GO:0070435

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Name Shc-EGFR complex
Categary Component
Go Slim No
Go Link GO:0070435
Unique Molecular Interactions 135
Total Molecular Interactions 212
Total Single Events 2075
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Shc-EGFR complex. They are ordered first by their pain relevance and then by number of times they were reported for Shc-EGFR complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
3 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
4 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
5 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
6 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
7 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
8 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
9 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
10 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
11 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
12 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
13 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
14 INT341211 Gopc Regulation of Shc1 1 0.02 0.68 0.45
15 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
16 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
17 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
18 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
19 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
20 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
21 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
22 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
23 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
24 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
25 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
26 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
27 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2
28 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
29 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
30 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
31 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
32 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
33 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
34 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
35 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
36 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
37 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
38 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
39 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
40 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
41 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
42 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
43 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
44 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
45 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
46 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
47 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
48 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
49 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07
50 INT340320 Binding of Shc1 and Positive_regulation of Pik3r1 1 0.23 0 0.07
51 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
52 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
53 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
54 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
55 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
56 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
57 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
58 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
59 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
60 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
61 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
62 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
63 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
64 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
65 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
66 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
67 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
68 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
69 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
70 INT333878 Shc1 Positive_regulation of EPHB2 1 0.08 0.3 0.03
71 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
72 INT187640 Binding of EGFR and KLF1 3 0.01 2.54 0
73 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
74 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
75 INT191097 Neu1 Positive_regulation of Shc1 1 0.04 1.96 0
76 INT145150 Positive_regulation of Binding of EGFR and JUN 1 0.24 0.11 0
77 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
78 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0
79 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0
80 INT225889 Binding of MET and SHC1 1 0.01 0 0
81 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0
82 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
83 INT225905 Binding of GRB2 and SHC1 1 0.00 0 0
84 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
85 INT213583 Binding of EGFR and NRG2 1 0.16 0.13 0
86 INT145148 Positive_regulation of Binding of EGFR and FOS 1 0.50 0.05 0
87 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0
88 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
89 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0
90 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0
91 INT191099 Erbb2 Positive_regulation of Shc1 1 0.08 1.95 0
92 INT277664 Negative_regulation of Binding of EGF and EGFR 1 0.18 0.5 0
93 INT298191 EGFR Regulation of IFI27 1 0.05 1.14 0
94 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0
95 INT345506 Binding of EGFR and FNDC3A 1 0.00 0.08 0
96 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
97 INT298195 Negative_regulation of EGFR Regulation of IFI27 1 0.08 0.58 0
98 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
99 INT334323 IL8 Positive_regulation of EGFR 1 0.50 1.29 0
100 INT145149 Binding of EGFR and JUN 1 0.16 0.11 0
101 INT171394 Binding of Grb2 and Shc1 1 0.05 0 0
102 INT279282 Binding of EGFR and ESR2 1 0.45 1.39 0
103 INT341856 Binding of EGFR and IgG1 1 0.27 1.12 0
104 INT278446 Binding of EGFR and EMR1 1 0.00 0.75 0
105 INT323506 ROS1 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.69 0
106 INT277663 Binding of EGFR and TTPA 1 0.05 0.41 0
107 INT344405 Binding of EGFR and Spp1 1 0.09 1.34 0
108 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0
109 INT191181 Binding of EGFR and H3F3B 1 0.32 0.17 0
110 INT307586 Binding of EGFR and CDCP1 1 0.01 0.51 0
111 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0
112 INT194362 PDGFA Regulation of EGFR 1 0.23 1.56 0
113 INT188734 Egfr Positive_regulation of Gene_expression of EGFR 1 0.52 0.61 0
114 INT277836 EGFR Positive_regulation of VEGFA 1 0.24 0.47 0
115 INT307585 Binding of EGFR and MET 1 0.11 0.52 0
116 INT220461 Binding of VCAN and EGFR 1 0.00 0.86 0
117 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0
118 INT242301 Binding of EGFR and ACCS 1 0.11 1.31 0
119 INT236615 Binding of RERE and EGFR 1 0.04 0.35 0
120 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0
121 INT339100 Binding of ASIP and EGFR 1 0.00 0.58 0
122 INT194361 VEGFA Regulation of EGFR 1 0.22 1.58 0
123 INT145151 Binding of EGFR and FOS 1 0.48 0.05 0
124 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 0.04 0.35 0
125 INT277772 Binding of EGFR and fc 1 0.01 0.57 0
126 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Shc-EGFR complex. They are ordered first by their pain relevance and then by number of times they were reported in Shc-EGFR complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
2 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
3 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
4 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
5 INT11154 Binding of EGFR 149 0.48 96.23 6.29
6 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
7 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1
8 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
9 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
10 INT72384 Positive_regulation of Phosphorylation of Shc1 1 0.32 0.48 2.9
11 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
12 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52
13 INT122534 Binding of Shc1 6 0.48 3.59 1.94
14 INT65545 Localization of EGFR 35 0.79 20.8 1.88
15 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
16 INT136680 Negative_regulation of Gene_expression of Shc1 4 0.43 3.36 1.57
17 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
18 INT136678 Positive_regulation of Gene_expression of Shc1 4 0.50 2.93 1.42
19 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
20 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
21 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
22 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
23 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
24 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
25 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
26 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
27 INT72380 Positive_regulation of Shc1 10 0.69 6.87 0.77
28 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
29 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
30 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
31 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
32 INT191347 Regulation of Shc1 6 0.27 3.6 0.6
33 INT136679 Negative_regulation of Shc1 3 0.59 2.5 0.51
34 INT72379 Localization of Shc1 4 0.74 0.89 0.49
35 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41
36 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
37 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
38 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
39 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
40 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
41 INT351894 Negative_regulation of SHC1 1 0.12 0.69 0.14
42 INT191353 Localization of SHC1 2 0.73 0.75 0.1
43 INT291370 Phosphorylation of SHC1 1 0.14 0.57 0.1
44 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
45 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
46 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
47 INT340308 Negative_regulation of Localization of Shc1 1 0.37 0 0.04
48 INT340312 Regulation of Binding of Shc1 1 0.39 0.05 0.03
49 INT201644 Positive_regulation of Positive_regulation of Shc1 1 0.07 0.82 0.03
50 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
51 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
52 INT191352 Regulation of SHC1 2 0.14 1.46 0
53 INT315831 Positive_regulation of Localization of EGFR 2 0.49 0.6 0
54 INT319331 Regulation of Localization of EGFR 2 0.32 1.85 0
55 INT176532 Binding of SHC1 1 0.36 1.3 0
56 INT191349 Transcription of Shc1 1 0.53 0.92 0
57 INT191348 Regulation of Transcription of Shc1 1 0.27 0.93 0
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