GO:0070372

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Name regulation of ERK1 and ERK2 cascade
Categary Process
Go Slim No
Go Link GO:0070372
Unique Molecular Interactions 770
Total Molecular Interactions 961
Total Single Events 11102
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported for regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
2 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
3 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
4 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
5 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
6 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
7 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
8 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
9 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
10 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
11 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85
12 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
13 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
14 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
15 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
16 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
17 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53
18 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
19 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
20 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
21 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
22 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
23 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
24 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
25 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
26 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
27 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
28 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
29 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
30 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
31 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17
32 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
33 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
34 INT269190 Positive_regulation of Ephb1 Positive_regulation of Ceacam3 1 0.03 0.66 1.12
35 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
36 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
37 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
38 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
39 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
40 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
41 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
42 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
43 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
44 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
45 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
46 INT199189 Binding of Aldh2 and Ros1 1 0.06 0.3 0.88
47 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
48 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
49 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
50 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
51 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
52 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84
53 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
54 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
55 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82
56 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82
57 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
58 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
59 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.98 0.79
60 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
61 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
62 INT162995 Positive_regulation of Binding of Ephb1 and Ppm1e 1 0.04 0.06 0.74
63 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
64 INT337157 Iqgap1 Regulation of Gene_expression of Ros1 1 0.07 1.91 0.72
65 INT275285 Ros1 Positive_regulation of Tnfrsf1a 1 0.27 1.06 0.72
66 INT275288 Trpv1 Positive_regulation of Gene_expression of Ros1 1 0.21 0.7 0.71
67 INT328625 NPL Regulation of Phosphorylation of Ephb1 1 0.04 0.42 0.7
68 INT154989 Phax Positive_regulation of Positive_regulation of Ephb1 1 0.22 0.92 0.69
69 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68
70 INT313993 Ros1 Positive_regulation of Nfkb1 1 0.05 1.61 0.68
71 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
72 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
73 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
74 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
75 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
76 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
77 INT324925 Ros1 Positive_regulation of Bdkrb1 1 0.08 0.67 0.6
78 INT327992 TRPV1 Positive_regulation of Gene_expression of ROS1 1 0.28 0.35 0.6
79 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
80 INT145429 oh Positive_regulation of Positive_regulation of Ros1 1 0.01 0.07 0.57
81 INT145431 Pax3 Positive_regulation of Positive_regulation of Ros1 1 0.02 0.07 0.57
82 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
83 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
84 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
85 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
86 INT312746 Ephb1 Positive_regulation of Localization of Ltp 1 0.05 0.07 0.55
87 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54
88 INT321842 Binding of Ros1 and SCFV 1 0.01 1.34 0.54
89 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
90 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
91 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
92 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53
93 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
94 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
95 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
96 INT153534 Binding of Ephb1 and NMS 1 0.29 1.13 0.5
97 INT275282 Ros1 Regulation of Positive_regulation of Trpv1 1 0.16 0.55 0.49
98 INT275286 Ros1 Regulation of Positive_regulation of Tnfrsf1a 1 0.16 0.55 0.49
