GO:0070330

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Name aromatase activity
Categary Function
Go Slim No
Go Link GO:0070330
Unique Molecular Interactions 245
Total Molecular Interactions 297
Total Single Events 3727
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for aromatase activity. They are ordered first by their pain relevance and then by number of times they were reported for aromatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
2 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
3 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
4 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
5 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 0.04 0 1.08
6 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
7 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
8 INT349592 GTF2H5 Negative_regulation of Cyp2c22 1 0.00 0.64 0.98
9 INT130282 Cyp3a23/3a1 Positive_regulation of Gene_expression of Npy 1 0.15 0 0.94
10 INT68799 Cyp3a62 Negative_regulation of Cyp2d1 1 0.35 0 0.91
11 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
12 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
13 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
14 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
15 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
16 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
17 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
18 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
19 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
20 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
21 INT130283 Cyp3a23/3a1 Positive_regulation of Transcription of Npy 1 0.10 0 0.79
22 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
23 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
24 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
25 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
26 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
27 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
28 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73
29 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
30 INT38512 Binding of Cyp2c22 and Atp6v1c2 1 0.00 0.17 0.73
31 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
32 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
33 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65
34 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
35 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
36 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
37 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
38 INT52816 Cyp3a23/3a1 Regulation of Localization of LH 1 0.03 0.16 0.6
39 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
40 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
41 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
42 INT43693 Cyp3a23/3a1 Positive_regulation of Localization of Prl 1 0.10 0 0.57
43 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
44 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55
45 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55
46 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
47 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
48 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
49 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
50 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
51 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
52 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
53 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
54 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
55 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
56 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46
57 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46
58 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
59 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
60 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
61 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
62 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
63 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
64 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
65 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
66 INT78064 Cyp3a23/3a1 Regulation of Localization of Il6 1 0.08 0.07 0.32
67 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
68 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
69 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
70 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
71 INT281970 Cyp3a23/3a1 Negative_regulation of Gene_expression of Tie1 1 0.00 0.46 0.3
72 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
73 INT59684 Binding of Gmfb and Cyp2c6 1 0.00 0 0.29
74 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
75 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
76 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
77 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
78 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
79 INT78065 Cyp3a23/3a1 Negative_regulation of Gene_expression of Il6 1 0.12 0.07 0.27
80 INT218931 Cyp3a23/3a1 Regulation of Gene_expression of Akp3 1 0.00 0.55 0.27
81 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
82 INT78061 Cyp3a23/3a1 Negative_regulation of Localization of Il6 1 0.12 0.07 0.27
83 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
84 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
85 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
86 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
87 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
88 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
89 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
90 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
91 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
92 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
93 INT53544 Binding of CYP2B6 and HRH1 1 0.28 0 0.23
94 INT57172 Binding of RYBP and Cyp2b1 1 0.02 0 0.23
95 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
96 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
97 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2
