GO:0070101

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Name positive regulation of chemokine-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0070101
Unique Molecular Interactions 125
Total Molecular Interactions 180
Total Single Events 1230
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of chemokine-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of chemokine-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
2 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
3 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
4 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
5 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
6 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
7 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
8 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
9 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
10 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
11 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
12 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
13 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
14 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
15 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
16 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
17 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
18 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
19 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
20 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
21 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
22 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
23 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
24 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
25 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
26 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
27 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
28 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
29 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
30 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
31 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
32 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
33 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
34 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
35 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
36 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
37 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
38 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
39 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
40 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
41 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
42 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
43 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
44 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
45 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
46 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
47 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
48 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
49 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
50 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
51 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
52 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
53 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
54 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
55 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
56 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
57 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
58 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
59 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
60 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
61 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
62 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
63 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
64 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
65 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
66 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
67 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
68 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
69 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
70 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
71 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
72 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
73 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
74 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
75 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
76 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
77 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
78 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
79 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
80 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
81 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
82 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
83 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
84 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
85 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
86 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
87 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
88 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
89 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
90 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
91 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
92 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
93 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
94 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
95 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
96 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04
97 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04
98 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
99 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04
100 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
101 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04
102 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
103 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
104 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
105 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
106 INT143438 HIF1A Regulation of Gene_expression of VEGFA 1 0.69 0.13 0
107 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
108 INT284143 EDN1 Positive_regulation of CA2 1 0.03 0.37 0
109 INT182267 EDN1 Regulation of Gene_expression of NOS2 1 0.36 0 0
110 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
111 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0
112 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
113 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0
114 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
115 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
116 INT182257 EDN1 Positive_regulation of Phosphorylation of AKT1 1 0.21 0.05 0
117 INT143439 Positive_regulation of HIF1A Regulation of Gene_expression of VEGFA 1 0.30 0.13 0
118 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0
119 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0
120 INT119044 HIF1A Regulation of TCEAL1 1 0.02 1.06 0
121 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
122 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 0.08 1.06 0
123 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of chemokine-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of chemokine-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
2 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
3 INT9191 Localization of EDN1 94 0.81 57.01 14.78
4 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
5 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
6 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
7 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
8 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
9 INT10237 Binding of EDN1 40 0.48 16 8.48
10 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
11 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
12 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
13 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
14 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
15 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
16 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
17 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
18 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
19 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
20 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
21 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
22 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
23 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
24 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
25 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
26 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
27 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
28 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
29 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
30 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
31 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
32 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
33 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
34 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
35 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
36 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
37 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
38 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
39 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
40 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
41 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
42 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
43 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
44 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
45 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
46 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
47 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
48 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
49 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
50 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
51 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
52 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
53 INT189606 Regulation of Transcription of HIF1A 1 0.06 0.46 0
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