99 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
100 INT146578 Hba Negative_regulation of Ros1 1 0.04 0.51 0.47
101 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
102 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
103 INT147444 PDGFA Positive_regulation of Gene_expression of Ros1 2 0.00 0.95 0.46
104 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
105 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
106 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
107 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46
108 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 0.03 1.25 0.46
109 INT149006 RPL7AP5 Negative_regulation of Phosphorylation of Ephb1 1 0.00 0.22 0.45
110 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45
111 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45
112 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
113 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45
114 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45
115 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
116 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
117 INT127390 Negative_regulation of Ephb1 Negative_regulation of Phosphorylation of Elk1 1 0.08 0.7 0.44
118 INT149005 RPL7AP5 Negative_regulation of Ephb1 1 0.00 0.21 0.44
119 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
120 INT342998 DUOX1 Positive_regulation of ROS1 1 0.23 0.25 0.43
121 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
122 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
123 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
124 INT342181 Binding of Igfals and Ros1 1 0.01 0.76 0.41
125 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
126 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
127 INT330110 Racgap1 Regulation of Gene_expression of Ros1 1 0.00 1.12 0.41
128 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41
129 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
130 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
131 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4
132 INT327991 Positive_regulation of TRPV1 Positive_regulation of ROS1 1 0.26 0.2 0.4
133 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
134 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39
135 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
136 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38
137 INT275287 Ros1 Positive_regulation of Trpv1 1 0.26 0.4 0.37
138 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
139 INT224284 BDNF Positive_regulation of Ephb1 1 0.36 0.22 0.36
140 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
141 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
142 INT175988 Ros1 Positive_regulation of Transcription of Gtf3a 1 0.01 1.56 0.34
143 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
144 INT175990 Ros1 Positive_regulation of Gene_expression of Gtf3a 1 0.01 1.56 0.34
145 INT309151 Dlat Positive_regulation of Positive_regulation of Ephb1 1 0.02 0.57 0.33
146 INT342882 Positive_regulation of Ephb1 Regulation of Gene_expression of Pdyn 1 0.01 0.36 0.33
147 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
148 INT309128 Edc4 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.58 0.33
149 INT275283 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Ros1 1 0.24 0.36 0.32
150 INT275289 Positive_regulation of Trpv1 Positive_regulation of Ros1 1 0.24 0.36 0.32
151 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
152 INT267123 ROS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.01 1.05 0.31
153 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
154 INT344396 Ucp2 Regulation of Ros1 1 0.04 1.31 0.31
155 INT199194 Ros1 Negative_regulation of Aldh2 1 0.07 0.27 0.3
156 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
157 INT135014 Binding of Ephb1 and Cabin1 1 0.09 0.32 0.3
158 INT199190 Ros1 Positive_regulation of Aldh2 1 0.08 0.27 0.3
159 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
160 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
161 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28
162 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
163 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 0.16 0.6 0.28
164 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
165 INT309121 Positive_regulation of Gsdmc Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.76 0.28
166 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28
167 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
168 INT132373 Ephb1 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.28
169 INT132364 Ephb1 Positive_regulation of Nfkb1 1 0.07 0.11 0.27
170 INT221236 Ros1 Positive_regulation of Localization of Prkca 1 0.01 0.15 0.27
171 INT309134 Edc4 Positive_regulation of Ephb1 1 0.01 0.54 0.27
172 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27
173 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
174 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
175 INT241911 Binding of Cat and Ros1 1 0.03 0.85 0.27
176 INT309133 Dlat Positive_regulation of Ephb1 1 0.02 0.54 0.27
177 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26
178 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26
179 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
180 INT149947 Ephb1 Positive_regulation of Prkcg 1 0.27 0.07 0.26
181 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25
182 INT149948 Ephb1 Negative_regulation of Phosphorylation of Map2 1 0.37 0.07 0.25
183 INT215286 Siglec1 Negative_regulation of Gene_expression of Ros1 1 0.00 2.76 0.25
184 INT98671 ROS1 Positive_regulation of Gene_expression of Penk 1 0.00 0.52 0.25
185 INT246688 exf Negative_regulation of Gene_expression of Ros1 1 0.01 0.43 0.25
186 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25
187 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.87 0.25
188 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
189 INT311531 IMMT Negative_regulation of Gene_expression of ROS1 1 0.11 1.09 0.24
190 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
191 INT246692 Zglp1 Regulation of Gene_expression of Ros1 1 0.04 0.38 0.24
192 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
193 INT164635 CSF2 Regulation of Gene_expression of ROS1 1 0.15 0.09 0.24
