GO:0070371

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Name ERK1 and ERK2 cascade
Categary Process
Go Slim No
Go Link GO:0070371
Unique Molecular Interactions 1606
Total Molecular Interactions 2295
Total Single Events 19182
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported for ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
2 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
3 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
4 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
5 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
6 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
7 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
8 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
9 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
10 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
11 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
12 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
13 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
14 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
15 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
16 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
17 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
18 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
19 INT45423 Avp Positive_regulation of Localization of Prl 4 0.67 1.37 1.98
20 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
21 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92
22 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
23 INT117269 Binding of Avp and Prl 1 0.25 0.47 1.8
24 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
25 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
26 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
27 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 0.00 0.76 1.62
28 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
29 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
30 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 0.07 0.85 1.52
31 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
32 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
33 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
34 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
35 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
36 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
37 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
38 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
39 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43
40 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
41 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
42 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
43 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
44 INT142490 Avp Regulation of Oxt 1 0.09 0.74 1.4
45 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4
46 INT140021 Avp Positive_regulation of Pag1 1 0.03 0.85 1.38
47 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 0.04 0.85 1.38
48 INT140020 Avp Positive_regulation of Localization of Pag1 1 0.03 0.85 1.38
49 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
50 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
51 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
52 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
53 INT140010 Avp Regulation of Gene_expression of Penk 1 0.25 0.58 1.19
54 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
55 INT75126 Pnoc Regulation of Localization of Avp 2 0.26 0.24 1.18
56 INT27621 Avp Positive_regulation of Protein_catabolism of Mbis1 1 0.00 0 1.18
57 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
58 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
59 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
60 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
61 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
62 INT140022 Avp Regulation of Localization of Pag1 1 0.01 0.57 1.17
63 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
64 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
65 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
66 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
67 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
68 INT164722 Avp Regulation of NT5C 1 0.06 0.88 1.15
69 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
70 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
71 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
72 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
73 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
74 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
75 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
76 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
77 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
78 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
79 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
80 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
81 INT63103 AVP Regulation of OXT 1 0.28 0.68 1.02
82 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02
83 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02
84 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
85 INT85320 Binding of Avp and Vas1 1 0.00 0.87 0.98
86 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
87 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
88 INT11392 Cck Positive_regulation of Cckbr 1 0.52 0 0.96
89 INT149471 Avp Regulation of Gene_expression of Crh 1 0.45 0.6 0.96
90 INT149474 Avp Regulation of Gene_expression of Oxt 1 0.27 0.6 0.96
91 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
92 INT43454 Pomc Regulation of Localization of Avp 2 0.24 0.89 0.94
93 INT51542 Negative_regulation of Binding of Avp and Penk 1 0.46 0.05 0.94
94 INT51541 Positive_regulation of Binding of Avp and Penk 1 0.74 0.05 0.94
95 INT51545 Binding of Avp and Penk 1 0.51 0.05 0.94
96 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
97 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
98 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
99 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
100 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
101 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
102 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
103 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
104 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
105 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
106 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
107 INT64127 Igfbp2 Regulation of Localization of Avp 1 0.39 0.19 0.9
108 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
109 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
110 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
111 INT121467 Binding of Avp and Ptafr 1 0.11 0.98 0.88
112 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
113 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
114 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
115 INT26529 Prl Regulation of Avp 1 0.08 0.26 0.85
116 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
117 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
118 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
119 INT41863 Avp Regulation of Cck 1 0.00 0 0.84
120 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
121 INT41857 Avp Regulation of Vip 1 0.01 0 0.84
122 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
123 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
124 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
125 INT16436 Ubqln1 Regulation of Localization of Avp 1 0.01 0 0.81
126 INT16439 Atp6v0d2 Regulation of Localization of Avp 1 0.02 0 0.81
127 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
128 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
129 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
130 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
131 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
