GO:0070373

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Name negative regulation of ERK1 and ERK2 cascade
Categary Process
Go Slim No
Go Link GO:0070373
Unique Molecular Interactions 948
Total Molecular Interactions 1417
Total Single Events 8211
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
5 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
6 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
7 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
8 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
9 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
10 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
11 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
12 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
13 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
14 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
15 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
16 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
17 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
18 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
19 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
20 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
21 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
22 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
23 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
24 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
25 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
26 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
27 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
28 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
29 INT8415 LIF Regulation of VIP 1 0.13 0.36 1.04
30 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
31 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
32 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
33 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
34 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
35 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
36 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
37 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
38 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
39 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
40 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
41 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
42 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
43 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
44 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
45 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
46 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
47 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
48 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
49 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
50 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82
51 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
52 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
53 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
54 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
55 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
56 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
57 INT149597 Lif Regulation of Regulation of Gal 1 0.30 0.69 0.73
58 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
59 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
60 INT149596 Lif Negative_regulation of Negative_regulation of Gal 1 0.10 0.5 0.7
61 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
62 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
63 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
64 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
65 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
66 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
67 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
68 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
69 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
70 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
71 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
72 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
73 INT82267 Lif Regulation of Gene_expression of Gal 1 0.40 2.76 0.62
74 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
75 INT149595 Lif Negative_regulation of Negative_regulation of Trpv1 1 0.34 0.44 0.61
76 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
77 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
78 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
79 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
80 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
81 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
82 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
83 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
84 INT118001 Csk Regulation of Trpv1 1 0.08 0.09 0.58
85 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
86 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
87 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
88 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
89 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
90 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
91 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
92 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
93 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
94 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
95 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
96 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
97 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
98 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
99 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
100 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
101 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
102 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
103 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
104 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
105 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
106 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
107 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
108 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
109 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
110 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
111 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
112 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
113 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
114 INT98480 Lif Positive_regulation of Pnoc 1 0.18 0.2 0.49
115 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
116 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
117 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
118 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
119 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
120 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
121 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
122 INT98484 Lif Regulation of Gene_expression of Gal 1 0.04 0.16 0.47
123 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
124 INT98482 Lif Positive_regulation of Gene_expression of Pnoc 1 0.16 0.17 0.46
125 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
126 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
127 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
128 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45
129 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
130 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
131 INT130975 Binding of ASIC3 and Slc9a3r1 1 0.06 0.26 0.43
132 INT188205 OSM Regulation of LIF 1 0.09 1.12 0.43
133 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
134 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
135 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
136 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
137 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
138 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
139 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
140 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
141 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
142 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
143 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
144 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
145 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
146 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
147 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
148 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
149 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
150 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
151 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
152 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
153 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
154 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38
155 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
156 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38
157 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
158 INT91719 Binding of BDNF and LIF 1 0.09 1.65 0.38
159 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38
160 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
161 INT118002 Binding of Trpv1 and Csk 1 0.06 0.08 0.38
162 INT58969 TNF Regulation of Regulation of RPS6KA6 1 0.35 0.34 0.38
163 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38
164 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
165 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
166 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
167 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38
168 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
169 INT58967 TNF Regulation of RPS6KA6 1 0.18 0.33 0.38
170 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
171 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
172 INT324821 Tlr4 Positive_regulation of Gene_expression of Maob 1 0.07 0.44 0.37
173 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
174 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
175 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
176 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
177 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
178 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
179 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
180 INT110135 Tlr4 Regulation of Localization of Gnrh1 1 0.01 0.2 0.36
181 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
182 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
183 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 0.08 0.29 0.36
184 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
185 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
186 INT202810 Pin1 Regulation of Csf2 1 0.03 0.82 0.36
187 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
188 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
189 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
190 INT110132 Tlr4 Regulation of Localization of LH 1 0.01 0.2 0.35
191 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
192 INT244324 Csf2 Positive_regulation of Tlr4 1 0.23 0.95 0.34
193 INT110134 Tlr4 Regulation of Regulation of Gnrh1 1 0.01 0.15 0.33
194 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
195 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
196 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