194 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
195 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
196 INT307013 MT1JP Negative_regulation of Binding of ROS1 1 0.02 0.64 0.23
197 INT252777 ROS1 Positive_regulation of Gene_expression of CCL2 1 0.31 0.77 0.23
198 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23
199 INT268946 Ros1 Regulation of Gene_expression of Ca2 1 0.00 0.18 0.23
200 INT229702 Binding of Ppara and Ros1 1 0.01 1.05 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported in regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
4 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
5 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
6 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
7 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
8 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
9 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
10 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
11 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
12 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
13 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
14 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
15 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
16 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
17 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
18 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
19 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27
20 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91
21 INT109379 Regulation of Phosphorylation of Ephb1 22 0.59 12.58 18.84
22 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
23 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
24 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93
25 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92
26 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71
27 INT55343 Localization of Ros1 39 0.60 34.51 12.5
28 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22
29 INT112003 Localization of ROS1 94 0.73 66.32 12.16
30 INT100821 Localization of Ros1 59 0.60 45.26 11.92
31 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
32 INT94784 Binding of ROS1 113 0.40 71.57 10.26
33 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14
34 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17
35 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93
36 INT141185 Regulation of Ros1 30 0.24 20.73 8.88
37 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
38 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
39 INT127853 Localization of Ephb1 20 0.74 5.47 7.96
40 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
41 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
42 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
43 INT69439 Regulation of ROS1 46 0.45 31.22 6.94
44 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78
45 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47
46 INT143357 Binding of Ros1 48 0.36 27.76 6
47 INT91159 Negative_regulation of Ros1 35 0.44 26.12 5.97
48 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
49 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
50 INT115528 Binding of Ros1 37 0.41 22.96 5.5
51 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
52 INT126847 Binding of Ephb1 15 0.46 6.47 5.17
53 INT155689 Phosphorylation of Ros1 6 0.32 5.1 4.36
54 INT91158 Regulation of Ros1 26 0.25 17 4.23
55 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
56 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75
57 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
58 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
59 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33
60 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
61 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14
62 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
63 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
64 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58
65 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
66 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
67 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27
68 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
69 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
70 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
71 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
72 INT156093 Negative_regulation of Positive_regulation of Ros1 8 0.23 5.17 2.03
73 INT127944 Negative_regulation of Localization of ROS1 8 0.36 3.14 2.02
74 INT190480 Positive_regulation of Localization of Ros1 11 0.34 8.29 1.81
75 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
76 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
77 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
78 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
79 INT117330 Negative_regulation of Binding of ROS1 13 0.37 8.33 1.67
80 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64
81 INT158773 Positive_regulation of Localization of Ephb1 1 0.34 0.08 1.64
82 INT117717 Negative_regulation of Regulation of Ephb1 3 0.41 0.61 1.61
83 INT147713 Localization of Ephb1 1 0.70 0 1.54
84 INT190519 Positive_regulation of Positive_regulation of Ros1 14 0.32 9.99 1.52
85 INT135907 Negative_regulation of Positive_regulation of Ephb1 1 0.38 0.42 1.51
86 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
87 INT135908 Regulation of Negative_regulation of Ephb1 1 0.24 0.4 1.49
88 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
89 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
90 INT135906 Positive_regulation of Positive_regulation of Ephb1 1 0.44 0.38 1.45
91 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42
92 INT199183 Regulation of Positive_regulation of Ros1 4 0.21 1.52 1.37
93 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
94 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
95 INT117719 Transcription of Ephb1 2 0.44 0.06 1.25
96 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
97 INT166274 Gene_expression of EPHB1 14 0.55 8.2 1.19
98 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
99 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
