GO:0070412

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Name R-SMAD binding
Categary Function
Go Slim No
Go Link GO:0070412
Unique Molecular Interactions 893
Total Molecular Interactions 1274
Total Single Events 21519
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for R-SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported for R-SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29
2 INT186566 Hpcl1 Positive_regulation of Fos 1 0.17 0.38 4.49
3 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79
4 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
5 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
6 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
7 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
8 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
9 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
10 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 3 0.17 0.15 1.98
11 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
12 INT125348 Decr1 Regulation of Gene_expression of Fos 1 0.00 0.1 1.92
13 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
14 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 0.03 0.28 1.8
15 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 1 0.23 0 1.76
16 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
17 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
18 INT160304 Npy Regulation of Gene_expression of Fos 3 0.67 1.43 1.68
19 INT54484 Npepo Positive_regulation of Gene_expression of Fos 1 0.43 0 1.63
20 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
21 INT158877 PRS Positive_regulation of Gene_expression of Fos 1 0.09 5.14 1.54
22 INT79021 Regulation of Binding of Jun and Fos 2 0.50 0.66 1.5
23 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 0.10 0.1 1.44
24 INT68723 Pomgnt1 Negative_regulation of Gene_expression of Fos 1 0.12 0 1.41
25 INT108583 Binding of Vip and Fos 1 0.36 0 1.39
26 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 0.03 0.1 1.32
27 INT120929 Prkcg Regulation of Gene_expression of Fos 2 0.50 0.34 1.31
28 INT66428 Dcc Positive_regulation of Fos 2 0.05 0.39 1.29
29 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
30 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 0.47 0.88 1.26
31 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
32 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 0.58 0.81 1.23
33 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 0.10 1.92 1.22
34 INT109380 Binding of Adarb1 and Fos 1 0.02 0.38 1.19
35 INT73075 Adarb1 Regulation of Fos 1 0.01 0.07 1.18
36 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
37 INT123454 CNR1 Regulation of Fos 1 0.00 0.06 1.12
38 INT130471 Prkcg Regulation of Regulation of Fos 1 0.45 0.27 1.12
39 INT112608 DNAJC15 Regulation of Gene_expression of Fos 1 0.02 0.14 1.12
40 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 0.00 0.06 1.12
41 INT143941 Il1f5 Negative_regulation of Gene_expression of Fos 1 0.00 1.03 1.11
42 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
43 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09
44 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
45 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
46 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07
47 INT100564 CRX Positive_regulation of Fos 1 0.04 0.89 1.06
48 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
49 INT270680 Fos Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.03 0.39 1.05
50 INT214875 Ap3d1 Negative_regulation of Gene_expression of Fos 1 0.00 0.39 1.04
51 INT146518 Tmem132a Positive_regulation of Gene_expression of Fos 1 0.68 0.06 1.04
52 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
53 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
54 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
55 INT139636 Jun Negative_regulation of Phosphorylation of Npy 1 0.33 1.07 1.01
56 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
57 INT143177 Apcs Negative_regulation of Gene_expression of Fos 1 0.02 0.36 1.01
58 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
59 INT11251 Negative_regulation of Cck Positive_regulation of Fos 2 0.48 0 1
60 INT139639 Jun Negative_regulation of Positive_regulation of Vip 1 0.53 1.07 1
61 INT139643 Jun Negative_regulation of Positive_regulation of Npy 1 0.33 1.07 1
62 INT71319 Binding of Penk and Fos 3 0.40 0.15 0.99
63 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 1 0.37 0.95 0.99
64 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
65 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 1 0.21 1.07 0.97
66 INT145823 Ngf Positive_regulation of Fos 1 0.52 0.95 0.97
67 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
68 INT145824 Negative_regulation of Ngf Positive_regulation of Fos 1 0.48 0.95 0.97
69 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 0.41 0.1 0.96
70 INT281380 Fos Negative_regulation of Gene_expression of FSCN1 1 0.07 0.4 0.96
71 INT139638 Positive_regulation of Jun Positive_regulation of Positive_regulation of Npy 1 0.36 1.18 0.96
72 INT103833 Sp5 Positive_regulation of Fos 1 0.51 0 0.96
73 INT155044 Negative_regulation of Ceacam3 Negative_regulation of Gene_expression of Fos 1 0.61 0 0.95
74 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