132 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
133 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
134 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
135 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
136 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
137 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
138 INT9527 Avp Positive_regulation of Localization of Pomc 7 0.58 0.29 0.77
139 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
140 INT147251 Binding of Avp and Gal 1 0.15 0.19 0.76
141 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
142 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
143 INT12396 Binding of Avp and IGKV1-5 3 0.04 1.38 0.75
144 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
145 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73
146 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
147 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
148 INT45305 Pomc Positive_regulation of Localization of Avp 1 0.12 0 0.73
149 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
150 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
151 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
152 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
153 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
154 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
155 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
156 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
157 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7
158 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
159 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
160 INT164713 Binding of Avp and Positive_regulation of Localization of Acot1 1 0.32 0.43 0.69
161 INT164715 Avp Positive_regulation of Localization of Acot1 1 0.28 0.43 0.69
162 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
163 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
164 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
165 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
166 INT48032 Binding of Avp and Pebp1 1 0.00 0 0.68
167 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
168 INT11611 Cck Positive_regulation of Localization of Avp 1 0.09 0 0.67
169 INT84213 Cck Regulation of Cckbr 1 0.41 0 0.67
170 INT11612 Cck Positive_regulation of Avp 1 0.10 0 0.67
171 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67
172 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
173 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66
174 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
175 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
176 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
177 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
178 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
179 INT164723 Binding of Avp and NT5C 1 0.07 0.45 0.65
180 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
181 INT164714 Binding of Avp and Acot1 1 0.26 0.45 0.64
182 INT48033 Binding of Avp and LH 1 0.08 0 0.64
183 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
184 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
185 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
186 INT36511 Binding of Htr2a and Eef1a1 1 0.22 0 0.62
187 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
188 INT25957 Gabrg1 Regulation of Localization of AVP 1 0.01 0 0.62
189 INT36512 Binding of Htr2a and Man2a2 1 0.19 0 0.62
190 INT32747 Avp Positive_regulation of Localization of Pomc 4 0.16 1.92 0.61
191 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
192 INT37555 FDX1 Positive_regulation of Regulation of Avp 1 0.04 0 0.61
193 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
194 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
195 INT42269 POMC Negative_regulation of Localization of AVP 1 0.09 0 0.61
196 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
197 INT281132 Binding of Ccr3 and Cxcl10 1 0.00 0.25 0.6
198 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
199 INT352496 AVP Regulation of Gene_expression of CRS 1 0.27 2.47 0.59
200 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59

Single Events

The table below shows the top 100 pain related interactions that have been reported for ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported in ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT477 Localization of Avp 813 0.81 131.58 300.4
2 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
3 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
4 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
5 INT4207 Regulation of Avp 267 0.62 63.72 115.33
6 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
7 INT214 Localization of AVP 370 0.81 208.51 91.09
8 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
9 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
10 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
11 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
12 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
13 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
14 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
15 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
16 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
17 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
18 INT685 Regulation of AVP 124 0.62 34.9 39.91
19 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
20 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
21 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
22 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
23 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
24 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
25 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
26 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
27 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
28 INT1158 Regulation of Agt 106 0.61 29.4 30.29
29 INT894 Binding of Avp 84 0.48 29.16 29.63
30 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
31 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
32 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
33 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
34 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
35 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88
36 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
37 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
38 INT11157 Binding of EGF 88 0.48 53.73 21.25
39 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
40 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96
41 INT5499 Transcription of Avp 52 0.72 7.98 19.87
42 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
43 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
44 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
45 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79
46 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64
47 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
48 INT2066 Localization of Agt 56 0.80 9.95 16.25
49 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
50 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
51 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
52 INT129 Localization of OXTR 51 0.80 11.08 15.36
53 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
54 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
55 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
56 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
57 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
58 INT3962 Regulation of AGT 50 0.62 20.96 13.01
59 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
60 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
61 INT4199 Binding of Agt 76 0.48 21.06 12.66
62 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62
63 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
64 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
65 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19
