GO:0070044

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Name synaptobrevin 2-SNAP-25-syntaxin-1a complex
Categary Component
Go Slim No
Go Link GO:0070044
Unique Molecular Interactions 159
Total Molecular Interactions 249
Total Single Events 1119
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for synaptobrevin 2-SNAP-25-syntaxin-1a complex. They are ordered first by their pain relevance and then by number of times they were reported for synaptobrevin 2-SNAP-25-syntaxin-1a complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144451 Napa Positive_regulation of Gene_expression of Nqo1 1 0.07 0.18 0.8
2 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77
3 INT252145 Binding of Napb and Snap25 9 0.19 0.85 0.75
4 INT284790 Trpa1 Positive_regulation of Regulation of Napa 1 0.19 0 0.59
5 INT284784 Trpv1 Positive_regulation of Regulation of Napa 1 0.20 0 0.59
6 INT255287 Binding of Stx1a and Vti1b 1 0.35 0 0.58
7 INT255283 Regulation of Binding of Napb and Snap25 1 0.24 0 0.39
8 INT249406 Binding of Napa and Dcaf12l2 1 0.01 0.1 0.35
9 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
10 INT284788 Napa Positive_regulation of Trpv1 1 0.31 0 0.35
11 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
12 INT255292 Regulation of Binding of Napb and Vamp2 1 0.07 0 0.3
13 INT328185 Slc3a1 Negative_regulation of Snap25 1 0.00 0.07 0.3
14 INT252140 Binding of Cck and Snap25 1 0.30 0.39 0.3
15 INT255286 Binding of Napb and Vamp2 1 0.09 0 0.29
16 INT255291 Binding of Napb and Stx1a 1 0.21 0 0.29
17 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
18 INT255288 Binding of Snap25 and Vti1b 1 0.36 0 0.29
19 INT255284 Binding of Vamp2 and Vti1b 1 0.16 0 0.29
20 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 0.05 0.86 0.28
21 INT284783 Napa Positive_regulation of Positive_regulation of Trpa1 1 0.20 0 0.25
22 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
23 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
24 INT94890 MBTPS1 Positive_regulation of SNAP25 1 0.16 0.39 0.2
25 INT284787 Napa Positive_regulation of Binding of Trpa1 1 0.22 0 0.2
26 INT284789 Napa Positive_regulation of Binding of Trpv1 1 0.22 0 0.2
27 INT284782 Napa Positive_regulation of Trpa1 1 0.30 0 0.2
28 INT63914 Napa Negative_regulation of Npy 1 0.26 0 0.16
29 INT273441 Binding of Vamp1 and Snap25 1 0.02 0.13 0.14
30 INT249403 Binding of Snap25 and Napa 1 0.19 0 0.14
31 INT249412 Frg1 Positive_regulation of Binding of Napa 1 0.02 0.13 0.13
32 INT234104 Binding of Snap25 and DTNBP1 1 0.29 0.09 0.13
33 INT249418 Stoml3 Regulation of Napa 1 0.00 0.3 0.12
34 INT214952 Vamp2 Regulation of Rims1 1 0.17 0 0.12
35 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
36 INT214957 Vamp2 Regulation of Neu3 1 0.00 0 0.1
37 INT113363 Napa Positive_regulation of Serpina3c 1 0.15 0.25 0.09
38 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
39 INT249413 Binding of Vamp2 and Napa 1 0.15 0.05 0.09
40 INT249411 Binding of Prkaca and Napa 1 0.12 0.1 0.09
41 INT249427 Binding of Gopc and Napa 1 0.10 0.12 0.07
42 INT263761 Grin1 Regulation of Localization of Vamp2 1 0.27 0.17 0.07
43 INT263777 Grin2a Regulation of Localization of Vamp2 1 0.26 0.17 0.07
44 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
45 INT252141 Binding of Snap25 and Spata20 1 0.01 0 0.07
46 INT263739 Grin2b Regulation of Localization of Vamp2 1 0.24 0.17 0.07
47 INT263735 Localization of Neto1 Regulation of Localization of Vamp2 1 0.35 0.18 0.05
48 INT249416 Binding of Scarb2 and Napa 1 0.02 0 0.05
49 INT268111 Binding of MARCKS and SNAP25 1 0.09 0 0.05
50 INT204387 Binding of Napa and Sds 1 0.00 0 0.05
51 INT273440 Positive_regulation of Binding of Vamp1 and Snap25 1 0.02 0.13 0.04
52 INT249415 Binding of Snap25 and Dcaf12l2 1 0.01 0.07 0.04
53 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
54 INT249414 Binding of Stx1a and Dcaf12l2 1 0.00 0 0.04
55 INT249404 Binding of Snap25 and Vamp2 1 0.16 0 0.04
56 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
57 INT249426 Mbp Positive_regulation of Stx1a 1 0.10 0.11 0
58 INT273443 Positive_regulation of Binding of Snap25 and Napa 1 0.05 0 0
59 INT312043 NAPA Regulation of TNF 1 0.26 0 0
60 INT249402 Binding of Mbp and Napa 1 0.17 0 0
61 INT249401 Mbp Positive_regulation of Snap25 1 0.17 0.11 0
62 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0
63 INT249408 Mbp Positive_regulation of Localization of Stx1a 1 0.11 0.33 0
64 INT323590 Binding of Aldh2 and Napa 1 0.01 0.16 0
65 INT320401 Dbn1 Regulation of Protein_catabolism of Snap25 1 0.02 0 0
66 INT249405 Binding of Mbp and Stx1a 1 0.11 0 0
67 INT249419 Mbp Positive_regulation of Localization of Snap25 1 0.17 0.33 0
68 INT320397 Tax1bp1 Regulation of Protein_catabolism of Snap25 1 0.04 0 0
69 INT130533 BACE1 Regulation of SNAP25 1 0.27 0.18 0
70 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
71 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
72 INT273446 Binding of Vamp1 and Napa 1 0.02 0 0
73 INT130532 BACE2 Regulation of SNAP25 1 0.12 0.18 0
74 INT323591 Negative_regulation of Binding of Aldh2 and Napa 1 0.02 0.17 0
75 INT312044 NAPA Negative_regulation of Phosphorylation of HIST2H3C 1 0.08 0 0
76 INT249425 Binding of Mbp and Snap25 1 0.16 0 0
77 INT249407 Mbp Positive_regulation of Localization of Vamp2 1 0.13 0.11 0
78 INT273442 Binding of Snap25 and Napa 1 0.05 0 0
79 INT249428 Mbp Negative_regulation of Binding of Napa 1 0.18 0 0
80 INT255290 Snap25 Positive_regulation of Gene_expression of Upf1 1 0.02 0 0
81 INT196209 Binding of REST and SNAP25 1 0.25 0 0
82 INT249422 Binding of Mbp and Vamp2 1 0.12 0 0
83 INT273449 Positive_regulation of Binding of Vamp1 and Napa 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for synaptobrevin 2-SNAP-25-syntaxin-1a complex. They are ordered first by their pain relevance and then by number of times they were reported in synaptobrevin 2-SNAP-25-syntaxin-1a complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184844 Gene_expression of Snap25 130 0.78 14.32 12.13
2 INT2513 Binding of Napa 80 0.42 4.29 6.51
3 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83
4 INT120339 Phosphorylation of SNAP25 5 0.51 2.97 5.3
5 INT290831 Positive_regulation of Napb 1 0.07 7.65 3.41
6 INT120334 Negative_regulation of Phosphorylation of SNAP25 4 0.37 1.71 3.21
7 INT115301 Negative_regulation of Binding of Napa 16 0.33 0.6 3.11
8 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84
9 INT252124 Transcription of Snap25 21 0.72 1.56 2.71
10 INT115300 Negative_regulation of Napa 7 0.23 1 2.68
11 INT346375 Protein_catabolism of Vamp2 1 0.33 1.56 2.46
12 INT109559 Localization of Napa 16 0.61 1.3 2.42
13 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4
14 INT81500 Protein_catabolism of Snap25 10 0.66 1.12 2.12
15 INT101582 Negative_regulation of SNAP25 9 0.57 4.34 2.12
16 INT190390 Binding of Napb 6 0.22 2.07 2.01
17 INT290830 Positive_regulation of Positive_regulation of Napb 1 0.07 4.23 2
18 INT115303 Localization of SNAP25 8 0.73 1.43 1.82
19 INT161459 Negative_regulation of Napb 6 0.20 0.6 1.82
20 INT184843 Regulation of Gene_expression of Snap25 4 0.62 2.15 1.74
21 INT151790 Binding of SNAP25 11 0.24 1.09 1.73
22 INT115299 Regulation of Napa 14 0.54 0.56 1.7
23 INT171816 Gene_expression of Stx1a 5 0.20 1.67 1.65
24 INT148426 Gene_expression of Snap25 12 0.68 1.72 1.63
25 INT139985 Negative_regulation of Snap25 20 0.59 3.73 1.41
26 INT252127 Negative_regulation of Gene_expression of Snap25 18 0.59 2.76 1.38
27 INT252133 Positive_regulation of Gene_expression of Snap25 19 0.70 2.36 1.35
28 INT120337 Positive_regulation of Phosphorylation of SNAP25 2 0.29 0.11 1.19
29 INT120331 Gene_expression of Napa 6 0.51 1.15 1.17
30 INT109443 Negative_regulation of Snap25 3 0.27 0.15 1.1
31 INT184841 Localization of Snap25 12 0.81 1.45 1.09
32 INT249383 Binding of Vamp2 5 0.23 0.33 1.03
33 INT120336 Positive_regulation of Gene_expression of SNAP25 2 0.37 0 1.03
34 INT234076 Regulation of Snap25 8 0.62 1.85 1.02
35 INT81501 Negative_regulation of Protein_catabolism of Snap25 1 0.30 0.1 0.99
36 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95
37 INT120332 Negative_regulation of Phosphorylation of Napa 1 0.08 0 0.95
38 INT234081 Gene_expression of Vamp2 9 0.51 0.71 0.94
39 INT120330 Phosphorylation of Napa 1 0.12 0 0.94
40 INT249377 Localization of Vamp2 4 0.51 0.4 0.93
41 INT201222 Positive_regulation of STX1A 1 0.45 0.51 0.93
42 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89
43 INT201251 Negative_regulation of NAPA 2 0.30 0 0.88
44 INT252131 Gene_expression of Napb 5 0.35 0.33 0.87
45 INT234091 Binding of Snap25 13 0.37 0.24 0.86
46 INT171818 Localization of Stx1a 1 0.08 0.22 0.85
47 INT234084 Positive_regulation of Binding of Napb 2 0.12 1.32 0.81
48 INT109441 Transcription of Snap25 1 0.34 0 0.79
49 INT123757 Positive_regulation of Snap25 3 0.47 0.41 0.77
50 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71
51 INT290829 Negative_regulation of Positive_regulation of Napb 1 0.04 1.18 0.71
52 INT246317 Positive_regulation of Snap25 10 0.50 0.74 0.67
53 INT148428 Binding of Snap25 6 0.37 0.22 0.67
54 INT148427 Positive_regulation of Gene_expression of Snap25 1 0.46 0.16 0.6
55 INT255281 Localization of Napb 2 0.37 0.85 0.54
56 INT148429 Regulation of Snap25 2 0.27 0.15 0.53
57 INT346370 Regulation of Localization of Vamp2 1 0.15 0.08 0.53
58 INT346393 Regulation of Protein_catabolism of Vamp2 1 0.09 0.08 0.53
59 INT148430 Regulation of Gene_expression of Snap25 1 0.27 0.15 0.53
60 INT120338 Regulation of Gene_expression of SNAP25 1 0.36 0 0.52
61 INT255274 Regulation of Transcription of Snap25 1 0.45 0 0.47
62 INT336690 Negative_regulation of Gene_expression of Vamp2 2 0.16 0.28 0.46
63 INT249396 Binding of Stx1a 9 0.15 0.23 0.42
64 INT255280 Regulation of Gene_expression of Napb 1 0.12 0 0.42
65 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41
66 INT284594 Regulation of Negative_regulation of Napa 1 0.24 0 0.41
67 INT290827 Positive_regulation of Localization of Napb 1 0.05 0.86 0.39
68 INT204379 Positive_regulation of Napa 16 0.35 0.23 0.38
69 INT196247 Negative_regulation of Localization of SNAP25 2 0.29 0.76 0.37
70 INT252134 Negative_regulation of Transcription of Snap25 4 0.43 0.54 0.33
71 INT268130 Regulation of Phosphorylation of SNAP25 1 0.28 0.07 0.32
72 INT290851 Regulation of Stx1a 1 0.09 0.26 0.24
73 INT249381 Regulation of Binding of Napa 1 0.47 0.14 0.23
74 INT255277 Positive_regulation of Transcription of Snap25 1 0.50 0 0.21
75 INT64080 Positive_regulation of Stx1a 3 0.08 0 0.2
76 INT234094 Regulation of Napb 2 0.12 0.06 0.18
77 INT204382 Positive_regulation of Binding of Napa 5 0.53 0 0.14
78 INT64081 Regulation of Stx1a 3 0.25 0.07 0.14
79 INT255272 Regulation of Binding of Napb 1 0.20 0 0.14
80 INT196239 Positive_regulation of Localization of SNAP25 1 0.47 0 0.13
81 INT346395 Positive_regulation of Protein_catabolism of Vamp2 1 0.16 0.13 0.13
82 INT290852 Binding of Stx1a 1 0.13 0 0.11
83 INT334306 Positive_regulation of Stx1a 1 0.10 0.65 0.11
84 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11
85 INT94891 Protein_catabolism of SNAP25 2 0.55 0.19 0.1
86 INT293259 Negative_regulation of Gene_expression of SNAP25 4 0.49 5.08 0.09
87 INT255269 Negative_regulation of Regulation of Snap25 1 0.43 0 0.09
88 INT249379 Positive_regulation of Vamp2 3 0.33 0 0.08
89 INT312058 Localization of NAPA 1 0.54 0.29 0.08
90 INT309563 Transcription of SNAP25 1 0.42 0 0.08
91 INT115302 Regulation of Localization of Napa 2 0.24 0 0.05
92 INT234092 Regulation of Vamp2 2 0.20 0.17 0.05
93 INT312052 Positive_regulation of Localization of NAPA 1 0.31 0.14 0.04
94 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04
95 INT312053 Negative_regulation of Localization of NAPA 1 0.27 0.14 0.04
96 INT312060 Binding of NAPA 1 0.27 0.11 0.03
97 INT252125 Regulation of Regulation of Snap25 1 0.27 0.36 0.03
98 INT249382 Positive_regulation of Regulation of Napa 1 0.38 0 0.03
99 INT336691 Regulation of Gene_expression of Vamp2 1 0.19 0.43 0.03
100 INT249392 Negative_regulation of Localization of Snap25 1 0.26 0 0.03
101 INT243247 Localization of Stx1a 3 0.42 0.53 0
102 INT246318 Negative_regulation of Protein_catabolism of Snap25 2 0.19 0.34 0
103 INT312054 Phosphorylation of NAPA 1 0.39 0 0
104 INT249387 Positive_regulation of Regulation of Stx1a 1 0.20 0.07 0
105 INT312066 Regulation of Gene_expression of NAPA 1 0.28 0 0
106 INT312067 Gene_expression of NAPA 1 0.48 0 0
107 INT249380 Positive_regulation of Phosphorylation of Stx1a 1 0.19 0.07 0
108 INT115305 Regulation of Localization of SNAP25 1 0.44 0 0
109 INT252138 Binding of STX1A 1 0.35 0 0
110 INT249397 Negative_regulation of Binding of Vamp2 1 0.28 0 0
111 INT249400 Negative_regulation of Binding of Stx1a 1 0.17 0.08 0
112 INT249394 Phosphorylation of Snap25 1 0.49 0 0
113 INT204380 Positive_regulation of Positive_regulation of Napa 1 0.04 0.15 0
114 INT249386 Regulation of Regulation of Napa 1 0.54 0.06 0
115 INT293260 Negative_regulation of Protein_catabolism of SNAP25 1 0.07 0 0
116 INT302015 Negative_regulation of Binding of SNAP25 1 0.27 0 0
117 INT249375 Phosphorylation of Stx1a 1 0.33 0.07 0
118 INT249376 Positive_regulation of Phosphorylation of Snap25 1 0.30 0 0
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