GO:0070365

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Name hepatocyte differentiation
Categary Process
Go Slim No
Go Link GO:0070365
Unique Molecular Interactions 38
Total Molecular Interactions 51
Total Single Events 429
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hepatocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for hepatocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
2 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
3 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
4 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
5 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
6 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
7 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
8 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
9 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
10 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22
11 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
12 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
13 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
14 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
15 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13
16 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
17 INT171792 GPER Regulation of Gene_expression of Itga2 1 0.00 0.54 0.12
18 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
19 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
20 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
21 INT311738 Binding of Anxa1 and Plat 1 0.19 0.63 0.1
22 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
23 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
24 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
25 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
26 INT332484 ANXA1 Positive_regulation of HSH2D 1 0.18 0.19 0.05
27 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
28 INT222532 Anxa1 Negative_regulation of Localization of Gh1 1 0.01 0.14 0.03
29 INT222538 Anxa1 Negative_regulation of Localization of Prl 1 0.04 0.14 0.03
30 INT222475 Anxa1 Negative_regulation of Localization of LH 1 0.01 0.14 0.03
31 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
32 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0
33 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
34 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0
35 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
36 INT332487 ANXA1 Regulation of Gene_expression of SGPP2 1 0.45 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hepatocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in hepatocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
2 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
3 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
4 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
5 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
6 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
7 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
8 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
9 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
10 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
11 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
12 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
13 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
14 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
15 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
16 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
17 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
18 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
19 INT122151 Localization of Anxa1 1 0.75 0.53 1
20 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
21 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
22 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
23 INT166836 Negative_regulation of Positive_regulation of ANXA1 2 0.39 1.15 0.57
24 INT122149 Binding of Anxa1 1 0.36 0.22 0.57
25 INT37750 Localization of ANXA1 2 0.74 1.72 0.56
26 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
27 INT37749 Positive_regulation of Localization of ANXA1 1 0.01 0.67 0.53
28 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
29 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51
30 INT166837 Binding of ANXA1 2 0.34 0.85 0.51
31 INT206858 Regulation of ANXA1 3 0.56 2.4 0.45
32 INT122150 Positive_regulation of Localization of Anxa1 1 0.47 0.28 0.44
33 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
34 INT166839 Negative_regulation of ANXA1 1 0.37 0.88 0.43
35 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
36 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
37 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
38 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
39 INT171788 Positive_regulation of Binding of Itga2 1 0.02 0.94 0.28
40 INT171790 Regulation of Binding of Itga2 1 0.01 0.93 0.28
41 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
42 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
43 INT171789 Binding of Itga2 1 0.02 0.92 0.27
44 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
45 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
46 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
47 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
48 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
49 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
50 INT353965 Negative_regulation of Gene_expression of Wnt1 1 0.41 0 0.18
51 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
52 INT217569 Binding of Wnt1 2 0.36 1.07 0.15
53 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
54 INT115521 Gene_expression of Itga2 1 0.04 0.62 0.12
55 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
56 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
57 INT115520 Regulation of Itga2 2 0.01 0.46 0.1
58 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
59 INT266241 Regulation of Wnt1 1 0.26 0.59 0.09
60 INT290117 Negative_regulation of Gene_expression of ANXA1 1 0.57 1.15 0.08
61 INT274054 Localization of CYP1A1 1 0.12 0 0.07
62 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
63 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
64 INT304937 Transcription of Wnt1 1 0.22 0.65 0.05
65 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
66 INT206862 Regulation of Gene_expression of ANXA1 2 0.18 1.76 0.04
67 INT332510 Protein_catabolism of ANXA1 1 0.60 0.08 0.04
68 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04
69 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
70 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0
71 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
72 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
73 INT337424 Phosphorylation of Wnt1 1 0.79 0 0
74 INT85223 Regulation of Localization of Cyp1a1 1 0.03 0.1 0
75 INT167111 Regulation of Binding of CYP1A1 1 0.43 0 0
76 INT311632 Positive_regulation of Wnt1 1 0.43 0.19 0
77 INT235058 Localization of Wnt1 1 0.64 0.56 0
78 INT197269 Regulation of Gene_expression of Cyp1a1 1 0.16 0 0
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