GO:0070557

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Name PCNA-p21 complex
Categary Component
Go Slim No
Go Link GO:0070557
Unique Molecular Interactions 108
Total Molecular Interactions 145
Total Single Events 1322
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for PCNA-p21 complex. They are ordered first by their pain relevance and then by number of times they were reported for PCNA-p21 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
4 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
5 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
6 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
7 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
8 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
9 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
10 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
11 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
12 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
13 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
14 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
15 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
16 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
17 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
18 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
19 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
20 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
21 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
22 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
23 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
24 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
25 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
26 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
27 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
28 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
29 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
30 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
31 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
32 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
33 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
34 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
35 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
36 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
37 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
38 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
39 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
40 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
41 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
42 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
43 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
44 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03
45 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
46 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
47 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
48 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
49 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
50 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
51 INT269932 Pcna Negative_regulation of Cdkn2b 1 0.09 0.07 0
52 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
53 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
54 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
55 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
56 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
57 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
58 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
59 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
60 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
61 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
62 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
63 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
64 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
65 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
66 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
67 INT269926 Cdkn2b Negative_regulation of Pcna 1 0.08 0.07 0
68 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
69 INT233274 Tpt1 Regulation of Cdkn1a 1 0.05 0.26 0
70 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
71 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
72 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0
73 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
74 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0
75 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
76 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
77 INT182935 KCNIP3 Regulation of CDKN1A 1 0.45 0.96 0
78 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
79 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
80 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
81 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0
82 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
83 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
84 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
85 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
86 INT269914 Tpt1 Negative_regulation of Pcna 1 0.08 0.07 0
87 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
88 INT238401 PPARA Positive_regulation of Gene_expression of CDKN1A 1 0.11 0.48 0
89 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0
90 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0
91 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0
92 INT182917 Binding of VDR and Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.31 0
93 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
94 INT338972 Binding of CDKN1A and TP53 1 0.10 0.98 0
95 INT269952 Pcna Negative_regulation of Tpt1 1 0.09 0.07 0
96 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
97 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
98 INT277694 Cdkn1a Positive_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
99 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
100 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
101 INT182931 VDR Positive_regulation of Gene_expression of CDKN1A 1 0.48 0.86 0
102 INT182911 KCNIP3 Positive_regulation of CDKN1A 1 0.51 0.35 0
103 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0
104 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0
105 INT182915 Binding of CDKN1A and KCNIP3 1 0.35 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for PCNA-p21 complex. They are ordered first by their pain relevance and then by number of times they were reported in PCNA-p21 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
2 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
3 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
4 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
5 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
6 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
7 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
8 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
9 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
10 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
11 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
12 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
13 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
14 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
15 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
16 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
17 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15
18 INT68952 Localization of PCNA 17 0.62 5.64 1.78
19 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
20 INT111485 Gene_expression of Pcna 2 0.75 0 0.83
21 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
22 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
23 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
24 INT111484 Positive_regulation of Gene_expression of Pcna 1 0.67 0 0.54
25 INT176264 Binding of PCNA 21 0.21 9.08 0.51
26 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
27 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
28 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
29 INT101568 Negative_regulation of Pcna 1 0.41 5.24 0.42
30 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
31 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
32 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
33 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
34 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
35 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
36 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
37 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
38 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
39 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
40 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19
41 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
42 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
43 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
44 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
45 INT256849 Regulation of Pcna 1 0.05 0.3 0.13
46 INT125588 Positive_regulation of Gene_expression of Pcna 5 0.49 1.57 0.11
47 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
48 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
49 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
50 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
51 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
52 INT269893 Negative_regulation of Gene_expression of Pcna 2 0.18 0.86 0.04
53 INT316430 Positive_regulation of Negative_regulation of Cdkn1a 1 0.19 1.24 0.04
54 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
55 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
56 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
57 INT176239 Regulation of Gene_expression of Pcna 1 0.04 0.58 0.03
58 INT176250 Positive_regulation of Pcna 6 0.13 3.52 0
59 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0
60 INT169956 Positive_regulation of Transcription of PCNA 2 0.10 0.09 0
61 INT271100 Regulation of Positive_regulation of CDKN1A 2 0.44 1.52 0
62 INT201643 Binding of Pcna 2 0.36 0 0
63 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0
64 INT233247 Transcription of Cdkn1a 1 0.39 0.26 0
65 INT277672 Localization of Cdkn1a 1 0.07 0.95 0
66 INT271087 Phosphorylation of Pcna 1 0.01 0.65 0
67 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0
68 INT114219 Positive_regulation of Pcna 1 0.06 0.45 0
69 INT201631 Localization of Pcna 1 0.01 0.5 0
70 INT282083 Regulation of Gene_expression of Cdkn1a 1 0.15 1.25 0
71 INT176244 Regulation of Pcna 1 0.02 0.31 0
72 INT234750 Regulation of Regulation of CDKN1A 1 0.09 0.45 0
73 INT225184 Positive_regulation of Binding of CDKN1A 1 0.43 0.87 0
74 INT277673 Positive_regulation of Localization of Cdkn1a 1 0.05 1.01 0
75 INT282089 Binding of Cdkn1a 1 0.12 0.36 0
76 INT252988 Negative_regulation of Binding of PCNA 1 0.06 1.25 0
77 INT288825 Positive_regulation of Binding of PCNA 1 0.06 1.29 0
78 INT250716 Positive_regulation of Transcription of CDKN1A 1 0.18 0.48 0
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