GO:0070120

From wiki-pain
Jump to: navigation, search
Name ciliary neurotrophic factor-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0070120
Unique Molecular Interactions 93
Total Molecular Interactions 124
Total Single Events 534
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for ciliary neurotrophic factor-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
2 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
3 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
4 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
5 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
6 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
7 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
8 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
9 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
10 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
11 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
12 INT56744 CNTF Positive_regulation of Cck 1 0.08 0.09 0.51
13 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
14 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
15 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
16 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
17 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45
18 INT291384 Cntf Positive_regulation of Slc1a3 1 0.26 0.34 0.45
19 INT291387 Cntf Positive_regulation of Slc1a2 1 0.12 0.34 0.45
20 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
21 INT291393 Cntf Regulation of GTS 1 0.05 0 0.42
22 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
23 INT91720 Binding of BDNF and CNTF 1 0.09 1.71 0.38
24 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
25 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
26 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
27 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
28 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
29 INT63988 Cntf Regulation of Positive_regulation of Sds 1 0.22 0 0.28
30 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24
31 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
32 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
33 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
34 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
35 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
36 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22
37 INT294694 REM1 Positive_regulation of LIFR 1 0.01 0.24 0.18
38 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
39 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
40 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
41 INT289245 Binding of Il6ra and Positive_regulation of Gene_expression of Ptger2 1 0.00 0.82 0.15
42 INT333764 Il6 Regulation of Gene_expression of Il6ra 1 0.02 0.52 0.12
43 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
44 INT299538 Lifr Positive_regulation of Ak5 1 0.07 0.23 0.09
45 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
46 INT355021 Cntf Positive_regulation of SOAT1 1 0.02 0.7 0.08
47 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08
48 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
49 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
50 INT289258 Binding of ABCA1 and Il6ra 1 0.00 0.33 0.07
51 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07
52 INT289244 Binding of Il11ra1 and Il6ra 1 0.01 0.33 0.07
53 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05
54 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
55 INT112280 Ntf3 Regulation of Cntf 1 0.11 0.13 0.05
56 INT198923 Gene_expression of Lrp8 Positive_regulation of Gene_expression of Lifr 1 0.01 0 0.04
57 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03
58 INT116407 Binding of Bdnf and Cntf 1 0.19 0.05 0
59 INT222569 Cntf Regulation of Localization of Prl 1 0.01 0.06 0
60 INT235594 Binding of LIFR and Rem1 1 0.02 0.36 0
61 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
62 INT294693 LPA Regulation of LIFR 1 0.00 0 0
63 INT222530 Cntf Regulation of Localization of Gh1 1 0.00 0.06 0
64 INT269138 Binding of Il6ra and Rps7 1 0.01 0.85 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in ciliary neurotrophic factor-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
2 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
3 INT174816 Binding of IL6R 14 0.09 11.26 3.63
4 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
5 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
6 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
7 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
8 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
9 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
10 INT333961 Binding of Il6r 1 0.07 3.67 2.29
11 INT228442 Localization of Cntf 8 0.63 4.2 2.12
12 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
13 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
14 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
15 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
16 INT143983 Gene_expression of Lifr 9 0.47 6.26 1.79
17 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73
18 INT8422 Binding of Cntf 8 0.37 4.54 1.72
19 INT68582 Localization of CNTF 4 0.73 2.02 1.68
20 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
21 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
22 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
23 INT159009 Regulation of Il6st 2 0.18 2 1.41
24 INT131255 Positive_regulation of Transcription of Lifr 1 0.01 0.99 1.28
25 INT131252 Transcription of Lifr 1 0.02 0.99 1.28
26 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
27 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
28 INT85963 Gene_expression of LIFR 23 0.75 9 0.98
29 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96
30 INT162783 Binding of LIFR 1 0.36 1.52 0.86
31 INT261600 Positive_regulation of Gene_expression of Il6ra 7 0.05 6.22 0.84
32 INT352587 Transcription of CNTF 1 0.30 5.18 0.84
33 INT178455 Localization of LIFR 6 0.61 2.24 0.83
34 INT333963 Localization of Il6r 1 0.10 0.75 0.83
35 INT286804 Negative_regulation of Gene_expression of Cntf 2 0.38 0.71 0.79
36 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78
37 INT289232 Localization of Il6ra 1 0.06 2.12 0.75
38 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
39 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67
40 INT333965 Binding of Il6st 1 0.08 0.9 0.65
41 INT70418 Negative_regulation of CNTF 1 0.58 0.62 0.63
42 INT169725 Binding of Il6ra 4 0.07 3.99 0.59
43 INT289237 Positive_regulation of Il6ra 1 0.05 3.84 0.59
44 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54
45 INT169726 Negative_regulation of Il6ra 3 0.05 3.14 0.53
46 INT286805 Positive_regulation of Localization of Cntf 1 0.40 1.3 0.52
47 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
48 INT228441 Negative_regulation of Localization of Cntf 1 0.19 0.07 0.49
49 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
50 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
51 INT182014 Positive_regulation of Lifr 1 0.06 0.47 0.38
52 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
53 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
54 INT81457 Positive_regulation of Regulation of Cntf 1 0.47 0.09 0.34
55 INT164399 Gene_expression of CNTF 5 0.65 1.73 0.33
56 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
57 INT171885 Binding of Lifr 2 0.34 2.27 0.3
58 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
59 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
60 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
61 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22
62 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
63 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
64 INT289982 Phosphorylation of CNTF 1 0.79 0.99 0.21
65 INT216455 Negative_regulation of Gene_expression of Lifr 1 0.36 1.71 0.2
66 INT148637 Gene_expression of Lifr 5 0.75 0.92 0.18
67 INT216452 Negative_regulation of Lifr 1 0.36 1.73 0.18
68 INT289348 Positive_regulation of Positive_regulation of Cntf 1 0.20 0.19 0.15
69 INT289225 Positive_regulation of Positive_regulation of Il6ra 1 0.04 0.77 0.14
70 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
71 INT333743 Regulation of Gene_expression of Il6ra 1 0.05 0.45 0.12
72 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
73 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
74 INT299520 Positive_regulation of Gene_expression of Lifr 1 0.18 0.23 0.09
75 INT144614 Binding of CNTF 2 0.36 1.44 0.07
76 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
77 INT349815 Regulation of Cntf 1 0.26 0.21 0.07
78 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
79 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
80 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
81 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
82 INT280667 Transcription of Il6r 1 0.62 0 0.05
83 INT294344 Localization of IL6ST 1 0.39 0 0.04
84 INT188226 Regulation of Gene_expression of LIFR 1 0.44 0.73 0.04
85 INT178453 Regulation of LIFR 3 0.50 0.31 0.03
86 INT235585 Negative_regulation of Negative_regulation of LIFR 1 0.16 0.35 0
87 INT178454 Regulation of Positive_regulation of LIFR 1 0.37 0.19 0
88 INT164401 Regulation of Gene_expression of CNTF 1 0.52 0.47 0
89 INT148636 Regulation of Lifr 1 0.20 0.27 0
90 INT299513 Regulation of Gene_expression of Lifr 1 0.23 0.14 0
91 INT164398 Regulation of CNTF 1 0.26 0.77 0
92 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
93 INT178452 Negative_regulation of Positive_regulation of LIFR 1 0.35 0.19 0
94 INT120602 Positive_regulation of Negative_regulation of Cntf 1 0.27 0 0
95 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
96 INT144616 Positive_regulation of Binding of CNTF 1 0.49 0.53 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox