GO:0070534

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Name protein K63-linked ubiquitination
Categary Process
Go Slim No
Go Link GO:0070534
Unique Molecular Interactions 138
Total Molecular Interactions 182
Total Single Events 1040
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein K63-linked ubiquitination. They are ordered first by their pain relevance and then by number of times they were reported for protein K63-linked ubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
3 INT141911 Arih2 Regulation of Positive_regulation of Cpox 1 0.01 1.19 0.76
4 INT141910 Arih2 Regulation of Cpox 1 0.01 1.19 0.76
5 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
6 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
7 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
8 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
9 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
10 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
11 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
12 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
13 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
14 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
15 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
16 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
17 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
18 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
19 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
20 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
21 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
22 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
23 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
24 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
25 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
26 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
27 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
28 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
29 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
30 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
31 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
32 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
33 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
34 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
35 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
36 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
37 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
38 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
39 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
40 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
41 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
42 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
43 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
44 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
45 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
46 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
47 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
48 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
49 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
50 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
51 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
52 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
53 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
54 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
55 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
56 INT304190 Binding of HP and ZFP91 1 0.00 2.74 0.03
57 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
58 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
59 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
60 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
61 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
62 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
63 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
64 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
65 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
66 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
67 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
68 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
69 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
70 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
71 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
72 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
73 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
74 INT317300 Binding of Park2 and Pink1 1 0.48 1.23 0
75 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0
76 INT342727 Pink1 Positive_regulation of Park2 1 0.29 0.62 0
77 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
78 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
79 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
80 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
81 INT348020 Binding of Traf6 and Irak2 1 0.13 0.05 0
82 INT333033 Binding of Itch and Laptm5 1 0.01 0 0
83 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
84 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0
85 INT348037 Irak2 Positive_regulation of Binding of Traf6 1 0.18 0.05 0
86 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
87 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
88 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 0.09 0 0
89 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
90 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
91 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
92 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
93 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
94 INT243628 Binding of Nfatc2 and Stub1 1 0.06 0 0
95 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
96 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
97 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
98 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
99 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
100 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0
101 INT333031 Binding of Itch and Mul1 1 0.02 0 0
102 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein K63-linked ubiquitination. They are ordered first by their pain relevance and then by number of times they were reported in protein K63-linked ubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
4 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
5 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
6 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
7 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
8 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
9 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
10 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
11 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
12 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
13 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
14 INT190067 Binding of Traf2 5 0.20 3.28 1.27
15 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
16 INT91610 Binding of ZFP91 4 0.31 2.86 1.11
17 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
18 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
19 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
20 INT53930 Positive_regulation of ZFP91 2 0.02 0.8 0.93
21 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
22 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
23 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
24 INT122497 Gene_expression of UBE2S 2 0.58 0.8 0.64
25 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
26 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
27 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
28 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
29 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
30 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
31 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
32 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
33 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
34 INT346819 Negative_regulation of ZFP91 1 0.36 0.97 0.55
35 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
36 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
37 INT60752 Gene_expression of ZFP91 6 0.58 2.55 0.53
38 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
39 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
40 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
41 INT89258 Localization of STUB1 3 0.14 0.67 0.49
42 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
43 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
44 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
45 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
46 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
47 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
48 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
49 INT217464 Binding of Traf6 5 0.29 1.28 0.35
50 INT50848 Regulation of ZFP91 5 0.38 2.45 0.35
51 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
52 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
53 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
54 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
55 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
56 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
57 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
58 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
59 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
60 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
61 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
62 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
63 INT203471 Localization of Stub1 1 0.23 0.5 0.21
64 INT168693 Negative_regulation of Binding of Nedd4 1 0.31 0.29 0.21
65 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
66 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
67 INT168696 Positive_regulation of Binding of Nedd4 1 0.34 0.29 0.21
68 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
69 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
70 INT252702 Binding of TRAF2 3 0.23 2.21 0.16
71 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
72 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
73 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
74 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
75 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
76 INT251559 Binding of Traf2 1 0.23 1.68 0.13
77 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
78 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
79 INT114041 Regulation of Arih2 1 0.34 0.25 0.09
80 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
81 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
82 INT184167 Binding of STUB1 5 0.07 0.72 0.08
83 INT243617 Binding of Stub1 3 0.09 0.16 0.08
84 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
85 INT321381 Localization of Arih2 1 0.08 1.63 0.08
86 INT342696 Gene_expression of Park2 1 0.65 1.19 0.08
87 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
88 INT247556 Binding of Ube2e3 2 0.07 1.24 0.04
89 INT317299 Binding of Park2 1 0.36 0.61 0.04
90 INT304195 Localization of ZFP91 1 0.09 1.59 0.04
91 INT290597 Transcription of ZFP91 1 0.04 1.58 0.04
92 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
93 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
94 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
95 INT196230 Regulation of STUB1 2 0.05 0.8 0
96 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
97 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
98 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
99 INT342695 Phosphorylation of Park2 1 0.79 0.62 0
100 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
101 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
102 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
103 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
104 INT342089 Regulation of Gene_expression of Stub1 1 0.02 0.16 0
105 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
106 INT276616 Binding of UBE2S 1 0.01 0.25 0
107 INT333019 Binding of Itch 1 0.13 0 0
108 INT298986 Positive_regulation of Gene_expression of Traf6 1 0.23 0.4 0
109 INT222849 Gene_expression of Traf2 1 0.12 0.38 0
110 INT333021 Negative_regulation of Positive_regulation of Itch 1 0.14 0 0
111 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
112 INT298982 Positive_regulation of Positive_regulation of Traf6 1 0.23 0.4 0
113 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
114 INT252712 Phosphorylation of TRAF2 1 0.28 1.38 0
115 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
116 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0
117 INT313091 Negative_regulation of Stub1 1 0.07 0.25 0
118 INT304198 Positive_regulation of Gene_expression of ZFP91 1 0.05 0.85 0
119 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
120 INT333024 Positive_regulation of Itch 1 0.17 0 0
121 INT247561 Positive_regulation of Binding of Ube2e3 1 0.09 0.64 0
122 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
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