GO:0070064

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Name proline-rich region binding
Categary Function
Go Slim No
Go Link GO:0070064
Unique Molecular Interactions 77
Total Molecular Interactions 104
Total Single Events 554
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for proline-rich region binding. They are ordered first by their pain relevance and then by number of times they were reported for proline-rich region binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
3 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
4 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
5 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
6 INT118001 Csk Regulation of Trpv1 1 0.08 0.09 0.58
7 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
8 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
9 INT263433 Abl1 Regulation of Abl1 1 0.04 0.28 0.38
10 INT118002 Binding of Trpv1 and Csk 1 0.06 0.08 0.38
11 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
12 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
13 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
14 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
15 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
16 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24
17 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
18 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
19 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
20 INT148800 VEGFA Positive_regulation of Positive_regulation of Csk 1 0.06 0 0.14
21 INT148802 Negative_regulation of VEGFA Positive_regulation of Csk 1 0.05 0 0.14
22 INT148801 VEGFA Positive_regulation of Csk 1 0.06 0 0.14
23 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
24 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12
25 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12
26 INT263429 Pdgfb Positive_regulation of Localization of Abl1 1 0.01 0 0.12
27 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11
28 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09
29 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07
30 INT267000 Mdk Negative_regulation of Positive_regulation of Baiap2 1 0.03 0.1 0.06
31 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
32 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
33 INT267040 Negative_regulation of NOS1 Negative_regulation of Positive_regulation of Baiap2 1 0.02 0.1 0.06
34 INT354963 Binding of Cttn and Shank1 1 0.12 0 0.04
35 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
36 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
37 INT263432 Trib3 Regulation of Abl1 1 0.00 0 0.04
38 INT263379 Abl1 Regulation of Bmx 1 0.04 0 0.04
39 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
40 INT259935 CSK Positive_regulation of Negative_regulation of LCK 1 0.09 0.57 0.03
41 INT286767 Binding of Abl1 and Tusc2 1 0.54 1.04 0.03
42 INT259940 CSK Positive_regulation of Phosphorylation of LCK 1 0.09 0.51 0.03
43 INT259939 Negative_regulation of Binding of CSK and PTPN22 1 0.19 0.62 0.03
44 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
45 INT356117 Binding of SORL1 and Apbb1 1 0.14 0.43 0
46 INT219791 Cttn Regulation of AICDA 1 0.21 0.42 0
47 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
48 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
49 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0
50 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
51 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
52 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
53 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0
54 INT285581 Binding of CSK and S100A8 1 0.09 0.2 0
55 INT219785 Cttn Regulation of Fank1 1 0.03 0.07 0
56 INT219782 Cttn Regulation of Hcls1 1 0.21 0.07 0
57 INT285582 Binding of ABL1 and S100A8 1 0.02 0.2 0
58 INT238114 Binding of CSK and SRC 1 0.07 0 0
59 INT238115 Binding of CSK and STAT3 1 0.09 0.06 0
60 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
61 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
62 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0
63 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
64 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0
65 INT198928 Binding of Apbb1 and Lrp8 1 0.07 0.17 0
66 INT149996 Npy6r Negative_regulation of Csk 1 0.01 0 0
67 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0
68 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for proline-rich region binding. They are ordered first by their pain relevance and then by number of times they were reported in proline-rich region binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9895 Binding of GHR 18 0.36 4.8 5.65
2 INT115348 Localization of Baiap2 1 0.68 1.76 2.99
3 INT22019 Regulation of GHR 9 0.62 2.56 2.39
4 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
5 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
6 INT148788 Binding of Csk 2 0.12 2.14 1.89
7 INT132837 Positive_regulation of Csk 5 0.45 1.75 1.79
8 INT263398 Positive_regulation of Abl1 1 0.60 1.44 1.66
9 INT148937 Positive_regulation of Csk 2 0.13 2.25 1.63
10 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
11 INT115350 Positive_regulation of Localization of Baiap2 1 0.45 0.76 1.36
12 INT72147 Phosphorylation of Cttn 3 0.28 0.64 1.27
13 INT126812 Gene_expression of Cttn 9 0.57 0.81 1.23
14 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
15 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
16 INT102758 Negative_regulation of Abl1 2 0.51 1.13 1.1
17 INT263387 Binding of Abl1 8 0.42 0.86 0.91
18 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
19 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87
20 INT132835 Phosphorylation of Csk 2 0.36 0 0.83
21 INT72149 Regulation of Cttn 3 0.31 0.95 0.76
22 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75
23 INT241499 Binding of Abl1 23 0.47 8.86 0.75
24 INT321007 Protein_catabolism of Cttn 1 0.03 0.05 0.71
25 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
