GO:0070555

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Name response to interleukin-1
Categary Process
Go Slim No
Go Link GO:0070555
Unique Molecular Interactions 769
Total Molecular Interactions 993
Total Single Events 7123
Pain Genes Associated 60

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-1. They are ordered first by their pain relevance and then by number of times they were reported for response to interleukin-1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38
2 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
3 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
4 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
5 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
6 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
7 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
8 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
9 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
10 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
11 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
12 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
13 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
14 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
15 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
16 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
17 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
18 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
19 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
20 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
21 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
22 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
23 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
24 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
25 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
26 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
27 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
28 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
29 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
30 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
31 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
32 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
33 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
34 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
35 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
36 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
37 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
38 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
39 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
40 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
41 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
42 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
43 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
44 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
45 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
46 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
47 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
48 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
49 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
50 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
51 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
52 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
53 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
54 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
55 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
56 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
57 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
58 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
59 INT256357 Phosphorylation of Rela Positive_regulation of Localization of Ik 1 0.00 0.05 0.96
60 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
61 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95
62 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
63 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
64 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
65 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
66 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
67 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
68 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
69 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
70 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
71 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
72 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
73 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88
74 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
75 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
76 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
77 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
78 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
79 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
80 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
81 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
82 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
83 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
84 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
85 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
86 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
87 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
88 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
89 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
90 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
91 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
92 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
93 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
94 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
95 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
96 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
97 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
98 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
99 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
100 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
101 INT228494 Binding of Ncoa5 and Rela 1 0.00 1.58 0.72
102 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
103 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
104 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
105 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
106 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
107 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
108 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
109 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7
110 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
111 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
112 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
113 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
114 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
115 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
116 INT334128 Acsm3 Positive_regulation of Sele 1 0.16 1.6 0.66
117 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
118 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
119 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
120 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
121 INT113338 Binding of EPO and KNCN 1 0.02 1.39 0.62
122 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
123 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
124 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
125 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
126 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
127 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
128 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
129 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
130 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
131 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
132 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
133 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
134 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56
135 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
136 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
137 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
138 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
139 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
140 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
141 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
142 INT176340 CHI3L1 Positive_regulation of Localization of CSF2 1 0.11 1.86 0.55
143 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
144 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
145 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
146 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
147 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
148 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
149 INT187101 Selp Regulation of Sele 1 0.20 1.23 0.53
150 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
151 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
152 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
153 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
154 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
155 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
156 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
157 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
158 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
159 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
160 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
161 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
162 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
163 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
164 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
165 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
166 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
167 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
168 INT203104 MMP3 Positive_regulation of Gene_expression of IFN1@ 1 0.25 0.33 0.48
169 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
170 INT341427 EPO Positive_regulation of BDNF 1 0.52 0.36 0.48
171 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
172 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
173 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
174 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
175 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
176 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
177 INT250858 Mmp3 Regulation of Protein_catabolism of Ecm1 1 0.01 1.11 0.47
178 INT341425 EPO Regulation of BDNF 1 0.51 0.5 0.47
179 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
180 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
181 INT138159 IL6 Positive_regulation of Gene_expression of Mmp3 1 0.00 0.23 0.46
182 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
183 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
184 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
185 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
186 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
187 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
188 INT138160 IL1B Positive_regulation of Gene_expression of Mmp3 1 0.03 0.23 0.46
189 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
190 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45
191 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
192 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
193 INT256356 Binding of Nfkb1 and Rela 1 0.21 0 0.44
194 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
195 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
196 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43
197 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
198 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
199 INT107704 IL1B Positive_regulation of Localization of RELA 1 0.02 0.13 0.41
200 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-1. They are ordered first by their pain relevance and then by number of times they were reported in response to interleukin-1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
4 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
5 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
6 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
7 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
8 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
9 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
10 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
11 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92
12 INT117527 Binding of Prkca 25 0.48 6.43 21.05
13 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
14 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41
15 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
16 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78
17 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
18 INT79458 Localization of Prkca 30 0.81 11.13 15.78
19 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
20 INT81486 Localization of MMP3 31 0.81 12.94 15.21
21 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
22 INT93482 Localization of Rela 56 0.78 24.52 14.82
23 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66
24 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
25 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75
26 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
27 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
28 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
29 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
30 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
31 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
32 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
33 INT158070 Localization of Aes 23 0.65 19.93 10.9
34 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16
35 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
36 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
37 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
38 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
39 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
40 INT66213 Localization of RELA 63 0.78 14.71 8.77
41 INT150422 Positive_regulation of Aes 24 0.43 15.63 8
42 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
43 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
44 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
45 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
46 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
47 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18
48 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05
49 INT3098 Positive_regulation of Epo 46 0.70 28.27 7
50 INT264641 Binding of AES 25 0.42 18.56 6.98
51 INT52180 Binding of Aes 38 0.42 23.16 6.7
52 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67
53 INT256345 Phosphorylation of Rela 21 0.75 9.51 6.56
54 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
55 INT3738 Regulation of Epo 25 0.61 13.73 6.18
56 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
57 INT188844 Gene_expression of AES 44 0.58 33.94 5.85
58 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84
59 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
60 INT9895 Binding of GHR 18 0.36 4.8 5.65
61 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
62 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
63 INT100222 Binding of Src 9 0.26 5.41 5.37
64 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
65 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
66 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27
67 INT62525 Positive_regulation of SELE 38 0.70 46 5.25
68 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
69 INT201130 Localization of AES 31 0.63 25.45 5.12
70 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12
71 INT107242 Binding of MMP3 14 0.47 12.06 5.11
72 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
73 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97
74 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
75 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
76 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
77 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
78 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
79 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
80 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
81 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71
82 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
83 INT121954 Binding of Mthfr 17 0.44 13.47 4.66
84 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
85 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
86 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
87 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
88 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
89 INT20459 Regulation of Ripk2 5 0.44 0 4.53
90 INT54895 Binding of Epo 24 0.48 11.38 4.48
91 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
92 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
93 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
94 INT181596 Binding of IL1R1 9 0.36 7.99 4.32
95 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
96 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25
97 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19
98 INT93483 Negative_regulation of Localization of Rela 11 0.57 5.1 4.19
99 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
100 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17
101 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
102 INT158377 Positive_regulation of Positive_regulation of Rela 6 0.49 3.08 4.11
103 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98
104 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
105 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
106 INT142754 Binding of Myd88 20 0.36 9.61 3.8
107 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74
108 INT133550 Negative_regulation of Gene_expression of Rela 14 0.40 4.64 3.73
109 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
110 INT63979 Regulation of Sele 13 0.54 10.64 3.7
111 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68
112 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
113 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65
114 INT122327 Regulation of Src 6 0.59 0.59 3.6
115 INT195527 Binding of Rela 17 0.25 4.42 3.56
116 INT61253 Negative_regulation of Sele 13 0.57 11.68 3.56
117 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5
118 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
119 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
120 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
121 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39
122 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
123 INT172689 Localization of Mmp3 15 0.68 5.52 3.32
124 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
125 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
126 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
127 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22
128 INT133557 Transcription of Rela 6 0.52 3.86 3.2
129 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
130 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
131 INT53065 Negative_regulation of Gene_expression of EPO 15 0.49 16.39 3.12
132 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
133 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
134 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
135 INT123595 Regulation of Snca 7 0.62 4.3 3.06
136 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
137 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
138 INT64437 Gene_expression of IL1R1 9 0.65 6.22 2.99
139 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92
140 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
141 INT51460 Negative_regulation of Gene_expression of Sele 8 0.52 10.18 2.89
142 INT45503 Binding of EPO 42 0.48 24.85 2.88
143 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88
144 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84
145 INT123139 Binding of Mmp3 7 0.37 1.98 2.84
146 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
147 INT8112 Regulation of EPO 38 0.58 22.04 2.76
148 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
149 INT153221 Positive_regulation of Rela 5 0.16 2.16 2.72
150 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
151 INT81411 Negative_regulation of Sele 8 0.38 7 2.7
152 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
153 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
154 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64
155 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
156 INT122424 Gene_expression of Prkci 1 0.58 0 2.56
157 INT8111 Localization of EPO 32 0.81 19.53 2.54
158 INT124417 Gene_expression of Mthfr 8 0.60 8.65 2.53
159 INT151309 Positive_regulation of Positive_regulation of MMP3 5 0.60 2.62 2.5
160 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
161 INT141195 Negative_regulation of Rela 14 0.29 8.61 2.44
162 INT162518 Positive_regulation of Localization of Rela 12 0.47 1.96 2.41
163 INT338117 Negative_regulation of Transcription of Mmp3 1 0.09 1.01 2.4
164 INT22019 Regulation of GHR 9 0.62 2.56 2.39
165 INT73671 Regulation of Gene_expression of Sele 8 0.45 7.01 2.39
166 INT120124 Transcription of MMP3 9 0.69 2.15 2.38
167 INT45597 Negative_regulation of Epo 22 0.59 12.47 2.35
168 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
169 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
170 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
171 INT173850 Negative_regulation of Localization of MMP3 3 0.48 3.32 2.25
172 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
173 INT121706 Negative_regulation of Positive_regulation of MMP3 4 0.38 2.68 2.19
174 INT9119 Negative_regulation of TAF9 4 0.42 5.21 2.16
175 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
176 INT262317 Binding of TAF9 7 0.31 9.67 2.15
177 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
178 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
179 INT93718 Protein_catabolism of Mmp3 9 0.73 4.32 2.11
180 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09
181 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07
182 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
183 INT122423 Negative_regulation of Gene_expression of Prkci 1 0.43 0 2.04
184 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
185 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
186 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
187 INT142049 Regulation of Mthfr 6 0.41 4.73 2
188 INT11905 Protein_catabolism of EPO 6 1.00 2.36 2
189 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
190 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95
191 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
192 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94
193 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
194 INT67895 Negative_regulation of IL1R1 7 0.57 5.76 1.9
195 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
196 INT124559 Gene_expression of Il1r1 4 0.54 2.14 1.89
197 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89
198 INT127125 Localization of Snca 6 0.81 8.24 1.88
199 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
200 INT144649 Negative_regulation of Positive_regulation of Rela 11 0.26 8.27 1.87
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