GO:0070374

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Name positive regulation of ERK1 and ERK2 cascade
Categary Process
Go Slim No
Go Link GO:0070374
Unique Molecular Interactions 4658
Total Molecular Interactions 6721
Total Single Events 49435
Pain Genes Associated 161

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
3 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
4 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
5 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
6 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
7 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
8 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
9 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
10 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
11 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
12 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
13 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
14 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
15 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
16 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
17 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
18 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
19 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
20 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
21 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
22 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
23 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
24 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
25 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
26 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
27 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
28 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
29 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
30 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
31 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
32 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
33 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
34 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
35 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
36 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
37 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
38 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
39 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
40 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
41 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
42 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
43 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
44 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
45 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
46 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
47 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
48 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
49 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
50 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
51 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
52 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
53 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
54 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
55 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
56 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
57 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
58 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
59 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
60 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
61 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
62 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
63 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
64 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
65 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
66 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
67 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
68 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
69 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
70 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
71 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
72 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
73 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
74 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
75 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
76 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
77 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
78 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
79 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
80 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
81 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
82 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
83 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
84 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
85 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
86 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
87 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
88 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
89 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
90 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
91 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
92 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
93 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
94 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
95 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
96 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
97 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
98 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
99 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
100 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
101 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
102 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
103 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
104 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
105 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
106 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
107 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
108 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
109 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
110 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
111 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
112 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
113 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
114 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
115 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
116 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
117 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
118 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
119 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
120 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
121 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
122 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
123 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
124 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
125 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
126 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
127 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
128 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
129 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
130 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
131 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
132 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
133 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
134 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
135 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
136 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
137 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
138 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
139 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
140 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
141 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
142 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
143 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
144 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
145 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
146 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
147 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
148 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
149 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
150 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
151 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
152 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
153 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
154 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
155 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
156 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
157 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
158 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
159 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
160 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
161 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
162 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
163 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
164 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
165 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
166 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
167 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 0.02 3.96 1.4
168 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
169 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
170 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
171 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
172 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
173 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
174 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
175 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
176 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
177 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
178 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
179 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
180 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
181 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
182 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
183 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
184 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
185 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
186 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
187 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
188 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
189 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
190 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
191 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
192 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
193 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
194 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
195 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
196 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
197 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
198 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
199 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
200 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of ERK1 and ERK2 cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of ERK1 and ERK2 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
5 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
6 INT6852 Localization of TNF 883 0.81 705.95 270.84
7 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
8 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
9 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
10 INT6481 Binding of TNF 624 0.48 510.2 214.82
11 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
12 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
13 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
14 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
15 INT9660 Regulation of TNF 363 0.62 312.94 139.99
16 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
17 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
18 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
19 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
20 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
21 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
22 INT12082 Localization of IL6 365 0.81 241.78 105.78
23 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
24 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
25 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
26 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
27 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
28 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
29 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
30 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
31 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
32 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
33 INT6849 Localization of IL1B 229 0.81 112.56 69.63
34 INT19511 Localization of Il6 212 0.81 118.17 67.67
35 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
36 INT11937 Localization of Il6 228 0.81 139.83 64.39
37 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
38 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
39 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
40 INT10706 Regulation of Il6 150 0.62 93.23 62.34
41 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
42 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
43 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
44 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
45 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
46 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
47 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
48 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
49 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
50 INT9210 Regulation of IL6 166 0.62 125.61 49.95
51 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
52 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
53 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
54 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
55 INT13354 Transcription of TNF 108 0.72 85.81 42.32
56 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
57 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
58 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
59 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
60 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
61 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
62 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
63 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
64 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
65 INT13501 Binding of Drd2 65 0.48 23.76 35.6
66 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
67 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
68 INT6484 Binding of IL1B 122 0.47 75.84 35.07
69 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
70 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
71 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
72 INT9655 Regulation of Il6 98 0.62 70.92 31.95
73 INT9347 Localization of Il1b 58 0.81 26.13 31.53
74 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
75 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
76 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
77 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
78 INT1473 Localization of Gcg 95 0.80 17.35 30.31
79 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
80 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
81 INT86437 Binding of IL6 154 0.48 121.22 29.3
82 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
83 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
84 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
85 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
86 INT116737 Localization of Mif 63 0.81 52.97 28.11
87 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
88 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
89 INT37296 Binding of Esr1 117 0.43 62.51 27.33
90 INT5966 Localization of Il1a 50 0.78 22.91 26.54
91 INT20462 Binding of ESR1 210 0.44 102.7 26.34
92 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
93 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
94 INT17625 Localization of GCG 210 0.80 55.69 24.97
95 INT12484 Binding of Drd2 45 0.48 15.17 24.72
96 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
97 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
98 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
99 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
100 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
101 INT134651 Binding of TLR4 89 0.48 66.96 23.19
102 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
103 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
104 INT48081 Localization of Il1b 46 0.80 21.59 22.4
105 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
106 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
107 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
108 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
109 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
110 INT117527 Binding of Prkca 25 0.48 6.43 21.05
111 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
112 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
113 INT49774 Binding of DRD2 48 0.48 17.42 20.73
114 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
115 INT51474 Binding of Il6 55 0.48 44.99 20.52
116 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
117 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
118 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
119 INT49985 Transcription of Il6 62 0.72 40.13 20.29
120 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
121 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
122 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
123 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
124 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
125 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
126 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
127 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
128 INT61626 Transcription of IL6 73 0.72 42.04 17.86
129 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
130 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
131 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
132 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
133 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
134 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
135 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
136 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
137 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
138 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
139 INT79458 Localization of Prkca 30 0.81 11.13 15.78
140 INT92354 Localization of ESR1 77 0.75 33.04 15.51
141 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
142 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
143 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46
144 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
145 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
146 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
147 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
148 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
149 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
150 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
151 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
152 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
153 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
154 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
155 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
156 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
157 INT141615 Gene_expression of Cysltr2 2 0.72 13.44 14.09
158 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
159 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
160 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
161 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
162 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
163 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
164 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
165 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
166 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
167 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
168 INT6575 Positive_regulation of Localization of Gcg 33 0.69 3.48 13.31
169 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
170 INT2038 Localization of Esr1 104 0.79 40.12 13.27
171 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
172 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
173 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
174 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96
175 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
176 INT54763 Binding of Il6 82 0.48 63.27 12.89
177 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
178 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
179 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
180 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
181 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
182 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
183 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
184 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
185 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
186 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
187 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
188 INT2586 Positive_regulation of Gcg 35 0.70 9.25 11.75
189 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
190 INT72949 Binding of Mif 31 0.46 23.12 11.65
191 INT50933 Transcription of Il6 38 0.72 24.31 11.58
192 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
193 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
194 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
195 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
196 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
197 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
198 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76
199 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
200 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
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