75 INT155043 Vta1 Regulation of Gene_expression of Fos 1 0.08 0 0.95
76 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
77 INT80601 Akr1d1 Regulation of Positive_regulation of Fos 1 0.06 0 0.94
78 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
79 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
80 INT48148 Fos Positive_regulation of Gene_expression of Pdyn 1 0.21 0 0.94
81 INT186568 Hpcl1 Regulation of Gene_expression of Fos 1 0.22 0.07 0.94
82 INT281377 FSCN1 Positive_regulation of Gene_expression of Fos 1 0.08 0.49 0.93
83 INT89514 Pnoc Regulation of Gene_expression of Fos 1 0.47 0.98 0.93
84 INT120380 Cnr1 Positive_regulation of Gene_expression of Fos 1 0.31 0.45 0.93
85 INT143578 Olr404 Negative_regulation of Positive_regulation of Fos 1 0.01 0.39 0.93
86 INT86350 Negative_regulation of Adarb1 Negative_regulation of Positive_regulation of Fos 1 0.04 0.8 0.92
87 INT151263 Jun Positive_regulation of S100a8 1 0.00 0.95 0.92
88 INT86349 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Fos 1 0.42 0.8 0.92
89 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
90 INT166221 Negative_regulation of Gls Negative_regulation of Gene_expression of Fos 1 0.50 0.37 0.9
91 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
92 INT164677 Ngf Positive_regulation of Gene_expression of Fos 1 0.52 0.08 0.89
93 INT87416 SNORD50A Regulation of Positive_regulation of Fos 1 0.13 0 0.87
94 INT73653 Binding of Creb1 and Fos 1 0.40 1.49 0.87
95 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
96 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
97 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
98 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
99 INT122833 AP1B1 Regulation of Gene_expression of Fos 1 0.16 0 0.83
100 INT108072 Grip2 Positive_regulation of Gene_expression of Fos 1 0.08 0.21 0.82
101 INT329278 Vta1 Positive_regulation of Gene_expression of Fos 1 0.22 0 0.82
102 INT186567 Negative_regulation of Hpcl1 Positive_regulation of Fos 1 0.11 0.07 0.82
103 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
104 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
105 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
106 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
107 INT111129 Adarb1 Regulation of Gene_expression of Fos 1 0.09 0 0.79
108 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
109 INT166222 Gene_expression of Fos Positive_regulation of Col6a6 1 0.01 0.57 0.77
110 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
111 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
112 INT90118 Jun Regulation of Gene_expression of Nfkb1 1 0.18 0.39 0.76
113 INT73087 Adarb1 Positive_regulation of Fos 1 0.02 0 0.76
114 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
115 INT108073 Pnoc Negative_regulation of Gene_expression of Fos 1 0.32 0.25 0.76
116 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
117 INT90123 Jun Positive_regulation of Gene_expression of Fos 1 0.47 0.39 0.76
118 INT142057 NLRP1 Regulation of Gene_expression of Fos 1 0.17 0 0.76
119 INT90122 Nfkb1 Positive_regulation of Gene_expression of Fos 1 0.39 0.39 0.75
120 INT83868 Oprd1 Positive_regulation of Gene_expression of Fos 1 0.01 0 0.75
121 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
122 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
123 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
124 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
125 INT186436 Phosphorylation of Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
126 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
127 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
128 INT186438 Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
129 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
130 INT108582 Binding of Grp and Fos 1 0.32 0 0.72
131 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
132 INT186440 Phosphorylation of Creb1 Regulation of Jun 1 0.21 0.43 0.72
133 INT108584 Binding of GRP and Fos 1 0.04 0 0.72
134 INT159569 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Fos 1 0.37 0.4 0.7
135 INT60371 Fos Positive_regulation of Pdyn 1 0.41 0.1 0.7
136 INT141171 Ptz1a Positive_regulation of Gene_expression of Fos 1 0.07 0.5 0.69
137 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
138 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
139 INT120381 Binding of CNR1 and Fos 1 0.00 0.52 0.68
140 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
141 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
142 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
143 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
144 INT153532 NMS Regulation of Gene_expression of Fos 1 0.23 1.33 0.67
145 INT110407 Htr1a Positive_regulation of Gene_expression of Fos 1 0.50 0.52 0.66
146 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
147 INT186569 Regulation of Hpcl1 Positive_regulation of Fos 1 0.07 0 0.65
148 INT82306 Bdnf Positive_regulation of Gene_expression of Fos 1 0.68 0.64 0.65
149 INT128869 Gabrg1 Positive_regulation of Transcription of Jun 1 0.09 0.55 0.62
150 INT54487 Rabep2 Regulation of Gene_expression of Jun 1 0.06 0 0.61
151 INT97916 Tinag Negative_regulation of Gene_expression of Fos 1 0.01 0.35 0.6
152 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
153 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
154 INT128606 Pomc Positive_regulation of Gene_expression of Fos 1 0.02 0.55 0.59
155 INT76237 Olr594 Positive_regulation of Gene_expression of Fos 1 0.05 0.09 0.59
156 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
157 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
158 INT73654 Binding of Jun and Pim3 1 0.02 0.99 0.58
159 INT107523 Negative_regulation of Grm5 Negative_regulation of Gene_expression of Fos 1 0.37 0.09 0.58
160 INT213727 Ngf Regulation of Gene_expression of Fos 1 0.21 0.27 0.58
161 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
162 INT93063 Binding of gr and Jun 3 0.14 0.79 0.57
163 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
164 INT11280 Fos Regulation of Transcription of Penk 1 0.04 0.55 0.57
165 INT76248 Tac1 Positive_regulation of Gene_expression of Fos 1 0.34 0.34 0.56
166 INT87613 LMOD1 Positive_regulation of Fos 1 0.00 0.15 0.56
167 INT51568 Acyp2-ps1 Positive_regulation of Positive_regulation of Fos 1 0.35 0.19 0.56
168 INT253835 Binding of DST and Fos 1 0.02 0 0.55
169 INT105421 Fos Positive_regulation of Gene_expression of Penk 1 0.54 0 0.55
170 INT118513 Par2 Positive_regulation of Gene_expression of Fos 1 0.19 0.23 0.54
171 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
172 INT137246 Slc6a14 Negative_regulation of Gene_expression of Fos 1 0.10 1.24 0.54
173 INT253832 Binding of Fos and Nts 1 0.14 0 0.54
174 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53
175 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
176 INT114647 Fos Positive_regulation of Gene_expression of PDYN 1 0.48 0.52 0.52
177 INT119546 Nfe2l2 Regulation of Gene_expression of Fos 1 0.48 0.94 0.52
178 INT98684 Tac2 Positive_regulation of Gene_expression of Fos 1 0.12 0.16 0.51
179 INT143939 Il1b Regulation of Gene_expression of Fos 1 0.10 0.44 0.49
180 INT90131 NOS1 Regulation of Fos 1 0.00 0.25 0.49
181 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
182 INT215543 Negative_regulation of Trim33 Negative_regulation of Gopc 1 0.15 0.35 0.48
183 INT121840 Sct Positive_regulation of Gene_expression of Fos 1 0.61 0 0.48
184 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
185 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
186 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
187 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
188 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
189 INT247639 Binding of Jun and Atf3 2 0.09 3.06 0.44
190 INT175802 Il1 Positive_regulation of Gene_expression of Fos 1 0.00 0.66 0.44
191 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
192 INT142456 Gal Positive_regulation of Positive_regulation of Fos 1 0.75 0.16 0.43
193 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
194 INT103132 Positive_regulation of DCSTAMP Positive_regulation of JUN 1 0.03 0.73 0.43
195 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
196 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
197 INT127075 Bdnf Regulation of Gene_expression of Jun 1 0.11 0.28 0.43
198 INT127073 Bdnf Regulation of Gene_expression of Fos 1 0.42 0.28 0.43
199 INT127072 Gdnf Regulation of Gene_expression of Fos 1 0.38 0.28 0.43
200 INT103129 DCSTAMP Positive_regulation of JUN 1 0.03 0.72 0.43

Single Events

The table below shows the top 100 pain related interactions that have been reported for R-SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported in R-SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02
2 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684
3 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87
4 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84
5 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54
6 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78
7 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
8 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05
9 INT5587 Regulation of Fos 191 0.62 40.81 99.7
10 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31
11 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
12 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98
13 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
14 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96
15 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82
16 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
17 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
18 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6
19 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
20 INT666 Gene_expression of Jun 124 0.78 54.61 33.67
21 INT6053 Transcription of Fos 107 0.72 20.97 31.88
22 INT47764 Binding of Jun 106 0.48 22.62 31.39
23 INT6058 Localization of Fos 73 0.81 16.7 30.84
24 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73
25 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
26 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41
27 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
28 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05
29 INT5586 Binding of Fos 47 0.48 12.7 21.33
30 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61
31 INT11275 Regulation of Fos 37 0.60 5.79 18.18
