GO:0070576

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Name vitamin D 24-hydroxylase activity
Categary Function
Go Slim No
Go Link GO:0070576
Unique Molecular Interactions 80
Total Molecular Interactions 103
Total Single Events 1056
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vitamin D 24-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported for vitamin D 24-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
2 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
3 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
4 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
5 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
6 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
7 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
8 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
9 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
10 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
11 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
12 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
13 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
14 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
15 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
16 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
17 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
18 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
19 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
20 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
21 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
22 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
23 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
24 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
25 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
26 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
27 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
28 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
29 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
30 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
31 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
32 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
33 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
34 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
35 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
36 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
37 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
38 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
39 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
40 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
41 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
42 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
43 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
44 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
45 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
46 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
47 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
48 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
49 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
50 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
51 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
52 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
53 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
54 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
55 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
56 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
57 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
58 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
59 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
60 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
61 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
62 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
63 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
64 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
65 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
66 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
67 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
68 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vitamin D 24-hydroxylase activity. They are ordered first by their pain relevance and then by number of times they were reported in vitamin D 24-hydroxylase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
2 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
3 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
4 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
5 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
6 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
7 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
8 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
9 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
10 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
11 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
12 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
13 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
14 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
15 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
16 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
17 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
18 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
19 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
20 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
21 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
22 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
23 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
24 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
25 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
26 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
27 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
28 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
29 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
30 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
31 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
32 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
33 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
34 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
35 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
36 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
37 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
38 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
39 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
40 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
41 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
42 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
43 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
44 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
45 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
46 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
47 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
48 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
49 INT274054 Localization of CYP1A1 1 0.12 0 0.07
50 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
51 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
52 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
53 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
54 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
55 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
56 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
57 INT85223 Regulation of Localization of Cyp1a1 1 0.03 0.1 0
58 INT167111 Regulation of Binding of CYP1A1 1 0.43 0 0
59 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
60 INT197269 Regulation of Gene_expression of Cyp1a1 1 0.16 0 0
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