26 INT148786 Negative_regulation of Csk 4 0.09 0.97 0.62
27 INT139186 Positive_regulation of APBB1 1 0.00 0.31 0.62
28 INT115347 Regulation of Localization of Baiap2 1 0.23 0.38 0.62
29 INT132836 Regulation of Csk 1 0.30 0.42 0.59
30 INT130791 Regulation of Csk 1 0.07 0.86 0.54
31 INT322158 Phosphorylation of Csk 2 0.10 1.49 0.52
32 INT263404 Regulation of Abl1 1 0.53 0.66 0.52
33 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
34 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39
35 INT181179 Binding of CYLD 4 0.43 7.06 0.39
36 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
37 INT158592 Negative_regulation of CSK 2 0.19 0.43 0.36
38 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
39 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
40 INT73854 Transcription of ABL1 4 0.52 2.26 0.34
41 INT263408 Gene_expression of Abl1 4 0.58 0.28 0.33
42 INT126864 Negative_regulation of Csk 1 0.12 0.58 0.3
43 INT228468 Localization of Csk 1 0.12 0.79 0.29
44 INT228467 Positive_regulation of Gene_expression of Csk 1 0.08 0.79 0.29
45 INT228473 Positive_regulation of Localization of Csk 1 0.08 0.79 0.29
46 INT228471 Gene_expression of Csk 1 0.11 0.79 0.29
47 INT263399 Positive_regulation of Gene_expression of Abl1 1 0.43 0 0.25
48 INT220582 Binding of Apbb1 2 0.14 0.69 0.24
49 INT241498 Regulation of Abl1 8 0.32 6.46 0.22
50 INT185452 Regulation of CYLD 6 0.40 6.09 0.21
51 INT263396 Localization of Abl1 1 0.61 0 0.21
52 INT168693 Negative_regulation of Binding of Nedd4 1 0.31 0.29 0.21
53 INT168696 Positive_regulation of Binding of Nedd4 1 0.34 0.29 0.21
54 INT239412 Binding of ABL1 8 0.28 5.39 0.18
55 INT263405 Phosphorylation of Abl1 1 0.71 0.05 0.18
56 INT141857 Regulation of Regulation of Cttn 1 0.11 0 0.17
57 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16
58 INT163461 Regulation of ABL1 8 0.32 5.98 0.14
59 INT148793 Negative_regulation of Positive_regulation of Csk 1 0.06 0 0.14
60 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14
61 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
62 INT263392 Positive_regulation of Phosphorylation of Abl1 1 0.60 0 0.13
63 INT185449 Regulation of Regulation of CYLD 1 0.21 2.03 0.13
64 INT148789 Negative_regulation of Binding of Csk 1 0.06 0 0.13
65 INT263411 Negative_regulation of Positive_regulation of Abl1 1 0.37 0.42 0.13
66 INT307240 Localization of CYLD 3 0.72 3.09 0.1
67 INT263386 Negative_regulation of Binding of Abl1 1 0.51 0.05 0.1
68 INT267034 Gene_expression of Baiap2 1 0.24 0.15 0.1
69 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09
70 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09
71 INT133407 Binding of APBB1 2 0.35 1.63 0.09
72 INT321675 Gene_expression of Apbb1 1 0.32 1 0.09
73 INT185440 Negative_regulation of Negative_regulation of CYLD 1 0.20 1.02 0.08
74 INT263421 Regulation of Localization of Abl1 1 0.23 0 0.08
75 INT238186 Phosphorylation of CSK 4 0.33 1.44 0.07
76 INT263389 Regulation of Regulation of Abl1 1 0.39 0.06 0.07
77 INT267025 Positive_regulation of Baiap2 1 0.15 0.1 0.06
78 INT163462 Negative_regulation of Regulation of ABL1 1 0.11 1.17 0.06
79 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05
80 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05
81 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05
82 INT273554 Positive_regulation of Binding of Abl1 2 0.40 2.05 0.05
83 INT315848 Positive_regulation of Negative_regulation of Abl1 1 0.20 0.61 0.05
84 INT321679 Positive_regulation of Gene_expression of Apbb1 1 0.28 0.56 0.05
85 INT263406 Protein_catabolism of Abl1 1 0.86 0 0.05
86 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05
87 INT184168 Localization of GHR 1 0.08 0.34 0.05
88 INT241506 Localization of Abl1 2 0.54 2.37 0.04
89 INT303073 Positive_regulation of Gene_expression of Csk 1 0.13 0.25 0.04
90 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04
91 INT238191 Positive_regulation of Phosphorylation of CSK 1 0.12 0.21 0.04
92 INT303070 Gene_expression of Csk 1 0.14 0.25 0.04
93 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03
94 INT321677 Localization of Apbb1 1 0.31 0.29 0.03
95 INT315842 Regulation of Gene_expression of Abl1 1 0.11 0.94 0.03
96 INT273548 Negative_regulation of Binding of Abl1 2 0.34 0.88 0
97 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0
98 INT198878 Regulation of Apbb1 1 0.11 0 0
99 INT219762 Binding of Cttn 1 0.24 0.35 0
100 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0
101 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
102 INT263393 Regulation of Binding of Abl1 1 0.39 0 0
103 INT350510 Localization of ABL1 1 0.40 2.51 0
104 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
105 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0
106 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0
107 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0
108 INT219769 Negative_regulation of Binding of Cttn 1 0.29 0.35 0
109 INT221550 Positive_regulation of Phosphorylation of Cttn 1 0.17 0.14 0
110 INT238205 Gene_expression of CSK 1 0.12 0.06 0
111 INT156466 Regulation of Negative_regulation of ABL1 1 0.44 0.63 0
112 INT324467 Gene_expression of APBB1 1 0.75 1.66 0
113 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0
114 INT165179 Regulation of Positive_regulation of ABL1 1 0.15 0.95 0
115 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0
116 INT283069 Negative_regulation of Gene_expression of Abl1 1 0.17 0.69 0
117 INT273558 Transcription of Abl1 1 0.57 0.3 0
118 INT315894 Localization of Cttn 1 0.08 1.12 0
119 INT219768 Negative_regulation of Cttn 1 0.40 0.35 0
120 INT273546 Negative_regulation of Transcription of Abl1 1 0.46 0.3 0
121 INT263391 Negative_regulation of Gene_expression of Abl1 1 0.37 0 0
122 INT350512 Positive_regulation of Phosphorylation of ABL1 1 0.27 0.75 0
123 INT307230 Regulation of Localization of CYLD 1 0.40 0.11 0
124 INT351489 Regulation of Transcription of ABL1 1 0.28 0.08 0
125 INT350508 Protein_catabolism of ABL1 1 0.54 0.5 0
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