98 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
99 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
100 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18
101 INT121380 Casr Positive_regulation of Positive_regulation of Cyp3a11 1 0.15 0.25 0.18
102 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
103 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
104 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
105 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
106 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
107 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
108 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
109 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
110 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
111 INT125549 Binding of CYP2B6 and FGFR1 1 0.00 0.07 0.13
112 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
113 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
114 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
115 INT20122 Cyp2c22 Negative_regulation of CYBB 1 0.00 0 0.1
116 INT339533 VEGFA Positive_regulation of Gene_expression of CYP2C8 1 0.09 0.57 0.09
117 INT20120 Gtf2e1 Negative_regulation of Cyp2c22 1 0.00 0 0.09
118 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
119 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
120 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
121 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
122 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
123 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
124 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
125 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
126 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
127 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
128 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
129 INT339534 VEGFA Positive_regulation of CYP2C18 1 0.04 0.57 0.08
130 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
131 INT80930 Tnf Positive_regulation of Negative_regulation of Cyp2b1 1 0.10 0.21 0.08
132 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
133 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
134 INT19725 Cyp2b1 Positive_regulation of Cyp2c22 1 0.02 0 0.07
135 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
136 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
137 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
138 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
139 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
140 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
141 INT56278 Binding of CYP2B6 and TACC2 1 0.40 0.32 0.06
142 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05
143 INT337692 Cyp2b2 Positive_regulation of Nr1i3 1 0.00 0.31 0.05
144 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
145 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
146 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05
147 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05
148 INT301661 Binding of CYP2B6 and Ros1 1 0.02 0.64 0.04
149 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
150 INT262171 Binding of Cyp3a11 and Rare1 1 0.02 0.15 0.03
151 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
152 INT262217 Casr Regulation of Cyp3a11 1 0.05 0.13 0.03
153 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
154 INT229205 Pc Regulation of Gene_expression of Cyp2c11 1 0.18 0.25 0.03
155 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
156 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
157 INT125643 Cyp2e1 Positive_regulation of Transcription of Cyp2c11 1 0.51 0 0
158 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
159 INT125656 Cyp2e1 Positive_regulation of Transcription of Cyp2b2 1 0.07 0 0
160 INT121551 Binding of CYP2B6 and Regulation of CYP3A 1 0.21 0 0
161 INT177277 CXADR Positive_regulation of CYP2B6 1 0.47 0 0
162 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
163 INT100609 Gnrhr Regulation of Cyp2c22 1 0.02 0.19 0
164 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0
165 INT199720 2610029G23Rik Regulation of CYP2B6 1 0.02 0.43 0
166 INT353189 Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0
167 INT125648 Cyp2c11 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.42 0 0
168 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0
169 INT125646 Cyp2b2 Positive_regulation of Transcription of Cyp2e1 1 0.07 0 0
170 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
171 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
172 INT125642 Cyp2b2 Positive_regulation of Transcription of Cyp2c6 1 0.06 0 0
173 INT121550 Binding of CYP2B6 and Regulation of CDH17 1 0.01 0 0
174 INT125655 Cyp2c6 Positive_regulation of Transcription of Cyp2b2 1 0.06 0 0
175 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0
176 INT125647 Cyp2c11 Positive_regulation of Transcription of Cyp2b2 1 0.07 0 0
177 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
178 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0
179 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
180 INT125652 Cyp2c6 Positive_regulation of Transcription of Cyp2e1 1 0.49 0 0
181 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
182 INT125658 Cyp2c6 Positive_regulation of Transcription of Cyp2c11 1 0.47 0 0
183 INT177252 SV2A Positive_regulation of CYP2B6 1 0.45 0 0
184 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0
185 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
186 INT125659 Cyp2b2 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.06 0 0
187 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
188 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
189 INT125650 Cyp2e1 Positive_regulation of Transcription of Cyp2c6 1 0.49 0 0
190 INT125661 Cyp2c11 Positive_regulation of Transcription of Cyp2e1 1 0.51 0 0
191 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
192 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
193 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
194 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
195 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
196 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
