GO:0070530

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Name K63-linked polyubiquitin binding
Categary Function
Go Slim No
Go Link GO:0070530
Unique Molecular Interactions 23
Total Molecular Interactions 35
Total Single Events 91
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for K63-linked polyubiquitin binding. They are ordered first by their pain relevance and then by number of times they were reported for K63-linked polyubiquitin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24
2 INT153738 TNFRSF11A Positive_regulation of SQSTM1 1 0.05 1.22 0.13
3 INT313308 Binding of SQSTM1 and KEAP1 1 0.46 1.16 0.1
4 INT313301 SQSTM1 Regulation of Protein_catabolism of KEAP1 1 0.43 0.58 0.1
5 INT217486 Binding of PDB1 and Sqstm1 1 0.03 1.19 0.08
6 INT237670 SQSTM1 Regulation of PDB1 1 0.34 1.13 0.06
7 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
8 INT316056 Binding of Ncor2 and Tab2 1 0.12 0.41 0.03
9 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03
10 INT313305 SQSTM1 Regulation of NFE2L2 1 0.35 0.09 0
11 INT313298 Negative_regulation of SQSTM1 Positive_regulation of KEAP1 1 0.39 0.39 0
12 INT313297 SQSTM1 Positive_regulation of Positive_regulation of NFE2L2 1 0.26 0 0
13 INT313304 Binding of SQSTM1 and GOPC 1 0.04 0.24 0
14 INT237669 Binding of PDB1 and SQSTM1 1 0.27 2.55 0
15 INT188435 PDB1 Negative_regulation of Binding of SQSTM1 1 0.41 0.49 0
16 INT313303 Negative_regulation of SQSTM1 Positive_regulation of GOPC 1 0.05 0.39 0
17 INT313292 Positive_regulation of SQSTM1 Regulation of NFE2L2 1 0.26 0.09 0
18 INT313295 Binding of SQSTM1 and GABARAPL2 1 0.32 0.13 0
19 INT313310 KEAP1 Regulation of Gene_expression of SQSTM1 1 0.43 0.35 0
20 INT313302 Regulation of TERT Positive_regulation of SQSTM1 1 0.01 0 0
21 INT313311 SQSTM1 Positive_regulation of Positive_regulation of KEAP1 1 0.45 0 0
22 INT313291 TERT Positive_regulation of SQSTM1 1 0.02 0 0
23 INT313294 Negative_regulation of SQSTM1 Positive_regulation of Positive_regulation of KEAP1 1 0.39 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for K63-linked polyubiquitin binding. They are ordered first by their pain relevance and then by number of times they were reported in K63-linked polyubiquitin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13243 Gene_expression of Sqstm1 4 0.30 2.07 2.06
2 INT217442 Regulation of Sqstm1 3 0.59 3.86 0.65
3 INT188448 Negative_regulation of SQSTM1 4 0.53 3.75 0.55
4 INT188444 Binding of SQSTM1 5 0.44 4.69 0.54
5 INT194031 Regulation of SQSTM1 2 0.41 2.07 0.27
6 INT141896 Positive_regulation of SQSTM1 6 0.50 5.58 0.26
7 INT313313 Positive_regulation of Gene_expression of SQSTM1 1 0.63 1.25 0.23
8 INT257782 Localization of TAB2 1 0.36 0.36 0.23
9 INT257783 Phosphorylation of TAB2 1 0.37 0.38 0.21
10 INT119542 Positive_regulation of Sqstm1 1 0.21 0.62 0.19
11 INT188446 Gene_expression of SQSTM1 5 0.71 5.34 0.18
12 INT231574 Binding of TAB2 2 0.04 0.35 0.15
13 INT313318 Negative_regulation of Localization of SQSTM1 1 0.39 0.59 0.14
14 INT313320 Localization of SQSTM1 1 0.68 0.59 0.14
15 INT313312 Positive_regulation of Binding of SQSTM1 1 0.46 0.44 0.11
16 INT217445 Positive_regulation of Binding of Sqstm1 1 0.48 0.39 0
17 INT313326 Regulation of Negative_regulation of SQSTM1 1 0.41 0 0
18 INT313315 Protein_catabolism of SQSTM1 1 0.52 0.12 0
19 INT285452 Regulation of Gene_expression of SQSTM1 1 0.09 0 0
20 INT217444 Binding of Sqstm1 1 0.46 0.38 0
21 INT313314 Positive_regulation of Negative_regulation of SQSTM1 1 0.40 0 0
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