32 INT8526 Negative_regulation of Positive_regulation of Fos 26 0.59 5.99 17.52
33 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
34 INT17593 Regulation of Jun 37 0.60 5.5 14.35
35 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37
36 INT15246 Regulation of FOS 32 0.60 15.34 12.94
37 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06
38 INT6051 Positive_regulation of Transcription of Fos 27 0.69 6.3 11.48
39 INT70816 Negative_regulation of Fos 32 0.58 13 11.18
40 INT52233 Transcription of Jun 37 0.66 6.39 11.15
41 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08
42 INT52657 Phosphorylation of Fos 20 0.80 6.36 10.64
43 INT60198 Binding of JUN 54 0.48 11.56 10.27
44 INT17592 Positive_regulation of Regulation of Fos 21 0.67 3.54 10.07
45 INT8527 Positive_regulation of Positive_regulation of Fos 20 0.70 6.87 9.62
46 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
47 INT61264 Regulation of Jun 36 0.61 18.42 8.71
48 INT47769 Phosphorylation of Fos 20 0.61 3.03 8.68
49 INT64815 Binding of Jun 49 0.48 21.47 8.59
50 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
51 INT53975 Positive_regulation of Binding of Jun 28 0.70 4.67 8.16
52 INT64816 Transcription of Jun 31 0.69 16.01 7.64
53 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
54 INT9476 Regulation of Gene_expression of Jun 14 0.43 4.25 7.61
55 INT10344 Localization of Jun 23 0.73 6.36 7.46
56 INT75497 Regulation of JUN 28 0.61 11.04 7.09
57 INT60196 Binding of FOS 33 0.47 13.11 6.95
58 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9
59 INT47817 Positive_regulation of Positive_regulation of Jun 21 0.66 3.7 6.83
60 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
61 INT5847 Transcription of FOS 31 0.69 11.11 6.41
62 INT47765 Negative_regulation of Binding of Jun 21 0.43 5.05 6.38
63 INT73649 Phosphorylation of Jun 28 0.80 11.01 5.87
64 INT8525 Regulation of Positive_regulation of Fos 9 0.60 4.04 5.75
65 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
66 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18
67 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78
68 INT54911 Localization of FOS 20 0.78 3.27 4.56
69 INT47766 Transcription of Fos 25 0.69 8.78 4.42
70 INT11277 Localization of Fos 22 0.78 6.58 4.19
71 INT67936 Transcription of JUN 18 0.52 9.52 4.13
72 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03
73 INT10808 Negative_regulation of Negative_regulation of Fos 3 0.57 1.08 3.92
74 INT6661 Positive_regulation of Positive_regulation of Jun 31 0.50 7.12 3.89
75 INT60924 Regulation of Regulation of Fos 6 0.44 1.04 3.89
76 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
77 INT64817 Positive_regulation of Binding of Jun 16 0.69 6.78 3.81
78 INT84232 Negative_regulation of Transcription of Fos 9 0.58 1.84 3.78
79 INT25251 Binding of Fos 19 0.36 7.96 3.73
80 INT15776 Localization of Jun 10 0.74 3.9 3.69
81 INT61570 Positive_regulation of Transcription of Jun 10 0.35 1.62 3.45
82 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
83 INT70387 Negative_regulation of Positive_regulation of Jun 14 0.37 3.76 3.23
84 INT50616 Positive_regulation of Regulation of Fos 4 0.49 0.72 3.17
85 INT169113 Negative_regulation of Phosphorylation of Fos 1 0.42 2.17 3.12
86 INT47768 Positive_regulation of Phosphorylation of Fos 6 0.11 0 3.11
87 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
88 INT48605 Positive_regulation of Localization of Fos 4 0.49 1.26 2.94
89 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
90 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
91 INT64819 Positive_regulation of Transcription of Jun 6 0.50 4.41 2.79
92 INT61096 Negative_regulation of Regulation of Fos 5 0.42 2.12 2.77
93 INT47770 Positive_regulation of Transcription of Fos 9 0.49 1.87 2.71
94 INT194495 Regulation of Transcription of Jun 4 0.26 2.85 2.6
95 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
96 INT109378 Regulation of Phosphorylation of Fos 3 0.26 1.61 2.45
97 INT123682 Localization of JUN 8 0.50 4.15 2.38
98 INT61029 Positive_regulation of Binding of Fos 3 0.49 0.82 2.38
99 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
100 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
101 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
102 INT50992 Regulation of Negative_regulation of Fos 2 0.26 0.73 2.22
103 INT53981 Regulation of Binding of Jun 5 0.44 0.63 2.12
104 INT59358 Regulation of Gene_expression of Jun 10 0.61 3.7 2.11
105 INT79020 Regulation of Binding of Fos 3 0.45 1.2 2.1
106 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
107 INT92522 Regulation of Regulation of Fos 3 0.23 0.25 1.98
108 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
109 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
110 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
111 INT53982 Regulation of Positive_regulation of Jun 4 0.54 0.9 1.89
112 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
113 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
114 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
115 INT121970 Negative_regulation of Transcription of Fos 4 0.42 2.52 1.48
116 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48
117 INT97560 Regulation of Transcription of Fos 6 0.44 2.71 1.46
118 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
