GO:0070527

From wiki-pain
Jump to: navigation, search
Name platelet aggregation
Categary Process
Go Slim No
Go Link GO:0070527
Unique Molecular Interactions 104
Total Molecular Interactions 125
Total Single Events 832
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for platelet aggregation. They are ordered first by their pain relevance and then by number of times they were reported for platelet aggregation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
2 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
3 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
4 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
5 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
6 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
7 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
8 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
9 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
10 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
11 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
12 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
13 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
14 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
15 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
16 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
17 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
18 INT118127 Binding of STXBP3 and Stx4 1 0.01 0.24 0.15
19 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
20 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
21 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
22 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
23 INT118126 Binding of STXBP3 and Snap23 1 0.18 0.24 0.15
24 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
25 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
26 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
27 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12
28 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
29 INT119454 Regulation of Binding of Itga2b and Gtf3a 1 0.00 0.14 0.1
30 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
31 INT119455 Binding of Itga2b and Gtf3a 1 0.00 0.14 0.1
32 INT119456 Binding of Itga2b and Fgg 1 0.00 0.14 0.1
33 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09
34 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
35 INT118417 Gata1 Regulation of Gene_expression of Serpinb9g 1 0.17 0.12 0.06
36 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
37 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
38 INT341021 Positive_regulation of Cp Positive_regulation of Positive_regulation of PIK3CB 1 0.00 0.15 0.04
39 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
40 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
41 INT341016 Reln Positive_regulation of Positive_regulation of PIK3CB 1 0.01 0.15 0.04
42 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
43 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0
44 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
45 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
46 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0
47 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
48 INT336033 PIK3CG Regulation of AKT1 1 0.03 0.43 0
49 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
50 INT340927 Negative_regulation of PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
51 INT176137 Negative_regulation of Binding of AKT1 and PIK3CG 1 0.17 0.25 0
52 INT341025 PIK3CB Positive_regulation of Regulation of Vim 1 0.01 0 0
53 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0
54 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0
55 INT354122 MIR126 Regulation of PIK3CG 1 0.03 2.01 0
56 INT233267 Hoxa10 Regulation of Itgb3 1 0.15 0.14 0
57 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
58 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0
59 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
60 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
61 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
62 INT340929 VLDLR Positive_regulation of PIK3CB 1 0.01 0.06 0
63 INT225903 Binding of GAB1 and PIK3CG 1 0.01 0.13 0
64 INT201773 Binding of BCL2L1 and Positive_regulation of Negative_regulation of PIK3CG 1 0.01 0.3 0
65 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0
66 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0
67 INT250666 ERBB2 Positive_regulation of PIK3CB 1 0.15 0.69 0
68 INT225876 PIK3CG Positive_regulation of Ilk 1 0.00 0 0
69 INT341020 PIK3CB Regulation of Gene_expression of Fabp7 1 0.02 0 0
70 INT250718 PIK3CB Regulation of Gene_expression of Birc5 1 0.23 0.91 0
71 INT293806 AR Positive_regulation of PIK3CG 1 0.06 0.12 0
72 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
73 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
74 INT275985 Binding of PLEK and Gp6 1 0.29 0 0
75 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0
76 INT340924 PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
77 INT270084 Binding of PLEK and PSMG1 1 0.09 0.26 0
78 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
79 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
80 INT294828 DPYD Positive_regulation of PIK3CB 1 0.00 0.51 0
81 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
82 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
83 INT347290 Positive_regulation of CCL16 Positive_regulation of PIK3CB 1 0.03 0.57 0
84 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
85 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
86 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
87 INT293816 Binding of AR and PIK3CG 1 0.03 0.27 0
88 INT250664 PIK3CB Positive_regulation of AKT1 1 0.09 0.62 0
89 INT225894 Binding of MET and PIK3CG 1 0.00 0.13 0
90 INT233270 Meis1 Regulation of Gene_expression of Itgb3 1 0.47 0 0
91 INT201759 Ngf Positive_regulation of PIK3CG 1 0.01 0.84 0
92 INT250660 PIK3CB Negative_regulation of AKT1 1 0.09 0.83 0
93 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
94 INT223578 INS Positive_regulation of PIK3CG 1 0.05 0.87 0
95 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
96 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0
97 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
98 INT341022 PIK3CB Regulation of Gene_expression of Erbb3 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for platelet aggregation. They are ordered first by their pain relevance and then by number of times they were reported in platelet aggregation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
2 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
3 INT18412 Binding of PLEK 49 0.47 17.82 10.72
4 INT3366 Localization of PLEK 44 0.78 15.83 9.55
5 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
