GO:0070498

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Name interleukin-1-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0070498
Unique Molecular Interactions 323
Total Molecular Interactions 380
Total Single Events 3408
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-1-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-1-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
2 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
3 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
4 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
5 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
6 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
7 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
8 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
9 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
10 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
11 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
12 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
13 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
14 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
15 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
16 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
17 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
18 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
19 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
20 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
21 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
22 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
23 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
24 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
25 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
26 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
27 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
28 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64
29 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
30 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61
31 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61
32 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
33 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
34 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
35 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
36 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
37 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
38 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
39 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
40 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
41 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
42 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
43 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
44 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45
45 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
46 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
47 INT339493 Binding of Irak1 and Irak3 1 0.02 0.17 0.41
48 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
49 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
50 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
51 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
52 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
53 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
54 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
55 INT90722 Nr4a1 Positive_regulation of Egr1 1 0.20 0.48 0.35
56 INT312124 EGR1 Regulation of Binding of PTGES 1 0.31 0.41 0.35
57 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
58 INT90724 Egr3 Positive_regulation of Egr1 1 0.33 0.48 0.35
59 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
60 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
61 INT229087 IL1R1 Negative_regulation of ACCS 1 0.03 0.86 0.33
62 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
63 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
64 INT100028 TNF Positive_regulation of Mapk3 1 0.22 0.79 0.32
65 INT255933 Tauph Positive_regulation of Rps6ka5 1 0.00 0.1 0.32
66 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
67 INT255945 MAPK14 Positive_regulation of Rps6ka5 1 0.06 0.1 0.32
68 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
69 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
70 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
71 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29
72 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
73 INT74334 Penk Regulation of Transcription of Egr1 1 0.40 0.25 0.29
74 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
75 INT74336 Crh Regulation of Transcription of Egr1 1 0.49 0.24 0.28
76 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28
77 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
78 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
79 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
80 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
81 INT147358 Egr1 Positive_regulation of Gene_expression of Gdf15 1 0.14 1.56 0.28
82 INT286701 Rps6ka5 Positive_regulation of Phosphorylation of Creb1 1 0.20 0.18 0.28
83 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28
84 INT166156 Ccr9 Positive_regulation of Mapk3 1 0.49 1.47 0.28
85 INT58182 Fos Regulation of Egr1 1 0.49 0.09 0.27
86 INT147359 Positive_regulation of Pik3cd Positive_regulation of Egr1 1 0.09 1.51 0.27
87 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
88 INT130931 Sis Negative_regulation of Egr1 1 0.01 0.52 0.27
89 INT58176 Junb Regulation of Egr1 1 0.46 0.09 0.27
90 INT147360 Pik3cd Positive_regulation of Egr1 1 0.12 1.51 0.27
91 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26
92 INT191876 Pbsn Positive_regulation of Mapk3 1 0.01 0.33 0.25
93 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
94 INT314045 THL Negative_regulation of Phosphorylation of Mapk3 1 0.13 0.7 0.25
95 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
96 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24
97 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
98 INT130060 PPARG Positive_regulation of Positive_regulation of Egr1 1 0.22 0.46 0.24
99 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24
100 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
101 INT191887 Pbsn Regulation of Phosphorylation of Mapk3 1 0.00 0.24 0.23
102 INT191879 Positive_regulation of Pbsn Negative_regulation of Positive_regulation of Mapk3 1 0.01 0.25 0.23
103 INT191885 Tlr4 Regulation of Phosphorylation of Mapk3 1 0.01 0.24 0.23
104 INT103359 Binding of Mapk3 and Mink1 1 0.09 0.17 0.22
105 INT184162 Egr1 Positive_regulation of Transcription of Ptges2 1 0.08 0.42 0.22
106 INT103356 Positive_regulation of Binding of Mapk1 and Mapk3 1 0.41 0.17 0.22
107 INT184160 Binding of Egr1 and Ptges2 1 0.07 0.4 0.22
108 INT103357 Binding of Mapk1 and Mapk3 1 0.32 0.17 0.22
109 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21
110 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21
111 INT259817 Ltp Positive_regulation of Egr1 1 0.03 0.28 0.2
112 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
113 INT306108 CCL2 Positive_regulation of Positive_regulation of Mapk3 1 0.03 0.15 0.2
114 INT127321 Gpx3 Regulation of Mapk3 1 0.00 0.27 0.2
115 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
116 INT259812 Gtf3a Regulation of Egr1 1 0.01 0.58 0.19
117 INT184159 Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
118 INT58178 Gtf3a Positive_regulation of Egr1 1 0.07 0.09 0.19
119 INT184161 Negative_regulation of Egr1 Positive_regulation of Ptges2 1 0.07 0.34 0.19
120 INT259814 Binding of Arc and Egr1 1 0.34 0.55 0.19
121 INT259813 Binding of Egr1 and Arc 1 0.32 0.55 0.19
122 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19
123 INT58181 Gtf3a Positive_regulation of Gene_expression of Egr1 1 0.07 0.1 0.19
124 INT312090 EGR1 Regulation of Positive_regulation of PTGES 1 0.42 0.21 0.18
125 INT121400 NTS Positive_regulation of Mapk3 1 0.46 0 0.18
126 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
127 INT317895 Fos Regulation of Transcription of Egr1 1 0.41 1.03 0.17
128 INT317897 Egr1 Regulation of Transcription of Fosb 1 0.34 1.08 0.17
129 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
130 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
131 INT317892 Egr1 Regulation of Transcription of Fos 1 0.41 1.03 0.17
132 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
133 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
134 INT146025 EGR1 Negative_regulation of Gene_expression of GDF15 1 0.28 0.81 0.15
135 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
136 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
137 INT168806 Tlr4 Positive_regulation of Gene_expression of Egr1 1 0.18 0.3 0.15
138 INT229088 IL1R1 Positive_regulation of Gene_expression of IL6 1 0.04 0.45 0.14
139 INT115140 PPARG Positive_regulation of EGR1 1 0.36 0.45 0.13
140 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
141 INT191877 Pbsn Positive_regulation of Phosphorylation of Mapk3 1 0.01 0.09 0.13
142 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
143 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
144 INT134401 Negative_regulation of MAPK3 Negative_regulation of Gene_expression of ARMC3 1 0.19 1.16 0.13
145 INT115141 TGM7 Positive_regulation of EGR1 1 0.26 0.44 0.13
146 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
147 INT191882 Tlr4 Positive_regulation of Phosphorylation of Mapk3 1 0.02 0.09 0.13
148 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
149 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
150 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
151 INT334257 Binding of Irak1 and Irak4 1 0.33 0.49 0.12
152 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
153 INT179424 Map2k2 Regulation of Mapk3 1 0.00 0.17 0.12
154 INT154803 Gene_expression of EGR1 Positive_regulation of Positive_regulation of GDF15 1 0.33 0.84 0.12
155 INT229089 IL1R1 Positive_regulation of IL6 1 0.03 0.45 0.12
156 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
157 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11
158 INT195121 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gopc 1 0.17 0.26 0.11
159 INT195119 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gfap 1 0.38 0.26 0.11
160 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1
161 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
162 INT339498 Binding of Il1rap and Positive_regulation of Irak1 1 0.01 0 0.1
163 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
164 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
165 INT334268 Irak4 Positive_regulation of Irak1 1 0.47 0.37 0.09
166 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
167 INT334255 Irak4 Positive_regulation of Phosphorylation of Irak1 1 0.32 0.38 0.09
168 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
169 INT115933 U Regulation of PLCB1 1 0.00 0.3 0.08
170 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
171 INT156839 Binding of CYP24A1 and MAPK3 1 0.31 0 0.07
172 INT179346 Pdgfa Positive_regulation of Positive_regulation of Mapk3 1 0.05 0.71 0.07
173 INT267016 Bdnf Positive_regulation of Egr1 1 0.12 0.09 0.07
174 INT129184 Gene_expression of EGR1 Positive_regulation of ATF3 1 0.72 0.22 0.07
175 INT156835 Binding of MAPK3 and TRPV6 1 0.21 0 0.07
176 INT179345 Pdgfa Positive_regulation of Mapk3 1 0.05 0.71 0.07
177 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
178 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
179 INT129183 EGR1 Negative_regulation of Positive_regulation of ATF3 1 0.44 0.19 0.06
180 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
181 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
182 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
183 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
184 INT191875 Pbsn Regulation of Gene_expression of Mapk3 1 0.01 0.13 0.05
185 INT191891 Prkca Regulation of Gene_expression of Mapk3 1 0.03 0.13 0.05
186 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
187 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
188 INT334259 Negative_regulation of Binding of Irak1 and Irak4 1 0.29 0.33 0.04
189 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
190 INT60221 Agt Regulation of Gene_expression of Egr1 1 0.42 0 0.04
191 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
192 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
193 INT243766 Binding of Egr1 and Proc 1 0.01 0.2 0.03
194 INT315167 Egfr Negative_regulation of Mapk3 1 0.04 0.83 0
195 INT348039 Binding of Myd88 and Irak2 1 0.22 0 0
196 INT165165 Dlat Positive_regulation of Positive_regulation of Mapk3 1 0.00 0 0
197 INT243318 MAPK3 Negative_regulation of FOS 1 0.04 0.14 0
198 INT346595 Binding of Mapk3 and Sh2d1b2 1 0.19 0.2 0
199 INT184955 EGR1 Regulation of Regulation of TGFB1 1 0.39 0.3 0
200 INT332409 Egr1 Regulation of Hgf 1 0.26 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-1-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-1-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
2 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
3 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
4 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
5 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
6 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
7 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
8 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
9 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
10 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
11 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
12 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
13 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
14 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
15 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
16 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
17 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
18 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
19 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
20 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
21 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
22 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
23 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
24 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
25 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5
26 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
27 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
28 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
29 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
30 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
31 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
32 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
33 INT57376 Transcription of EGR1 20 0.69 12.94 4.84
34 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
35 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45
36 INT181596 Binding of IL1R1 9 0.36 7.99 4.32
37 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
38 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
