GO:0070102

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Name interleukin-6-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0070102
Unique Molecular Interactions 1429
Total Molecular Interactions 2102
Total Single Events 16967
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-6-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-6-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
2 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
3 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
4 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
5 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
8 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
9 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
10 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
11 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
12 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
13 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
14 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
15 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
16 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
17 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
18 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
19 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
20 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
21 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
22 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
23 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
24 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
25 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
26 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
27 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
28 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
29 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
30 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
31 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
32 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
33 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
34 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
35 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
36 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
37 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
38 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
39 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
40 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
41 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
42 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
43 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
44 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
45 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
46 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
47 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
48 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
49 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
50 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
51 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
52 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
53 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
54 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
55 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
56 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
57 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
58 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
59 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
60 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
61 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
62 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
63 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
64 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
65 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
66 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
67 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
68 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
69 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
70 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
71 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
72 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
73 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
74 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
75 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
76 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
77 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
78 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
79 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
80 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
81 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
82 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
83 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
84 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
85 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
86 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
87 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
88 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
89 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
90 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
91 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
92 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
93 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
94 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
95 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
96 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
97 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
98 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
99 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
100 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
101 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
102 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
103 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
104 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
105 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
106 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
107 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
108 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
109 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
110 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
111 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
112 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
113 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
114 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
115 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
116 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
117 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
118 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
119 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
120 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
121 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
122 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
123 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
124 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
125 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
126 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
127 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
128 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72
129 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
130 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
131 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
132 INT209059 Il6 Positive_regulation of Cxcl1 1 0.06 0.38 0.72
133 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
134 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
