GO:0070423

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Name nucleotide-binding oligomerization domain containing signaling pathway
Categary Process
Go Slim No
Go Link GO:0070423
Unique Molecular Interactions 76
Total Molecular Interactions 90
Total Single Events 733
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nucleotide-binding oligomerization domain containing signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for nucleotide-binding oligomerization domain containing signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
2 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
3 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
4 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
5 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
6 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
7 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
8 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
9 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
10 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
11 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
12 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
13 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
14 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
15 INT346228 MAP2K6 Positive_regulation of Positive_regulation of MAPK14 1 0.44 0.68 0.34
16 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
17 INT346236 Binding of MAPK14 and MAP2K6 1 0.32 0.65 0.33
18 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
19 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
20 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24
21 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23
22 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23
23 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21
24 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
25 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
26 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
27 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
28 INT318305 Binding of NOD2 and NLRP3 1 0.08 1.76 0.15
29 INT246365 CALM1 Regulation of MAP2K6 1 0.00 0.34 0.15
30 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
31 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
32 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
33 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
34 INT139787 Negative_regulation of TNFAIP8 Positive_regulation of IKBKG 1 0.10 0.89 0.11
35 INT139783 TNFAIP8 Positive_regulation of IKBKG 1 0.12 0.88 0.11
36 INT139786 TNFAIP8 Positive_regulation of Phosphorylation of IKBKG 1 0.12 0.89 0.11
37 INT139792 TNFAIP8 Positive_regulation of Protein_catabolism of IKBKG 1 0.12 0.89 0.11
38 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
39 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
40 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
41 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
42 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
43 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06
44 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
45 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
46 INT194727 MAP3K4 Positive_regulation of MAP2K6 1 0.06 0 0.04
47 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
48 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
49 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
50 INT244129 Binding of RNGTT and NOD1 1 0.11 0 0.04
51 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
52 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
53 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
54 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
55 INT268520 MIR19B1 Regulation of CASP8 1 0.14 1 0
56 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0
57 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0
58 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
59 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
60 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
61 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
62 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
63 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
64 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
65 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
66 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
67 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
68 INT237923 CFLAR Positive_regulation of Localization of CASP8 1 0.02 1.54 0
69 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
70 INT348529 TNF Positive_regulation of Gene_expression of IKBKG 1 0.01 0.23 0
71 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
72 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
73 INT265455 CSPG4 Negative_regulation of Positive_regulation of CASP8 1 0.04 0.27 0
74 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
75 INT122482 Negative_regulation of CASP3 Negative_regulation of Positive_regulation of CASP8 1 0.14 1.15 0
76 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nucleotide-binding oligomerization domain containing signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in nucleotide-binding oligomerization domain containing signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
2 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
3 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
4 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
5 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
6 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
7 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
8 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
9 INT103910 Binding of NOD2 19 0.47 12.24 2.93
10 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
11 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
12 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
13 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
14 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
15 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
16 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
17 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
18 INT132893 Binding of CHUK 1 0.00 0.63 2.25
19 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
20 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
21 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
22 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
23 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
24 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
25 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
26 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
27 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
28 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
29 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
30 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
31 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
32 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
33 INT119348 Binding of IKBKG 7 0.15 4.03 1.14
34 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1
