GO:0070670

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Name response to interleukin-4
Categary Process
Go Slim No
Go Link GO:0070670
Unique Molecular Interactions 52
Total Molecular Interactions 68
Total Single Events 453
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-4. They are ordered first by their pain relevance and then by number of times they were reported for response to interleukin-4. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
2 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
3 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
4 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
5 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
6 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
7 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
8 INT231751 Binding of Il2rg and Jak3 1 0.03 1.56 0.67
9 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
10 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
11 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
12 INT231750 LOC690550 Negative_regulation of Jak3 1 0.02 1.3 0.52
13 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
14 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
15 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41
16 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
17 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
18 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
19 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
20 INT170996 CCL11 Positive_regulation of SPARCL1 1 0.00 0.49 0.36
21 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
22 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
23 INT50107 Ei24 Positive_regulation of Localization of CTSB 3 0.00 0.6 0.29
24 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28
25 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26
26 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
27 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
28 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25
29 INT80292 IL4 Positive_regulation of Gene_expression of CCL11 1 0.05 0.37 0.23
30 INT80279 IFNG Positive_regulation of Gene_expression of CCL11 1 0.06 0.37 0.23
31 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 0.25 1.01 0.22
32 INT226346 Binding of IL21 and Positive_regulation of Positive_regulation of JAK3 1 0.08 0.48 0.18
33 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18
34 INT226541 BTPs Negative_regulation of CCL11 1 0.03 0.28 0.16
35 INT140648 Binding of CRP and CCL11 1 0.14 0.88 0.13
36 INT171645 Negative_regulation of CTSB Positive_regulation of PRSS1 1 0.44 0.36 0.1
37 INT171644 CTSB Positive_regulation of PRSS1 1 0.52 0.36 0.1
38 INT171648 Binding of CTSB and PRSS1 1 0.27 0.42 0.1
39 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
40 INT304100 Binding of CCL11 and Il13 1 0.05 0.86 0.08
41 INT62030 Bche Regulation of Localization of CTSB 1 0.09 0.15 0.06
42 INT304103 Il13 Positive_regulation of Gene_expression of CCL11 1 0.64 0.69 0.04
43 INT304101 Il13 Positive_regulation of CCL11 1 0.43 0.69 0.04
44 INT110967 REG1A Positive_regulation of Gene_expression of CTSB 1 0.01 0 0.04
45 INT354622 CTSB Regulation of PRDX5 1 0.00 0.38 0
46 INT342556 CCL11 Positive_regulation of Positive_regulation of EOE2 1 0.02 0.68 0
47 INT342552 Binding of MAPK1 and CCL11 1 0.05 1.07 0
48 INT342554 Positive_regulation of Binding of MAPK1 and CCL11 1 0.06 1.07 0
49 INT171647 CTSB Positive_regulation of NXF1 1 0.23 0.47 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to interleukin-4. They are ordered first by their pain relevance and then by number of times they were reported in response to interleukin-4. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
2 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
3 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83
4 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
5 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
6 INT50105 Localization of CTSB 29 0.78 10.98 5.21
7 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
8 INT158573 Negative_regulation of Jak3 3 0.43 8.2 3.99
9 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
10 INT145298 Gene_expression of Jak3 5 0.78 7.69 3.07
11 INT78702 Positive_regulation of CCL11 13 0.68 12.94 2.74
12 INT110980 Gene_expression of CTSB 17 0.45 8.02 2.69
13 INT152434 Localization of CCL11 6 0.78 9.47 2.68
14 INT73028 Positive_regulation of Transcription of Ctsb 1 0.55 1.53 2.54
15 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53
16 INT37427 Positive_regulation of Gene_expression of Ctsb 2 0.37 1.02 2.33
17 INT7173 Regulation of Positive_regulation of Ctsb 1 0.49 0 2.29
18 INT145297 Positive_regulation of Jak3 3 0.50 5.52 2.14
19 INT140650 Positive_regulation of Gene_expression of CCL11 10 0.68 5.43 2.08
20 INT50106 Positive_regulation of Localization of CTSB 9 0.33 3.15 1.69
21 INT278981 Negative_regulation of JAK3 5 0.46 2.12 1.69
22 INT73027 Transcription of Ctsb 1 0.56 1.01 1.68
23 INT78704 Binding of CCL11 10 0.37 11.38 1.44
24 INT42335 Binding of CTSB 11 0.34 5.98 1.37
25 INT226444 Negative_regulation of CCL11 3 0.41 2.32 1.12
26 INT20317 Localization of Ctsb 3 0.81 0.68 1.12
27 INT59136 Negative_regulation of Positive_regulation of CTSB 3 0.41 2.02 1.11
28 INT152435 Positive_regulation of Localization of CCL11 2 0.67 4.85 1.07
29 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97
30 INT226480 Positive_regulation of JAK3 4 0.45 0.96 0.95
31 INT7175 Negative_regulation of Positive_regulation of Ctsb 1 0.34 0 0.86
32 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
33 INT167942 Binding of Stat5b 1 0.26 0 0.82
34 INT79243 Negative_regulation of Localization of CTSB 2 0.57 1.35 0.73
35 INT71307 Regulation of CCL11 2 0.60 1.54 0.72
36 INT20318 Regulation of Ctsb 1 0.54 0.19 0.69
37 INT59137 Protein_catabolism of CTSB 5 0.96 3.92 0.62
38 INT171018 Negative_regulation of Gene_expression of CCL11 2 0.18 0.78 0.58
39 INT126367 Positive_regulation of Gene_expression of CTSB 3 0.04 1.57 0.52
40 INT193736 Regulation of Positive_regulation of CTSB 1 0.04 1.13 0.52
41 INT170980 Transcription of CCL11 2 0.19 0.86 0.49
42 INT237738 Positive_regulation of Gene_expression of Jak3 1 0.32 1.98 0.49
43 INT237739 Gene_expression of Jak3 1 0.44 1.97 0.48
44 INT345936 Regulation of JAK3 1 0.02 0.41 0.46
45 INT231744 Negative_regulation of Gene_expression of Jak3 1 0.32 0.9 0.43
46 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
47 INT71302 Regulation of Gene_expression of CCL11 2 0.44 3.59 0.37
48 INT171036 Negative_regulation of Localization of CCL11 1 0.15 0.45 0.37
49 INT278972 Regulation of Negative_regulation of JAK3 1 0.21 0.36 0.37
50 INT126366 Regulation of Binding of CTSB 1 0.01 0.31 0.28
51 INT140649 Positive_regulation of Binding of CCL11 1 0.49 1.38 0.27
52 INT328812 Binding of Jak3 1 0.24 0.33 0.26
53 INT293346 Binding of JAK3 1 0.12 0.34 0.26
54 INT328816 Regulation of Negative_regulation of Jak3 1 0.30 0.88 0.24
55 INT278139 Regulation of Jak3 1 0.06 0.97 0.22
56 INT278146 Localization of Jak3 1 0.35 0.97 0.22
57 INT45092 Positive_regulation of Localization of Ctsb 1 0.50 0 0.19
58 INT278142 Binding of Jak3 1 0.17 0.67 0.19
59 INT167940 Regulation of Stat5b 1 0.43 0 0.19
60 INT278141 Negative_regulation of Negative_regulation of Jak3 1 0.20 0.66 0.15
61 INT237736 Positive_regulation of Jak3 1 0.37 0.33 0.12
62 INT278140 Regulation of Negative_regulation of Jak3 1 0.21 0.43 0.11
63 INT278144 Positive_regulation of Negative_regulation of Jak3 1 0.23 0.55 0.11
64 INT226489 Protein_catabolism of CCL11 1 0.21 0.27 0.1
65 INT62029 Regulation of Localization of CTSB 2 0.05 0.21 0.09
66 INT228800 Regulation of Gene_expression of Jak3 1 0.13 0.29 0.09
67 INT55785 Negative_regulation of Localization of Ctsb 1 0.23 0.51 0.07
68 INT171654 Regulation of Regulation of CTSB 1 0.18 0.18 0
69 INT353174 Gene_expression of Stat5b 1 0.48 0 0
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