135 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
136 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
137 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72
138 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
139 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
140 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
141 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
142 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
143 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
144 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
145 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
146 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
147 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
148 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
149 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
150 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
151 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
152 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
153 INT82384 Penk Positive_regulation of Gene_expression of Il6 1 0.15 0 0.66
154 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
155 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
156 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
157 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
158 INT209055 S100a8 Positive_regulation of Gene_expression of Il6 1 0.01 0.45 0.64
159 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
160 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63
161 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
162 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
163 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
164 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
165 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
166 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
167 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
168 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
169 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
170 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
171 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
172 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
173 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
174 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
175 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
176 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
177 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
178 INT140890 Il10 Regulation of Il6 1 0.35 0.73 0.58
179 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
180 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
181 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
182 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
183 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
184 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57
185 INT142312 Lalba Negative_regulation of Localization of Il6 1 0.23 0.73 0.57
186 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57
187 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
188 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56
189 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
190 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
191 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
192 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
193 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54
194 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54
195 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53
196 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53
197 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53
198 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
199 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
200 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-6-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-6-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
7 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
8 INT12082 Localization of IL6 365 0.81 241.78 105.78
9 INT19511 Localization of Il6 212 0.81 118.17 67.67
10 INT11937 Localization of Il6 228 0.81 139.83 64.39
11 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
12 INT10706 Regulation of Il6 150 0.62 93.23 62.34
13 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
14 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
15 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
16 INT9210 Regulation of IL6 166 0.62 125.61 49.95
17 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
18 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
19 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
20 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
21 INT9655 Regulation of Il6 98 0.62 70.92 31.95
22 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
23 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
24 INT86437 Binding of IL6 154 0.48 121.22 29.3
25 INT51474 Binding of Il6 55 0.48 44.99 20.52
26 INT49985 Transcription of Il6 62 0.72 40.13 20.29
27 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
28 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
29 INT61626 Transcription of IL6 73 0.72 42.04 17.86
30 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
31 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
32 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
33 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
34 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
35 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
36 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
37 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
38 INT54763 Binding of Il6 82 0.48 63.27 12.89
39 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
40 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
41 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
42 INT50933 Transcription of Il6 38 0.72 24.31 11.58
43 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
44 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
45 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
46 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
47 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
48 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
49 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
50 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28
51 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
52 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
53 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
54 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
55 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
56 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
57 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
58 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
59 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06
60 INT121818 Binding of STAT3 25 0.47 11.16 3.67
61 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
62 INT174816 Binding of IL6R 14 0.09 11.26 3.63
63 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
64 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
65 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
66 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
67 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
68 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
69 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
70 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
71 INT97393 Localization of Stat3 11 0.75 7.33 3.01
72 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
73 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
74 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
75 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
76 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61