66 INT13743 Regulation of Gene_expression of Avp 30 0.62 6.9 11.66
67 INT398 Localization of AGT 45 0.78 16.97 11.54
68 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
69 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
70 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
71 INT8065 Binding of AGT 54 0.48 20.54 10.85
72 INT15262 Negative_regulation of Positive_regulation of Avp 22 0.58 3.28 10.81
73 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
74 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69
75 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
76 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
77 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
78 INT102525 Gene_expression of CCR3 24 0.71 16.19 10
79 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
80 INT2036 Localization of EGF 42 0.77 21.5 9.74
81 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64
82 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
83 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
84 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38
85 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
86 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
87 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
88 INT684 Binding of AVP 38 0.48 13.9 8.85
89 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76
90 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
91 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
92 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
93 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62
94 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
95 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
96 INT13739 Positive_regulation of Positive_regulation of Avp 18 0.70 4.78 8.2
97 INT27785 Regulation of HTR2A 11 0.44 8 8.18
98 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83
99 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81
100 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
101 INT6856 Gene_expression of Cckbr 10 0.77 1.8 7.69
102 INT51062 Negative_regulation of Cckbr 7 0.59 1.98 7.68
103 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
104 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
105 INT168915 Gene_expression of Oxtr 49 0.75 20.53 7.22
106 INT19806 Regulation of Avp 29 0.53 14.17 6.94
107 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
108 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
109 INT66811 Positive_regulation of Transcription of Avp 11 0.70 2.1 6.46
110 INT13822 Localization of Egf 30 0.81 13.79 6.4
111 INT40962 Localization of Avp 40 0.80 20.5 6.38
112 INT7138 Regulation of Regulation of Avp 10 0.36 1.99 6.37
113 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
114 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
115 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
116 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
117 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
118 INT19805 Negative_regulation of Avp 18 0.59 4.57 5.87
119 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
120 INT69974 Positive_regulation of Oxtr 30 0.70 2.44 5.73
121 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
122 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47
123 INT21380 Regulation of Transcription of Avp 10 0.62 2.6 5.46
124 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
125 INT37227 Regulation of EGF 19 0.45 11.16 5.17
126 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03
127 INT26008 Positive_regulation of Cckbr 5 0.65 1.47 5.01
128 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
129 INT130 Negative_regulation of OXTR 19 0.43 4.63 4.96
130 INT88062 Gene_expression of Ptger4 13 0.77 2.4 4.94
131 INT21650 Regulation of OXTR 29 0.61 5.99 4.91
132 INT49748 Binding of HTR2C 10 0.47 3.03 4.76
133 INT105403 Positive_regulation of Gene_expression of CCR3 10 0.60 7.99 4.74
134 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56
135 INT54776 Binding of Cckbr 5 0.42 0 4.45
136 INT88059 Positive_regulation of Ptger4 9 0.69 1.41 4.4
137 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
138 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
139 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
140 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
141 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
142 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
143 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
144 INT78033 Positive_regulation of Gene_expression of Oxtr 10 0.70 2.5 4.15
145 INT23653 Binding of Egf 22 0.36 11.34 4.12
146 INT19301 Regulation of Regulation of AVP 9 0.45 3.15 4.09
147 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
148 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
149 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
150 INT17975 Positive_regulation of Localization of OXTR 11 0.69 1.72 3.72
151 INT60667 Transcription of HTR2A 5 0.67 0.44 3.71
152 INT52170 Regulation of Cckbr 5 0.58 1.34 3.69
153 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
154 INT18920 Binding of Egf 24 0.48 9.43 3.57
155 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
156 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
157 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
158 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
159 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
160 INT66617 Localization of HTR2A 6 0.80 1.35 3.32
161 INT18838 Positive_regulation of Regulation of Avp 3 0.47 0.48 3.32
162 INT30131 Positive_regulation of Negative_regulation of Avp 5 0.50 1.94 3.3
163 INT119470 Regulation of Ptger4 6 0.43 3.94 3.24
164 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
165 INT19553 Negative_regulation of Regulation of Avp 5 0.43 1.74 3.06
166 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
167 INT19206 Regulation of Gene_expression of OXTR 5 0.62 0.58 2.96
168 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
169 INT46650 Localization of Trf 13 0.61 4.4 2.91
170 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
171 INT128 Negative_regulation of Localization of OXTR 7 0.59 2.92 2.86
172 INT54754 Localization of Htr2a 6 0.73 0.73 2.85
173 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
174 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84
175 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
176 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
177 INT68962 Positive_regulation of Ptger4 20 0.67 7.3 2.79
178 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
179 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
180 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
181 INT58166 Regulation of Gene_expression of Avp 13 0.57 2.63 2.76
182 INT78702 Positive_regulation of CCL11 13 0.68 12.94 2.74
183 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
184 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71
185 INT11300 Positive_regulation of Gene_expression of Avp 24 0.50 10.18 2.69
186 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68
187 INT152434 Localization of CCL11 6 0.78 9.47 2.68
188 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
189 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
190 INT53780 Binding of Avp 19 0.48 6.16 2.55
191 INT20593 Positive_regulation of Positive_regulation of Htr2a 6 0.49 1.29 2.55
192 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
193 INT46159 Positive_regulation of Positive_regulation of AVP 4 0.50 1.24 2.45
194 INT186731 Positive_regulation of Ccl11 10 0.45 10.09 2.44
195 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
196 INT6638 Binding of Oxtr 14 0.34 1.52 2.43
197 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
198 INT30857 Binding of OXTR 10 0.48 2.27 2.42
199 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42
200 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
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