GO:0070305

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Name response to cGMP
Categary Process
Go Slim No
Go Link GO:0070305
Unique Molecular Interactions 63
Total Molecular Interactions 72
Total Single Events 2657
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to cGMP. They are ordered first by their pain relevance and then by number of times they were reported for response to cGMP. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
2 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
3 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
4 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
5 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
6 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
7 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
8 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
9 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
10 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
11 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
12 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
13 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
14 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
15 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
16 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
17 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
18 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
19 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
20 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
21 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
22 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
23 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
24 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
25 INT34717 Positive_regulation of Vip Positive_regulation of Localization of Ren 1 0.46 0 0.17
26 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
27 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12
28 INT345289 CRS Regulation of REN 1 0.03 1.02 0.12
29 INT316372 Positive_regulation of Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
30 INT316374 Gopc Positive_regulation of Ren1 1 0.06 0.13 0.11
31 INT316377 Gopc Positive_regulation of Positive_regulation of Ren1 1 0.06 0.13 0.11
32 INT2194 HIST2H2BD Regulation of REN 1 0.00 0.07 0.09
33 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
34 INT88137 Ren Regulation of Gene_expression of Spp1 1 0.04 0.24 0.09
35 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09
36 INT311811 Binding of REN and RASGRP1 1 0.16 0.68 0.08
37 INT354753 Ren Regulation of Agt 1 0.14 0.98 0.08
38 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08
39 INT354754 Regulation of Ren Regulation of Agt 1 0.14 0.98 0.08
40 INT344963 Phc1 Regulation of REN 1 0.15 0.66 0.06
41 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05
42 INT316371 Ang Negative_regulation of Ren1 1 0.16 0.64 0.05
43 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04
44 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
45 INT230816 Binding of ras and Ren1 1 0.11 0.77 0.04
46 INT199734 Binding of PRB1 and REN 1 0.01 0.08 0
47 INT172759 INS Positive_regulation of Localization of REN 1 0.03 0.64 0
48 INT229713 Binding of Agt and Ren 1 0.14 0 0
49 INT229714 Positive_regulation of Binding of Agt and Ren 1 0.18 0 0
50 INT34762 Binding of PTGIR and REN 1 0.30 0.24 0
51 INT316373 Binding of Ren1 and Gopc 1 0.05 0.44 0
52 INT209802 MRXS5 Positive_regulation of Localization of Ren1 1 0.01 0 0
53 INT327447 Binding of REN and Positive_regulation of PPP1R1A 1 0.43 0.13 0
54 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 0.52 0.23 0
55 INT281910 Binding of REN and AKR1A1 1 0.01 0.08 0
56 INT327448 Binding of REN and PPAP2B 1 0.01 0.26 0
57 INT336133 Binding of EXTL3 and REN 1 0.03 0.37 0
58 INT288910 REN Regulation of Gene_expression of AGT 1 0.40 1.34 0
59 INT336130 Binding of ANG and REN 1 0.06 0.38 0
60 INT172828 Iapp Positive_regulation of Localization of REN 1 0.02 0.64 0
61 INT34765 Binding of PTGER2 and REN 1 0.16 0.24 0
62 INT92824 AGT Regulation of Gene_expression of REN 1 0.05 0 0
63 INT263249 Binding of ADD1 and REN 1 0.03 0.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to cGMP. They are ordered first by their pain relevance and then by number of times they were reported in response to cGMP. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT46 Localization of Ren 233 0.81 46.15 62.44
2 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
3 INT654 Localization of REN 250 0.81 75.12 47.86
4 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
5 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
6 INT1116 Regulation of Ren 103 0.62 27.66 33.26
7 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
8 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
9 INT2140 Regulation of REN 104 0.62 28.24 24.49
10 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
11 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
12 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
13 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
14 INT661 Gene_expression of REN 100 0.78 48.21 11.36
15 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
16 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
17 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
18 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
19 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
20 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
21 INT3097 Binding of Ren 12 0.48 3.15 4.4
22 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
23 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
24 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
25 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
26 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
27 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
28 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
29 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
30 INT3533 Binding of REN 24 0.37 10.84 2.16
31 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
32 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
33 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
34 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
35 INT44164 Localization of Ren1 18 0.49 10.53 1.49
36 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
37 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
38 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
39 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
40 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
41 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
42 INT99723 Binding of Ren1 7 0.27 3.98 0.82
43 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
44 INT5312 Regulation of Gene_expression of REN 4 0.41 0.73 0.76
45 INT2592 Positive_regulation of Negative_regulation of REN 3 0.24 0.34 0.64
46 INT3552 Regulation of Gene_expression of Ren 3 0.41 1.39 0.6
47 INT27723 Regulation of Negative_regulation of Ren 4 0.45 1.14 0.44
48 INT162823 Regulation of Gene_expression of Ren1 4 0.62 2.69 0.35
49 INT86135 Regulation of Localization of Ren1 4 0.25 1.67 0.35
50 INT25424 Transcription of Ren 2 0.57 1.21 0.33
51 INT93527 Positive_regulation of Localization of Ren1 2 0.28 1.27 0.27
52 INT104734 Negative_regulation of Gene_expression of Ren1 2 0.34 1.9 0.21
53 INT99724 Transcription of Ren1 2 0.36 0.14 0.18
54 INT41621 Negative_regulation of Positive_regulation of Ren1 2 0.43 0.6 0.18
55 INT142511 Regulation of Binding of Ren 1 0.45 0.81 0.17
56 INT316364 Regulation of Negative_regulation of Ren1 1 0.25 0.53 0.16
57 INT10584 Regulation of Regulation of REN 2 0.18 0.26 0.15
58 INT26755 Positive_regulation of Regulation of REN 1 0.16 0.19 0.13
59 INT3532 Transcription of REN 2 0.60 1.06 0.12
60 INT3329 Protein_catabolism of REN 5 1.00 0.95 0.11
61 INT37403 Negative_regulation of Regulation of REN 1 0.43 0.35 0.11
62 INT25423 Regulation of Transcription of Ren 1 0.11 0.1 0.1
63 INT230801 Positive_regulation of Negative_regulation of Ren1 2 0.28 1.12 0.08
64 INT3334 Positive_regulation of Protein_catabolism of REN 1 0.42 0.61 0.07
65 INT209798 Protein_catabolism of Ren1 1 0.08 0.78 0.06
66 INT104732 Positive_regulation of Transcription of Ren1 1 0.31 0 0.04
67 INT253090 Negative_regulation of Binding of REN 1 0.25 0.14 0
68 INT316368 Negative_regulation of Localization of Ren1 1 0.24 2.15 0
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