77 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
78 INT129917 Negative_regulation of Phosphorylation of Stat3 6 0.41 0.85 2.51
79 INT140993 Negative_regulation of Positive_regulation of Stat3 6 0.38 3.39 2.39
80 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
81 INT333961 Binding of Il6r 1 0.07 3.67 2.29
82 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27
83 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
84 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
85 INT140268 Negative_regulation of Positive_regulation of Stat3 9 0.47 7.59 2.05
86 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05
87 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04
88 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
89 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
90 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
91 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
92 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
93 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73
94 INT165617 Localization of STAT3 28 0.78 9.04 1.72
95 INT192965 Localization of Stat3 15 0.74 7.05 1.68
96 INT135275 Regulation of Negative_regulation of Il6 4 0.45 0.89 1.67
97 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55
98 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
99 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
100 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
101 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
102 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
103 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
104 INT159009 Regulation of Il6st 2 0.18 2 1.41
105 INT121207 Negative_regulation of Phosphorylation of Stat3 16 0.45 9.35 1.4
106 INT97394 Regulation of Stat3 6 0.41 2.52 1.34
107 INT136470 Positive_regulation of Positive_regulation of Stat3 3 0.40 0.75 1.23
108 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
109 INT91368 Negative_regulation of Phosphorylation of STAT3 14 0.59 9.22 1.2
110 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
111 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1
112 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
113 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
114 INT142068 Positive_regulation of Localization of Stat3 3 0.47 1.6 1.07
115 INT155053 Transcription of Stat3 6 0.50 3.97 1
116 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
117 INT101240 Regulation of Phosphorylation of STAT3 5 0.57 3.04 0.98
118 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98
119 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92
120 INT115192 Phosphorylation of IL6 7 0.70 1.55 0.84
121 INT261600 Positive_regulation of Gene_expression of Il6ra 7 0.05 6.22 0.84
122 INT333963 Localization of Il6r 1 0.10 0.75 0.83
123 INT192851 Phosphorylation of Il6 7 0.68 3.12 0.82
124 INT54940 Positive_regulation of Gab1 1 0.04 0.48 0.79
125 INT300843 Regulation of Transcription of Il6 3 0.37 3.4 0.76
126 INT289232 Localization of Il6ra 1 0.06 2.12 0.75
127 INT178186 Regulation of Stat3 7 0.44 6.23 0.74
128 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
129 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74
130 INT205476 Binding of Stat3 12 0.47 4.73 0.72
131 INT158354 Negative_regulation of Binding of Il6 2 0.20 2.21 0.71
132 INT333965 Binding of Il6st 1 0.08 0.9 0.65
133 INT228246 Negative_regulation of Gene_expression of Stat3 10 0.58 8.11 0.64
134 INT261602 Positive_regulation of Binding of Il6 2 0.50 1.75 0.62
135 INT138730 Negative_regulation of Negative_regulation of Il6 3 0.09 1.04 0.61
136 INT264490 Regulation of Negative_regulation of Il6 2 0.23 1.18 0.6
137 INT169725 Binding of Il6ra 4 0.07 3.99 0.59
138 INT165618 Negative_regulation of Localization of STAT3 2 0.39 0.31 0.59
139 INT289237 Positive_regulation of Il6ra 1 0.05 3.84 0.59
140 INT54939 Regulation of Gab1 1 0.04 0.39 0.59
141 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56
142 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56
143 INT169726 Negative_regulation of Il6ra 3 0.05 3.14 0.53
144 INT91372 Negative_regulation of Positive_regulation of STAT3 8 0.40 2 0.5
145 INT205477 Transcription of Stat3 4 0.68 3.15 0.5
146 INT220268 Regulation of Regulation of Il6 2 0.12 0.89 0.49
147 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
148 INT115189 Regulation of Phosphorylation of IL6 1 0.04 0 0.48
149 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46
150 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
151 INT98447 Positive_regulation of Negative_regulation of Il6 1 0.44 0.75 0.45
152 INT54937 Negative_regulation of Gab1 1 0.03 0.27 0.42
153 INT285471 Negative_regulation of Binding of Il6 2 0.21 1.33 0.41
154 INT121816 Positive_regulation of Binding of STAT3 3 0.49 0.8 0.4
155 INT101242 Regulation of Gene_expression of STAT3 4 0.62 2.11 0.39
156 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
157 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
158 INT82552 Negative_regulation of Regulation of Il6 2 0.38 1.43 0.36
159 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
160 INT119371 Regulation of Positive_regulation of STAT3 2 0.42 0.36 0.35
161 INT155054 Regulation of Gene_expression of Stat3 2 0.50 4.73 0.32
162 INT101241 Positive_regulation of Negative_regulation of STAT3 1 0.70 1.53 0.32
163 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
164 INT143536 Protein_catabolism of Il6 2 0.69 1.89 0.31
165 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
166 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
167 INT179341 Binding of Stat3 3 0.23 0.95 0.27
168 INT276919 Regulation of Phosphorylation of Stat3 3 0.35 1.32 0.27
169 INT289579 Negative_regulation of Gene_expression of Stat3 2 0.28 1.01 0.27
170 INT194162 Protein_catabolism of Il6 2 0.12 0.79 0.27
171 INT211287 Regulation of Binding of Il6 1 0.06 0.1 0.27
172 INT144038 Transcription of STAT3 4 0.56 0.99 0.25
173 INT201071 Positive_regulation of Regulation of Il6 2 0.39 0.45 0.25
174 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
175 INT298665 Positive_regulation of Protein_catabolism of IL6 1 0.09 2.03 0.25
176 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
177 INT289227 Regulation of Gene_expression of Stat3 4 0.47 3.66 0.21
178 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
179 INT206166 Negative_regulation of Binding of STAT3 4 0.55 1.13 0.2
180 INT335080 Negative_regulation of Negative_regulation of Stat3 1 0.16 0.46 0.18
181 INT129583 Protein_catabolism of Stat3 1 0.41 0.83 0.16
182 INT276934 Negative_regulation of Localization of Stat3 4 0.45 1.99 0.15
183 INT158508 Negative_regulation of Gene_expression of STAT3 2 0.43 1.74 0.15
184 INT290661 Regulation of Regulation of Stat3 1 0.29 0.36 0.14
185 INT289225 Positive_regulation of Positive_regulation of Il6ra 1 0.04 0.77 0.14
186 INT206163 Positive_regulation of Localization of STAT3 4 0.29 0.43 0.13
187 INT188222 Positive_regulation of Regulation of IL6 2 0.29 0.51 0.13
188 INT290655 Positive_regulation of Transcription of Stat3 1 0.33 0.41 0.13
189 INT298669 Negative_regulation of Protein_catabolism of IL6 1 0.08 1.02 0.13
190 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
191 INT276922 Positive_regulation of Localization of Stat3 1 0.39 1.34 0.12
192 INT333743 Regulation of Gene_expression of Il6ra 1 0.05 0.45 0.12
193 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
194 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
195 INT144039 Negative_regulation of Negative_regulation of STAT3 2 0.55 0.85 0.07
196 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
197 INT292967 Positive_regulation of Gene_expression of Stat3 4 0.48 1.35 0.06
198 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
199 INT253097 Negative_regulation of Phosphorylation of Il6 1 0.35 0.23 0.06
200 INT206143 Positive_regulation of Transcription of STAT3 1 0.21 0.34 0.06
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