GO:0070375

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Name ERK5 cascade
Categary Process
Go Slim No
Go Link GO:0070375
Unique Molecular Interactions 15
Total Molecular Interactions 17
Total Single Events 129
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ERK5 cascade. They are ordered first by their pain relevance and then by number of times they were reported for ERK5 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144608 Mapk7 Negative_regulation of Gene_expression of Fos 2 0.65 0.43 0.42
2 INT137418 MAPK7 Negative_regulation of Gene_expression of TNF 1 0.01 0.63 0.28
3 INT113668 Mapk7 Positive_regulation of Positive_regulation of Rhox7 1 0.03 0 0.24
4 INT113141 Mapk7 Regulation of Gene_expression of Fos 1 0.62 0.26 0.23
5 INT113669 Mapk7 Positive_regulation of Gene_expression of Fos 1 0.54 0 0.22
6 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
7 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
8 INT156836 ETS1 Positive_regulation of Phosphorylation of MAPK7 1 0.14 0 0.1
9 INT156838 MAPK7 Positive_regulation of Phosphorylation of ETS1 1 0.13 0 0.1
10 INT156832 MAPK7 Positive_regulation of Transcription of CYP24A1 1 0.35 0 0.1
11 INT272513 Binding of Mef2a and Eif2s2 1 0.03 0 0
12 INT297209 Myoz1 Regulation of Mef2a 1 0.04 0.09 0
13 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
14 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0
15 INT320554 Mapk14 Positive_regulation of MEF2A 1 0.26 1.31 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ERK5 cascade. They are ordered first by their pain relevance and then by number of times they were reported in ERK5 cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113667 Positive_regulation of Mapk7 15 0.70 12.24 9.72
2 INT92571 Regulation of Mapk7 8 0.54 4.8 5.25
3 INT92572 Gene_expression of Mapk7 17 0.78 3.71 4.76
4 INT92570 Negative_regulation of Mapk7 6 0.53 2.53 4.34
5 INT144607 Positive_regulation of Gene_expression of Mapk7 8 0.61 2.09 2.82
6 INT103988 Localization of Mapk7 2 0.71 1.07 1.57
7 INT169656 Positive_regulation of Regulation of Mapk7 1 0.44 0.76 1.27
8 INT153127 Negative_regulation of Gene_expression of Mapk7 2 0.17 1.02 1.24
9 INT113140 Positive_regulation of Negative_regulation of Mapk7 2 0.42 0.61 0.88
10 INT103990 Positive_regulation of Localization of Mapk7 1 0.36 0.27 0.66
11 INT303716 Negative_regulation of Positive_regulation of MAPK7 1 0.14 0.86 0.66
12 INT303715 Positive_regulation of MAPK7 3 0.52 5.52 0.62
13 INT159938 Regulation of Localization of Mapk7 1 0.27 0.54 0.61
14 INT159939 Regulation of Positive_regulation of Mapk7 1 0.45 0.54 0.61
15 INT139965 Phosphorylation of Mapk7 2 0.82 1.09 0.49
16 INT139963 Regulation of Phosphorylation of Mapk7 1 0.35 0.94 0.49
17 INT139962 Positive_regulation of Positive_regulation of Mapk7 2 0.41 0.78 0.45
18 INT137420 Gene_expression of MAPK7 4 0.59 3.22 0.33
19 INT251938 Positive_regulation of Gene_expression of MEF2A 1 0.12 0.14 0.17
20 INT251939 Gene_expression of MEF2A 1 0.18 0.14 0.16
21 INT249108 Regulation of MEF2A 1 0.17 0.28 0.14
22 INT294379 Phosphorylation of Mef2a 1 0.56 0 0.1
23 INT294371 Positive_regulation of Phosphorylation of Mef2a 1 0.42 0 0.1
24 INT156851 Positive_regulation of Phosphorylation of MAPK7 1 0.32 0 0.1
25 INT156856 Phosphorylation of MAPK7 1 0.52 0 0.1
26 INT156853 Negative_regulation of MAPK7 2 0.32 0.75 0.09
27 INT156843 Negative_regulation of Gene_expression of MAPK7 1 0.27 0 0.09
28 INT290401 Gene_expression of Mef2a 1 0.64 1.81 0.07
29 INT290426 Positive_regulation of Mef2a 1 0.38 0.46 0.03
30 INT290422 Transcription of Mef2a 1 0.65 0 0.03
31 INT272480 Negative_regulation of Mef2a 2 0.40 0 0
32 INT159940 Negative_regulation of Positive_regulation of Mapk7 1 0.38 0 0
33 INT320531 Transcription of MEF2A 1 0.23 1.54 0
34 INT290405 Regulation of Gene_expression of Mef2a 1 0.43 0.06 0
35 INT320535 Positive_regulation of Gene_expression of MAPK7 1 0.52 2.06 0
36 INT272473 Negative_regulation of Localization of Mef2a 1 0.23 0.41 0
37 INT320540 Positive_regulation of MEF2A 1 0.17 1.32 0
38 INT272468 Localization of Mef2a 1 0.40 0.4 0
39 INT221828 Binding of MAPK7 1 0.11 0.7 0
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