100 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
101 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08
102 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
103 INT274898 Positive_regulation of Positive_regulation of Lyn 1 0.35 1.51 1.05
104 INT240461 Regulation of Negative_regulation of Ephb1 4 0.37 1.66 0.96
105 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
106 INT146939 Negative_regulation of Lyn 3 0.53 2.97 0.95
107 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
108 INT149383 Binding of Lyn 1 0.36 1.14 0.91
109 INT127866 Regulation of Gene_expression of Ros1 9 0.22 5.49 0.88
110 INT196392 Negative_regulation of Positive_regulation of Ros1 7 0.17 4.94 0.88
111 INT88718 Negative_regulation of Erbb2 11 0.58 12.98 0.84
112 INT291914 Negative_regulation of Localization of Ros1 5 0.34 1.36 0.84
113 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84
114 INT160885 Positive_regulation of Regulation of ROS1 1 0.18 0.06 0.84
115 INT147716 Negative_regulation of Localization of Ephb1 1 0.51 0 0.84
116 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
117 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
118 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
119 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
120 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
121 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
122 INT97782 Protein_catabolism of Ephb1 5 0.86 1.27 0.76
123 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
124 INT187508 Positive_regulation of Localization of Ros1 7 0.15 3.85 0.71
125 INT252704 Regulation of Localization of ROS1 5 0.28 3.54 0.7
126 INT28889 Transcription of Crhr2 2 0.64 1.13 0.66
127 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
128 INT158136 Binding of FGFR2 9 0.26 4.5 0.63
129 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
130 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62
131 INT202140 Protein_catabolism of ROS1 7 0.28 2.58 0.62
132 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
133 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
134 INT127854 Regulation of Localization of Ephb1 1 0.25 0.69 0.62
135 INT181916 Regulation of Binding of ROS1 4 0.28 2.72 0.61
136 INT132324 Localization of SYK 2 0.78 1.9 0.59
137 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
138 INT117091 Positive_regulation of Lyn 1 0.49 0.41 0.56
139 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
140 INT101949 Negative_regulation of Binding of Crhr2 1 0.24 0.6 0.55
141 INT249507 Regulation of Binding of Ephb1 1 0.38 0.58 0.55
142 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
143 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
144 INT202196 Transcription of Erbb2 3 0.69 3.87 0.51
145 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
146 INT126849 Positive_regulation of Binding of Ephb1 3 0.49 0.24 0.5
147 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
148 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
149 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
150 INT333283 Positive_regulation of Gene_expression of Ephb1 3 0.32 1.17 0.47
151 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
152 INT193819 Regulation of Positive_regulation of ROS1 6 0.36 3.73 0.45
153 INT240839 Negative_regulation of Negative_regulation of Ros1 4 0.12 2.42 0.45
154 INT274928 Negative_regulation of Binding of Ephb1 1 0.40 0 0.44
155 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
156 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
157 INT148784 Negative_regulation of Crhr2 2 0.40 0.76 0.42
158 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
159 INT199174 Positive_regulation of Binding of Ros1 6 0.10 2.82 0.41
160 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
161 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
162 INT55345 Negative_regulation of Localization of Ros1 1 0.37 0 0.4
163 INT115527 Negative_regulation of Binding of Ros1 3 0.28 0.93 0.38
164 INT193542 Regulation of Regulation of Ephb1 2 0.25 0.79 0.38
165 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
166 INT325423 Localization of Gstp1 1 0.06 0.85 0.37
167 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37
168 INT199559 Binding of Erbb2 5 0.36 4.23 0.36
169 INT144599 Gene_expression of Crhr2 3 0.49 2.16 0.36
170 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
171 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
172 INT260316 Regulation of Localization of Ros1 3 0.08 1.58 0.35
173 INT154175 Regulation of SYK 2 0.62 1.48 0.34
174 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33
175 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
176 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32
177 INT342308 Negative_regulation of Protein_catabolism of Ros1 1 0.02 1.47 0.32
178 INT342305 Protein_catabolism of Ros1 1 0.03 1.45 0.32
179 INT342303 Positive_regulation of Protein_catabolism of Ros1 1 0.02 1.45 0.32
180 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
181 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
182 INT181756 Positive_regulation of Erbb2 6 0.46 4.12 0.28
183 INT179917 Negative_regulation of Negative_regulation of Ephb1 2 0.25 1.17 0.28
184 INT163893 Positive_regulation of Phosphorylation of EPHB1 1 0.49 0.43 0.27
185 INT163892 Phosphorylation of EPHB1 1 0.80 0.42 0.27
186 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
187 INT252757 Negative_regulation of PTPN6 4 0.10 0.74 0.25
188 INT186256 Transcription of ROS1 4 0.39 2.37 0.25
189 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
190 INT178191 Regulation of Erbb2 7 0.36 4.11 0.24
191 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
192 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
193 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
194 INT278154 Regulation of Syk 1 0.05 0.98 0.22
195 INT278147 Localization of Syk 1 0.30 0.98 0.22
196 INT161803 Negative_regulation of Phosphorylation of ROS1 2 0.12 0.91 0.21
197 INT143393 Transcription of Crhr2 1 0.52 0.19 0.21
198 INT261820 Phosphorylation of Lyn 5 0.30 1.41 0.2
199 INT274731 Binding of EPHB1 3 0.22 0.76 0.2
200 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
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