35 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
36 INT117435 Negative_regulation of IKBKB 3 0.37 2.67 0.97
37 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
38 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
39 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
40 INT150546 Positive_regulation of Phosphorylation of MAP2K6 3 0.49 1.14 0.93
41 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
42 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
43 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
44 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
45 INT346246 Positive_regulation of Gene_expression of MAP2K6 1 0.45 1.74 0.78
46 INT151468 Regulation of MAP2K6 2 0.11 0.68 0.74
47 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
48 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
49 INT244153 Positive_regulation of Gene_expression of NOD1 1 0.46 1.36 0.63
50 INT244161 Positive_regulation of NOD1 4 0.64 1.83 0.62
51 INT91330 Regulation of Localization of IKBKG 1 0.01 0.76 0.61
52 INT91328 Regulation of Gene_expression of IKBKG 1 0.01 0.75 0.61
53 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
54 INT58742 Localization of MAP2K6 1 0.61 0.16 0.58
55 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
56 INT162791 Regulation of NOD1 2 0.13 0.58 0.55
57 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
58 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
59 INT135620 Regulation of IKBKB 1 0.39 1.23 0.48
60 INT12768 Negative_regulation of Localization of IKBKG 1 0.07 0 0.48
61 INT117436 Binding of IKBKB 2 0.26 1.44 0.47
62 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
63 INT346258 Negative_regulation of Gene_expression of MAP2K6 1 0.38 1.08 0.45
64 INT346260 Regulation of Gene_expression of MAP2K6 1 0.41 1.09 0.45
65 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
66 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
67 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
68 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
69 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
70 INT37187 Positive_regulation of Localization of IKBKG 1 0.10 0.35 0.4
71 INT181179 Binding of CYLD 4 0.43 7.06 0.39
72 INT141493 Negative_regulation of CHUK 2 0.07 1.15 0.38
73 INT171764 Localization of NOD2 2 0.74 0.86 0.37
74 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
75 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
76 INT244143 Positive_regulation of Positive_regulation of NOD1 1 0.46 0.68 0.31
77 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
78 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
79 INT244171 Negative_regulation of NOD1 3 0.47 0 0.28
80 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
81 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
82 INT176260 Binding of CASP8 5 0.36 2.73 0.27
83 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
84 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
85 INT30059 Regulation of Positive_regulation of IKBKG 1 0.08 0 0.24
86 INT318992 Localization of NOD1 1 0.11 1.1 0.23
87 INT257782 Localization of TAB2 1 0.36 0.36 0.23
88 INT119347 Regulation of Binding of IKBKG 1 0.18 0.28 0.22
89 INT185452 Regulation of CYLD 6 0.40 6.09 0.21
90 INT222271 Transcription of NOD1 2 0.66 0.32 0.21
91 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
92 INT257783 Phosphorylation of TAB2 1 0.37 0.38 0.21
93 INT117434 Negative_regulation of Binding of IKBKB 1 0.30 1.39 0.2
94 INT145832 Gene_expression of IKBKB 1 0.02 1.23 0.19
95 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
96 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
97 INT296766 Transcription of IKBKG 1 0.04 1.02 0.17
98 INT227586 Negative_regulation of Gene_expression of IKBKG 1 0.21 0 0.16
99 INT231574 Binding of TAB2 2 0.04 0.35 0.15
100 INT139795 Negative_regulation of IKBKG 2 0.21 1.14 0.15
101 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
102 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
103 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
104 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14
105 INT185449 Regulation of Regulation of CYLD 1 0.21 2.03 0.13
106 INT222274 Regulation of Regulation of NOD2 1 0.27 0.45 0.13
107 INT323746 Phosphorylation of IRAK1 1 0.46 0.81 0.12
108 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
109 INT323732 Regulation of Gene_expression of IRAK1 1 0.26 0.82 0.12
110 INT139796 Positive_regulation of Phosphorylation of IKBKG 1 0.25 0.89 0.11
111 INT139800 Positive_regulation of Protein_catabolism of IKBKG 1 0.25 0.89 0.11
112 INT335789 Negative_regulation of Transcription of IRAK1 1 0.22 0.45 0.11
113 INT335817 Transcription of IRAK1 1 0.35 0.45 0.11
114 INT139794 Negative_regulation of Phosphorylation of IKBKG 1 0.21 0.89 0.11
115 INT139802 Phosphorylation of IKBKG 1 0.41 0.88 0.11
116 INT139793 Protein_catabolism of IKBKG 1 0.50 0.88 0.11
117 INT139797 Negative_regulation of Protein_catabolism of IKBKG 1 0.29 0.89 0.11
118 INT307240 Localization of CYLD 3 0.72 3.09 0.1
119 INT335806 Negative_regulation of IRAK1 1 0.30 0.36 0.1
120 INT185901 Localization of CASP8 7 0.55 5.38 0.09
121 INT53444 Positive_regulation of Gene_expression of IKBKG 1 0.42 0.56 0.09
122 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
123 INT185440 Negative_regulation of Negative_regulation of CYLD 1 0.20 1.02 0.08
124 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05
125 INT222267 Regulation of Transcription of NOD2 1 0.45 0 0.05
126 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05
127 INT336053 Regulation of Positive_regulation of CASP8 2 0.04 1.44 0.04
128 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
129 INT244158 Regulation of Gene_expression of NOD1 1 0.56 0 0.03
130 INT237978 Negative_regulation of Negative_regulation of CASP8 1 0.07 1.65 0.03
131 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0
132 INT217333 Positive_regulation of TNFAIP3 3 0.23 2.65 0
133 INT265477 Positive_regulation of Gene_expression of CASP8 2 0.17 1.57 0
134 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0
135 INT203927 Positive_regulation of Localization of CASP8 2 0.08 1.98 0
136 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0
137 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0
138 INT348456 Protein_catabolism of TNFAIP3 1 0.22 1.13 0
139 INT348453 Positive_regulation of Positive_regulation of TNFAIP3 1 0.17 1.06 0
140 INT175213 Negative_regulation of Binding of UBC 1 0.02 0.13 0
141 INT156902 Positive_regulation of UBC 1 0.49 0 0
142 INT322579 Positive_regulation of Binding of CASP8 1 0.09 0.25 0
143 INT343496 Negative_regulation of Gene_expression of NOD1 1 0.12 0 0
144 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0
145 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0
146 INT343493 Protein_catabolism of NOD1 1 0.25 0 0
147 INT222273 Positive_regulation of Regulation of NOD2 1 0.46 0.09 0
148 INT175222 Binding of UBC 1 0.02 0.54 0
149 INT343495 Negative_regulation of Protein_catabolism of NOD1 1 0.12 0 0
150 INT307230 Regulation of Localization of CYLD 1 0.40 0.11 0
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