197 INT316183 Binding of CYP2C8 and ENO2 1 0.02 2.15 0
198 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
199 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
200 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for aromatase activity. They are ordered first by their pain relevance and then by number of times they were reported in aromatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
3 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
4 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
5 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
6 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
7 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
8 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
9 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
10 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
11 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
12 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
13 INT14111 Positive_regulation of Cyp2c22 41 0.67 7.24 17.88
14 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
15 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
16 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22
17 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
18 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96
19 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
20 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
21 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
22 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
23 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
24 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
25 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
26 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76
27 INT13675 Gene_expression of Cyp2c22 23 0.39 4.52 7.71
28 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
29 INT76025 Positive_regulation of Cyp3a11 20 0.69 5.88 6.91
30 INT17145 Binding of Cyp2c22 19 0.42 1.39 6.8
31 INT17143 Regulation of Cyp2c22 18 0.60 3.02 6.7
32 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
33 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
34 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
35 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79
36 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
37 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
38 INT12183 Negative_regulation of Cyp2d1 11 0.58 3.11 5.49
39 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
40 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
41 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
42 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
43 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
44 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
45 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
46 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78
47 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
48 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
49 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7
50 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
51 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56
52 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
53 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
54 INT53395 Positive_regulation of Cyp2c6 6 0.70 0.07 3.73
55 INT55516 Gene_expression of Cyp2d1 5 0.60 0.83 3.58
56 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
57 INT14110 Positive_regulation of Positive_regulation of Cyp2c22 6 0.67 1.45 3.45
58 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
59 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33
60 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
61 INT69564 Binding of Cyp3a23/3a1 11 0.34 4.67 3.2
62 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16
63 INT53388 Negative_regulation of Cyp2c11 18 0.53 2.66 3.11
64 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
65 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
66 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
67 INT28934 Negative_regulation of Gene_expression of Cyp2c22 9 0.12 2.15 2.86
68 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
69 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
70 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
71 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
72 INT53448 Positive_regulation of Negative_regulation of Cyp2c22 3 0.58 0.71 2.42
73 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
74 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
75 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
76 INT80391 Negative_regulation of Cyp2b2 4 0.54 0.12 2.36
77 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
78 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
79 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
80 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
81 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
82 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
83 INT53392 Positive_regulation of Cyp2b1 8 0.68 0.68 2.13
84 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13
85 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
86 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
87 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
88 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02
89 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
90 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
91 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
92 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97
93 INT95797 Positive_regulation of CYP2C8 8 0.50 0.55 1.94
94 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
95 INT113683 Positive_regulation of Negative_regulation of Cyp3a23/3a1 2 0.49 0.48 1.94
96 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92
97 INT96723 Regulation of Cyp3a11 5 0.44 2 1.83
98 INT154727 Regulation of Cyp2b2 2 0.25 0 1.76
99 INT113806 Transcription of CYP2B6 7 0.67 1.75 1.73
100 INT113684 Negative_regulation of Gene_expression of Cyp3a23/3a1 5 0.36 2.04 1.71
101 INT53546 Negative_regulation of Binding of CYP2B6 5 0.43 0.24 1.67
102 INT67704 Negative_regulation of Negative_regulation of CYP2B6 3 0.41 1.69 1.66
103 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
104 INT12842 Binding of Cyp2b1 4 0.48 0 1.56
105 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
106 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
107 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
108 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
109 INT4402 Positive_regulation of Binding of CYP2B6 3 0.49 0.33 1.35
110 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
111 INT110550 Regulation of CYP2C8 3 0.45 1.59 1.34
112 INT50031 Negative_regulation of Gene_expression of CYP2B6 5 0.57 2.37 1.29
113 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
114 INT57169 Gene_expression of Cyp2b1 5 0.72 1.39 1.2
115 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
116 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
117 INT53285 Gene_expression of Cyp2c11 20 0.76 5.43 1.17
118 INT46898 Negative_regulation of Positive_regulation of Cyp2c22 2 0.29 0.36 1.17
119 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
120 INT59679 Binding of Cyp2c6 3 0.48 0.2 1.14
121 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
122 INT29695 Regulation of Positive_regulation of Cyp2c22 2 0.15 0.56 1.14
123 INT134957 Positive_regulation of Transcription of Cyp3a11 1 0.42 0.43 1.11
124 INT134956 Transcription of Cyp3a11 1 0.48 0.43 1.1
125 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09
126 INT149035 Positive_regulation of Cyp2c11 5 0.62 3.35 1.08
127 INT168395 Transcription of Cyp19a1 2 0.51 2.5 1.06
128 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06
129 INT84385 Binding of Cyp2c11 3 0.36 0.51 1
130 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
131 INT207325 Positive_regulation of Localization of Cyp3a23/3a1 1 0.42 0.61 0.98
132 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
133 INT168398 Localization of Cyp19a1 1 0.08 0.89 0.97
134 INT61241 Gene_expression of Cyp2b2 1 0.56 0 0.92
135 INT28168 Regulation of Binding of Cyp2c22 1 0.39 0 0.9
136 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
137 INT157981 Binding of Cyp2b2 1 0.44 0 0.86
138 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
139 INT157982 Positive_regulation of Gene_expression of Cyp2b2 1 0.43 0 0.85
140 INT166416 Positive_regulation of Negative_regulation of CYP2B6 1 0.49 0.8 0.83
141 INT130750 Negative_regulation of Localization of CYP2B6 1 0.41 0 0.82
142 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
143 INT78669 Negative_regulation of CYP2C18 2 0.33 1.45 0.79
144 INT96879 Positive_regulation of CYP1B1 14 0.70 5.73 0.78
145 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
146 INT96725 Regulation of Gene_expression of Cyp3a11 2 0.30 0.3 0.77
147 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
148 INT142923 Binding of Cyp3a11 1 0.36 0.38 0.76
149 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
150 INT93574 Protein_catabolism of CYP2B6 3 0.96 0.16 0.75
151 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
152 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
153 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
154 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
155 INT149036 Regulation of Positive_regulation of Cyp2c11 1 0.45 0 0.69
156 INT133835 Regulation of Cyp2c6 1 0.45 0 0.69
157 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
158 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
159 INT125635 Negative_regulation of Cyp2c6 3 0.59 0.18 0.66
160 INT207326 Regulation of Localization of Cyp3a23/3a1 1 0.43 0.74 0.65
161 INT53394 Negative_regulation of Gene_expression of Cyp2c11 5 0.55 1.13 0.64
162 INT133836 Regulation of Positive_regulation of Cyp2c6 1 0.27 0 0.64
163 INT53396 Regulation of Gene_expression of Cyp3a23/3a1 7 0.38 3.04 0.63
164 INT174239 Gene_expression of CYP2C18 5 0.65 2.25 0.63
165 INT187379 Positive_regulation of Transcription of CYP2B6 1 0.02 0.25 0.63
166 INT34755 Negative_regulation of Cyp2b1 5 0.56 1.2 0.61
167 INT115823 Transcription of Cyp3a23/3a1 3 0.54 0.82 0.61
168 INT53391 Negative_regulation of Positive_regulation of Cyp2b1 2 0.41 0.24 0.61
169 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
170 INT154728 Regulation of Gene_expression of Cyp2b1 1 0.42 0 0.59
171 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
172 INT58130 Positive_regulation of Cyp2d1 3 0.45 0 0.56
173 INT117903 Positive_regulation of Protein_catabolism of CYP2B6 1 0.49 0 0.56
174 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
175 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
176 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
177 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
178 INT139306 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.45 0.31 0.52
179 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
180 INT137556 Negative_regulation of Cyp19a1 3 0.35 1.53 0.48
181 INT80929 Negative_regulation of Positive_regulation of Cyp3a23/3a1 3 0.43 0.83 0.48
182 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
183 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
184 INT135306 Binding of CYP2C8 10 0.46 4.37 0.46
185 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
186 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
187 INT262087 Gene_expression of Cyp2d9 1 0.01 1.64 0.44
188 INT57326 Regulation of Positive_regulation of CYP2B6 4 0.44 2.08 0.43
189 INT28016 Negative_regulation of Localization of Cyp3a23/3a1 2 0.04 0 0.43
190 INT28169 Negative_regulation of Binding of Cyp2c22 1 0.50 0 0.43
191 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
192 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
193 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
194 INT123325 Gene_expression of CYP3A7 2 0.21 0.49 0.4
195 INT52178 Regulation of Cyp2d1 2 0.59 0.31 0.4
196 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
197 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
198 INT61236 Gene_expression of Cyp2c6 3 0.78 1.55 0.35
199 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
200 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
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