6 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
7 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
8 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
9 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
10 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
11 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
12 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
13 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
14 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
15 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
16 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
17 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
18 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34
19 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
20 INT79840 Binding of Itga2b 4 0.16 2.51 1.28
21 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
22 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
23 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
24 INT250708 Negative_regulation of PIK3CB 17 0.30 3.09 0.94
25 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
26 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
27 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
28 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
29 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
30 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
31 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
32 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
33 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
34 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
35 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
36 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
37 INT83273 Gene_expression of Itga2b 4 0.34 6.95 0.46
38 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
39 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
40 INT132780 Positive_regulation of Phosphorylation of PIK3CG 1 0.01 0.37 0.4
41 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
42 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
43 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
44 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
45 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
46 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
47 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
48 INT119451 Negative_regulation of Itga2b 1 0.04 0.35 0.26
49 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25
50 INT125780 Negative_regulation of Itgb3 2 0.39 0.66 0.25
51 INT250712 Regulation of PIK3CB 2 0.15 0.88 0.25
52 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22
53 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
54 INT42593 Transcription of PLEK 1 0.67 0 0.2
55 INT178118 Positive_regulation of PIK3CB 12 0.32 5.06 0.19
56 INT91278 Positive_regulation of Itgb3 4 0.31 1.73 0.19
57 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18
58 INT233246 Localization of Itgb3 3 0.54 0.25 0.17
59 INT239859 Protein_catabolism of Itgb3 1 0.64 0.25 0.17
60 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
61 INT151741 Regulation of PDGFRA 2 0.44 0.78 0.16
62 INT83274 Negative_regulation of Gene_expression of Itga2b 2 0.11 1.71 0.16
63 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
64 INT118123 Localization of STXBP3 1 0.48 0.24 0.14
65 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
66 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
67 INT91498 Positive_regulation of Itga2b 1 0.22 0.49 0.13
68 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
69 INT233217 Gene_expression of Itgb3 16 0.75 0.98 0.11
70 INT262775 Negative_regulation of Phosphorylation of PIK3CG 1 0.28 1.1 0.09
71 INT233253 Regulation of Gene_expression of Itgb3 1 0.41 0.34 0.09
72 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08
73 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
74 INT232713 Binding of PDGFRA 1 0.35 1.43 0.08
75 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07
76 INT200602 Positive_regulation of Gene_expression of Itga2b 1 0.04 1.21 0.07
77 INT200608 Regulation of Gene_expression of Itga2b 1 0.04 1.03 0.05
78 INT341853 Negative_regulation of Negative_regulation of PIK3CG 1 0.14 0.85 0.04
79 INT201693 Negative_regulation of Positive_regulation of PIK3CG 1 0.05 1.04 0.04
80 INT176162 Binding of PIK3CG 5 0.15 1.3 0.03
81 INT250703 Negative_regulation of Negative_regulation of PIK3CB 2 0.20 1.16 0.03
82 INT219663 Binding of Itgb3 1 0.08 1.18 0.03
83 INT233234 Negative_regulation of Gene_expression of Itgb3 3 0.29 0.65 0
84 INT250702 Positive_regulation of Gene_expression of PIK3CB 3 0.23 1.79 0
85 INT347315 Binding of PIK3CB 2 0.19 1.57 0
86 INT176151 Regulation of Negative_regulation of PIK3CG 2 0.28 0.92 0
87 INT340980 Negative_regulation of Positive_regulation of PIK3CB 2 0.12 0.59 0
88 INT322525 Phosphorylation of PIK3CB 2 0.42 1.09 0
89 INT214465 Localization of Wnt3a 2 0.52 0.29 0
90 INT251053 Gene_expression of Wnt3a 2 0.47 0.5 0
91 INT326853 Positive_regulation of Gene_expression of Wnt3a 1 0.36 0.2 0
92 INT200603 Regulation of Itga2b 1 0.01 0.18 0
93 INT233231 Regulation of Transcription of Itgb3 1 0.30 0.12 0
94 INT352608 Binding of Pdgfra 1 0.27 0.7 0
95 INT251054 Regulation of Localization of Wnt3a 1 0.27 0.07 0
96 INT233238 Negative_regulation of Localization of Itgb3 1 0.29 0 0
97 INT180099 Binding of Plek 1 0.02 0 0
98 INT295427 Localization of PDGFRA 1 0.40 1.04 0
99 INT340989 Localization of PIK3CB 1 0.06 0 0
100 INT233251 Regulation of Localization of Itgb3 1 0.30 0 0
101 INT352609 Positive_regulation of Gene_expression of Pdgfra 1 0.58 1.18 0
102 INT193985 Regulation of Phosphorylation of PIK3CG 1 0.03 0.32 0
103 INT251066 Regulation of Gene_expression of Wnt3a 1 0.31 0.07 0
104 INT271099 Regulation of Gene_expression of PIK3CB 1 0.08 0.62 0
105 INT176159 Regulation of Positive_regulation of PIK3CG 1 0.18 0.21 0
106 INT322533 Negative_regulation of Gene_expression of PIK3CB 1 0.11 0.57 0
107 INT200836 Transcription of Pdgfra 1 0.30 0.26 0
108 INT262679 Phosphorylation of Gata1 1 0.18 0.55 0
109 INT233240 Negative_regulation of Transcription of Itgb3 1 0.29 0 0
110 INT233257 Transcription of Itgb3 1 0.48 0.11 0
111 INT340998 Positive_regulation of Positive_regulation of PIK3CB 1 0.04 0.14 0
112 INT233227 Positive_regulation of Transcription of Itgb3 1 0.47 0.12 0
113 INT322530 Negative_regulation of Phosphorylation of PIK3CB 1 0.15 0.24 0
114 INT326843 Negative_regulation of Gene_expression of Wnt3a 1 0.22 0.29 0
115 INT233228 Regulation of Itgb3 1 0.30 0 0
116 INT262696 Binding of Gata1 1 0.08 0.56 0
117 INT322527 Regulation of Negative_regulation of PIK3CB 1 0.07 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox