GO:0070094

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Name positive regulation of glucagon secretion
Categary Process
Go Slim No
Go Link GO:0070094
Unique Molecular Interactions 70
Total Molecular Interactions 96
Total Single Events 706
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of glucagon secretion. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of glucagon secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
2 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
3 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
4 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
5 INT55429 Binding of Gip and Glp1r 1 0.39 0 0.31
6 INT55425 Gip Positive_regulation of Localization of Glp1r 1 0.44 0 0.3
7 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
8 INT60359 GIP Regulation of NTS 1 0.20 0 0.24
9 INT164924 GIP Regulation of GYPC 1 0.07 0.33 0.23
10 INT60358 GIP Regulation of CCK 1 0.29 0 0.23
11 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
12 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
13 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
14 INT164923 INS Positive_regulation of GIP 1 0.43 0.18 0.11
15 INT246844 Binding of Irs1 and Myl7 1 0.05 0.43 0.11
16 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09
17 INT56111 Ins1 Regulation of Localization of Gip 1 0.13 0.23 0.09
18 INT113723 Gip Regulation of MIA3 2 0.00 1.28 0.08
19 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
20 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
21 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08
22 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
23 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
24 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
25 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08
26 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08
27 INT321465 Gip Regulation of DPP4 1 0.03 0.59 0.06
28 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
29 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
30 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05
31 INT332638 Gip Regulation of Glp1r 1 0.02 0.47 0.05
32 INT332632 Gip Negative_regulation of Localization of Gcg 1 0.05 0.47 0.04
33 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04
34 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
35 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
36 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
37 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03
38 INT24104 Gip Positive_regulation of Localization of Ins1 1 0.39 0 0.03
39 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
40 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
41 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
42 INT179949 Binding of Ins1 and Irs1 1 0.31 0.32 0.03
43 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
44 INT24102 Grp Regulation of Localization of Gip 1 0.18 0 0
45 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0
46 INT145815 Gip Regulation of INS 1 0.00 0.08 0
47 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
48 INT145817 Gip Positive_regulation of INS 1 0.01 0.08 0
49 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
50 INT321722 Negative_regulation of Binding of Irs1 and Ppp1r13b 1 0.20 0.07 0
51 INT321715 Regulation of Binding of Irs1 and Ppp1r13b 1 0.15 0.05 0
52 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
53 INT240880 Mapk8 Positive_regulation of Protein_catabolism of Irs1 1 0.21 0.14 0
54 INT145820 Gip Positive_regulation of MIA3 1 0.00 0.08 0
55 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0
56 INT342360 Binding of H2-K1 and Irs1 1 0.10 0 0
57 INT24103 Gal Regulation of Localization of Gip 1 0.24 0 0
58 INT240900 Negative_regulation of Ros1 Positive_regulation of Gene_expression of Irs1 1 0.08 0.13 0
59 INT255041 DPP4 Positive_regulation of GIP 1 0.49 0.32 0
60 INT255021 DPP4 Negative_regulation of Protein_catabolism of GIP 1 0.32 0.78 0
61 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
62 INT342361 Binding of Irs1 and Rdh9 1 0.38 0 0
63 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0
64 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
65 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0
66 INT240901 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs1 1 0.07 0.15 0
67 INT321713 Ins1 Positive_regulation of Irs1 1 0.04 0.05 0
68 INT255023 Negative_regulation of DPP4 Positive_regulation of GIP 1 0.35 0.27 0
69 INT342357 Binding of Irs1 and Irf6 1 0.37 0 0
70 INT24112 GRP Regulation of Localization of Gip 1 0.05 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of glucagon secretion. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of glucagon secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2257 Localization of Gip 31 0.74 11.08 7.92
2 INT4034 Negative_regulation of Gip 16 0.53 6.46 5.65
3 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
4 INT2258 Positive_regulation of Gip 16 0.60 5.51 3.67
5 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
6 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
7 INT4186 Negative_regulation of Localization of Gip 7 0.53 2.11 2.98
8 INT2256 Regulation of Gip 14 0.47 4.69 2.91
9 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
10 INT41136 Negative_regulation of Positive_regulation of Gip 4 0.37 1.66 2.45
11 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
12 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
13 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
14 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
15 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
16 INT36226 Gene_expression of GIP 13 0.67 3.05 1.25
17 INT29372 Localization of GIP 18 0.69 7.23 1.01
18 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
19 INT4036 Positive_regulation of Localization of Gip 3 0.45 1.92 0.9
20 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
21 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
22 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
23 INT37289 Regulation of GIP 5 0.39 0.3 0.74
24 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
25 INT242655 Binding of Irs1 1 0.29 1.45 0.66
26 INT136833 Gene_expression of Gip 1 0.78 2.26 0.6
27 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
28 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
29 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
30 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
31 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
32 INT246828 Binding of Irs1 9 0.37 2.68 0.42
33 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
34 INT255071 Binding of GIP 2 0.28 1.39 0.42
35 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
36 INT2254 Gene_expression of Gip 5 0.47 2.21 0.4
37 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
38 INT2255 Regulation of Localization of Gip 3 0.26 0.91 0.4
39 INT55423 Binding of Gip 2 0.45 0 0.39
40 INT46473 Negative_regulation of Negative_regulation of Gip 1 0.39 1.08 0.36
41 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
42 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
43 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
44 INT46472 Positive_regulation of Positive_regulation of Gip 1 0.37 0.53 0.23
45 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
46 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
47 INT255068 Positive_regulation of GIP 4 0.38 1.59 0.21
48 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
49 INT39916 Negative_regulation of Localization of GIP 1 0.30 0 0.17
50 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
51 INT240841 Regulation of Gene_expression of Irs1 3 0.45 0.75 0.15
52 INT39917 Negative_regulation of GIP 3 0.46 1.08 0.15
53 INT120962 Negative_regulation of Negative_regulation of Irs1 1 0.25 0.38 0.15
54 INT96536 Protein_catabolism of Gip 1 0.64 0 0.15
55 INT39920 Regulation of Localization of GIP 1 0.42 0 0.15
56 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15
57 INT230807 Regulation of Phosphorylation of Irs1 3 0.45 1.59 0.13
58 INT280037 Localization of Gip 2 0.25 2.22 0.13
59 INT136832 Positive_regulation of Gene_expression of Gip 1 0.44 0.29 0.12
60 INT246818 Negative_regulation of Gene_expression of Irs1 3 0.42 1.25 0.1
61 INT304385 Protein_catabolism of IRS1 2 0.42 1.8 0.1
62 INT240850 Regulation of Irs1 2 0.47 0.64 0.09
63 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09
64 INT46553 Regulation of Gene_expression of Gip 1 0.09 0.08 0.08
65 INT246819 Negative_regulation of Binding of Irs1 3 0.42 0.62 0.07
66 INT39918 Positive_regulation of Localization of GIP 1 0.37 0 0.07
67 INT267922 Positive_regulation of Gene_expression of Gip 1 0.04 0.97 0.05
68 INT301556 Negative_regulation of Positive_regulation of Irs1 1 0.10 1.63 0.04
69 INT332626 Protein_catabolism of Gip 1 0.27 0.49 0.04
70 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04
71 INT235632 Binding of IRS1 2 0.28 1.01 0.03
72 INT321462 Negative_regulation of Negative_regulation of Gip 1 0.05 0.69 0.03
73 INT339939 Positive_regulation of Transcription of GIP 1 0.33 0.51 0.03
74 INT321463 Negative_regulation of Gip 1 0.05 0.68 0.03
75 INT284335 Regulation of Gene_expression of IRS1 1 0.18 0.06 0.03
76 INT246829 Localization of Irs1 2 0.74 0.9 0
77 INT246826 Positive_regulation of Localization of Irs1 1 0.50 0.76 0
78 INT339937 Transcription of GIP 1 0.45 0.51 0
79 INT323089 Positive_regulation of Transcription of Irs1 1 0.44 0.26 0
80 INT304382 Positive_regulation of Protein_catabolism of IRS1 1 0.16 0.77 0
81 INT284324 Positive_regulation of Gene_expression of IRS1 1 0.31 0.24 0
82 INT255067 Negative_regulation of Binding of GIP 1 0.32 0.31 0
83 INT323107 Transcription of Irs1 1 0.50 0.26 0
84 INT280661 Negative_regulation of Transcription of Irs1 1 0.37 0 0
85 INT304383 Negative_regulation of Protein_catabolism of IRS1 1 0.15 0.77 0
86 INT67344 Negative_regulation of Regulation of Gip 1 0.25 0.17 0
87 INT179948 Negative_regulation of Positive_regulation of Irs1 1 0.45 0.36 0
88 INT255031 Protein_catabolism of GIP 1 0.83 0.32 0
89 INT235630 Localization of IRS1 1 0.70 0.38 0
90 INT179947 Positive_regulation of Irs1 1 0.53 0.83 0
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