39 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
40 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
41 INT123502 Binding of Egr1 11 0.35 6.7 3.77
42 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
43 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
44 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
45 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
46 INT64437 Gene_expression of IL1R1 9 0.65 6.22 2.99
47 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84
48 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48
49 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47
50 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41
51 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
52 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
53 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
54 INT15243 Regulation of Egr1 19 0.61 7.6 2.13
55 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
56 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
57 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
58 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
59 INT67895 Negative_regulation of IL1R1 7 0.57 5.76 1.9
60 INT124559 Gene_expression of Il1r1 4 0.54 2.14 1.89
61 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87
62 INT73023 Binding of EGR1 7 0.48 4.23 1.86
63 INT85492 Localization of IL1R1 6 0.72 2.44 1.85
64 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
65 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
66 INT57375 Regulation of EGR1 5 0.40 1.94 1.78
67 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75
68 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
69 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
70 INT57877 Negative_regulation of Positive_regulation of Egr1 4 0.42 1.63 1.57
71 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
72 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
73 INT52873 Localization of Il1r1 4 0.56 1.28 1.48
74 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
75 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42
76 INT141344 Transcription of Egr1 11 0.70 5.59 1.34
77 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
78 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
79 INT124560 Negative_regulation of Il1r1 2 0.07 0.77 1.14
80 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
81 INT98633 Negative_regulation of Transcription of EGR1 3 0.43 0.79 1.11
82 INT98489 Binding of Il1r1 3 0.36 1.46 1.06
83 INT123503 Positive_regulation of Binding of Egr1 3 0.13 2.34 1.04
84 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03
85 INT123501 Negative_regulation of Binding of Egr1 2 0.12 2.04 0.99
86 INT51947 Regulation of Transcription of Egr1 2 0.59 0.15 0.96
87 INT151946 Positive_regulation of Regulation of Mapk3 1 0.16 1.31 0.96
88 INT98638 Positive_regulation of Transcription of EGR1 3 0.49 2.83 0.91
89 INT254188 Positive_regulation of Irak1 7 0.44 3.46 0.87
90 INT286689 Phosphorylation of Rps6ka5 2 0.53 0.51 0.84
91 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81
92 INT255849 Positive_regulation of Rps6ka5 2 0.36 0.45 0.81
93 INT95786 Positive_regulation of Positive_regulation of Mapk3 2 0.40 1.27 0.8
94 INT151626 Negative_regulation of Gene_expression of Il1r1 1 0.20 1.33 0.8
95 INT112947 Regulation of Il1r1 2 0.24 0.36 0.78
96 INT167081 Binding of Mapk3 2 0.29 0.27 0.76
97 INT112945 Transcription of Il1r1 1 0.39 0.32 0.76
98 INT98636 Negative_regulation of Positive_regulation of EGR1 3 0.58 2.21 0.73
99 INT6050 Localization of Egr1 4 0.68 0.53 0.7
100 INT195104 Positive_regulation of Il1r1 4 0.40 2.18 0.68
101 INT168411 Binding of Irak1 1 0.18 1.08 0.68
102 INT145697 Regulation of Phosphorylation of Mapk3 1 0.60 0.24 0.68
103 INT141341 Binding of Egr1 5 0.48 2.65 0.67
104 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
105 INT102686 Phosphorylation of Egr1 3 0.59 2.57 0.64
106 INT64438 Regulation of IL1R1 2 0.26 1.62 0.64
107 INT219030 Positive_regulation of Localization of Mapk3 1 0.34 0.49 0.63
108 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
109 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
110 INT337103 Positive_regulation of Phosphorylation of Rps6ka5 1 0.33 0.34 0.59
111 INT73020 Positive_regulation of Binding of EGR1 1 0.49 0.46 0.56
112 INT166018 Protein_catabolism of MAPK3 1 0.23 0.59 0.56
113 INT334219 Phosphorylation of Irak1 6 0.73 1.21 0.55
114 INT98632 Negative_regulation of EGR1 6 0.42 3.38 0.54
115 INT81061 Regulation of Negative_regulation of Egr1 1 0.22 0 0.53
116 INT334230 Negative_regulation of Irak1 2 0.38 0.3 0.51
117 INT284454 Binding of Tirap 4 0.26 2.07 0.49
118 INT168801 Localization of Egr1 4 0.78 0.7 0.48
119 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
120 INT67894 Transcription of IL1R1 4 0.67 2.17 0.45
121 INT141342 Negative_regulation of Transcription of Egr1 4 0.43 2.39 0.45
122 INT191861 Negative_regulation of Gene_expression of Mapk3 3 0.08 1.07 0.45
123 INT112709 Negative_regulation of Gene_expression of Mapk3 3 0.38 4.15 0.45
124 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
125 INT167980 Regulation of Regulation of Mapk3 1 0.07 0.92 0.45
126 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
127 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
128 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
129 INT339480 Negative_regulation of Positive_regulation of Irak3 1 0.05 0.12 0.41
130 INT243756 Regulation of Positive_regulation of Egr1 7 0.45 1.18 0.4
131 INT334241 Binding of Irak1 1 0.43 1.09 0.38
132 INT217464 Binding of Traf6 5 0.29 1.28 0.35
133 INT324756 Regulation of Irak1 5 0.40 0.87 0.35
134 INT144968 Positive_regulation of Localization of EGR1 1 0.69 0.82 0.35
135 INT74604 Negative_regulation of Gene_expression of PLCB1 1 0.41 0.25 0.35
136 INT201841 Negative_regulation of Negative_regulation of IL1R1 1 0.01 0.78 0.34
137 INT229092 Positive_regulation of Localization of IL1R1 1 0.14 0.41 0.34
138 INT144970 Localization of EGR1 1 0.80 0.82 0.34
139 INT119081 Negative_regulation of Gene_expression of MAPK3 2 0.41 2 0.33
140 INT149995 Negative_regulation of Mapk3 5 0.52 2.64 0.32
141 INT188498 Negative_regulation of Transcription of Egr1 3 0.41 0.14 0.32
142 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
143 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
144 INT59816 Positive_regulation of Gene_expression of PLCB1 2 0.49 0.22 0.31
145 INT235857 Binding of PLCB1 1 0.36 0.35 0.29
146 INT124558 Regulation of Gene_expression of Il1r1 1 0.07 0.29 0.28
147 INT121780 Regulation of Transcription of Mapk3 1 0.18 0.31 0.27
148 INT314021 Negative_regulation of Localization of Mapk3 1 0.12 1.52 0.27
149 INT121779 Transcription of Mapk3 1 0.48 0.31 0.27
150 INT314020 Localization of Mapk3 1 0.19 1.51 0.27
151 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
152 INT201860 Negative_regulation of Transcription of IL1R1 1 0.01 0.85 0.26
153 INT177838 Regulation of Gene_expression of EGR1 2 0.17 2.38 0.25
154 INT230491 Regulation of Il1r1 1 0.01 0.76 0.25
155 INT141343 Positive_regulation of Transcription of Egr1 1 0.47 1.43 0.24
156 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
157 INT157956 Regulation of Phosphorylation of PLCB1 1 0.00 0.22 0.22
158 INT346813 Positive_regulation of Regulation of Egr1 1 0.49 0.27 0.21
159 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
160 INT334224 Positive_regulation of Phosphorylation of Irak1 1 0.44 0.12 0.19
161 INT324780 Localization of Irak1 1 0.33 1.03 0.19
162 INT74602 Negative_regulation of Positive_regulation of PLCB1 1 0.41 0.25 0.19
163 INT102793 Regulation of Phosphorylation of Egr1 1 0.33 0 0.17
164 INT115159 Regulation of Positive_regulation of EGR1 1 0.20 0.18 0.16
165 INT229093 Negative_regulation of Localization of IL1R1 1 0.12 0.39 0.15
166 INT240987 Binding of Mapk3 1 0.19 0.15 0.15
167 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
168 INT298988 Positive_regulation of Gene_expression of Irak1 2 0.44 0.25 0.14
169 INT323746 Phosphorylation of IRAK1 1 0.46 0.81 0.12
170 INT280912 Gene_expression of Irak2 1 0.36 0.88 0.12
171 INT323732 Regulation of Gene_expression of IRAK1 1 0.26 0.82 0.12
172 INT346814 Phosphorylation of Egr1 1 0.62 0 0.12
173 INT346495 Positive_regulation of Irak1 1 0.45 0.33 0.11
174 INT335789 Negative_regulation of Transcription of IRAK1 1 0.22 0.45 0.11
175 INT335817 Transcription of IRAK1 1 0.35 0.45 0.11
176 INT335806 Negative_regulation of IRAK1 1 0.30 0.36 0.1
177 INT270150 Positive_regulation of Positive_regulation of Irak1 3 0.25 0.91 0.09
178 INT346807 Regulation of Transcription of Egr1 1 0.44 0.27 0.09
179 INT270154 Regulation of Positive_regulation of Irak1 1 0.19 0.48 0.09
180 INT334238 Positive_regulation of Binding of Irak1 1 0.44 0.14 0.09
181 INT59820 Regulation of Gene_expression of PLCB1 1 0.44 0 0.09
182 INT115930 Regulation of PLCB1 1 0.02 0.29 0.08
183 INT334231 Positive_regulation of Regulation of Irak1 1 0.44 0.63 0.08
184 INT74606 Regulation of Negative_regulation of PLCB1 1 0.44 0.19 0.07
185 INT320268 Positive_regulation of Negative_regulation of EGR1 1 0.26 0.69 0.07
186 INT334235 Negative_regulation of Binding of Irak1 1 0.38 0.33 0.04
187 INT59814 Positive_regulation of Negative_regulation of PLCB1 1 0.45 0 0.04
188 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
189 INT265554 Transcription of Mapk3 1 0.14 0.87 0
190 INT149993 Positive_regulation of Gene_expression of Mapk3 1 0.39 0 0
191 INT298986 Positive_regulation of Gene_expression of Traf6 1 0.23 0.4 0
192 INT254185 Positive_regulation of Tirap 1 0.32 0 0
193 INT254183 Regulation of Positive_regulation of Tirap 1 0.29 0 0
194 INT285638 Regulation of Negative_regulation of Egr1 1 0.37 0.14 0
195 INT254176 Positive_regulation of Positive_regulation of Tirap 1 0.32 0 0
196 INT298982 Positive_regulation of Positive_regulation of Traf6 1 0.23 0.4 0
197 INT149992 Regulation of Gene_expression of Mapk3 1 0.21 0 0
198 INT129753 Regulation of Localization of Mapk3 1 0.44 0 0
199 INT347997 Phosphorylation of Irak2 1 0.38 0 0
200 INT265550 Negative_regulation of Transcription of Mapk3 1 0.09 0.88 0
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