197 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
198 INT295198 Tlr4 Positive_regulation of Gene_expression of Ptger2 1 0.01 0.15 0.32
199 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
200 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
5 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
6 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
7 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
8 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
9 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
10 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
11 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
12 INT134651 Binding of TLR4 89 0.48 66.96 23.19
13 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
14 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
15 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
16 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
17 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
18 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
19 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
20 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
21 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
22 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
23 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
24 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
25 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
26 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
27 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
28 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
29 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
30 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
31 INT34777 Localization of IGF1 82 0.80 42.68 8.62
32 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
33 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
34 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
35 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
36 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
37 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
38 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76
39 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
40 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
41 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
42 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
43 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
44 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
45 INT97797 Localization of TLR4 18 0.77 13.78 6
46 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
47 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
48 INT151032 Localization of Igf1 49 0.76 26.32 5.71
49 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
50 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
51 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
52 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
53 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
54 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
55 INT49360 Localization of Igf1 22 0.76 6.96 4.26
56 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
57 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
58 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
59 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
60 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
61 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7
62 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
63 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
64 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
65 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4
66 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
67 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
68 INT76240 Positive_regulation of Lif 6 0.69 6.04 3.13
69 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
70 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
71 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
72 INT16130 Binding of IGF1 67 0.48 27.43 2.95
73 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
74 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
75 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
76 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
77 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
78 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
79 INT66544 Binding of Igf1 23 0.46 8.33 2.44
80 INT202792 Negative_regulation of Pin1 1 0.56 3.77 2.37
81 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34
82 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
83 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
84 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
85 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
86 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
87 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
88 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
89 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
90 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
91 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
92 INT44027 Positive_regulation of Lif 7 0.40 2.76 1.9
93 INT148788 Binding of Csk 2 0.12 2.14 1.89
94 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
95 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
96 INT132837 Positive_regulation of Csk 5 0.45 1.75 1.79
97 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
98 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
99 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
100 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
101 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
102 INT148937 Positive_regulation of Csk 2 0.13 2.25 1.63
103 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
104 INT253751 Localization of Lif 3 0.73 3.94 1.58
105 INT50437 Regulation of LIF 6 0.44 2.12 1.53
106 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
107 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
108 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
109 INT50436 Negative_regulation of Positive_regulation of LIF 1 0.37 0.33 1.42
110 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
111 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
112 INT34933 Positive_regulation of Gene_expression of LIF 6 0.67 3.41 1.38
113 INT90491 Binding of Igf1 25 0.44 9.75 1.36
114 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
115 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
116 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
117 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
118 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
119 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
120 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
121 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
122 INT274898 Positive_regulation of Positive_regulation of Lyn 1 0.35 1.51 1.05
123 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
124 INT118738 Transcription of Tlr4 4 0.70 1.39 1
125 INT149594 Positive_regulation of Gene_expression of Lif 2 0.47 0.89 1
126 INT126279 Gene_expression of Rgs14 1 0.67 0.34 0.98
127 INT146939 Negative_regulation of Lyn 3 0.53 2.97 0.95
128 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
129 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
130 INT149383 Binding of Lyn 1 0.36 1.14 0.91
131 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
132 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
133 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
134 INT202790 Binding of Pin1 1 0.46 3.02 0.88
135 INT102819 Regulation of Lif 8 0.53 2.05 0.87
136 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
137 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86
138 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
139 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84
140 INT82262 Regulation of Lif 3 0.31 1.67 0.83
141 INT132835 Phosphorylation of Csk 2 0.36 0 0.83
142 INT202786 Regulation of Pin1 1 0.43 2.16 0.83
143 INT354449 Positive_regulation of Localization of Lif 1 0.33 1.24 0.83
144 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
145 INT6602 Gene_expression of RPS6KA6 3 0.56 1.75 0.82
146 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
147 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
148 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
149 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
150 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
151 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
152 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
153 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
154 INT68794 Negative_regulation of LIF 6 0.41 1.38 0.7
155 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
156 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
157 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
158 INT2109 Negative_regulation of Gene_expression of LIF 4 0.41 0.89 0.66
159 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
160 INT202806 Gene_expression of Pin1 1 0.74 1.87 0.66
161 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
162 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
163 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
164 INT148786 Negative_regulation of Csk 4 0.09 0.97 0.62
165 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
166 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
167 INT285478 Negative_regulation of Rgs14 1 0.27 1.25 0.6
168 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
169 INT130971 Binding of Slc9a3r1 2 0.39 0.32 0.59
170 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
171 INT132836 Regulation of Csk 1 0.30 0.42 0.59
172 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
173 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
174 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
175 INT117091 Positive_regulation of Lyn 1 0.49 0.41 0.56
176 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
177 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
178 INT130791 Regulation of Csk 1 0.07 0.86 0.54
179 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
180 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
181 INT322158 Phosphorylation of Csk 2 0.10 1.49 0.52
182 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
183 INT202801 Positive_regulation of Pin1 1 0.67 1.37 0.52
184 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
185 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
186 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
187 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
188 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
189 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
190 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
191 INT216834 Localization of Lif 2 0.34 0.23 0.46
192 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
193 INT299516 Phosphorylation of Lif 1 0.26 0.56 0.46
194 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
195 INT2110 Localization of LIF 5 0.73 1.59 0.44
196 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
197 INT130969 Positive_regulation of Binding of Slc9a3r1 1 0.09 0.26 0.43
198 INT202805 Negative_regulation of Negative_regulation of Pin1 1 0.41 0.77 0.43
199 INT32207 Regulation of Gene_expression of Lif 3 0.19 1.01 0.42
200 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
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