119 INT5588 Positive_regulation of Negative_regulation of Fos 3 0.49 0.68 1.42
120 INT106142 Positive_regulation of Phosphorylation of Fos 4 0.49 0.71 1.4
121 INT96063 Positive_regulation of Phosphorylation of Jun 7 0.67 4.06 1.38
122 INT90528 Negative_regulation of Binding of Fos 4 0.41 0.25 1.36
123 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
124 INT47767 Negative_regulation of Phosphorylation of Fos 3 0.42 0.86 1.3
125 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26
126 INT120764 Negative_regulation of Binding of JUN 7 0.25 2.65 1.23
127 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22
128 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
129 INT64818 Regulation of Binding of Jun 3 0.33 1.06 1.17
130 INT17332 Regulation of Positive_regulation of FOS 6 0.44 0.78 1.11
131 INT75503 Regulation of Gene_expression of JUN 6 0.21 2.87 1.11
132 INT69394 Positive_regulation of Binding of FOS 6 0.49 3.54 1.11
133 INT48982 Positive_regulation of Regulation of FOS 2 0.45 0.15 1.11
134 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
135 INT50409 Regulation of Localization of Fos 3 0.44 0.2 1.07
136 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
137 INT155467 Negative_regulation of Regulation of Fos 1 0.42 1.18 0.96
138 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
139 INT215518 Negative_regulation of Trim33 2 0.57 0.43 0.88
140 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
141 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
142 INT53978 Regulation of Regulation of Jun 4 0.38 0.18 0.83
143 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
144 INT88179 Negative_regulation of Transcription of FOS 3 0.41 0.96 0.78
145 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
146 INT106523 Positive_regulation of Phosphorylation of Jun 7 0.45 3.1 0.74
147 INT124739 Negative_regulation of Binding of Jun 2 0.40 1.45 0.74
148 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
149 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
150 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
151 INT215519 Protein_catabolism of Trim33 1 0.86 0.39 0.69
152 INT154019 Protein_catabolism of Jun 2 0.61 0.07 0.67
153 INT138479 Protein_catabolism of Fos 2 0.86 0.67 0.67
154 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
155 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
156 INT303710 Negative_regulation of Transcription of JUN 1 0.06 0.84 0.65
157 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
158 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
159 INT197832 Localization of MEN1 1 0.80 11.01 0.63
160 INT307186 Negative_regulation of Phosphorylation of Jun 4 0.10 2.91 0.61
161 INT127262 Negative_regulation of Transcription of Jun 1 0.30 0.52 0.61
162 INT123681 Positive_regulation of Localization of JUN 2 0.25 1.3 0.59
163 INT113840 Negative_regulation of Gene_expression of JUN 10 0.58 5.23 0.56
164 INT124875 Regulation of Localization of FOS 1 0.44 0.18 0.55
165 INT17594 Positive_regulation of Regulation of Jun 1 0.43 0 0.55
166 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
167 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
168 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
169 INT252719 Positive_regulation of Localization of FOS 1 0.06 1.47 0.49
170 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
171 INT131715 Positive_regulation of Binding of Fos 2 0.40 0.11 0.47
172 INT74209 Positive_regulation of Negative_regulation of JUN 1 0.45 0.26 0.47
173 INT133283 Negative_regulation of Localization of FOS 2 0.41 0.29 0.46
174 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
175 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43
176 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
177 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
178 INT139522 Positive_regulation of Regulation of JUN 1 0.49 0.37 0.41
179 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
180 INT121971 Regulation of Transcription of Fos 3 0.43 0.14 0.39
181 INT148519 Regulation of Regulation of FOS 1 0.44 1.74 0.39
182 INT93816 Regulation of Phosphorylation of Fos 1 0.06 0 0.38
183 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
184 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
185 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
186 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
187 INT108357 Regulation of Phosphorylation of FOS 1 0.60 0.1 0.37
188 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
189 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
190 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
191 INT92100 Binding of Smad4 5 0.31 2.23 0.3
192 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
193 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
194 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
195 INT243668 Negative_regulation of Phosphorylation of Jun 4 0.19 0.94 0.29
196 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
197 INT244913 Regulation of Transcription of FOS 2 0.10 1.09 0.28
198 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
199 INT286394 Negative_regulation of Negative_regulation of Fos 2 0.42 1.08 0.26
200 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
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