.93
30 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89
31 INT234091 Binding of Snap25 13 0.37 0.24 0.86
32 INT171818 Localization of Stx1a 1 0.08 0.22 0.85
33 INT109441 Transcription of Snap25 1 0.34 0 0.79
34 INT123757 Positive_regulation of Snap25 3 0.47 0.41 0.77
35 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71
36 INT246317 Positive_regulation of Snap25 10 0.50 0.74 0.67
37 INT148428 Binding of Snap25 6 0.37 0.22 0.67
38 INT148427 Positive_regulation of Gene_expression of Snap25 1 0.46 0.16 0.6
39 INT148429 Regulation of Snap25 2 0.27 0.15 0.53
40 INT346370 Regulation of Localization of Vamp2 1 0.15 0.08 0.53
41 INT346393 Regulation of Protein_catabolism of Vamp2 1 0.09 0.08 0.53
42 INT148430 Regulation of Gene_expression of Snap25 1 0.27 0.15 0.53
43 INT120338 Regulation of Gene_expression of SNAP25 1 0.36 0 0.52
44 INT255274 Regulation of Transcription of Snap25 1 0.45 0 0.47
45 INT336690 Negative_regulation of Gene_expression of Vamp2 2 0.16 0.28 0.46
46 INT249396 Binding of Stx1a 9 0.15 0.23 0.42
47 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41
48 INT196247 Negative_regulation of Localization of SNAP25 2 0.29 0.76 0.37
49 INT252134 Negative_regulation of Transcription of Snap25 4 0.43 0.54 0.33
50 INT268130 Regulation of Phosphorylation of SNAP25 1 0.28 0.07 0.32
51 INT290851 Regulation of Stx1a 1 0.09 0.26 0.24
52 INT255277 Positive_regulation of Transcription of Snap25 1 0.50 0 0.21
53 INT64080 Positive_regulation of Stx1a 3 0.08 0 0.2
54 INT64081 Regulation of Stx1a 3 0.25 0.07 0.14
55 INT196239 Positive_regulation of Localization of SNAP25 1 0.47 0 0.13
56 INT346395 Positive_regulation of Protein_catabolism of Vamp2 1 0.16 0.13 0.13
57 INT290852 Binding of Stx1a 1 0.13 0 0.11
58 INT334306 Positive_regulation of Stx1a 1 0.10 0.65 0.11
59 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11
60 INT94891 Protein_catabolism of SNAP25 2 0.55 0.19 0.1
61 INT293259 Negative_regulation of Gene_expression of SNAP25 4 0.49 5.08 0.09
62 INT255269 Negative_regulation of Regulation of Snap25 1 0.43 0 0.09
63 INT249379 Positive_regulation of Vamp2 3 0.33 0 0.08
64 INT309563 Transcription of SNAP25 1 0.42 0 0.08
65 INT234092 Regulation of Vamp2 2 0.20 0.17 0.05
66 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04
67 INT252125 Regulation of Regulation of Snap25 1 0.27 0.36 0.03
68 INT336691 Regulation of Gene_expression of Vamp2 1 0.19 0.43 0.03
69 INT249392 Negative_regulation of Localization of Snap25 1 0.26 0 0.03
70 INT243247 Localization of Stx1a 3 0.42 0.53 0
71 INT246318 Negative_regulation of Protein_catabolism of Snap25 2 0.19 0.34 0
72 INT249387 Positive_regulation of Regulation of Stx1a 1 0.20 0.07 0
73 INT249380 Positive_regulation of Phosphorylation of Stx1a 1 0.19 0.07 0
74 INT115305 Regulation of Localization of SNAP25 1 0.44 0 0
75 INT252138 Binding of STX1A 1 0.35 0 0
76 INT249397 Negative_regulation of Binding of Vamp2 1 0.28 0 0
77 INT249400 Negative_regulation of Binding of Stx1a 1 0.17 0.08 0
78 INT249394 Phosphorylation of Snap25 1 0.49 0 0
79 INT293260 Negative_regulation of Protein_catabolism of SNAP25 1 0.07 0 0
80 INT302015 Negative_regulation of Binding of SNAP25 1 0.27 0 0
81 INT249375 Phosphorylation of Stx1a 1 0.33 0.07 0
82 INT249376 Positive_regulation of Phosphorylation of Snap25 1 0.30 0 0
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